CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pyrrolizine alkaloid
Accession: CHEBI:38521
browse the term
Synonyms: related_synonym: pyrrolizine alkaloids
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
EXP
riddelliine results in increased expression of ABCB1 mRNA; riddelliine results in increased expression of ABCB1A mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcb9
ATP binding cassette subfamily B member 9
decreases expression
EXP
riddelliine results in decreased expression of ABCB9 mRNA
CTD
PMID:18047722
NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
riddelliine results in increased expression of ABCC3 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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Abcc8
ATP binding cassette subfamily C member 8
decreases expression
EXP
riddelliine results in decreased expression of ABCC8 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
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Abcc9
ATP binding cassette subfamily C member 9
decreases expression
EXP
riddelliine results in decreased expression of ABCC9 mRNA
CTD
PMID:18047727
NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
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Adm
adrenomedullin
decreases expression
EXP
riddelliine results in decreased expression of ADM mRNA
CTD
PMID:18047727
NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
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Ahr
aryl hydrocarbon receptor
increases expression
EXP
riddelliine results in increased expression of AHR mRNA
CTD
PMID:18047727
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Atp13a5
ATPase 13A5
decreases expression
EXP
riddelliine results in decreased expression of ATP13A5 mRNA
CTD
PMID:18047722
NCBI chr11:74,984,538...75,124,249
Ensembl chr11:74,984,613...75,124,249
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Ces2h
carboxylesterase 2H
increases expression
EXP
riddelliine results in increased expression of CES2 mRNA
CTD
PMID:18047722
NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
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Cxcr1
C-X-C motif chemokine receptor 1
increases expression
EXP
riddelliine results in increased expression of CXCR1 mRNA
CTD
PMID:18047727
NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
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Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
increases expression
EXP
riddelliine results in increased expression of CYP26A1 mRNA
CTD
PMID:18047727
NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression
EXP
riddelliine results in decreased expression of CYP2C mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
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Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
increases expression
EXP
riddelliine results in increased expression of CYP2C12 mRNA
CTD
PMID:18047727
NCBI chr 1:258,709,726...258,766,873
Ensembl chr 1:258,709,721...258,766,881
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Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
decreases expression
EXP
riddelliine results in decreased expression of CYP2C13 mRNA
CTD
PMID:18047727
NCBI chr 1:258,796,624...258,877,023
Ensembl chr 1:258,796,622...258,877,045
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Cyp2c22
cytochrome P450, family 2, subfamily c, polypeptide 22
decreases expression
EXP
riddelliine results in decreased expression of CYP2C22 mRNA
CTD
PMID:18047727
NCBI chr 1:259,257,658...259,297,270
Ensembl chr 1:259,257,657...259,287,684
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
riddelliine results in increased expression of CYP2E1 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Cyp3a18
cytochrome P450, family 3, subfamily a, polypeptide 18
decreases expression
EXP
riddelliine results in decreased expression of CYP3A18 mRNA
CTD
PMID:18047727
NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases expression
EXP
riddelliine results in decreased expression of CYP3A2 mRNA
CTD
PMID:18047727
NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
EXP
riddelliine results in increased expression of CYP3A9 mRNA
CTD
PMID:18047727
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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Cyp4a8
cytochrome P450, family 4, subfamily a, polypeptide 8
decreases expression
EXP
riddelliine results in decreased expression of CYP4A8 mRNA
CTD
PMID:18047727
NCBI chr 5:133,978,953...134,008,255
Ensembl chr 5:133,978,954...134,008,255
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Egr1
early growth response 1
increases expression
EXP
riddelliine results in increased expression of EGR1 mRNA
CTD
PMID:18047727
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
decreases expression
EXP
riddelliine results in decreased expression of ENPP2 mRNA
CTD
PMID:18047727
NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
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F11r
F11 receptor
decreases expression
EXP
riddelliine results in decreased expression of F11R mRNA
CTD
PMID:18047727
NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
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F3
coagulation factor III, tissue factor
decreases expression
EXP
riddelliine results in decreased expression of F3 mRNA
CTD
PMID:18047727
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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F7
coagulation factor VII
increases expression
EXP
riddelliine results in increased expression of F7 mRNA
CTD
PMID:18047727
NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
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Fas
Fas cell surface death receptor
increases expression
EXP
riddelliine results in increased expression of FAS mRNA
CTD
PMID:18047727
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Fmo5
flavin containing dimethylaniline monoxygenase 5
increases expression
EXP
riddelliine results in increased expression of FMO5 mRNA
CTD
PMID:18047722
NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
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Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
