Angpt1 (angiopoietin 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Angpt1 (angiopoietin 1) Rattus norvegicus
Analyze
Symbol: Angpt1
Name: angiopoietin 1
RGD ID: 628896
Description: Enables identical protein binding activity. Involved in several processes, including liver regeneration; response to estrogen; and response to vitamin B3. Located in extracellular space. Biomarker of gastric ulcer; in situ carcinoma; myocardial infarction; nephrosis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in alcohol dependence; brain ischemia; diabetic retinopathy; hereditary angioedema; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1); PARTICIPATES IN angiopoietin signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Agpt; Agpt1; Ang-1; angiopoietin; angiopoietin-1; LOC360422
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8775,415,959 - 75,668,696 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl775,418,218 - 75,668,696 (-)EnsemblGRCr8
mRatBN7.2773,528,345 - 73,783,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl773,531,486 - 73,784,067 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx775,390,636 - 75,634,234 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0777,593,123 - 77,836,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0777,461,245 - 77,704,839 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0781,338,327 - 81,592,459 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl781,342,280 - 81,592,206 (-)Ensemblrn6Rnor6.0
Rnor_5.0781,364,881 - 81,618,559 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4778,195,504 - 78,451,471 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera770,543,119 - 70,792,915 (-)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP,ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
baicalin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ferric oxide  (EXP)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
iloprost  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-serine  (EXP)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (EXP)
nicotinic acid  (EXP,ISO)
nitrates  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD123319  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
poly(vinyl chloride)  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP)
rofecoxib  (ISO)
rotenone  (EXP)
roxarsone  (ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thiram  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of transmembrane receptor protein tyrosine kinase activity  (ISO)
angiogenesis  (IBA,IEA,ISO)
animal organ regeneration  (IEP)
blood coagulation  (IEA)
cell differentiation  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (ISO)
cell-substrate adhesion  (ISO)
glomerulus vasculature development  (IEA,IMP,ISO)
hemopoiesis  (ISO)
heparin proteoglycan biosynthetic process  (IEA,ISO)
in utero embryonic development  (ISO)
liver regeneration  (IEP)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of cell adhesion  (IEA,ISO)
negative regulation of cytokine production involved in immune response  (ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein import into nucleus  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (IEA,ISO)
negative regulation of vascular permeability  (IEA,ISO)
ovarian follicle development  (IMP)
positive chemotaxis  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of blood-brain barrier permeability  (IEA,ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of coagulation  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of receptor internalization  (IEA,ISO)
protein localization to cell surface  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of macrophage migration inhibitory factor signaling pathway  (ISO)
regulation of skeletal muscle satellite cell proliferation  (IEA,ISO)
regulation of tumor necrosis factor production  (ISO)
response to estrogen  (IEP)
response to hypoxia  (IEP)
response to vitamin B3  (IEP)
sprouting angiogenesis  (IEA,ISO)
Tie signaling pathway  (IBA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Ardelt AA, etal., Stroke. 2005 Feb;36(2):337-41. Epub 2005 Jan 6.
2. High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile. Baldewijns MM, etal., Br J Cancer. 2007 Jun 18;96(12):1888-95. Epub 2007 May 15.
3. Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Carswell HV, etal., Methods Mol Med 2005;104:49-74.
4. An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Chen G, etal., Addict Biol. 2017 Nov;22(6):1475-1485. doi: 10.1111/adb.12402. Epub 2016 May 5.
5. Niaspan increases angiogenesis and improves functional recovery after stroke. Chen J, etal., Ann Neurol. 2007 Jul;62(1):49-58.
6. Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock. Childs EW, etal., Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2285-95. Epub 2008 Mar 14.
7. A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1. Chu D, etal., Ann Thorac Surg. 2004 Feb;77(2):449-56; discussion 456-7.
8. Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle. Facchinetti MM and de Boland AR, Cell Signal. 1999 Jan;11(1):39-44.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Localized expression of angiopoietin 1 and 2 may explain unique characteristics of the rat testicular microvasculature. Haggstrom Rudolfsson S, etal., Biol Reprod 2003 Oct;69(4):1231-7. Epub 2003 May 28.
11. Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy. Hammes HP, etal., Diabetes. 2004 Apr;53(4):1104-10.
12. Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer. Hata K, etal., Oncology. 2002;62(4):340-8.
13. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. Hori S, etal., J Neurochem 2004 Apr;89(2):503-13.
14. Suppression of diabetic retinopathy with angiopoietin-1. Joussen AM, etal., Am J Pathol. 2002 May;160(5):1683-93.
15. AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. Kim JW, etal., Lab Invest. 2000 Apr;80(4):587-94.
16. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Kosacka J, etal., Cell Tissue Res. 2005 Apr;320(1):11-9. Epub 2005 Feb 16.
17. Vascular endothelial growth factor and angiopoietin in liver regeneration. Kraizer Y, etal., Biochem Biophys Res Commun 2001 Sep 14;287(1):209-15.
18. Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor. Lee JS, etal., Cardiovasc Res. 2008 Jun 1;78(3):572-80. Epub 2008 Feb 19.
19. Angiopoietins and Tie2 in health and disease. Li LY, etal., Pediatr Endocrinol Rev. 2005 Mar;2(3):399-408.
20. Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis. Lu YH, etal., Acta Pharmacol Sin. 2006 May;27(5):579-87.
21. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Machein MR, etal., Am J Pathol 2004 Nov;165(5):1557-70.
22. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. Madsen K, etal., J Am Soc Nephrol. 2010 Mar;21(3):448-59. doi: 10.1681/ASN.2009010045. Epub 2010 Jan 7.
23. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Mandriota SJ and Pepper MS, Circ Res 1998 Oct 19;83(8):852-9.
24. Effects of aspirin on intra-platelet vascular endothelial growth factor, angiopoietin-1, and p-selectin levels in hypertensive patients. Nadar S, etal., Am J Hypertens. 2006 Sep;19(9):970-7; discussion 978.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. Onda T, etal., J Cereb Blood Flow Metab. 2007 Jul 18;.
27. Intrabursal Administration of the Antiangiopoietin 1 Antibody Produces a Delay in Rat Follicular Development Associated with an Increase in Ovarian Apoptosis Mediated by Changes in the Expression of BCL2 Related Genes. Parborell F, etal., Biol Reprod. 2007 Nov 7;.
28. Expression of angiopoietin-1 and -2 in the rat brain during chronic hypoxia and de-adaptation. Pichiule P and LaManna JC, Adv Exp Med Biol 2003;510:331-5.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. Alteration of the vascular endothelial growth factor and angiopoietins-1 and -2 pathways in transitional cell carcinomas of the urinary bladder associated with tumor progression. Quentin T, etal., Anticancer Res. 2004 Sep-Oct;24(5A):2745-56.
31. Early effects of hypoxia/reoxygenation on VEGF, ang-1, ang-2 and their receptors in the rat myocardium: implications for myocardial angiogenesis. Ray PS, etal., Mol Cell Biochem. 2000 Oct;213(1-2):145-53.
32. The role of angiopoietins during angiogenesis in gliomas. Reiss Y, etal., Brain Pathol. 2005 Oct;15(4):311-7.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. Angiogenic factors in normal endometrium and endometrial adenocarcinoma. Saito M, etal., Pathol Int. 2007 Mar;57(3):140-7.
38. Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat. Sandhu R, etal., Cardiovasc Res. 2004 Oct 1;64(1):115-24.
39. Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats. Shimizu H, etal., World J Gastroenterol. 2005 Dec 14;11(46):7254-60.
40. Protective role of COMP-Ang1 in ischemic rat brain. Shin HY, etal., J Neurosci Res. 2009 Nov 2.
41. Antiangiogenic treatment with Sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Tugues S, etal., Hepatology. 2007 Dec;46(6):1919-26.
42. Postischemic angiogenic factor expression in stroke-prone rats. Wang MM, etal., Exp Neurol 2002 Feb;173(2):283-8.
43. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen CY, etal., J Gastroenterol. 2003;38(5):431-5.
