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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:OSU-03012
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Accession:CHEBI:131196 term browser browse the term
Definition:A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.
Synonyms:exact_synonym: N-{4-[5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}glycinamide
 related_synonym: AR-12;   Formula=C26H19F3N4O;   InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34);   InChIKey=YULUCECVQOCQFQ-UHFFFAOYSA-N;   PDK1 inhibitor AR-12;   SMILES=C(=O)(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=4C(=C5C(=CC4)C=CC=C5)C=C3)C(F)(F)F)CN
 xref: CAS:742112-33-0
 xref_mesh: MESH:C500894
 xref: PMID:22354011;   PMID:23652278;   PMID:23706161;   PMID:25103559;   PMID:25267669;   PMID:25447826;   PMID:25482718;   PMID:25546329;   PMID:25689303;   PMID:25736380;   PMID:26419972;   PMID:26768723;   PMID:26787696;   PMID:26887051;   Reaxys:11001693;   Wikipedia:OSU-03012


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OSU-03012 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases response to substance		 ISO OSU 03012 results in decreased phosphorylation of AKT1 protein
AKT1 protein modified form results in decreased susceptibility to OSU 03012		 CTD PMID:15205346 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions
decreases response to substance		 ISO OSU 03012 binds to and results in decreased activity of PDPK1 protein
PDPK1 protein modified form results in decreased susceptibility to OSU 03012		 CTD PMID:15205346 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        xenobiotic 18737
          phenanthrenes 256
            OSU-03012 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        amino acid 15954
                                          alpha-amino acid 13872
                                            L-alpha-amino acid 12862
                                              serine family amino acid 5573
                                                glycine 3106
                                                  glycine derivative 3096
                                                    OSU-03012 2
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