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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrrolizine alkaloid
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Accession:CHEBI:38521 term browser browse the term
Synonyms:related_synonym: pyrrolizine alkaloids

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riddelliine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP riddelliine results in increased expression of ABCB1 mRNA; riddelliine results in increased expression of ABCB1A mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 decreases expression EXP riddelliine results in decreased expression of ABCB9 mRNA CTD PMID:18047722 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP riddelliine results in increased expression of ABCC3 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 decreases expression EXP riddelliine results in decreased expression of ABCC8 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression EXP riddelliine results in decreased expression of ABCC9 mRNA CTD PMID:18047727 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424 		JBrowse link
G Adm adrenomedullin decreases expression EXP riddelliine results in decreased expression of ADM mRNA CTD PMID:18047727 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP riddelliine results in increased expression of AHR mRNA CTD PMID:18047727 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Atp13a5 ATPase 13A5 decreases expression EXP riddelliine results in decreased expression of ATP13A5 mRNA CTD PMID:18047722 NCBI chr11:74,984,538...75,124,249
Ensembl chr11:74,984,613...75,124,249 		JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP riddelliine results in increased expression of CES2 mRNA CTD PMID:18047722 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression EXP riddelliine results in increased expression of CXCR1 mRNA CTD PMID:18047727 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression EXP riddelliine results in increased expression of CYP26A1 mRNA CTD PMID:18047727 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP riddelliine results in decreased expression of CYP2C mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases expression EXP riddelliine results in increased expression of CYP2C12 mRNA CTD PMID:18047727 NCBI chr 1:258,709,726...258,766,873
Ensembl chr 1:258,709,721...258,766,881 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP riddelliine results in decreased expression of CYP2C13 mRNA CTD PMID:18047727 NCBI chr 1:258,796,624...258,877,023
Ensembl chr 1:258,796,622...258,877,045 		JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP riddelliine results in decreased expression of CYP2C22 mRNA CTD PMID:18047727 NCBI chr 1:259,257,658...259,297,270
Ensembl chr 1:259,257,657...259,287,684 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP riddelliine results in increased expression of CYP2E1 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 decreases expression EXP riddelliine results in decreased expression of CYP3A18 mRNA CTD PMID:18047727 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP riddelliine results in decreased expression of CYP3A2 mRNA CTD PMID:18047727 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP riddelliine results in increased expression of CYP3A9 mRNA CTD PMID:18047727 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 decreases expression EXP riddelliine results in decreased expression of CYP4A8 mRNA CTD PMID:18047727 NCBI chr 5:133,978,953...134,008,255
Ensembl chr 5:133,978,954...134,008,255 		JBrowse link
G Egr1 early growth response 1 increases expression EXP riddelliine results in increased expression of EGR1 mRNA CTD PMID:18047727 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression EXP riddelliine results in decreased expression of ENPP2 mRNA CTD PMID:18047727 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001 		JBrowse link
G F11r F11 receptor decreases expression EXP riddelliine results in decreased expression of F11R mRNA CTD PMID:18047727 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression EXP riddelliine results in decreased expression of F3 mRNA CTD PMID:18047727 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G F7 coagulation factor VII increases expression EXP riddelliine results in increased expression of F7 mRNA CTD PMID:18047727 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP riddelliine results in increased expression of FAS mRNA CTD PMID:18047727 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression EXP riddelliine results in increased expression of FMO5 mRNA CTD PMID:18047722 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP riddelliine results in increased expression of GSTA3 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP riddelliine results in decreased expression of GSTM1 mRNA CTD PMID:18047727 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP riddelliine results in decreased expression of GSTM2 mRNA CTD PMID:18047727 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP riddelliine results in increased expression of HGF mRNA CTD PMID:18047727 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP riddelliine results in increased expression of IGFBP1 mRNA CTD PMID:18047727 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP riddelliine results in increased expression of IGFBP2 mRNA CTD PMID:18047727 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789 		JBrowse link
