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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiro-epoxide
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Accession:CHEBI:133131 term browser browse the term
Definition:An oxaspiro compound in which a carbon atom of an epoxide ring is the only common member of two rings.
Synonyms:related_synonym: spiro-epoxides;   spiroepoxide;   spiroepoxides



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fumagillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA] CTD PMID:15682466 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Metap1 methionyl aminopeptidase 1 decreases activity
multiple interactions
ISO fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293 NCBI chr 2:226,991,305...227,024,360
Ensembl chr 2:226,991,301...227,024,434
JBrowse link
G Metap2 methionyl aminopeptidase 2 multiple interactions
decreases activity
EXP
ISO
fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293 PMID:15516829 PMID:15682466 NCBI chr 7:28,412,771...28,440,458
Ensembl chr 7:28,411,608...28,440,434
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA] CTD PMID:15682466 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein CTD PMID:14534293 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
JBrowse link
O-(chloroacetylcarbamoyl)fumagillol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CCND1 protein CTD PMID:15276080 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CDKN1A protein CTD PMID:15276080 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases expression
ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of FGF2 protein
O-(chloroacetylcarbamoyl)fumagillol results in decreased expression of FGF2 protein
CTD PMID:12576464 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of MMP9 protein CTD PMID:12576464 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein] CTD PMID:16061884 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO O-(chloroacetylcarbamoyl)fumagillol results in decreased phosphorylation of RB1 protein CTD PMID:15276080 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:17761372 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tp53 tumor protein p53 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of TP53 protein CTD PMID:15276080 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
otosenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO otosenine results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]
Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
CTD PMID:12235267 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases expression
increases activity
ISO [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of N-desmethyltamoxifen; [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Tamoxifen; Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Fluoxetine]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of triflumuron]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Troleandomycin promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Troleandomycin results in increased expression of and results in increased activity of CYP3A4 protein
Troleandomycin results in increased expression of CYP3A4 mRNA
Troleandomycin results in increased activity of CYP3A4 protein
CTD PMID:1740010 PMID:2271712 PMID:9512926 PMID:9600717 PMID:11409940 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Troleandomycin results in increased expression of CYP3A23-3A1 mRNA CTD PMID:12971794 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
decreases activity
ISO Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]
Troleandomycin results in decreased activity of CYP3A5 protein
CTD PMID:15557344 PMID:15731592 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Troleandomycin results in increased expression of FN1 mRNA CTD PMID:12971794 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Troleandomycin results in increased expression of GSTA2 mRNA CTD PMID:12971794 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Troleandomycin inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Troleandomycin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Troleandomycin inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    chemical entity 20049
      molecular entity 20047
        main group molecular entity 19948
          gas molecular entity 18247
            oxirane 9778
              epoxide 9777
                spiro-epoxide 25
                  (+)-flavipucine 0
                  (-)-flavipucine 0
                  14,15-dihydroajugapitin 0
                  14,15-dihydroclerodin 0
                  14-hydro-15-hydroxyajugachin A 0
                  14-hydro-15-hydroxyajugapitin 0
                  15-epi-lupulin B 0
                  15-hydroxyajubractin C 0
                  3-epi-14,15-dihydrocaryoptin 0
                  3-epi-caryoptin 0
                  6-(2,2,3-trimethylcyclopent-3-enyl)-1-oxaspiro[2.5]oct-5-ene 0
                  FR901464 0
                  FR901465 0
                  O-(chloroacetylcarbamoyl)fumagillol 10
                  Petasitenine 0
                  ajubractin A 0
                  ajubractin B 0
                  ajubractin C 0
                  ajubractin D 0
                  ajubractin E 0
                  ajugaciliatin H 0
                  ajugacumbin A 0
                  ajugalide B 0
                  ajugalide C 0
                  ajugamarin A1 0
                  ajugamarin A2 0
                  ajugamarin B1 0
                  ajugamarin G1 0
                  ajugamarin H1 0
                  ajuganipponin A 0
                  ajuganipponin B 0
                  ajugapantin A 0
                  ajugapitin 0
                  ajugatakasin A 0
                  ajugatakasin B 0
                  caryoptin 0
                  clerodin 0
                  coriatin 0
                  curvularol 0
                  florosenine 0
                  fumagillin + 5
                  fumagillol + 15
                  ivain II 0
                  jacobine N-oxide 0
                  jacozine + 0
                  jacozine N-oxide 0
                  oleandolide + 9
                  otosenine + 1
                  pentalenolactone 0
                  pentalenolactone F 0
                  streptolydigin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  organic heteromonocyclic compound 17157
                                    saturated organic heteromonocyclic parent 9807
                                      oxirane 9778
                                        epoxide 9777
                                          spiro-epoxide 25
                                            (+)-flavipucine 0
                                            (-)-flavipucine 0
                                            14,15-dihydroajugapitin 0
                                            14,15-dihydroclerodin 0
                                            14-hydro-15-hydroxyajugachin A 0
                                            14-hydro-15-hydroxyajugapitin 0
                                            15-epi-lupulin B 0
                                            15-hydroxyajubractin C 0
                                            3-epi-14,15-dihydrocaryoptin 0
                                            3-epi-caryoptin 0
                                            6-(2,2,3-trimethylcyclopent-3-enyl)-1-oxaspiro[2.5]oct-5-ene 0
                                            FR901464 0
                                            FR901465 0
                                            O-(chloroacetylcarbamoyl)fumagillol 10
                                            Petasitenine 0
                                            ajubractin A 0
                                            ajubractin B 0
                                            ajubractin C 0
                                            ajubractin D 0
                                            ajubractin E 0
                                            ajugaciliatin H 0
                                            ajugacumbin A 0
                                            ajugalide B 0
                                            ajugalide C 0
                                            ajugamarin A1 0
                                            ajugamarin A2 0
                                            ajugamarin B1 0
                                            ajugamarin G1 0
                                            ajugamarin H1 0
                                            ajuganipponin A 0
                                            ajuganipponin B 0
                                            ajugapantin A 0
                                            ajugapitin 0
                                            ajugatakasin A 0
                                            ajugatakasin B 0
                                            caryoptin 0
                                            clerodin 0
                                            coriatin 0
                                            curvularol 0
                                            florosenine 0
                                            fumagillin + 5
                                            fumagillol + 15
                                            ivain II 0
                                            jacobine N-oxide 0
                                            jacozine + 0
                                            jacozine N-oxide 0
                                            oleandolide + 9
                                            otosenine + 1
                                            pentalenolactone 0
                                            pentalenolactone F 0
                                            streptolydigin 0
paths to the root