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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfisoxazole
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Accession:CHEBI:102484 term browser browse the term
Definition:A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.
Synonyms:exact_synonym: 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide
 related_synonym: 3,4-Dimethyl-5-sulfanilamidoisoxazole;   3,4-Dimethyl-5-sulfonamidoisoxazole;   3,4-Dimethyl-5-sulphanilamidoisoxazole;   3,4-Dimethyl-5-sulphonamidoisoxazole;   3,4-Dimethylisoxazole-5-sulfanilamide;   3,4-Dimethylisoxazole-5-sulphanilamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide;   5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole;   5-Sulfanilamido-3,4-dimethylisoxazole;   5-Sulphanilamido-3,4-dimethyl-isoxazole;   Formula=C11H13N3O3S;   InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3;   InChIKey=NHUHCSRWZMLRLA-UHFFFAOYSA-N;   N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide;   SMILES=Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C;   Sulfadimethylisoxazole;   Sulfafurazol;   Sulfaisoxazole;   Sulfasoxazole;   Sulfisonazole;   Sulfisoxasole;   Sulfisoxazol;   Sulfofurazole;   Sulphadimethylisoxazole;   Sulphafurazol;   Sulphafurazole;   Sulphaisoxazole;   Sulphisoxazol;   Sulphofurazole;   sulfafurazole;   sulfafurazolum
 alt_id: CHEBI:9343
 xref: Beilstein:263871;   CAS:127-69-5;   DrugBank:DB00263;   Drug_Central:2529;   Gmelin:864477;   KEGG:C07318;   KEGG:D00450;   LINCS:LSM-3120
 xref_mesh: MESH:D013444
 xref: PMID:1861917;   PMID:4960234;   PMID:7356572;   Patent:US2430094;   Wikipedia:Sulfisoxazole


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sulfisoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein] CTD PMID:21280114 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO Sulfisoxazole results in increased expression of CYP3A4 mRNA
Sulfisoxazole results in increased expression of and results in increased activity of CYP3A4 protein		 CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfisoxazole decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Sulfisoxazole results in decreased activity of PON1 protein CTD PMID:28665493 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulfisoxazole results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        antimicrobial agent 18260
          sulfonamide antibiotic 2937
            sulfisoxazole 5
              sulfisoxazole diolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            inorganic hydride 18176
                              pnictogen hydride 18166
                                nitrogen hydride 18079
                                  azane 17886
                                    ammonia 17885
                                      organic amino compound 17885
                                        aromatic amine 15498
                                          anilines 14436
                                            substituted aniline 14067
                                              sulfanilamide 2932
                                                sulfisoxazole 5
                                                  sulfisoxazole diolamine 0
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