G Il11 interleukin 11 increases expression EXP riddelliine results in increased expression of IL11 mRNA CTD PMID:18047727 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255 		JBrowse link
G Il15 interleukin 15 increases expression EXP riddelliine results in increased expression of IL15 mRNA CTD PMID:18047727 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594 		JBrowse link
G Il7 interleukin 7 decreases expression EXP riddelliine results in decreased expression of IL7 mRNA CTD PMID:18047727 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977 		JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP riddelliine results in decreased expression of INMT mRNA CTD PMID:18047722 NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231 		JBrowse link
G Itga4 integrin subunit alpha 4 increases expression EXP riddelliine results in increased expression of ITGA4 mRNA CTD PMID:18047727 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960 		JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression EXP riddelliine results in decreased expression of ITGA6 mRNA CTD PMID:18047727 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions
increases expression		 EXP riddelliine results in increased phosphorylation of and results in increased activity of KDR protein
riddelliine results in increased expression of KDR protein		 CTD PMID:12460743 PMID:15384251 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis ISO riddelliine results in increased mutagenesis of KRAS gene CTD PMID:13678655 PMID:20737008 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Lepr leptin receptor increases expression EXP riddelliine results in increased expression of LEPR mRNA CTD PMID:18047727 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression EXP riddelliine results in decreased expression of MMP7 mRNA CTD PMID:18047727 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP riddelliine results in increased expression of MT1A mRNA CTD PMID:18047727 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression EXP riddelliine results in decreased expression of MTHFD2 mRNA CTD PMID:18047727 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP riddelliine results in increased expression of NQO1 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression EXP riddelliine results in decreased expression of PPARG mRNA CTD PMID:18047727 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkca protein kinase C, alpha increases expression EXP riddelliine results in increased expression of PRKCA mRNA CTD PMID:18047727 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP riddelliine results in increased expression of PRKCZ mRNA CTD PMID:18047727 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421 		JBrowse link
G Ren renin increases expression EXP riddelliine results in increased expression of REN mRNA CTD PMID:18047727 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 decreases expression EXP riddelliine results in decreased expression of S1PR2 mRNA CTD PMID:18047727 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806 		JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases expression EXP riddelliine results in decreased expression of SLC13A5 mRNA CTD PMID:18047722 NCBI chr10:58,806,581...58,835,549
Ensembl chr10:58,810,058...58,834,538 		JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression EXP riddelliine results in decreased expression of SLC16A4 mRNA CTD PMID:18047722 NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP riddelliine results in decreased expression of SLC22A6 mRNA CTD PMID:18047722 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP riddelliine results in decreased expression of SLC22A8 mRNA CTD PMID:18047722 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slc25a21 solute carrier family 25 member 21 increases expression EXP riddelliine results in increased expression of SLC25A21 mRNA CTD PMID:18047722 NCBI chr 6:77,624,384...78,121,339
Ensembl chr 6:77,624,385...77,848,434 		JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP riddelliine results in decreased expression of SLC25A30 mRNA CTD PMID:18047722 NCBI chr15:57,811,612...57,834,173
Ensembl chr15:57,813,356...57,834,173 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression EXP riddelliine results in increased expression of SLC7A5 mRNA CTD PMID:18047727 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression EXP riddelliine results in increased expression of SRC mRNA CTD PMID:18047727 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP riddelliine results in decreased expression of SULT1C1 mRNA CTD PMID:18047722 NCBI chr 9:4,931,038...4,978,847
Ensembl chr 9:4,930,818...4,978,892 		JBrowse link
