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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrrolidin-2-ones
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Accession:CHEBI:74223 term browser browse the term
Definition:A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.
Synonyms:related_synonym: 2-pyrrolidinones;   2-pyrrolidones;   Formula=C4NOR7;   SMILES=[*]N1C(=O)C([*])([*])C([*])([*])C1([*])[*];   pyrrolidine-2-ones


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(-)-cotinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of AGER gene CTD PMID:34009014 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor affects methylation ISO Cotinine affects the methylation of AHRR gene CTD PMID:22851337 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions 		ISO Cotinine results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein] 		CTD PMID:22687995 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bsg basigin multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of BSG gene CTD PMID:34009014 NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:22687995 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein] CTD PMID:22687995 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Cotinine results in increased expression of CCND1 protein CTD PMID:31678612 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein CTD PMID:29617909 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA CTD PMID:29617909 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
multiple interactions 		ISO CHRNA7 protein mutant form results in increased susceptibility to Cotinine
Cotinine binds to and results in increased activity of CHRNA7 protein 		CTD PMID:10082212 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858 		JBrowse link
G Cntnap2 contactin associated protein 2 affects methylation ISO Cotinine affects the methylation of CNTNAP2 gene CTD PMID:22851337 NCBI chr 4:75,109,358...77,366,258
Ensembl chr 4:75,109,858...77,366,258 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects methylation ISO Cotinine affects the methylation of CYP1A1 gene CTD PMID:22851337 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
decreases activity 		ISO Cotinine results in increased activity of CYP1A2 protein
Cotinine results in decreased activity of CYP1A2 protein 		CTD PMID:15916432 PMID:16203240 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases abundance
multiple interactions 		EXP CYP2B1 protein results in increased abundance of Cotinine
[Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine 		CTD PMID:10799646 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of Cotinine CTD PMID:12488541 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Dcx doublecortin multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of DCX mRNA CTD PMID:37914285 NCBI chr  X:112,227,455...112,370,291
Ensembl chr  X:112,227,455...112,304,161 		JBrowse link
G Dlgap2 DLG associated protein 2 multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of DLGAP2 gene CTD PMID:34009014 NCBI chr16:81,489,059...82,198,693
Ensembl chr16:81,494,649...82,198,684 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 affects methylation ISO Cotinine affects the methylation of EXT1 gene CTD PMID:22851337 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of FHIT gene CTD PMID:34009014 NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor affects methylation ISO Cotinine affects the methylation of GFI1 gene CTD PMID:22851337 NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,187,286...2,196,730 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA CTD PMID:29617909 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA CTD PMID:29617909 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of MAP2 mRNA CTD PMID:37914285 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK1 protein CTD PMID:31678612 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK3 protein CTD PMID:31678612 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Cotinine results in increased expression of MKI67 protein CTD PMID:31678612 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Myo1g myosin IG affects methylation ISO Cotinine affects the methylation of MYO1G gene CTD PMID:22851337 NCBI chr14:85,600,619...85,615,760
Ensembl chr14:85,600,619...85,615,760 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
affects abundance 		ISO [NAT1 gene SNP affects the susceptibility to Tobacco Smoke Pollution] which results in increased abundance of Cotinine; NAT1 gene polymorphism affects the reaction [Tobacco Smoke Pollution results in increased abundance of Cotinine]
NAT1 gene polymorphism affects the abundance of Cotinine 		CTD PMID:25156213 PMID:31809667 NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of PAX6 mRNA CTD PMID:37914285 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein CTD PMID:29617909 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of PRKG1 gene CTD PMID:34009014 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005 		JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of RBFOX3 mRNA CTD PMID:37914285 NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945 		JBrowse link
G Runx1 RUNX family transcription factor 1 affects methylation ISO Cotinine affects the methylation of RUNX1 gene CTD PMID:22851337 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein CTD PMID:29617909 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein CTD PMID:29617909 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA CTD PMID:29617909 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cotinine results in increased phosphorylation of STAT3 protein CTD PMID:31678612 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA CTD PMID:29617909 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ttc7b tetratricopeptide repeat domain 7B affects methylation ISO Cotinine affects the methylation of TTC7B gene CTD PMID:22851337 NCBI chr 6:125,317,011...125,528,843
Ensembl chr 6:125,316,789...125,528,779 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Cotinine CTD PMID:14570768 PMID:16141602 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Cotinine CTD PMID:16141602 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [NR1I2 protein affects the susceptibility to Pregnenolone Carbonitrile] which affects the abundance of Pyrrolidonecarboxylic Acid CTD PMID:38971454 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
aniracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of AKT1 protein CTD PMID:15287886 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased expression of BDNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased expression of BDNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased secretion of BDNF protein]; [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased expression of BDNF mRNA; [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased secretion of BDNF protein; U 0126 inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased expression of BDNF mRNA] CTD PMID:15287886 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of aniracetam CTD PMID:9300133 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of aniracetam CTD PMID:9300133 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of LYN protein CTD PMID:15287886 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK1 protein]; [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK1 protein; Wortmannin inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK1 protein] CTD PMID:15287886 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK3 protein]; [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK3 protein; Wortmannin inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK3 protein] CTD PMID:15287886 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of NTRK2 protein CTD PMID:15287886 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
doxapram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone increases expression EXP Doxapram results in increased expression of CRH mRNA; Doxapram results in increased expression of CRH protein CTD PMID:16269353 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Prl prolactin increases expression ISO Doxapram results in increased expression of PRL protein CTD PMID:15741000 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
levetiracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases transport
decreases activity 		EXP
ISO 		Amino Acids, Peptides, and Proteins inhibits the reaction [Levetiracetam results in increased expression of ABCB1 protein]
ABCB1A protein results in increased transport of Levetiracetam
Levetiracetam results in decreased activity of ABCB1 protein 		CTD PMID:17045309 PMID:18408562 PMID:18473823 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Levetiracetam results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Levetiracetam results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Acvrl1 activin A receptor like type 1 decreases expression EXP Levetiracetam results in decreased expression of ACVRL1 mRNA CTD PMID:20345932 NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305 		JBrowse link
G Amy1 amylase alpha 1 decreases activity EXP Levetiracetam results in decreased activity of AMY1 protein CTD PMID:37572749 NCBI chr 2:204,071,101...204,085,910
Ensembl chr 2:204,071,098...204,086,239 		JBrowse link
G Arhgef1 Rho guanine nucleotide exchange factor 1 decreases expression EXP Levetiracetam results in decreased expression of ARHGEF1 mRNA CTD PMID:20345932 NCBI chr 1:89,626,884...89,648,823
Ensembl chr 1:89,628,266...89,649,067 		JBrowse link
G Atg7 autophagy related 7 decreases expression
multiple interactions 		EXP Levetiracetam results in decreased expression of ATG7 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of ATG7 protein] 		CTD PMID:37098359 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		EXP Levetiracetam results in decreased expression of BCL2 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of BCL2 protein] 		CTD PMID:37098359 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 decreases expression EXP Levetiracetam results in decreased expression of CACNB1 mRNA CTD PMID:20345932 NCBI chr10:83,494,509...83,515,164
Ensembl chr10:83,494,509...83,515,146 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions 		EXP Levetiracetam results in increased activity of CASP3 protein
Quercetin inhibits the reaction [Levetiracetam results in increased activity of CASP3 protein] 		CTD PMID:37098359 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions
decreases expression 		ISO
EXP 		Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of CAT protein] 		CTD PMID:17205390 PMID:37098359 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnh cyclin H increases expression EXP Levetiracetam results in increased expression of CCNH mRNA CTD PMID:20345932 NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases activity
decreases expression 		ISO Levetiracetam results in increased activity of CHRM2 protein
Levetiracetam results in decreased expression of CHRM2 protein 		CTD PMID:15967574 NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression EXP Levetiracetam results in increased expression of CXCR3 mRNA CTD PMID:20345932 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:70,883,958...70,886,871 		JBrowse link
G Cycs cytochrome c, somatic increases expression
multiple interactions 		EXP Levetiracetam results in increased expression of CYCS protein
Quercetin inhibits the reaction [Levetiracetam results in increased expression of CYCS protein] 		CTD PMID:37098359 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Levetiracetam results in decreased expression of CYP17A1 mRNA CTD PMID:19566492 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Levetiracetam results in decreased expression of CYP19A1 mRNA CTD PMID:19566492 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Dao D-amino-acid oxidase increases expression EXP Levetiracetam results in increased expression of DAO mRNA CTD PMID:20345932 NCBI chr12:48,252,900...48,275,964
Ensembl chr12:48,252,902...48,273,300 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP Levetiracetam results in decreased expression of DBP mRNA CTD PMID:20345932 NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205 		JBrowse link
G Des desmin increases expression EXP Levetiracetam results in increased expression of DES mRNA CTD PMID:20345932 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression 		EXP Quercetin inhibits the reaction [Levetiracetam results in increased expression of GJA1 protein] CTD PMID:37098359 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gle1 GLE1 RNA export mediator increases expression EXP Levetiracetam results in increased expression of GLE1 mRNA CTD PMID:20345932 NCBI chr 3:33,607,160...33,638,879 JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity EXP Levetiracetam results in increased activity of GOT1 protein CTD PMID:37572749 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Levetiracetam results in increased activity of GPT protein CTD PMID:37572749 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
decreases expression