riddelliine results in increased expression of GSTA3 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 8:85,640,081...85,645,621
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Gstm1
glutathione S-transferase mu 1
decreases expression
EXP
riddelliine results in decreased expression of GSTM1 mRNA
CTD
PMID:18047727
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
riddelliine results in decreased expression of GSTM2 mRNA
CTD
PMID:18047727
NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
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Hgf
hepatocyte growth factor
increases expression
EXP
riddelliine results in increased expression of HGF mRNA
CTD
PMID:18047727
NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
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Igfbp1
insulin-like growth factor binding protein 1
increases expression
EXP
riddelliine results in increased expression of IGFBP1 mRNA
CTD
PMID:18047727
NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
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Igfbp2
insulin-like growth factor binding protein 2
increases expression
EXP
riddelliine results in increased expression of IGFBP2 mRNA
CTD
PMID:18047727
NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
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Il11
interleukin 11
increases expression
EXP
riddelliine results in increased expression of IL11 mRNA
CTD
PMID:18047727
NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
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Il15
interleukin 15
increases expression
EXP
riddelliine results in increased expression of IL15 mRNA
CTD
PMID:18047727
NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
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Il7
interleukin 7
decreases expression
EXP
riddelliine results in decreased expression of IL7 mRNA
CTD
PMID:18047727
NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
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Inmt
indolethylamine N-methyltransferase
decreases expression
EXP
riddelliine results in decreased expression of INMT mRNA
CTD
PMID:18047722
NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
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Itga4
integrin subunit alpha 4
increases expression
EXP
riddelliine results in increased expression of ITGA4 mRNA
CTD
PMID:18047727
NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
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Itga6
integrin subunit alpha 6
decreases expression
EXP
riddelliine results in decreased expression of ITGA6 mRNA
CTD
PMID:18047727
NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
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Kdr
kinase insert domain receptor
multiple interactions increases expression
EXP
riddelliine results in increased phosphorylation of and results in increased activity of KDR protein riddelliine results in increased expression of KDR protein
CTD
PMID:12460743 PMID:15384251
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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Kras
KRAS proto-oncogene, GTPase
increases mutagenesis
ISO
riddelliine results in increased mutagenesis of KRAS gene
CTD
PMID:13678655 PMID:20737008
NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
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Lepr
leptin receptor
increases expression
EXP
riddelliine results in increased expression of LEPR mRNA
CTD
PMID:18047727
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Mmp7
matrix metallopeptidase 7
decreases expression
EXP
riddelliine results in decreased expression of MMP7 mRNA
CTD
PMID:18047727
NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
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Mt1
metallothionein 1
increases expression
EXP
riddelliine results in increased expression of MT1A mRNA
CTD
PMID:18047727
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
decreases expression
EXP
riddelliine results in decreased expression of MTHFD2 mRNA
CTD
PMID:18047727
NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
riddelliine results in increased expression of NQO1 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Pparg
peroxisome proliferator-activated receptor gamma
decreases expression
EXP
riddelliine results in decreased expression of PPARG mRNA
CTD
PMID:18047727
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Prkca
protein kinase C, alpha
increases expression
EXP
riddelliine results in increased expression of PRKCA mRNA
CTD
PMID:18047727
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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Prkcz
protein kinase C, zeta
increases expression
EXP
riddelliine results in increased expression of PRKCZ mRNA
CTD
PMID:18047727
NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
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Ren
renin
increases expression
EXP
riddelliine results in increased expression of REN mRNA
CTD
PMID:18047727
NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
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S1pr2
sphingosine-1-phosphate receptor 2
decreases expression
EXP
riddelliine results in decreased expression of S1PR2 mRNA
CTD
PMID:18047727
NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
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Slc13a5
solute carrier family 13 member 5
decreases expression
EXP
riddelliine results in decreased expression of SLC13A5 mRNA
CTD
PMID:18047722
NCBI chr10:58,806,581...58,835,549
Ensembl chr10:58,810,058...58,834,538
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Slc16a4
solute carrier family 16, member 4
decreases expression
EXP
riddelliine results in decreased expression of SLC16A4 mRNA
CTD
PMID:18047722
NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502
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Slc22a6
solute carrier family 22 member 6
decreases expression
EXP
riddelliine results in decreased expression of SLC22A6 mRNA
CTD
PMID:18047722
NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
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Slc22a8
solute carrier family 22 member 8
decreases expression
EXP