G Tgfa transforming growth factor alpha decreases expression EXP riddelliine results in decreased expression of TGFA mRNA CTD PMID:18047727 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP riddelliine results in decreased expression of TNF mRNA CTD PMID:18047727 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression EXP riddelliine results in increased expression of TNFSF10 mRNA CTD PMID:18047727 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tp53 tumor protein p53 increases expression
increases mutagenesis		 EXP
ISO		 riddelliine results in increased expression of TP53 protein
riddelliine results in increased mutagenesis of TRP53 gene		 CTD PMID:12460743 PMID:13678655 PMID:20737008 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
senecionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO senecionine results in decreased expression of ABCB11 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO senecionine results in decreased expression of ABCB1 mRNA CTD PMID:31606820 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP senecionine results in increased expression of ABCB1B mRNA CTD PMID:32419051 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO senecionine results in decreased expression of ABCB4 mRNA CTD PMID:31606820 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO senecionine results in increased expression of ABCC1 mRNA CTD PMID:31606820 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO senecionine results in decreased expression of ABCC2 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression		 EXP
ISO		 senecionine results in increased expression of ABCC3 mRNA
senecionine results in decreased expression of ABCC3 mRNA		 CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression ISO senecionine results in decreased expression of ABCC4 mRNA CTD PMID:31606820 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression ISO senecionine results in decreased expression of ABCC6 mRNA CTD PMID:26100227 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSL3 mRNA CTD PMID:26100227 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565 		JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSM3 mRNA CTD PMID:26100227 NCBI chr 1:189,514,504...189,541,233
Ensembl chr 1:189,514,553...189,541,224 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP senecionine results in increased expression of ADAM8 mRNA CTD PMID:32419051 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349 		JBrowse link
G Aff3 AF4/FMR2 family, member 3 decreases expression ISO senecionine results in decreased expression of AFF3 mRNA CTD PMID:26100227 NCBI chr 9:44,837,979...45,291,964
Ensembl chr 9:44,839,960...45,292,047 		JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression ISO senecionine results in decreased expression of AGXT mRNA CTD PMID:26100227 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP senecionine results in increased expression of ALDH1A1 mRNA CTD PMID:32419051 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO senecionine results in increased expression of ALDH6A1 mRNA CTD PMID:26100227 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 decreases expression ISO senecionine results in decreased expression of ALDH8A1 mRNA CTD PMID:26100227 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481 		JBrowse link
G Areg amphiregulin increases expression ISO senecionine results in increased expression of AREG mRNA CTD PMID:26100227 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179 		JBrowse link
G Arhgap11a Rho GTPase activating protein 11A increases expression EXP senecionine results in increased expression of ARHGAP11A mRNA CTD PMID:32419051 NCBI chr 3:105,281,827...105,298,108
Ensembl chr 3:105,281,827...105,298,108 		JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression EXP senecionine results in increased expression of ATAD2 mRNA CTD PMID:32419051 NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052 		JBrowse link
G Axin2 axin 2 decreases expression ISO senecionine results in decreased expression of AXIN2 mRNA CTD PMID:31606820 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression EXP
ISO		 senecionine results in decreased expression of BAAT mRNA CTD PMID:24641316 PMID:26100227 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO senecionine results in decreased expression of BCL2L1 protein CTD PMID:29458164 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp12 caspase 12 increases expression EXP senecionine results in increased expression of CASP12 mRNA CTD PMID:32419051 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP3 protein CTD PMID:29458164 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:29458164 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity ISO senecionine results in increased activity of CASP9 protein CTD PMID:29458164 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccna2 cyclin A2 increases expression EXP senecionine results in increased expression of CCNA2 mRNA CTD PMID:32419051 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccne2 cyclin E2 increases expression EXP senecionine results in increased expression of CCNE2 mRNA CTD PMID:32419051 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP senecionine results in increased expression of CCNG1 mRNA CTD PMID:32419051 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP senecionine results in increased expression of CDKN1A mRNA CTD PMID:32419051 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cenpq centromere protein Q increases expression EXP senecionine results in increased expression of CENPQ mRNA CTD PMID:32419051 NCBI chr 9:23,352,271...23,368,774 JBrowse link