multiple interactions 		EXP Levetiracetam results in decreased activity of GPX1 protein
Levetiracetam results in decreased expression of GPX1 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of GPX1 protein] 		CTD PMID:37098359 PMID:37572749 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases expression EXP Levetiracetam results in decreased expression of HCN2 mRNA CTD PMID:20345932 NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:10,620,422...10,639,457 		JBrowse link
G Hdac10 histone deacetylase 10 decreases expression EXP Levetiracetam results in decreased expression of HDAC10 mRNA CTD PMID:20345932 NCBI chr 7:122,078,768...122,084,457
Ensembl chr 7:122,078,768...122,083,870 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Levetiracetam results in decreased expression of HMOX1 protein CTD PMID:37098359 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of HMOX2 protein] CTD PMID:37098359 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases expression ISO Levetiracetam results in decreased expression of HSD3B2 mRNA CTD PMID:19566492 NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases activity 		EXP Quercetin inhibits the reaction [Levetiracetam results in increased activity of IL1B protein] CTD PMID:37098359 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 increases expression EXP Levetiracetam results in increased expression of KCNA4 mRNA CTD PMID:20345932 NCBI chr 3:114,211,091...114,218,545
Ensembl chr 3:114,210,998...114,344,932 		JBrowse link
G Kctd3 potassium channel tetramerization domain containing 3 increases expression EXP Levetiracetam results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr13:103,041,488...103,080,069
Ensembl chr13:103,041,490...103,080,009 		JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 increases expression EXP Levetiracetam results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 9:41,943,029...42,449,687
Ensembl chr 9:41,943,050...42,412,905 		JBrowse link
G Lap3 leucine aminopeptidase 3 increases expression EXP Levetiracetam results in increased expression of LAP3 mRNA CTD PMID:20345932 NCBI chr14:69,820,907...69,839,891
Ensembl chr14:69,820,908...69,839,891 		JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated increases expression EXP Levetiracetam results in increased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr16:72,980,075...72,991,581
Ensembl chr16:72,979,686...73,022,396 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression 		EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of MTOR protein] CTD PMID:37098359 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nap1l2 nucleosome assembly protein 1-like 2 increases expression EXP Levetiracetam results in increased expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:72,239,849...72,242,247
Ensembl chr  X:72,238,310...72,242,464 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression 		EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NFE2L2 protein] CTD PMID:37098359 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Ngly1 N-glycanase 1 increases expression EXP Levetiracetam results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr15:11,584,475...11,640,977
Ensembl chr15:11,584,475...11,635,328 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
decreases expression 		EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NOX1 protein] CTD PMID:37098359 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression EXP Levetiracetam results in decreased expression of PHLDB1 mRNA CTD PMID:20345932 NCBI chr 8:53,900,338...53,948,325
Ensembl chr 8:53,900,338...53,949,518 		JBrowse link
G Pon1 paraoxonase 1 affects activity ISO Levetiracetam affects the activity of PON1 protein CTD PMID:28032682 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit increases expression EXP Levetiracetam results in increased expression of PRKX mRNA CTD PMID:20345932 NCBI chr  X:45,701,747...45,745,210
Ensembl chr  X:45,701,747...45,745,066 		JBrowse link
G Psip1 PC4 and SRSF1 interacting protein 1 increases expression EXP Levetiracetam results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 5:102,892,929...102,925,191
Ensembl chr 5:102,892,932...102,925,170 		JBrowse link
G Serinc1 serine incorporator 1 increases expression EXP Levetiracetam results in increased expression of SERINC1 mRNA CTD PMID:20345932 NCBI chr20:37,396,497...37,415,433
Ensembl chr20:37,396,497...37,443,124 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression EXP Levetiracetam results in increased expression of SLC23A2 mRNA CTD PMID:20345932 NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 increases expression EXP Levetiracetam results in increased expression of SLC4A7 mRNA CTD PMID:20345932 NCBI chr15:13,015,854...13,095,485
Ensembl chr15:13,015,854...13,095,292 		JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP Levetiracetam results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 5:71,592,428...71,648,636
Ensembl chr 5:71,602,308...71,648,632 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
multiple interactions
decreases expression 		EXP Levetiracetam results in decreased activity of SOD1 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of SOD1 protein] 		CTD PMID:37098359 PMID:37572749 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Levetiracetam results in decreased expression of STAR mRNA CTD PMID:19566492 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Tent2 terminal nucleotidyltransferase 2 increases expression EXP Levetiracetam results in increased expression of TENT2 mRNA CTD PMID:20345932 NCBI chr 2:26,115,150...26,167,465
Ensembl chr 2:26,115,240...26,167,113 		JBrowse link
G Tmt1b thiol methyltransferase 1B increases expression EXP Levetiracetam results in increased expression of TMT1B mRNA CTD PMID:20345932 NCBI chr 7:1,973,334...1,975,980
Ensembl chr 7:1,973,337...1,975,980 		JBrowse link
G Tnf tumor necrosis factor increases activity
multiple interactions 		EXP Levetiracetam results in increased activity of TNF protein
Quercetin inhibits the reaction [Levetiracetam results in increased activity of TNF protein] 		CTD PMID:37098359 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions 		EXP Levetiracetam results in increased activity of TP53 protein
Quercetin inhibits the reaction [Levetiracetam results in increased activity of TP53 protein] 		CTD PMID:37098359 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP Levetiracetam results in decreased expression of TRDMT1 mRNA CTD PMID:20345932 NCBI chr17:81,510,740...81,554,036
Ensembl chr17:81,521,200...81,577,639 		JBrowse link
