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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-threonine
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Accession:CHEBI:16857 term browser browse the term
Definition:An optically active form of threonine having L-configuration.
Synonyms:related_synonym: (2S)-threonine;   (2S,3R)-(-)-Threonine;   (2S,3R)-2-amino-3-hydroxybutanoic acid;   2-Amino-3-hydroxybutyric acid;   Formula=C4H9NO3;   InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1;   InChIKey=AYFVYJQAPQTCCC-GBXIJSLDSA-N;   L-2-Amino-3-hydroxybutyric acid;   L-Threonin;   L-alpha-amino-beta-hydroxybutyric acid;   SMILES=C[C@@H](O)[C@H](N)C(O)=O;   T;   THREONINE;   Thr
 alt_id: CHEBI:13175;   CHEBI:21403;   CHEBI:42083;   CHEBI:45843;   CHEBI:45983;   CHEBI:6308
 xref: Beilstein:1721646;   CAS:72-19-5;   DrugBank:DB00156;   Drug_Central:4254;   ECMDB:ECMDB00167;   Gmelin:82510;   HMDB:HMDB0000167;   KEGG:C00188;   KEGG:D00041;   KNApSAcK:C00001394
 xref_mesh: MESH:D013912
 xref: PDBeChem:THR;   PMID:11964235;   PMID:12523390;   PMID:16659349;   PMID:17379183;   PMID:22289691;   PMID:22342587;   PMID:22513921;   PMID:22770225;   PMID:24671569;   Reaxys:1721646;   UM-BBD_compID:c0413;   Wikipedia:Threonine;   YMDB:YMDB00214
 cyclic_relationship: is_conjugate_acid_of CHEBI:32820;   is_conjugate_base_of CHEBI:32822;   is_enantiomer_of CHEBI:16398;   is_tautomer_of CHEBI:57926


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L-threonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO [[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein] CTD PMID:26262998 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; [MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein] CTD PMID:26262998 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22221
    role 22206
      application 21789
        pharmaceutical 21202
          drug 21202
            nutraceutical 13758
              L-threonine 2
                Ala-Leu-Leu-Thr 0
                Ala-Leu-Thr-Gln 0
                Ala-Leu-Thr-Pro 0
                Ala-Phe-Thr-Ser 0
                Ala-Thr-Ala-Pro 0
                Arg-Thr-Cys-Cys 0
                Arg-Thr-Thr-Asp 0
                Asn-Met-Thr-Thr 0
                Asp-Leu-Thr-Asp 0
                Asp-Leu-Thr-Ser 0
                Asp-Met-Thr-Pro 0
                Asp-Thr 0
                Cys-Met-Thr-Tyr 0
                Glu-Arg-Gly-Met-Thr 0
                Glu-Thr 0
                Glu-Thr-Thr-Tyr 0
                Glu-Val-Thr-Leu-Tyr peptide residue 0
                Ile-Thr 0
                L-threonin-O(3)-yl group 0
                L-threonine derivative + 0
                L-threonine residue + 0
                L-threonino group 0
                L-threonyl group 0
                Leu-Thr 0
                Leu-Thr-Ala 0
                Leu-Thr-Asp 0
                Leu-Thr-Gln 0
                Leu-Thr-Ser 0
                Lys-Glu-Thr 0
                Lys-Thr 0
                Lys-Thr-Pro-Pro 0
                Lys-Thr-Trp-Tyr 0
                Met-Thr 0
                Phe-Arg-Thr 0
                Phe-Pro-Thr 0
                Phe-Thr 0
                Pro-Thr 0
                Ser-Thr 0
                Thr-Ala-Ala 0
                Thr-Ala-Asp 0
                Thr-Ala-His 0
                Thr-Ala-Ser 0
                Thr-Asn 0
                Thr-Asp-Gly 0
                Thr-His 0
                Thr-Ile 0
                Thr-Lys 0
                Thr-Pro 0
                Thr-Pro-Pro 0
                Thr-Pro-Tyr 0
                Thr-Ser 0
                Thr-Thr 0
                Thr-Thr-Asp 0
                Thr-Thr-Thr 0
                Thr-Trp 0
                Thr-Trp-Asp 0
                Thr-Tyr 0
                Trp-Thr 0
                Tyr-Thr 0
                delanzomib 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22221
    subatomic particle 22213
      composite particle 22213
        hadron 22213
          baryon 22213
            nucleon 22213
              atomic nucleus 22213
                atom 22213
                  main group element atom 22147
                    main group molecular entity 22147
                      s-block molecular entity 21742
                        hydrogen molecular entity 21658
                          hydrides 20788
                            inorganic hydride 18707
                              pnictogen hydride 18687
                                nitrogen hydride 18556
                                  azane 18462
                                    ammonia 18461
                                      organic amino compound 18461
                                        amino acid 16451
                                          alpha-amino acid 14249
                                            2-amino-3-hydroxybutanoic acid 2
                                              threonine 2
                                                L-threonine 2
                                                  Ala-Leu-Leu-Thr 0
                                                  Ala-Leu-Thr-Gln 0
                                                  Ala-Leu-Thr-Pro 0
                                                  Ala-Phe-Thr-Ser 0
                                                  Ala-Thr-Ala-Pro 0
                                                  Arg-Thr-Cys-Cys 0
                                                  Arg-Thr-Thr-Asp 0
                                                  Asn-Met-Thr-Thr 0
                                                  Asp-Leu-Thr-Asp 0
                                                  Asp-Leu-Thr-Ser 0
                                                  Asp-Met-Thr-Pro 0
                                                  Asp-Thr 0
                                                  Cys-Met-Thr-Tyr 0
                                                  Glu-Arg-Gly-Met-Thr 0
                                                  Glu-Thr 0
                                                  Glu-Thr-Thr-Tyr 0
                                                  Glu-Val-Thr-Leu-Tyr peptide residue 0
                                                  Ile-Thr 0
                                                  L-threonin-O(3)-yl group 0
                                                  L-threonine derivative + 0
                                                  L-threonine residue + 0
                                                  L-threonino group 0
                                                  L-threonyl group 0
                                                  Leu-Thr 0
                                                  Leu-Thr-Ala 0
                                                  Leu-Thr-Asp 0
                                                  Leu-Thr-Gln 0
                                                  Leu-Thr-Ser 0
                                                  Lys-Glu-Thr 0
                                                  Lys-Thr 0
                                                  Lys-Thr-Pro-Pro 0
                                                  Lys-Thr-Trp-Tyr 0
                                                  Met-Thr 0
                                                  Phe-Arg-Thr 0
                                                  Phe-Pro-Thr 0
                                                  Phe-Thr 0
                                                  Pro-Thr 0
                                                  Ser-Thr 0
                                                  Thr-Ala-Ala 0
                                                  Thr-Ala-Asp 0
                                                  Thr-Ala-His 0
                                                  Thr-Ala-Ser 0
                                                  Thr-Asn 0
                                                  Thr-Asp-Gly 0
                                                  Thr-His 0
                                                  Thr-Ile 0
                                                  Thr-Lys 0
                                                  Thr-Pro 0
                                                  Thr-Pro-Pro 0
                                                  Thr-Pro-Tyr 0
                                                  Thr-Ser 0
                                                  Thr-Thr 0
                                                  Thr-Thr-Asp 0
                                                  Thr-Thr-Thr 0
                                                  Thr-Trp 0
                                                  Thr-Trp-Asp 0
                                                  Thr-Tyr 0
                                                  Trp-Thr 0
                                                  Tyr-Thr 0
                                                  delanzomib 0
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