G Cenpw centromere protein W increases expression EXP senecionine results in increased expression of CENPW mRNA CTD PMID:32419051 NCBI chr 1:29,915,443...29,920,598
Ensembl chr 1:29,915,443...29,920,598 		JBrowse link
G Ckap2 cytoskeleton associated protein 2 increases expression EXP senecionine results in increased expression of CKAP2 mRNA CTD PMID:32419051 NCBI chr16:74,752,655...74,779,184
Ensembl chr16:74,752,655...74,779,184 		JBrowse link
G Clec4f C-type lectin domain family 4, member F decreases expression EXP senecionine results in decreased expression of CLEC4F mRNA CTD PMID:32419051 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052 		JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases expression EXP senecionine results in decreased expression of CSF1R mRNA CTD PMID:32419051 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP11A1 mRNA CTD PMID:26100227 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1A1 mRNA CTD PMID:26100227 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression		 ISO senecionine results in increased expression of CYP1A2 mRNA
senecionine results in decreased expression of CYP1A2 mRNA		 CTD PMID:26100227 PMID:31606820 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1B1 mRNA CTD PMID:26100227 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO senecionine affects the expression of CYP2B10 mRNA CTD PMID:31606820 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO senecionine results in increased expression of CYP2B6 mRNA CTD PMID:26100227 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO senecionine results in decreased expression of CYP2C18 mRNA CTD PMID:26100227 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
decreases expression		 ISO senecionine results in increased expression of CYP2E1 mRNA
senecionine results in decreased expression of CYP2E1 mRNA		 CTD PMID:26100227 PMID:31606820 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression ISO senecionine results in increased expression of CYP3A43 mRNA CTD PMID:26100227 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO senecionine results in increased expression of CYP3A4 mRNA CTD PMID:26100227 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression ISO senecionine results in decreased expression of CYP3A5 mRNA CTD PMID:26100227 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO senecionine results in decreased expression of CYP4F12 mRNA CTD PMID:26100227 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP
ISO		 senecionine results in decreased expression of CYP7A1 mRNA CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO senecionine results in decreased expression of CYP8B1 mRNA CTD PMID:26100227 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Cyria CYFIP related Rac1 interactor A increases expression EXP senecionine results in increased expression of CYRIA mRNA CTD PMID:32419051 NCBI chr 6:37,555,167...37,661,196
Ensembl chr 6:37,555,182...37,665,064 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression EXP senecionine results in increased expression of DDIAS mRNA CTD PMID:32419051 NCBI chr 1:157,675,754...157,700,064
Ensembl chr 1:157,675,765...157,700,064 		JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO senecionine results in increased expression of DHRS2 mRNA CTD PMID:26100227 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO senecionine results in increased expression of DHRS9 mRNA CTD PMID:26100227 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325 		JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression EXP senecionine results in increased expression of DIAPH3 mRNA CTD PMID:32419051 NCBI chr15:69,928,507...70,400,077
Ensembl chr15:70,039,424...70,399,924 		JBrowse link
G Dlgap5 DLG associated protein 5 increases expression EXP senecionine results in increased expression of DLGAP5 mRNA CTD PMID:32419051 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO senecionine results in decreased expression of DPYD mRNA CTD PMID:26100227 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog increases expression EXP senecionine results in increased expression of DTL mRNA CTD PMID:32419051 NCBI chr13:110,219,276...110,257,345
Ensembl chr13:110,220,283...110,257,367 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression EXP senecionine results in increased expression of EDA2R mRNA CTD PMID:32419051 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO senecionine results in decreased expression of EPHX2 mRNA CTD PMID:26100227 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression EXP senecionine results in increased expression of ESCO2 mRNA CTD PMID:32419051 NCBI chr15:42,500,929...42,519,019
Ensembl chr15:42,500,929...42,518,855 		JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase decreases expression EXP senecionine results in decreased expression of ETHE1 mRNA CTD PMID:32419051 NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097 		JBrowse link