riddelliine results in decreased expression of SLC22A8 mRNA
CTD
PMID:18047722
NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
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Slc25a21
solute carrier family 25 member 21
increases expression
EXP
riddelliine results in increased expression of SLC25A21 mRNA
CTD
PMID:18047722
NCBI chr 6:77,624,384...78,121,339
Ensembl chr 6:77,624,385...77,848,434
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Slc25a30
solute carrier family 25, member 30
decreases expression
EXP
riddelliine results in decreased expression of SLC25A30 mRNA
CTD
PMID:18047722
NCBI chr15:57,811,612...57,834,173
Ensembl chr15:57,813,356...57,834,173
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Slc7a5
solute carrier family 7 member 5
increases expression
EXP
riddelliine results in increased expression of SLC7A5 mRNA
CTD
PMID:18047727
NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
increases expression
EXP
riddelliine results in increased expression of SRC mRNA
CTD
PMID:18047727
NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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Sult1c3
sulfotransferase family 1C member 3
decreases expression
EXP
riddelliine results in decreased expression of SULT1C1 mRNA
CTD
PMID:18047722
NCBI chr 9:4,931,038...4,978,847
Ensembl chr 9:4,930,818...4,978,892
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Tgfa
transforming growth factor alpha
decreases expression
EXP
riddelliine results in decreased expression of TGFA mRNA
CTD
PMID:18047727
NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
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Tnf
tumor necrosis factor
decreases expression
EXP
riddelliine results in decreased expression of TNF mRNA
CTD
PMID:18047727
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tnfsf10
TNF superfamily member 10
increases expression
EXP
riddelliine results in increased expression of TNFSF10 mRNA
CTD
PMID:18047727
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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Tp53
tumor protein p53
increases expression increases mutagenesis
EXP ISO
riddelliine results in increased expression of TP53 protein riddelliine results in increased mutagenesis of TRP53 gene
CTD
PMID:12460743 PMID:13678655 PMID:20737008
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression
ISO
senecionine results in decreased expression of ABCB11 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression
ISO
senecionine results in decreased expression of ABCB1 mRNA
CTD
PMID:31606820
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcb1b
ATP-binding cassette, subfamily B (MDR/TAP), member 1B
increases expression
EXP
senecionine results in increased expression of ABCB1B mRNA
CTD
PMID:32419051
NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
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Abcb4
ATP binding cassette subfamily B member 4
decreases expression
ISO
senecionine results in decreased expression of ABCB4 mRNA
CTD
PMID:31606820
NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
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Abcc1
ATP binding cassette subfamily C member 1
increases expression
ISO
senecionine results in increased expression of ABCC1 mRNA
CTD
PMID:31606820
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Abcc2
ATP binding cassette subfamily C member 2
decreases expression
ISO
senecionine results in decreased expression of ABCC2 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcc3
ATP binding cassette subfamily C member 3
increases expression decreases expression
EXP ISO
senecionine results in increased expression of ABCC3 mRNA senecionine results in decreased expression of ABCC3 mRNA
CTD
PMID:24641316 PMID:26100227 PMID:31606820
NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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Abcc4
ATP binding cassette subfamily C member 4
decreases expression
ISO
senecionine results in decreased expression of ABCC4 mRNA
CTD
PMID:31606820
NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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Abcc6
ATP binding cassette subfamily C member 6
decreases expression
ISO
senecionine results in decreased expression of ABCC6 mRNA
CTD
PMID:26100227
NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
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Acsl3
acyl-CoA synthetase long-chain family member 3
decreases expression
ISO
senecionine results in decreased expression of ACSL3 mRNA
CTD
PMID:26100227
NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
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Acsm3
acyl-CoA synthetase medium-chain family member 3
decreases expression
ISO
senecionine results in decreased expression of ACSM3 mRNA
CTD
PMID:26100227
NCBI chr 1:189,514,504...189,541,233
Ensembl chr 1:189,514,553...189,541,224
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Adam8
ADAM metallopeptidase domain 8
increases expression
EXP
senecionine results in increased expression of ADAM8 mRNA
CTD
PMID:32419051
NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
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Aff3
AF4/FMR2 family, member 3
decreases expression
ISO
senecionine results in decreased expression of AFF3 mRNA
CTD
PMID:26100227
NCBI chr 9:44,837,979...45,291,964
Ensembl chr 9:44,839,960...45,292,047
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Agxt
alanine--glyoxylate and serine--pyruvate aminotransferase
decreases expression
ISO
senecionine results in decreased expression of AGXT mRNA
CTD
PMID:26100227
NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
senecionine results in increased expression of ALDH1A1 mRNA
CTD
PMID:32419051
NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
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Aldh6a1
aldehyde dehydrogenase 6 family, member A1
increases expression
ISO
senecionine results in increased expression of ALDH6A1 mRNA
CTD
PMID:26100227
NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
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Aldh8a1
aldehyde dehydrogenase 8 family, member A1
decreases expression
ISO