G Vars2 valyl-tRNA synthetase 2, mitochondrial decreases expression EXP Levetiracetam results in decreased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr20:3,081,869...3,092,907
Ensembl chr20:3,081,893...3,092,901 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression EXP Levetiracetam results in decreased expression of XRCC1 mRNA CTD PMID:20345932 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613 		JBrowse link
G Zfp266 zinc finger protein 266 increases expression EXP Levetiracetam results in increased expression of ZFP266 mRNA CTD PMID:20345932 NCBI chr 8:27,307,015...27,338,624
Ensembl chr 8:27,307,015...27,320,143 		JBrowse link
N-Vinyl-2-pyrrolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of ABCC2 mRNA CTD PMID:22037397 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of ABCC3 mRNA CTD PMID:22037397 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of AKT1 mRNA CTD PMID:22037397 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of AKT2 mRNA CTD PMID:22037397 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of BCAR1 mRNA CTD PMID:22037397 NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190 		JBrowse link
G Capn1 calpain 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CAPN1 mRNA CTD PMID:22037397 NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CRK mRNA CTD PMID:22037397 NCBI chr10:61,028,736...61,054,971
Ensembl chr10:61,028,757...61,082,988 		JBrowse link
G Csnk1d casein kinase 1, delta multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK1D mRNA CTD PMID:22037397 NCBI chr10:106,713,497...106,754,953
Ensembl chr10:106,694,279...106,754,953 		JBrowse link
G Csnk1e casein kinase 1, epsilon multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK1E mRNA CTD PMID:22037397 NCBI chr 7:112,863,726...112,887,338
Ensembl chr 7:112,863,731...112,884,101 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK2A1 mRNA CTD PMID:22037397 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK2A2 mRNA CTD PMID:22037397 NCBI chr19:9,562,340...9,602,136
Ensembl chr19:9,562,321...9,602,136 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CYP2B1 mRNA CTD PMID:22037397 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CYP3A23-3A1 mRNA CTD PMID:22037397 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CYP3A9 mRNA CTD PMID:22037397 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of DDR1 mRNA CTD PMID:22037397 NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276 		JBrowse link
G Foxg1 forkhead box G1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of FOXG1 mRNA CTD PMID:22037397 NCBI chr 6:72,401,582...72,404,392
Ensembl chr 6:72,394,239...72,427,392 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of HDAC1 mRNA CTD PMID:22037397 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Ilk integrin-linked kinase multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of ILK mRNA CTD PMID:22037397 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of LEF1 mRNA CTD PMID:22037397 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of MDM2 mRNA CTD PMID:22037397 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of PIK3R2 mRNA CTD PMID:22037397 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of PPP2R1A mRNA CTD PMID:22037397 NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of SLC5A5 mRNA CTD PMID:22037397 NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691 		JBrowse link
G Tcf3 transcription factor 3 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TCF3 mRNA CTD PMID:22037397 NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,928,685...9,953,044 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TGFB1 mRNA CTD PMID:22037397 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TGFBR2 mRNA CTD PMID:22037397 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Tpo thyroid peroxidase multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TPO mRNA CTD PMID:22037397 NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TSHB protein CTD PMID:22037397 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of UGT2B1 mRNA CTD PMID:22037397 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331 		JBrowse link
G Wnt4 Wnt family member 4 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of WNT4 mRNA CTD PMID:22037397 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128 		JBrowse link
rolipram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions ISO Rolipram promotes the reaction [ADCYAP1 protein affects the secretion of Acids] CTD PMID:20388963 NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:120,550,328...120,556,383 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation 		EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Rolipram results in increased phosphorylation of AKT1 protein]; Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Rolipram inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:93,859,690...93,868,600
Ensembl chr11:93,859,690...93,868,480 		JBrowse link
G Areg amphiregulin increases expression ISO Rolipram results in increased expression of AREG mRNA CTD PMID:15284208 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein] CTD PMID:31161640 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein] CTD PMID:31161640 PMID:37431890 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression 		EXP Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]; Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]
Rolipram results in increased expression of BDNF mRNA 		CTD PMID:8601816 PMID:31161640 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Rolipram inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein] CTD PMID:37431890 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein] CTD PMID:31161640 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Rolipram inhibits the reaction [Oxygen results in increased expression of CCL2 protein] CTD PMID:18941502 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Rolipram inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Rolipram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:9863660 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression 		ISO PDE4D protein inhibits the reaction [Rolipram results in increased expression of CDH1 protein]
Rolipram results in increased expression of CDH1 mRNA; Rolipram results in increased expression of CDH1 protein 		CTD PMID:37020384 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP Rolipram promotes the reaction [FSHB protein results in increased expression of CEBPB protein] CTD PMID:25253736 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