G Fancd2 FA complementation group D2 increases expression EXP senecionine results in increased expression of FANCD2 mRNA CTD PMID:32419051 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP		 senecionine metabolite results in increased expression of FAS mRNA
senecionine results in increased expression of FAS mRNA		 CTD PMID:30465738 PMID:32419051 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 decreases expression ISO senecionine results in decreased expression of FMO4 mRNA CTD PMID:26100227 NCBI chr13:80,685,385...80,703,575
Ensembl chr13:80,685,325...80,703,615 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases expression ISO senecionine results in decreased expression of FMO5 mRNA CTD PMID:26100227 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO senecionine results in increased expression of GEM mRNA CTD PMID:26100227 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661 		JBrowse link
G Gls glutaminase increases expression ISO senecionine results in increased expression of GLS mRNA CTD PMID:26100227 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872 		JBrowse link
G Glyat glycine-N-acyltransferase decreases expression ISO senecionine results in decreased expression of GLYAT mRNA CTD PMID:26100227 NCBI chr 1:229,060,125...229,081,113
Ensembl chr 1:229,063,714...229,080,410 		JBrowse link
G Gnmt glycine N-methyltransferase increases expression ISO senecionine results in increased expression of GNMT mRNA CTD PMID:26100227 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627 		JBrowse link
G Gphn gephyrin decreases expression ISO senecionine results in decreased expression of GPHN mRNA CTD PMID:26100227 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO senecionine results in increased expression of GPRC5A mRNA CTD PMID:26100227 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
increases expression
multiple interactions		 EXP
ISO		 senecionine results in increased activity of GPT protein
senecionine results in increased expression of GPT protein
POR protein affects the reaction [senecionine results in increased expression of GPT protein]		 CTD PMID:24641316 PMID:31606820 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP senecionine results in increased expression of GRIA3 mRNA CTD PMID:32419051 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO senecionine results in decreased expression of GSTA4 mRNA CTD PMID:26100227 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression ISO senecionine results in decreased expression of GSTT1 mRNA CTD PMID:26100227 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Gzma granzyme A decreases expression EXP senecionine results in decreased expression of GZMA mRNA CTD PMID:32419051 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458 		JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 increases expression EXP senecionine results in increased expression of HERC6 mRNA CTD PMID:32419051 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression EXP senecionine results in increased expression of HMMR mRNA CTD PMID:32419051 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639 		JBrowse link
G Hnmt histamine N-methyltransferase decreases expression ISO senecionine results in decreased expression of HNMT mRNA CTD PMID:26100227 NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression EXP senecionine results in increased expression of IFIT2 mRNA CTD PMID:32419051 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726 		JBrowse link
G Il11 interleukin 11 increases expression ISO senecionine metabolite results in increased expression of IL11 mRNA CTD PMID:30465738 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255 		JBrowse link
G Il17rd interleukin 17 receptor D increases expression EXP senecionine results in increased expression of IL17RD mRNA CTD PMID:32419051 NCBI chr16:2,670,471...2,737,271
Ensembl chr16:2,670,618...2,731,808 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO senecionine metabolite results in increased expression of IL1B mRNA CTD PMID:30465738 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP senecionine results in decreased expression of INMT mRNA CTD PMID:32419051 NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO senecionine results in increased expression of ISG20 mRNA CTD PMID:26100227 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946 		JBrowse link
G Jam3 junctional adhesion molecule 3 increases expression EXP senecionine results in increased expression of JAM3 mRNA CTD PMID:32419051 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466 		JBrowse link
G Kif11 kinesin family member 11 increases expression EXP senecionine results in increased expression of KIF11 mRNA CTD PMID:32419051 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299 		JBrowse link
G Kif18a kinesin family member 18A increases expression EXP senecionine results in increased expression of KIF18A mRNA CTD PMID:32419051 NCBI chr 3:100,366,168...100,426,867
Ensembl chr 3:100,366,168...100,427,030 		JBrowse link
G Kntc1 kinetochore associated 1 increases expression EXP senecionine results in increased expression of KNTC1 mRNA CTD PMID:32419051 NCBI chr12:38,200,463...38,274,162