senecionine results in decreased expression of ALDH8A1 mRNA
CTD
PMID:26100227
NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
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Areg
amphiregulin
increases expression
ISO
senecionine results in increased expression of AREG mRNA
CTD
PMID:26100227
NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
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Arhgap11a
Rho GTPase activating protein 11A
increases expression
EXP
senecionine results in increased expression of ARHGAP11A mRNA
CTD
PMID:32419051
NCBI chr 3:105,281,827...105,298,108
Ensembl chr 3:105,281,827...105,298,108
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Atad2
ATPase family, AAA domain containing 2
increases expression
EXP
senecionine results in increased expression of ATAD2 mRNA
CTD
PMID:32419051
NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052
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Axin2
axin 2
decreases expression
ISO
senecionine results in decreased expression of AXIN2 mRNA
CTD
PMID:31606820
NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
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Baat
bile acid CoA:amino acid N-acyltransferase
decreases expression
EXP ISO
senecionine results in decreased expression of BAAT mRNA
CTD
PMID:24641316 PMID:26100227
NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
senecionine results in decreased expression of BCL2L1 protein
CTD
PMID:29458164
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
G
Casp12
caspase 12
increases expression
EXP
senecionine results in increased expression of CASP12 mRNA
CTD
PMID:32419051
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
G
Casp3
caspase 3
multiple interactions
ISO
senecionine results in increased activity of and results in increased cleavage of CASP3 protein
CTD
PMID:29458164
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp8
caspase 8
multiple interactions
ISO
senecionine results in increased activity of and results in increased cleavage of CASP8 protein
CTD
PMID:29458164
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
G
Casp9
caspase 9
increases activity
ISO
senecionine results in increased activity of CASP9 protein
CTD
PMID:29458164
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
G
Ccna2
cyclin A2
increases expression
EXP
senecionine results in increased expression of CCNA2 mRNA
CTD
PMID:32419051
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
G
Ccne2
cyclin E2
increases expression
EXP
senecionine results in increased expression of CCNE2 mRNA
CTD
PMID:32419051
NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
G
Ccng1
cyclin G1
increases expression
EXP
senecionine results in increased expression of CCNG1 mRNA
CTD
PMID:32419051
NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
EXP
senecionine results in increased expression of CDKN1A mRNA
CTD
PMID:32419051
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
G
Cenpq
centromere protein Q
increases expression
EXP
senecionine results in increased expression of CENPQ mRNA
CTD
PMID:32419051
NCBI chr 9:23,352,271...23,368,774
G
Cenpw
centromere protein W
increases expression
EXP
senecionine results in increased expression of CENPW mRNA
CTD
PMID:32419051
NCBI chr 1:29,915,443...29,920,598
Ensembl chr 1:29,915,443...29,920,598
G
Ckap2
cytoskeleton associated protein 2
increases expression
EXP
senecionine results in increased expression of CKAP2 mRNA
CTD
PMID:32419051
NCBI chr16:74,752,655...74,779,184
Ensembl chr16:74,752,655...74,779,184
G
Clec4f
C-type lectin domain family 4, member F
decreases expression
EXP
senecionine results in decreased expression of CLEC4F mRNA
CTD
PMID:32419051
NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052
G
Csf1r
colony stimulating factor 1 receptor
decreases expression
EXP
senecionine results in decreased expression of CSF1R mRNA
CTD
PMID:32419051
NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
ISO
senecionine results in increased expression of CYP11A1 mRNA
CTD
PMID:26100227
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
senecionine results in increased expression of CYP1A1 mRNA
CTD
PMID:26100227
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression decreases expression
ISO
senecionine results in increased expression of CYP1A2 mRNA senecionine results in decreased expression of CYP1A2 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
senecionine results in increased expression of CYP1B1 mRNA
CTD
PMID:26100227
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
affects expression
ISO
senecionine affects the expression of CYP2B10 mRNA
CTD
PMID:31606820
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
senecionine results in increased expression of CYP2B6 mRNA
CTD
PMID:26100227
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
G
Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
decreases expression
ISO
senecionine results in decreased expression of CYP2C18 mRNA
CTD
PMID:26100227
NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression decreases expression
ISO
senecionine results in increased expression of CYP2E1 mRNA senecionine results in decreased expression of CYP2E1 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
G
Cyp3a18
cytochrome P450, family 3, subfamily a, polypeptide 18
increases expression
ISO
senecionine results in increased expression of CYP3A43 mRNA
CTD
PMID:26100227
NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278
G
Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
increases expression
ISO
senecionine results in increased expression of CYP3A4 mRNA
CTD
PMID:26100227
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
decreases expression
ISO
senecionine results in decreased expression of CYP3A5 mRNA
CTD
PMID:26100227
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
G
Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
decreases expression
ISO
senecionine results in decreased expression of CYP4F12 mRNA
CTD
PMID:26100227
NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
EXP ISO
senecionine results in decreased expression of CYP7A1 mRNA
CTD
PMID:24641316 PMID:26100227 PMID:31606820
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO
senecionine results in decreased expression of CYP8B1 mRNA
CTD
PMID:26100227
NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
G
Cyria
CYFIP related Rac1 interactor A
increases expression
EXP
senecionine results in increased expression of CYRIA mRNA
CTD
PMID:32419051
NCBI chr 6:37,555,167...37,661,196
Ensembl chr 6:37,555,182...37,665,064
G
Ddias
DNA damage-induced apoptosis suppressor
increases expression
EXP
senecionine results in increased expression of DDIAS mRNA
CTD
PMID:32419051
NCBI chr 1:157,675,754...157,700,064
Ensembl chr 1:157,675,765...157,700,064
G
Dhrs2
dehydrogenase/reductase 2
increases expression
ISO
senecionine results in increased expression of DHRS2 mRNA
CTD
PMID:26100227
NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
G
Dhrs9
dehydrogenase/reductase 9
increases expression
ISO
senecionine results in increased expression of DHRS9 mRNA
CTD
PMID:26100227
NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
G
Diaph3
diaphanous-related formin 3
increases expression
EXP
senecionine results in increased expression of DIAPH3 mRNA
CTD
PMID:32419051
NCBI chr15:69,928,507...70,400,077
Ensembl chr15:70,039,424...70,399,924
G
Dlgap5
DLG associated protein 5
increases expression
EXP
senecionine results in increased expression of DLGAP5 mRNA
CTD
PMID:32419051
NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
G
Dpyd
dihydropyrimidine dehydrogenase
decreases expression
ISO
senecionine results in decreased expression of DPYD mRNA
CTD
PMID:26100227
NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
G
Dtl
denticleless E3 ubiquitin protein ligase homolog
increases expression
EXP
senecionine results in increased expression of DTL mRNA
CTD
PMID:32419051
NCBI chr13:110,219,276...110,257,345
Ensembl chr13:110,220,283...110,257,367
G
Eda2r
ectodysplasin A2 receptor
increases expression
EXP
senecionine results in increased expression of EDA2R mRNA
CTD
PMID:32419051
NCBI chr X:66,560,200...66,602,509
Ensembl chr X:66,561,286...66,602,506
G
Ephx2
epoxide hydrolase 2
decreases expression
ISO
senecionine results in decreased expression of EPHX2 mRNA
CTD
PMID:26100227
NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
G
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
increases expression
EXP
senecionine results in increased expression of ESCO2 mRNA
CTD
PMID:32419051
NCBI chr15:42,500,929...42,519,019
Ensembl chr15:42,500,929...42,518,855
G
Ethe1
ETHE1, persulfide dioxygenase
decreases expression
EXP
senecionine results in decreased expression of ETHE1 mRNA
CTD
PMID:32419051
NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097
G
Fancd2
FA complementation group D2
increases expression
EXP
senecionine results in increased expression of FANCD2 mRNA
CTD
PMID:32419051
NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
G
Fas
Fas cell surface death receptor
increases expression
ISO EXP
senecionine metabolite results in increased expression of FAS mRNA senecionine results in increased expression of FAS mRNA
CTD
PMID:30465738 PMID:32419051
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
G
Fmo4
flavin containing dimethylaniline monoxygenase 4
decreases expression
ISO
senecionine results in decreased expression of FMO4 mRNA
CTD
PMID:26100227
NCBI chr13:80,685,385...80,703,575
Ensembl chr13:80,685,325...80,703,615
G
Fmo5
flavin containing dimethylaniline monoxygenase 5
decreases expression
ISO
senecionine results in decreased expression of FMO5 mRNA
CTD
PMID:26100227
NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
G
Gem
GTP binding protein overexpressed in skeletal muscle
increases expression
ISO
senecionine results in increased expression of GEM mRNA
CTD
PMID:26100227
NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
G
Gls
glutaminase
increases expression
ISO
senecionine results in increased expression of GLS mRNA
CTD
PMID:26100227
NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
G
Glyat
glycine-N-acyltransferase
decreases expression
ISO
senecionine results in decreased expression of GLYAT mRNA
CTD
PMID:26100227
NCBI chr 1:229,060,125...229,081,113
Ensembl chr 1:229,063,714...229,080,410
G
Gnmt
glycine N-methyltransferase
increases expression
ISO
senecionine results in increased expression of GNMT mRNA
CTD
PMID:26100227
NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
G
Gphn
gephyrin
decreases expression
ISO
senecionine results in decreased expression of GPHN mRNA
CTD
PMID:26100227
NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
G
Gprc5a
G protein-coupled receptor, class C, group 5, member A
increases expression
ISO
senecionine results in increased expression of GPRC5A mRNA
CTD
PMID:26100227
NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
G
Gpt
glutamic--pyruvic transaminase
increases activity increases expression multiple interactions
EXP ISO
senecionine results in increased activity of GPT protein senecionine results in increased expression of GPT protein POR protein affects the reaction [senecionine results in increased expression of GPT protein]
CTD
PMID:24641316 PMID:31606820
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
G
Gria3
glutamate ionotropic receptor AMPA type subunit 3
increases expression
EXP
senecionine results in increased expression of GRIA3 mRNA
CTD
PMID:32419051
NCBI chr X:127,561,843...127,829,763
Ensembl chr X:127,562,660...127,829,753
G
Gsta4
glutathione S-transferase alpha 4
decreases expression
ISO
senecionine results in decreased expression of GSTA4 mRNA
CTD
PMID:26100227
NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
G
Gstt1
glutathione S-transferase theta 1
decreases expression
ISO
senecionine results in decreased expression of GSTT1 mRNA
CTD
PMID:26100227
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
G
Gzma
granzyme A
decreases expression
EXP
senecionine results in decreased expression of GZMA mRNA
CTD
PMID:32419051
NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
G
Herc6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
increases expression
EXP
senecionine results in increased expression of HERC6 mRNA
CTD
PMID:32419051
NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
G
Hmmr
hyaluronan-mediated motility receptor
increases expression
EXP