decreases activity 		ISO Rolipram promotes the reaction [CFTR protein affects the secretion of Chlorides]
Rolipram results in increased activity of CFTR protein
Rolipram results in decreased activity of CFTR protein 		CTD PMID:12714375 PMID:15611099 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
increases expression 		EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]; Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Rolipram results in increased phosphorylation of CREB1 protein
Rolipram results in increased expression of CREB1 mRNA 		CTD PMID:8601816 PMID:10908723 PMID:18276108 PMID:31161640 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Rolipram results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]] CTD PMID:28859905 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Edn1 endothelin 1 increases activity EXP Rolipram results in increased activity of EDN1 protein CTD PMID:15464066 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Rolipram inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:73,164,096...73,175,180
Ensembl chr10:73,164,096...73,175,180 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP
ISO 		Rolipram promotes the reaction [FSHB protein results in increased expression of CEBPB protein]; Rolipram promotes the reaction [FSHB protein results in increased expression of STAR mRNA]
Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]]; Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] 		CTD PMID:25253736 PMID:28859905 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Rolipram results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 decreases expression
decreases secretion 		ISO Rolipram results in decreased expression of IL13 mRNA
Rolipram results in decreased secretion of IL13 protein 		CTD PMID:16083514 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]
Rolipram promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]
Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA] 		CTD PMID:8904084 PMID:16442096 PMID:18710439 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL6 protein]
Rolipram promotes the reaction [TNF protein results in increased expression of IL6 mRNA] 		CTD PMID:16442096 PMID:24771768 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein] CTD PMID:21457779 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rolipram results in decreased activity of KCNH2 protein CTD PMID:17146843 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Rolipram results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein] CTD PMID:35137321 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein] CTD PMID:35137321 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression 		ISO PDE4D protein inhibits the reaction [Rolipram results in decreased expression of MMP9 protein]
Rolipram results in decreased expression of MMP9 mRNA; Rolipram results in decreased expression of MMP9 protein 		CTD PMID:37020384 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP 		Rolipram inhibits the reaction [Picryl Chloride results in increased activity of MPO protein]
Rolipram inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Rolipram inhibits the reaction [Indomethacin results in increased activity of MPO protein] 		CTD PMID:14567935 PMID:16442096 PMID:18710439 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:18710439 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions 		EXP
ISO 		Rolipram results in increased expression of NTRK2 mRNA
Rolipram inhibits the reaction [NTRK2 protein binds to AP2M1 protein] 		CTD PMID:8601816 PMID:31631060 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Pde4a phosphodiesterase 4A multiple interactions
decreases activity 		ISO
EXP 		[Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA
Rolipram results in decreased activity of PDE4A protein 		CTD PMID:10763856 PMID:15922051 PMID:31195342 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924 		JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions
decreases activity 		ISO
EXP 		[Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA
Rolipram results in decreased activity of PDE4B protein
Rolipram inhibits the reaction [Manganese results in increased expression of PDE4B protein]
Rolipram inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] 		CTD PMID:10763856 PMID:20384571 PMID:31161640 PMID:31195342 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267 		JBrowse link
G Pde4d phosphodiesterase 4D decreases expression
multiple interactions 		ISO Rolipram results in decreased expression of PDE4D protein
PDE4D protein inhibits the reaction [Rolipram results in decreased expression of MMP9 protein]; PDE4D protein inhibits the reaction [Rolipram results in decreased expression of TIMP1 protein]; PDE4D protein inhibits the reaction [Rolipram results in decreased expression of VIM protein]; PDE4D protein inhibits the reaction [Rolipram results in increased expression of CDH1 protein] 		CTD PMID:37020384 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions EXP Rolipram affects the reaction [Colforsin results in increased activity of RAP1A protein] CTD PMID:10908723 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family multiple interactions EXP Rolipram affects the reaction [Colforsin results in increased activity of RAP1B protein] CTD PMID:10908723 NCBI chr 7:55,308,922...55,342,217
Ensembl chr 7:55,308,922...55,342,217 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 multiple interactions
increases expression 		EXP RAPGEF3 mutant form inhibits the reaction [Rolipram results in increased phosphorylation of AKT1 protein]
Rolipram results in increased expression of RAPGEF3 protein 		CTD PMID:18276108 NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:130,754,871...130,777,668 		JBrowse link
G Sele selectin E multiple interactions ISO [Colforsin co-treated with Rolipram] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein] CTD PMID:8780174 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Smad1 SMAD family member 1 decreases expression ISO Rolipram results in decreased expression of SMAD1 protein CTD PMID:37020384 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957 		JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Rolipram results in decreased expression of SMAD4 protein CTD PMID:37020384 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression 		ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]; [[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein; dorsomorphin inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]
