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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:otosenine
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Accession:CHEBI:136467 term browser browse the term
Definition:A pyrrolizine alkaloid that is produced by several Jacobaea and Senecio species.
Synonyms:exact_synonym: (1R,3'S,4S,6R,7R,11Z)-7-hydroxy-3',6,7,14-tetramethyl-3H,8H,17H-spiro[2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-4,2'-oxirane]-3,8,17-trione
 related_synonym: (-)-Octosenine;   Formula=C19H27NO7;   InChI=1S/C19H27NO7/c1-11-9-19(12(2)27-19)17(23)26-14-6-8-20(4)7-5-13(15(14)21)10-25-16(22)18(11,3)24/h5,11-12,14,24H,6-10H2,1-4H3/b13-5-/t11-,12+,14-,18-,19+/m1/s1;   InChIKey=CZQLULNMKQAIQL-GZSSMBGUSA-N;   Othosenin;   Othosenine;   SMILES=[C@@]12([C@H](C)O1)C(O[C@H]3C(C(=CCN(CC3)C)COC([C@]([C@@H](C2)C)(C)O)=O)=O)=O;   Tomentosine;   d-Otocenime;   d-Otosenine
 xref: AGR:IND605427552;   CAS:16958-29-5
 xref_mesh: MESH:C432462
 xref: PMID:11449528;   PMID:12182538;   PMID:17402047;   PMID:17404929;   PMID:17913058;   PMID:3210016;   PMID:4427963;   PMID:488324;   PMID:9581524;   Reaxys:4890096


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otosenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO otosenine results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        biochemical role 19598
          metabolite 19585
            alkaloid 8013
              pyrrolizine alkaloid 630
                otosenine 1
                  florosenine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                organic heterocyclic compound 18909
                                  organic heteromonocyclic compound 17831
                                    saturated organic heteromonocyclic parent 11295
                                      oxirane 11275
                                        epoxide 11274
                                          spiro-epoxide 25
                                            otosenine 1
                                              florosenine 0
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