senecionine results in increased expression of HMMR mRNA
CTD
PMID:32419051
NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
G
Hnmt
histamine N-methyltransferase
decreases expression
ISO
senecionine results in decreased expression of HNMT mRNA
CTD
PMID:26100227
NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102
G
Ifit2
interferon-induced protein with tetratricopeptide repeats 2
increases expression
EXP
senecionine results in increased expression of IFIT2 mRNA
CTD
PMID:32419051
NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
G
Il11
interleukin 11
increases expression
ISO
senecionine metabolite results in increased expression of IL11 mRNA
CTD
PMID:30465738
NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
G
Il17rd
interleukin 17 receptor D
increases expression
EXP
senecionine results in increased expression of IL17RD mRNA
CTD
PMID:32419051
NCBI chr16:2,670,471...2,737,271
Ensembl chr16:2,670,618...2,731,808
G
Il1b
interleukin 1 beta
increases expression
ISO
senecionine metabolite results in increased expression of IL1B mRNA
CTD
PMID:30465738
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Inmt
indolethylamine N-methyltransferase
decreases expression
EXP
senecionine results in decreased expression of INMT mRNA
CTD
PMID:32419051
NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
G
Isg20
interferon stimulated exonuclease gene 20
increases expression
ISO
senecionine results in increased expression of ISG20 mRNA
CTD
PMID:26100227
NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
G
Jam3
junctional adhesion molecule 3
increases expression
EXP
senecionine results in increased expression of JAM3 mRNA
CTD
PMID:32419051
NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
G
Kif11
kinesin family member 11
increases expression
EXP
senecionine results in increased expression of KIF11 mRNA
CTD
PMID:32419051
NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
G
Kif18a
kinesin family member 18A
increases expression
EXP
senecionine results in increased expression of KIF18A mRNA
CTD
PMID:32419051
NCBI chr 3:100,366,168...100,426,867
Ensembl chr 3:100,366,168...100,427,030
G
Kntc1
kinetochore associated 1
increases expression
EXP
senecionine results in increased expression of KNTC1 mRNA
CTD
PMID:32419051
NCBI chr12:38,200,463...38,274,162
Ensembl chr12:38,200,463...38,274,036
G
Kyat1
kynurenine aminotransferase 1
decreases expression
ISO
senecionine results in decreased expression of KYAT1 mRNA
CTD
PMID:26100227
NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
G
Lbp
lipopolysaccharide binding protein
increases expression
EXP
senecionine results in increased expression of LBP mRNA
CTD
PMID:32419051
NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
G
Lcn2
lipocalin 2
increases expression
ISO
senecionine results in increased expression of LCN2 mRNA
CTD
PMID:31606820
NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
G
Lgr5
leucine rich repeat containing G protein coupled receptor 5
decreases expression
ISO
senecionine results in decreased expression of LGR5 mRNA
CTD
PMID:31606820
NCBI chr 7:58,447,097...58,587,787
Ensembl chr 7:58,448,277...58,587,787
G
LOC100911204
protein CASC5-like
increases expression
EXP
senecionine results in increased expression of KNL1 mRNA
CTD
PMID:32419051
NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634
G
Mad2l1
mitotic arrest deficient 2 like 1
increases expression
EXP
senecionine results in increased expression of MAD2L1 mRNA
CTD
PMID:32419051
NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
G
Maff
MAF bZIP transcription factor F
increases expression
ISO
senecionine results in increased expression of MAFF mRNA
CTD
PMID:26100227
NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
G
Maoa
monoamine oxidase A
decreases expression
ISO
senecionine results in decreased expression of MAOA mRNA
CTD
PMID:26100227
NCBI chr X:6,554,698...6,620,722
Ensembl chr X:6,554,698...6,620,722
G
Mastl
microtubule associated serine/threonine kinase-like
increases expression
EXP
senecionine results in increased expression of MASTL mRNA
CTD
PMID:32419051
NCBI chr17:89,839,562...89,875,855
Ensembl chr17:89,742,140...89,876,825
G
Mcm3
minichromosome maintenance complex component 3
increases expression
EXP
senecionine results in increased expression of MCM3 mRNA
CTD
PMID:32419051
NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
G
Mcm5
minichromosome maintenance complex component 5
increases expression
EXP
senecionine results in increased expression of MCM5 mRNA
CTD
PMID:32419051
NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
G
Mgmt
O-6-methylguanine-DNA methyltransferase
increases expression
EXP
senecionine results in increased expression of MGMT mRNA
CTD
PMID:32419051
NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
G
Mki67
marker of proliferation Ki-67
increases expression
EXP
senecionine results in increased expression of MKI67 mRNA
CTD
PMID:32419051
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
G
Mmp1
matrix metallopeptidase 1
increases expression
ISO
senecionine results in increased expression of MMP1 mRNA
CTD
PMID:26100227
NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
G
Mt2A
metallothionein 2A
increases expression
ISO
senecionine results in increased expression of MT2 mRNA
CTD
PMID:31606820
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
G
Mybl1
MYB proto-oncogene like 1
increases expression
EXP
senecionine results in increased expression of MYBL1 mRNA
CTD
PMID:32419051
NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
G
Mybl2
MYB proto-oncogene like 2
increases expression
EXP
senecionine results in increased expression of MYBL2 mRNA
CTD
PMID:32419051
NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
G
Ncaph
non-SMC condensin I complex, subunit H
increases expression
EXP
senecionine results in increased expression of NCAPH mRNA
CTD
PMID:32419051
NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
G
Ndc80
NDC80 kinetochore complex component
increases expression
EXP
senecionine results in increased expression of NDC80 mRNA
CTD
PMID:32419051
NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
G
Neb
nebulin
decreases expression
ISO
senecionine results in decreased expression of NEB mRNA
CTD
PMID:26100227