Rolipram results in increased expression of SOCS3 protein 		CTD PMID:23782265 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 mRNA]; Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 protein] CTD PMID:18941502 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO 		Rolipram promotes the reaction [FSHB protein results in increased expression of STAR mRNA]
Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] 		CTD PMID:25253736 PMID:28859905 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion ISO Rolipram results in decreased secretion of TGFB1 protein CTD PMID:37020384 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions 		ISO Rolipram results in decreased expression of TIMP1 mRNA; Rolipram results in decreased expression of TIMP1 protein
PDE4D protein inhibits the reaction [Rolipram results in decreased expression of TIMP1 protein] 		CTD PMID:37020384 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression 		ISO
EXP 		Rolipram inhibits the reaction [[Lipopolysaccharides co-treated with deoxynivalenol] results in increased expression of TNF protein]
[Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein]; Rolipram inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Rolipram promotes the reaction [TNF protein results in increased expression of IL6 mRNA]
Rolipram results in decreased secretion of TNF protein
Rolipram results in decreased expression of TNF protein
Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of TNF mRNA] 		CTD PMID:8780174 PMID:8937731 PMID:9819297 PMID:11922776 PMID:15231041 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vim vimentin decreases expression
multiple interactions 		ISO Rolipram results in decreased expression of VIM protein
PDE4D protein inhibits the reaction [Rolipram results in decreased expression of VIM protein] 		CTD PMID:37020384 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19580
            nitrogen molecular entity 19598
              organonitrogen compound 19405
                organonitrogen heterocyclic compound 18530
                  pyrrolidines 2346
                    pyrrolidinone 194
                      pyrrolidin-2-ones 171
                        (-)-cotinine + 42
                        (1E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}prop-1-ene-1-sulfonamide 0
                        (2R)-N-hydroxy-2-[(3S)-3-methyl-3-\{4-[(2-methylquinolin-4-yl)methoxy]phenyl\}-2-oxopyrrolidin-1-yl]propanamide 0
                        (2S)-2-[(3S)-3-\{[(6-chloronaphthalen-2-yl)sulfonyl]amino\}-2-oxopyrrolidin-1-yl]-N-(1-methylethyl)-N-\{2-[(methylsulfonyl)amino]ethyl\}propanamide 0
                        (2S)-N-((1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-\{[(8S,11S)-8-[(1S)-1-methylpropyl]-7,10-dioxo-2-oxa-6,9-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-11-yl]amino\}propyl)-3-methyl-2-(2-oxopyrrolidin-1-yl)butanamide 0
                        (3S)-1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide 0
                        (3S)-3-[(2S)-2-amino-3-hydroxybutyl]pyrrolidin-2-one 0
                        (3S)-3-[(2S)-2-amino-3-oxobutyl]pyrrolidin-2-one 0
                        (3S)-3-[(2S)-2-amino-4-hydroxy-3-oxobutyl]pyrrolidin-2-one 0
                        (3S)-N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                        (3S)-N-(3-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                        (3S)-N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                        (3Z)-ravenic acid 0
                        (E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethenesulfonamide 0
                        (beta-D-glucosyl)-O-mycofactocinone + 0
                        1,5,5-trimethylpyrrolidin-2-one 0
                        1-(4-carboxy-2-guanidinophenyl)-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                        1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                        1-dodecylpyrrolidin-2-one 0
                        2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid 0
                        2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethanesulfonamide 0
                        3,3-diethyl-2-pyrrolidinone 0
                        3-(Dichloromethylene)-2,5-pyrrolidinedione 0
                        3-(\{[(2S)-5-oxopyrrolidin-2-yl]methyl\}sulfonyl)-N-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alanin[N-(1-cyanocyclopropyl)]amide 0
                        3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one 0
                        3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}-L-phenylalaninamide 0
                        3-nitro-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide 0
                        3-oxo-N-[(3S)-2-oxopyrrolidin-3-yl]dodecanamide 0
                        4-[(2R)-2-(aminomethyl)-2-(hydroxymethyl)-5-oxopyrrolidin-1-yl]-3-[(1-ethylpropyl)amino]benzoic acid 0
                        4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine 0
                        5-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-1,2,4-triazole-3-sulfonamide 0
                        5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one 0
                        5-\{[(2-amino-9H-purin-6-yl)oxy]methyl\}pyrrolidin-2-one 0
                        5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                        5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-indole-2-sulfonamide 0
                        5-cyclohexylmethyl-2-Pyrrolidinone 0
                        5-oxoproline + 3
                        5-oxopyrrolidine-2-carbaldehyde 0
                        6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                        6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}naphthalene-2-sulfonamide 0
                        Clonostalactam 0
                        Fischerellin B 0
                        N-(3-acetamidopropyl)pyrrolidin-2-one 0
                        N-(3-furoyl)-D-valyl-L-valyl-N-((1R,2Z)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-D-leucinamide 0
                        N-(tert-butoxycarbonyl)-L-seryl-L-valyl-N-\{(2S,3E)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                        N-Vinyl-2-pyrrolidone 30
                        N-[(2S)-3-cyclohexyl-1-oxo-1-(\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}amino)propan-2-yl]-1H-indole-2-carboxamide 0
                        N-[(3S,6R)-6-\{(S,E)-4-ethoxycarbonyl-1-[(S)-2-oxopyrrolidin-3-yl]but-3-en-2-ylcarbamoyl\}-2,9-dimethyl-4-oxodec-8-en-3-yl]-5-methylisoxazole-3-carboxamide 0