Ensembl chr12:38,200,463...38,274,036 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases expression ISO senecionine results in decreased expression of KYAT1 mRNA CTD PMID:26100227 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP senecionine results in increased expression of LBP mRNA CTD PMID:32419051 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO senecionine results in increased expression of LCN2 mRNA CTD PMID:31606820 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 decreases expression ISO senecionine results in decreased expression of LGR5 mRNA CTD PMID:31606820 NCBI chr 7:58,447,097...58,587,787
Ensembl chr 7:58,448,277...58,587,787 		JBrowse link
G LOC100911204 protein CASC5-like increases expression EXP senecionine results in increased expression of KNL1 mRNA CTD PMID:32419051 NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression EXP senecionine results in increased expression of MAD2L1 mRNA CTD PMID:32419051 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO senecionine results in increased expression of MAFF mRNA CTD PMID:26100227 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095 		JBrowse link
G Maoa monoamine oxidase A decreases expression ISO senecionine results in decreased expression of MAOA mRNA CTD PMID:26100227 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Mastl microtubule associated serine/threonine kinase-like increases expression EXP senecionine results in increased expression of MASTL mRNA CTD PMID:32419051 NCBI chr17:89,839,562...89,875,855
Ensembl chr17:89,742,140...89,876,825 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP senecionine results in increased expression of MCM3 mRNA CTD PMID:32419051 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP senecionine results in increased expression of MCM5 mRNA CTD PMID:32419051 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP senecionine results in increased expression of MGMT mRNA CTD PMID:32419051 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP senecionine results in increased expression of MKI67 mRNA CTD PMID:32419051 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO senecionine results in increased expression of MMP1 mRNA CTD PMID:26100227 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO senecionine results in increased expression of MT2 mRNA CTD PMID:31606820 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression EXP senecionine results in increased expression of MYBL1 mRNA CTD PMID:32419051 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114 		JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression EXP senecionine results in increased expression of MYBL2 mRNA CTD PMID:32419051 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086 		JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression EXP senecionine results in increased expression of NCAPH mRNA CTD PMID:32419051 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136 		JBrowse link
G Ndc80 NDC80 kinetochore complex component increases expression EXP senecionine results in increased expression of NDC80 mRNA CTD PMID:32419051 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382 		JBrowse link
G Neb nebulin decreases expression ISO senecionine results in decreased expression of NEB mRNA CTD PMID:26100227 NCBI chr 3:37,658,081...37,855,843
Ensembl chr 3:37,658,563...37,854,561 		JBrowse link
G Nnmt nicotinamide N-methyltransferase decreases expression ISO senecionine results in decreased expression of NNMT mRNA CTD PMID:26100227 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO senecionine results in increased expression of NQO1 mRNA CTD PMID:26100227 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP
ISO		 senecionine results in decreased expression of NR0B2 mRNA CTD PMID:24641316 PMID:31606820 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP senecionine results in decreased expression of NR1H4 mRNA CTD PMID:24641316 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO senecionine results in decreased expression of NR1I3 mRNA CTD PMID:31606820 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP senecionine results in decreased expression of NR3C1 mRNA CTD PMID:32419051 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP senecionine results in increased expression of NRCAM mRNA CTD PMID:32419051 NCBI chr 6:64,297,843...64,867,408
Ensembl chr 6:64,297,888...64,864,996 		JBrowse link
G Nrg1 neuregulin 1 increases expression EXP senecionine results in increased expression of NRG1 mRNA CTD PMID:32419051 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression EXP senecionine results in increased expression of NUSAP1 mRNA CTD PMID:32419051 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO senecionine results in decreased expression of PARP1 protein CTD PMID:29458164 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pclaf PCNA clamp associated factor increases expression EXP senecionine results in increased expression of PCLAF mRNA CTD PMID:32419051 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182 		JBrowse link
