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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiro-epoxide
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Accession:CHEBI:133131 term browser browse the term
Definition:An oxaspiro compound in which a carbon atom of an epoxide ring is the only common member of two rings.
Synonyms:related_synonym: spiro-epoxides;   spiroepoxide;   spiroepoxides


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fumagillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA] CTD PMID:15682466 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Metap1 methionyl aminopeptidase 1 decreases activity
multiple interactions
ISO fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293 NCBI chr 2:243,744,620...243,777,673
Ensembl chr 2:243,744,620...243,777,673
JBrowse link
G Metap2 methionyl aminopeptidase 2 multiple interactions
decreases activity
EXP
ISO
fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293, PMID:15516829, PMID:15682466 NCBI chr 7:34,762,241...34,789,456
Ensembl chr 7:34,762,231...34,789,479
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA] CTD PMID:15682466 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein CTD PMID:14534293 NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
JBrowse link
O-(chloroacetylcarbamoyl)fumagillol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CCND1 protein CTD PMID:15276080 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CDKN1A protein CTD PMID:15276080 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases expression
ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of FGF2 protein
O-(chloroacetylcarbamoyl)fumagillol results in decreased expression of FGF2 protein
CTD PMID:12576464 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of MMP9 protein CTD PMID:12576464 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein] CTD PMID:16061884 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO O-(chloroacetylcarbamoyl)fumagillol results in decreased phosphorylation of RB1 protein CTD PMID:15276080 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:17761372 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tp53 tumor protein p53 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of TP53 protein CTD PMID:15276080 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]
Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
CTD PMID:12235267 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Troleandomycin results in increased expression of CYP3A23-3A1 mRNA CTD PMID:12971794 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
decreases activity
ISO Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]
Troleandomycin results in decreased activity of CYP3A5 protein
CTD PMID:15557344, PMID:15731592 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Troleandomycin results in increased expression of FN1 mRNA CTD PMID:12971794 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Troleandomycin results in increased expression of GSTA2 mRNA CTD PMID:12971794 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Troleandomycin inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:12,918,352...12,922,509
Ensembl chr 7:12,918,710...12,922,112
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Troleandomycin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Troleandomycin inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        main group molecular entity 19672
          gas molecular entity 17546
            oxirane 5746
              epoxide 5744
                spiro-epoxide 23
                  (+)-flavipucine 0
                  (-)-flavipucine 0
                  14,15-dihydroajugapitin 0
                  14,15-dihydroclerodin 0
                  14-hydro-15-hydroxyajugachin A 0
                  14-hydro-15-hydroxyajugapitin 0
                  15-epi-lupulin B 0
                  15-hydroxyajubractin C 0
                  3-epi-14,15-dihydrocaryoptin 0
                  3-epi-caryoptin 0
                  6-(2,2,3-trimethylcyclopent-3-enyl)-1-oxaspiro[2.5]oct-5-ene 0
                  FR901464 0
                  FR901465 0
                  O-(chloroacetylcarbamoyl)fumagillol 10
                  Petasitenine 0
                  ajubractin A 0
                  ajubractin B 0
                  ajubractin C 0
                  ajubractin D 0
                  ajubractin E 0
                  ajugaciliatin H 0
                  ajugacumbin A 0
                  ajugalide B 0
                  ajugalide C 0
                  ajugamarin A1 0
                  ajugamarin A2 0
                  ajugamarin B1 0
                  ajugamarin G1 0
                  ajugamarin H1 0
                  ajuganipponin A 0
                  ajuganipponin B 0
                  ajugapantin A 0
                  ajugapitin 0
                  ajugatakasin A 0
                  ajugatakasin B 0
                  caryoptin 0
                  clerodin 0
                  coriatin 0
                  curvularol 0
                  florosenine 0
                  fumagillin + 5
                  fumagillol + 15
                  ivain II 0
                  jacobine N-oxide 0
                  jacozine + 0
                  jacozine N-oxide 0
                  oleandolide + 8
                  otosenine + 0
                  pentalenolactone 0
                  pentalenolactone F 0
                  streptolydigin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteromonocyclic compound 16445
                                    saturated organic heteromonocyclic parent 5779
                                      oxirane 5746
                                        epoxide 5744
                                          spiro-epoxide 23
                                            (+)-flavipucine 0
                                            (-)-flavipucine 0
                                            14,15-dihydroajugapitin 0
                                            14,15-dihydroclerodin 0
                                            14-hydro-15-hydroxyajugachin A 0
                                            14-hydro-15-hydroxyajugapitin 0
                                            15-epi-lupulin B 0
                                            15-hydroxyajubractin C 0
                                            3-epi-14,15-dihydrocaryoptin 0
                                            3-epi-caryoptin 0
                                            6-(2,2,3-trimethylcyclopent-3-enyl)-1-oxaspiro[2.5]oct-5-ene 0
                                            FR901464 0
                                            FR901465 0
                                            O-(chloroacetylcarbamoyl)fumagillol 10
                                            Petasitenine 0
                                            ajubractin A 0
                                            ajubractin B 0
                                            ajubractin C 0
                                            ajubractin D 0
                                            ajubractin E 0
                                            ajugaciliatin H 0
                                            ajugacumbin A 0
                                            ajugalide B 0
                                            ajugalide C 0
                                            ajugamarin A1 0
                                            ajugamarin A2 0
                                            ajugamarin B1 0
                                            ajugamarin G1 0
                                            ajugamarin H1 0
                                            ajuganipponin A 0
                                            ajuganipponin B 0
                                            ajugapantin A 0
                                            ajugapitin 0
                                            ajugatakasin A 0
                                            ajugatakasin B 0
                                            caryoptin 0
                                            clerodin 0
                                            coriatin 0
                                            curvularol 0
                                            florosenine 0
                                            fumagillin + 5
                                            fumagillol + 15
                                            ivain II 0
                                            jacobine N-oxide 0
                                            jacozine + 0
                                            jacozine N-oxide 0
                                            oleandolide + 8
                                            otosenine + 0
                                            pentalenolactone 0
                                            pentalenolactone F 0
                                            streptolydigin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.