                        N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-\{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                        N-[(5-methylisoxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N(1)-((1S)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-L-leucinamide 0
                        N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-3-cyclohexyl-N-[(1S)-2-hydroxy-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}ethyl]-L-alaninamide 0
                        N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide 0
                        N-methylpyrrolidin-2-one 0
                        PF-00835231 + 0
                        PF-07304814 0
                        PHA-533533 0
                        Pericoannosin C 0
                        Pericoannosin D 0
                        Pericoannosin E 0
                        Pericoannosin F 0
                        Pterolactam 0
                        SG85 0
                        Salinazinone B 0
                        Spinoxazine A 0
                        Spinoxazine B 0
                        Sulfosuccinimidyl oleate 0
                        aniracetam 8
                        cotinine N-oxide 0
                        doxapram + 2
                        ethyl (2E,4S)-4-[((2R)-2-\{[N-(tert-butoxycarbonyl)-L-valyl]amino\}-2-phenylethanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate 0
                        ethyl (4R)-4-[((2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-\{[(5-methylisoxazol-3-yl)carbonyl]amino\}-4-oxoheptanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate 0
                        fradafiban + 0
                        gamma-Valerolactam 0
                        ivosidenib 0
                        lefradafiban 0
                        levetiracetam 59
                        lilaline 0
                        melophlin P 0
                        melophlin Q 0
                        melophlin R 0
                        melophlin S 0
                        nirmatrelvir + 0
                        premycofactocin + 0
                        pyranonigrin I 0
                        pyranonigrin J 0
                        pyrrolidin-2-one 0
                        rolapitant 0
                        rolipram + 51
                        sch 210971 0
                        sch 210972 + 0
                        sch 213766 0
                        tenuazonic acid 0
                        tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
                        trans-3-hydroxycotinine + 0
                        trans-3-hydroxycotinine beta-D-glucuronide 0
                        vibrioferrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20207
                              organochalcogen compound 19905
                                organooxygen compound 19807
                                  carbon oxoacid 19157
                                    carboxylic acid 19154
                                      carboacyl group 18089
                                        univalent carboacyl group 18071
                                          carbamoyl group 17906
                                            carboxamide 17925
                                              lactam 8432
                                                gamma-lactam 6682
                                                  pyrrolidin-2-ones 171
                                                    (-)-cotinine + 42
                                                    (1E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}prop-1-ene-1-sulfonamide 0
                                                    (2R)-N-hydroxy-2-[(3S)-3-methyl-3-\{4-[(2-methylquinolin-4-yl)methoxy]phenyl\}-2-oxopyrrolidin-1-yl]propanamide 0
                                                    (2S)-2-[(3S)-3-\{[(6-chloronaphthalen-2-yl)sulfonyl]amino\}-2-oxopyrrolidin-1-yl]-N-(1-methylethyl)-N-\{2-[(methylsulfonyl)amino]ethyl\}propanamide 0
                                                    (2S)-N-((1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-\{[(8S,11S)-8-[(1S)-1-methylpropyl]-7,10-dioxo-2-oxa-6,9-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-11-yl]amino\}propyl)-3-methyl-2-(2-oxopyrrolidin-1-yl)butanamide 0
                                                    (3S)-1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide 0
                                                    (3S)-3-[(2S)-2-amino-3-hydroxybutyl]pyrrolidin-2-one 0
                                                    (3S)-3-[(2S)-2-amino-3-oxobutyl]pyrrolidin-2-one 0
                                                    (3S)-3-[(2S)-2-amino-4-hydroxy-3-oxobutyl]pyrrolidin-2-one 0
                                                    (3S)-N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                                                    (3S)-N-(3-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                                                    (3S)-N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                                                    (3Z)-ravenic acid 0
                                                    (E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethenesulfonamide 0
                                                    (beta-D-glucosyl)-O-mycofactocinone + 0
                                                    1,5,5-trimethylpyrrolidin-2-one 0
                                                    1-(4-carboxy-2-guanidinophenyl)-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                                                    1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                                                    1-dodecylpyrrolidin-2-one 0
                                                    2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid 0
                                                    2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethanesulfonamide 0
                                                    3,3-diethyl-2-pyrrolidinone 0
                                                    3-(Dichloromethylene)-2,5-pyrrolidinedione 0
                                                    3-(\{[(2S)-5-oxopyrrolidin-2-yl]methyl\}sulfonyl)-N-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alanin[N-(1-cyanocyclopropyl)]amide 0
                                                    3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one 0
                                                    3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}-L-phenylalaninamide 0
                                                    3-nitro-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide 0