G Plk4 polo-like kinase 4 increases expression EXP senecionine results in increased expression of PLK4 mRNA CTD PMID:32419051 NCBI chr 2:127,686,911...127,705,518
Ensembl chr 2:127,686,925...127,705,518 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
affects response to substance		 ISO POR protein affects the reaction [senecionine results in increased expression of GPT protein]
POR protein affects the susceptibility to senecionine		 CTD PMID:31606820 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP senecionine results in increased expression of PRC1 mRNA CTD PMID:32419051 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746 		JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO senecionine metabolite results in decreased expression of PTGIS mRNA; senecionine metabolite results in decreased expression of PTGIS protein CTD PMID:30465738 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO senecionine metabolite results in increased expression of PTGS2 mRNA; senecionine metabolite results in increased expression of PTGS2 protein CTD PMID:30465738 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO senecionine results in decreased expression of PTPRD mRNA CTD PMID:26100227 NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO senecionine results in decreased expression of RAPGEF4 mRNA CTD PMID:26100227 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO senecionine results in increased expression of RRAD mRNA CTD PMID:26100227 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression EXP senecionine results in increased expression of RRM1 mRNA CTD PMID:32419051 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO senecionine results in increased expression of SAT1 mRNA CTD PMID:26100227 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765 		JBrowse link
G Sgcb sarcoglycan, beta increases expression EXP senecionine results in increased expression of SGCB mRNA CTD PMID:32419051 NCBI chr14:37,113,194...37,128,623
Ensembl chr14:37,113,210...37,128,737 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP
ISO		 senecionine results in decreased expression of SLC10A1 mRNA CTD PMID:24641316 PMID:31606820 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression ISO senecionine results in decreased expression of SLC22A1 mRNA CTD PMID:31606820 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases expression ISO senecionine results in decreased expression of SLC22A9 mRNA CTD PMID:26100227 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO senecionine results in decreased expression of SLC22A7 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP senecionine results in decreased expression of SLCO1A2 mRNA CTD PMID:24641316 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP
ISO		 senecionine results in decreased expression of SLCO1B2 mRNA
senecionine results in decreased expression of SLCO1B3 mRNA		 CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP senecionine results in increased expression of SMC2 mRNA CTD PMID:32419051 NCBI chr 5:68,717,509...68,764,080
Ensembl chr 5:68,717,519...68,763,850 		JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression EXP senecionine results in increased expression of SMC4 mRNA CTD PMID:32419051 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415 		JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP senecionine results in decreased expression of STAC3 mRNA CTD PMID:32419051 NCBI chr 7:70,807,427...70,815,271
Ensembl chr 7:70,807,867...70,815,270 		JBrowse link
G Stil STIL, centriolar assembly protein increases expression EXP senecionine results in increased expression of STIL mRNA CTD PMID:32419051 NCBI chr 5:133,819,302...133,851,362
Ensembl chr 5:133,819,726...133,851,416 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP senecionine results in increased expression of STMN1 mRNA CTD PMID:32419051 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO senecionine results in decreased expression of SULT1E1 mRNA CTD PMID:26100227 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO senecionine results in decreased expression of SULT2A1 mRNA CTD PMID:31606820 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Tcf19 transcription factor 19 increases expression EXP senecionine results in increased expression of TCF19 mRNA CTD PMID:32419051 NCBI chr20:3,740,454...3,746,964
Ensembl chr20:3,744,395...3,746,964 		JBrowse link
G Tenm1 teneurin transmembrane protein 1 decreases expression ISO senecionine results in decreased expression of TENM1 mRNA CTD PMID:26100227 NCBI chr  X:129,034,755...129,336,023
NCBI chr  X:128,923,951...128,951,520 		JBrowse link
G Tenm2 teneurin transmembrane protein 2 decreases expression ISO senecionine results in decreased expression of TENM2 mRNA CTD PMID:26100227 NCBI chr10:20,846,091...21,791,771
Ensembl chr10:20,844,899...21,265,026 		JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP senecionine results in increased expression of TOP2A mRNA CTD PMID:32419051 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression ISO senecionine results in increased expression of TPMT mRNA CTD PMID:26100227 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor increases expression EXP senecionine results in increased expression of TPX2 mRNA CTD PMID:32419051 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187 		JBrowse link