NCBI chr 3:37,658,081...37,855,843
Ensembl chr 3:37,658,563...37,854,561
G
Nnmt
nicotinamide N-methyltransferase
decreases expression
ISO
senecionine results in decreased expression of NNMT mRNA
CTD
PMID:26100227
NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
senecionine results in increased expression of NQO1 mRNA
CTD
PMID:26100227
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression
EXP ISO
senecionine results in decreased expression of NR0B2 mRNA
CTD
PMID:24641316 PMID:31606820
NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
decreases expression
EXP
senecionine results in decreased expression of NR1H4 mRNA
CTD
PMID:24641316
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
decreases expression
ISO
senecionine results in decreased expression of NR1I3 mRNA
CTD
PMID:31606820
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases expression
EXP
senecionine results in decreased expression of NR3C1 mRNA
CTD
PMID:32419051
NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
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Nrcam
neuronal cell adhesion molecule
increases expression
EXP
senecionine results in increased expression of NRCAM mRNA
CTD
PMID:32419051
NCBI chr 6:64,297,843...64,867,408
Ensembl chr 6:64,297,888...64,864,996
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Nrg1
neuregulin 1
increases expression
EXP
senecionine results in increased expression of NRG1 mRNA
CTD
PMID:32419051
NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
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Nusap1
nucleolar and spindle associated protein 1
increases expression
EXP
senecionine results in increased expression of NUSAP1 mRNA
CTD
PMID:32419051
NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
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Parp1
poly (ADP-ribose) polymerase 1
decreases expression
ISO
senecionine results in decreased expression of PARP1 protein
CTD
PMID:29458164
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pclaf
PCNA clamp associated factor
increases expression
EXP
senecionine results in increased expression of PCLAF mRNA
CTD
PMID:32419051
NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
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Plk4
polo-like kinase 4
increases expression
EXP
senecionine results in increased expression of PLK4 mRNA
CTD
PMID:32419051
NCBI chr 2:127,686,911...127,705,518
Ensembl chr 2:127,686,925...127,705,518
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Por
cytochrome p450 oxidoreductase
multiple interactions affects response to substance
ISO
POR protein affects the reaction [senecionine results in increased expression of GPT protein] POR protein affects the susceptibility to senecionine
CTD
PMID:31606820
NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
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Prc1
protein regulator of cytokinesis 1
increases expression
EXP
senecionine results in increased expression of PRC1 mRNA
CTD
PMID:32419051
NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
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Ptgis
prostaglandin I2 synthase
decreases expression
ISO
senecionine metabolite results in decreased expression of PTGIS mRNA; senecionine metabolite results in decreased expression of PTGIS protein
CTD
PMID:30465738
NCBI chr 3:163,950,746...163,986,129
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
senecionine metabolite results in increased expression of PTGS2 mRNA; senecionine metabolite results in increased expression of PTGS2 protein
CTD
PMID:30465738
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Ptprd
protein tyrosine phosphatase, receptor type, D
decreases expression
ISO
senecionine results in decreased expression of PTPRD mRNA
CTD
PMID:26100227
NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202
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Rapgef4
Rap guanine nucleotide exchange factor 4
decreases expression
ISO
senecionine results in decreased expression of RAPGEF4 mRNA
CTD
PMID:26100227
NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
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Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
increases expression
ISO
senecionine results in increased expression of RRAD mRNA
CTD
PMID:26100227
NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930
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Rrm1
ribonucleotide reductase catalytic subunit M1
increases expression
EXP
senecionine results in increased expression of RRM1 mRNA
CTD
PMID:32419051
NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
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Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
ISO
senecionine results in increased expression of SAT1 mRNA
CTD
PMID:26100227
NCBI chr X:43,626,480...43,629,767
Ensembl chr X:43,625,169...43,629,765
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Sgcb
sarcoglycan, beta
increases expression
EXP
senecionine results in increased expression of SGCB mRNA
CTD
PMID:32419051
NCBI chr14:37,113,194...37,128,623
Ensembl chr14:37,113,210...37,128,737
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Slc10a1
solute carrier family 10 member 1
decreases expression
EXP ISO
senecionine results in decreased expression of SLC10A1 mRNA
CTD
PMID:24641316 PMID:31606820
NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
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Slc22a1
solute carrier family 22 member 1
decreases expression
ISO
senecionine results in decreased expression of SLC22A1 mRNA
CTD
PMID:31606820
NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
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Slc22a25
solute carrier family 22, member 25
decreases expression
ISO
senecionine results in decreased expression of SLC22A9 mRNA
CTD
PMID:26100227
NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
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Slc22a7
solute carrier family 22 member 7
decreases expression
ISO
senecionine results in decreased expression of SLC22A7 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
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Slco1a4