                                                    3-oxo-N-[(3S)-2-oxopyrrolidin-3-yl]dodecanamide 0
                                                    4-[(2R)-2-(aminomethyl)-2-(hydroxymethyl)-5-oxopyrrolidin-1-yl]-3-[(1-ethylpropyl)amino]benzoic acid 0
                                                    4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine 0
                                                    5-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-1,2,4-triazole-3-sulfonamide 0
                                                    5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one 0
                                                    5-\{[(2-amino-9H-purin-6-yl)oxy]methyl\}pyrrolidin-2-one 0
                                                    5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                                                    5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-indole-2-sulfonamide 0
                                                    5-cyclohexylmethyl-2-Pyrrolidinone 0
                                                    5-oxoproline + 3
                                                    5-oxopyrrolidine-2-carbaldehyde 0
                                                    6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                                                    6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}naphthalene-2-sulfonamide 0
                                                    Clonostalactam 0
                                                    Fischerellin B 0
                                                    N-(3-acetamidopropyl)pyrrolidin-2-one 0
                                                    N-(3-furoyl)-D-valyl-L-valyl-N-((1R,2Z)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-D-leucinamide 0
                                                    N-(tert-butoxycarbonyl)-L-seryl-L-valyl-N-\{(2S,3E)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                                                    N-Vinyl-2-pyrrolidone 30
                                                    N-[(2S)-3-cyclohexyl-1-oxo-1-(\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}amino)propan-2-yl]-1H-indole-2-carboxamide 0
                                                    N-[(3S,6R)-6-\{(S,E)-4-ethoxycarbonyl-1-[(S)-2-oxopyrrolidin-3-yl]but-3-en-2-ylcarbamoyl\}-2,9-dimethyl-4-oxodec-8-en-3-yl]-5-methylisoxazole-3-carboxamide 0
                                                    N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-\{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                                                    N-[(5-methylisoxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N(1)-((1S)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-L-leucinamide 0
                                                    N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-3-cyclohexyl-N-[(1S)-2-hydroxy-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}ethyl]-L-alaninamide 0
                                                    N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide 0
                                                    N-methylpyrrolidin-2-one 0
                                                    PF-00835231 + 0
                                                    PF-07304814 0
                                                    PHA-533533 0
                                                    Pericoannosin C 0
                                                    Pericoannosin D 0
                                                    Pericoannosin E 0
                                                    Pericoannosin F 0
                                                    Pterolactam 0
                                                    SG85 0
                                                    Salinazinone B 0
                                                    Spinoxazine A 0
                                                    Spinoxazine B 0
                                                    Sulfosuccinimidyl oleate 0
                                                    aniracetam 8
                                                    cotinine N-oxide 0
                                                    doxapram + 2
                                                    ethyl (2E,4S)-4-[((2R)-2-\{[N-(tert-butoxycarbonyl)-L-valyl]amino\}-2-phenylethanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate 0
                                                    ethyl (4R)-4-[((2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-\{[(5-methylisoxazol-3-yl)carbonyl]amino\}-4-oxoheptanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate 0
                                                    fradafiban + 0
                                                    gamma-Valerolactam 0
                                                    ivosidenib 0
                                                    lefradafiban 0
                                                    levetiracetam 59
                                                    lilaline 0
                                                    melophlin P 0
                                                    melophlin Q 0
                                                    melophlin R 0
                                                    melophlin S 0
                                                    nirmatrelvir + 0
                                                    premycofactocin + 0
                                                    pyranonigrin I 0
                                                    pyranonigrin J 0
                                                    pyrrolidin-2-one 0
                                                    rolapitant 0
                                                    rolipram + 51
                                                    sch 210971 0
                                                    sch 210972 + 0
                                                    sch 213766 0
                                                    tenuazonic acid 0
                                                    tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
                                                    trans-3-hydroxycotinine + 0
                                                    trans-3-hydroxycotinine beta-D-glucuronide 0
                                                    vibrioferrin 0
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