G Ttk Ttk protein kinase increases expression EXP senecionine results in increased expression of TTK mRNA CTD PMID:32419051 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993 		JBrowse link
G Tyms thymidylate synthetase increases expression EXP senecionine results in increased expression of TYMS mRNA CTD PMID:32419051 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 increases expression ISO senecionine results in increased expression of UCHL3 mRNA CTD PMID:26100227 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glycosylation
multiple interactions		 ISO UGT1A4 protein results in increased glycosylation of senecionine
[hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine		 CTD PMID:20092275 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression ISO senecionine results in decreased expression of UGT2A3 mRNA CTD PMID:26100227 NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression ISO senecionine results in decreased expression of UGT2B1 mRNA CTD PMID:31606820 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B decreases expression ISO senecionine results in decreased expression of VPS13B mRNA CTD PMID:26100227 NCBI chr 7:74,118,834...74,722,341 JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP senecionine results in increased expression of ZFP367 mRNA CTD PMID:32419051 NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021 		JBrowse link
G Zwilch zwilch kinetochore protein increases expression EXP senecionine results in increased expression of ZWILCH mRNA CTD PMID:32419051 NCBI chr 8:69,089,449...69,121,420
Ensembl chr 8:69,091,955...69,121,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        biochemical role 19339
          metabolite 19319
            alkaloid 5366
              pyrrolizine alkaloid 214
                18-hydroxyjacobine 0
                acetylerucifoline 0
                acetylerucifoline N-oxide 0
                acetylseneciphylline 0
                acetylseneciphylline N-oxide 0
                dehydrojacoline 0
                dehydrojaconine 0
                desacetyldoronine 0
                erucifoline + 0
                erucifoline N-oxide 0
                floridanine 0
                florosenine 0
                jacobine + 0
                jacobine N-oxide 0
                jacoline + 0
                jacoline N-oxide 0
                jaconine + 0
                jaconine N-oxide 0
                jacozine + 0
                jacozine N-oxide 0
                onetine + 0
                otosenine + 0
                riddelliine + 64
                riddelliine N-oxide 0
                senecionan + 214
                seneciphylline + 0
                seneciphylline N-oxide 0
                senecivernine N-oxide 0
                spartioidine + 0
                spartioidine N-oxide 0
                usaramine N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organic heteropolycyclic compound 17883
                                    organic heterobicyclic compound 16814
                                      pyrrolizines 384
                                        pyrrolizine alkaloid 214
                                          18-hydroxyjacobine 0
                                          acetylerucifoline 0
                                          acetylerucifoline N-oxide 0
                                          acetylseneciphylline 0
                                          acetylseneciphylline N-oxide 0
                                          dehydrojacoline 0
                                          dehydrojaconine 0
                                          desacetyldoronine 0
                                          erucifoline + 0
                                          erucifoline N-oxide 0
                                          floridanine 0
                                          florosenine 0
                                          jacobine + 0
                                          jacobine N-oxide 0
                                          jacoline + 0
                                          jacoline N-oxide 0
                                          jaconine + 0
                                          jaconine N-oxide 0
                                          jacozine + 0
                                          jacozine N-oxide 0
                                          onetine + 0
                                          otosenine + 0
                                          riddelliine + 64
                                          riddelliine N-oxide 0
                                          senecionan + 214
                                          seneciphylline + 0
                                          seneciphylline N-oxide 0
                                          senecivernine N-oxide 0
                                          spartioidine + 0
                                          spartioidine N-oxide 0
                                          usaramine N-oxide 0
paths to the root