solute carrier organic anion transporter family, member 1a4
decreases expression
EXP
senecionine results in decreased expression of SLCO1A2 mRNA
CTD
PMID:24641316
NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
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Slco1b2
solute carrier organic anion transporter family member 1B2
decreases expression
EXP ISO
senecionine results in decreased expression of SLCO1B2 mRNA senecionine results in decreased expression of SLCO1B3 mRNA
CTD
PMID:24641316 PMID:26100227 PMID:31606820
NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
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Smc2
structural maintenance of chromosomes 2
increases expression
EXP
senecionine results in increased expression of SMC2 mRNA
CTD
PMID:32419051
NCBI chr 5:68,717,509...68,764,080
Ensembl chr 5:68,717,519...68,763,850
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Smc4
structural maintenance of chromosomes 4
increases expression
EXP
senecionine results in increased expression of SMC4 mRNA
CTD
PMID:32419051
NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415
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Stac3
SH3 and cysteine rich domain 3
decreases expression
EXP
senecionine results in decreased expression of STAC3 mRNA
CTD
PMID:32419051
NCBI chr 7:70,807,427...70,815,271
Ensembl chr 7:70,807,867...70,815,270
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Stil
STIL, centriolar assembly protein
increases expression
EXP
senecionine results in increased expression of STIL mRNA
CTD
PMID:32419051
NCBI chr 5:133,819,302...133,851,362
Ensembl chr 5:133,819,726...133,851,416
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Stmn1
stathmin 1
increases expression
EXP
senecionine results in increased expression of STMN1 mRNA
CTD
PMID:32419051
NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
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Sult1e1
sulfotransferase family 1E member 1
decreases expression
ISO
senecionine results in decreased expression of SULT1E1 mRNA
CTD
PMID:26100227
NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
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Sult2a1
sulfotransferase family 2A member 1
decreases expression
ISO
senecionine results in decreased expression of SULT2A1 mRNA
CTD
PMID:31606820
NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
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Tcf19
transcription factor 19
increases expression
EXP
senecionine results in increased expression of TCF19 mRNA
CTD
PMID:32419051
NCBI chr20:3,740,454...3,746,964
Ensembl chr20:3,744,395...3,746,964
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Tenm1
teneurin transmembrane protein 1
decreases expression
ISO
senecionine results in decreased expression of TENM1 mRNA
CTD
PMID:26100227
NCBI chr X:129,034,755...129,336,023 NCBI chr X:128,923,951...128,951,520
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Tenm2
teneurin transmembrane protein 2
decreases expression
ISO
senecionine results in decreased expression of TENM2 mRNA
CTD
PMID:26100227
NCBI chr10:20,846,091...21,791,771
Ensembl chr10:20,844,899...21,265,026
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Top2a
DNA topoisomerase II alpha
increases expression
EXP
senecionine results in increased expression of TOP2A mRNA
CTD
PMID:32419051
NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
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Tpmt
thiopurine S-methyltransferase
increases expression
ISO
senecionine results in increased expression of TPMT mRNA
CTD
PMID:26100227
NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
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Tpx2
TPX2, microtubule nucleation factor
increases expression
EXP
senecionine results in increased expression of TPX2 mRNA
CTD
PMID:32419051
NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187
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Ttk
Ttk protein kinase
increases expression
EXP
senecionine results in increased expression of TTK mRNA
CTD
PMID:32419051
NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
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Tyms
thymidylate synthetase
increases expression
EXP
senecionine results in increased expression of TYMS mRNA
CTD
PMID:32419051
NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
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Uchl3
ubiquitin C-terminal hydrolase L3
increases expression
ISO
senecionine results in increased expression of UCHL3 mRNA
CTD
PMID:26100227
NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glycosylation multiple interactions
ISO
UGT1A4 protein results in increased glycosylation of senecionine [hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine
CTD
PMID:20092275
NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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Ugt2a3
UDP glucuronosyltransferase family 2 member A3
decreases expression
ISO
senecionine results in decreased expression of UGT2A3 mRNA
CTD
PMID:26100227
NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968
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Ugt2b17
UDP glucuronosyltransferase family 2 member B17
decreases expression
ISO
senecionine results in decreased expression of UGT2B1 mRNA
CTD
PMID:31606820
NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
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Vps13b
vacuolar protein sorting 13 homolog B
decreases expression
ISO
senecionine results in decreased expression of VPS13B mRNA
CTD
PMID:26100227
NCBI chr 7:74,118,834...74,722,341
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Zfp367
zinc finger protein 367
increases expression
EXP
senecionine results in increased expression of ZFP367 mRNA
CTD
PMID:32419051
NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
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Zwilch
zwilch kinetochore protein
increases expression
EXP
senecionine results in increased expression of ZWILCH mRNA
CTD
PMID:32419051
NCBI chr 8:69,089,449...69,121,420
Ensembl chr 8:69,091,955...69,121,192
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