44. The expression of angiopoietins and their receptor Tie-2 in human prostate carcinoma. Wurmbach JH, etal., Anticancer Res. 2000 Nov-Dec;20(6D):5217-20.
45. Downregulation of angiopoietin-1 and Tie2 in chronic hypoxic pulmonary hypertension. Yamamoto A, etal., Respiration. 2008;75(3):328-38. Epub 2007 Dec 10.
46. Expression of angiogenic factors is upregulated in DMBA-induced rat mammary pathologies. Yan M, etal., Pathobiology. 2004;71(5):253-60.
47. [The expression and significance of the angiopoietin-1 in the kidney of diabetic rats] Yang YB, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):93-6, 104.
48. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Ye F, etal., Steroids 2002 Mar;67(3-4):305-10.
49. Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. Zacharek A, etal., J Cereb Blood Flow Metab. 2007 Mar 14;.
Additional References at PubMed
PMID:8980223   PMID:8980224   PMID:9560344   PMID:9660821   PMID:9846489   PMID:10218485   PMID:10617467   PMID:11172728   PMID:11507774   PMID:12458684   PMID:12958144   PMID:14512515  
PMID:14966366   PMID:14978158   PMID:15260986   PMID:15851516   PMID:16493688   PMID:16762501   PMID:17559808   PMID:17562701   PMID:18272601   PMID:18425120   PMID:18471417   PMID:18497305  
PMID:18505784   PMID:18929864   PMID:18947490   PMID:19148554   PMID:19199708   PMID:19297368   PMID:19379779   PMID:19409199   PMID:19424712   PMID:19615361   PMID:19674970   PMID:19689429  
PMID:19712575   PMID:19733541   PMID:19821086   PMID:19922791   PMID:20060382   PMID:20860549   PMID:20969813   PMID:21701128   PMID:21704119   PMID:22336210   PMID:22336306   PMID:22374674  
PMID:22843181   PMID:22869617   PMID:22927341   PMID:23486192   PMID:23850469   PMID:24606182   PMID:24664592   PMID:25004887   PMID:25446117   PMID:25759532   PMID:27439004   PMID:27868196  
PMID:29197611   PMID:29774773   PMID:30729120   PMID:31581897   PMID:33820492  


Genomics

Comparative Map Data
Angpt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8775,415,959 - 75,668,696 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl775,418,218 - 75,668,696 (-)EnsemblGRCr8
mRatBN7.2773,528,345 - 73,783,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl773,531,486 - 73,784,067 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx775,390,636 - 75,634,234 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0777,593,123 - 77,836,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0777,461,245 - 77,704,839 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0781,338,327 - 81,592,459 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl781,342,280 - 81,592,206 (-)Ensemblrn6Rnor6.0
Rnor_5.0781,364,881 - 81,618,559 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4778,195,504 - 78,451,471 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera770,543,119 - 70,792,915 (-)NCBICelera
Cytogenetic Map7q31NCBI
ANGPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388107,249,482 - 107,497,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8107,249,482 - 107,498,055 (-)Ensemblhg38GRCh38
GRCh378108,261,710 - 108,510,146 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368108,330,886 - 108,579,430 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348108,330,885 - 108,579,430NCBI
Celera8104,448,513 - 104,696,524 (-)NCBICelera
Cytogenetic Map8q23.1NCBI
HuRef8103,581,813 - 103,830,178 (-)NCBIHuRef
CHM1_18108,301,960 - 108,550,507 (-)NCBICHM1_1
T2T-CHM13v2.08108,377,097 - 108,625,564 (-)NCBIT2T-CHM13v2.0
Angpt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391542,288,063 - 42,540,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1542,288,119 - 42,540,373 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381542,424,667 - 42,676,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1542,424,723 - 42,676,977 (-)Ensemblmm10GRCm38
MGSCv371542,256,269 - 42,508,341 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361542,254,797 - 42,506,869 (-)NCBIMGSCv36mm8
Celera1542,923,801 - 43,172,633 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1516.69NCBI
Angpt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541730,198,842 - 30,386,266 (-)Ensembl
ChiLan1.0NW_00495541730,199,508 - 30,386,695 (-)NCBIChiLan1.0ChiLan1.0
ANGPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27124,617,718 - 124,863,319 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18100,139,400 - 100,383,799 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08103,893,234 - 104,137,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18106,039,873 - 106,287,245 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8106,042,041 - 106,286,783 (-)EnsemblpanPan2panpan1.1
ANGPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1138,068,920 - 8,312,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl138,048,205 - 8,311,618 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha138,012,976 - 8,253,361 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0138,330,622 - 8,573,873 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl138,330,895 - 8,573,753 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1138,089,554 - 8,329,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,207,290 - 8,447,896 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0138,284,694 - 8,525,154 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Angpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530329,679,371 - 29,900,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647037,105,466 - 37,328,190 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647037,105,469 - 37,328,183 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl429,933,135 - 30,233,960 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1429,925,203 - 30,233,434 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2432,833,909 - 32,855,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2432,433,135 - 32,433,409 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2432,646,874 - 32,751,649 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18102,020,346 - 102,268,443 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603938,309,531 - 38,560,517 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angpt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476322,646,231 - 22,718,294 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476322,645,807 - 22,818,592 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Angpt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11217,083,735 - 217,322,914 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Angpt1
1746 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:32
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000007979
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
BE113273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2773,593,761 - 73,593,956 (+)MAPPERmRatBN7.2
Rnor_6.0781,402,125 - 81,402,319NCBIRnor6.0
Rnor_5.0781,428,195 - 81,428,389UniSTSRnor5.0
RGSC_v3.4778,256,277 - 78,256,471UniSTSRGSC3.4
Celera770,603,605 - 70,603,799UniSTS
RH 3.4 Map7524.6UniSTS
Cytogenetic Map7q31UniSTS
PMC316637P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2773,783,688 - 73,783,954 (+)MAPPERmRatBN7.2
Rnor_6.0781,592,035 - 81,592,300NCBIRnor6.0
Rnor_5.0781,618,105 - 81,618,370UniSTSRnor5.0
RGSC_v3.4778,451,207 - 78,451,472UniSTSRGSC3.4
Celera770,792,651 - 70,792,916UniSTS
Cytogenetic Map7q31UniSTS
Angpt1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2773,783,609 - 73,783,788 (+)MAPPERmRatBN7.2
Rnor_6.0781,591,956 - 81,592,134NCBIRnor6.0
Rnor_5.0781,618,026 - 81,618,204UniSTSRnor5.0
RGSC_v3.4778,451,128 - 78,451,306UniSTSRGSC3.4
Celera770,792,572 - 70,792,750UniSTS
Cytogenetic Map7q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 138 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000007979   ⟹   ENSRNOP00000007979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl775,418,218 - 75,668,696 (-)Ensembl
mRatBN7.2 Ensembl773,531,486 - 73,784,067 (-)Ensembl
Rnor_6.0 Ensembl781,342,280 - 81,592,206 (-)Ensembl
RefSeq Acc Id: NM_053546   ⟹   NP_445998
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8775,418,218 - 75,668,696 (-)NCBI
mRatBN7.2773,533,462 - 73,783,953 (-)NCBI
Rnor_6.0781,342,374 - 81,592,299 (-)NCBI
Rnor_5.0781,364,881 - 81,618,559 (-)NCBI
RGSC_v3.4778,195,504 - 78,451,471 (-)RGD
Celera770,543,119 - 70,792,915 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241609   ⟹   XP_006241671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8775,415,959 - 75,668,405 (-)NCBI
mRatBN7.2773,528,345 - 73,783,694 (-)NCBI
Rnor_6.0781,338,327 - 81,592,459 (-)NCBI
Rnor_5.0781,364,881 - 81,618,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264351   ⟹   XP_063120421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8775,415,959 - 75,667,235 (-)NCBI
RefSeq Acc Id: XM_063264352   ⟹   XP_063120422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8775,415,959 - 75,668,075 (-)NCBI
RefSeq Acc Id: NP_445998   ⟸   NM_053546
- Peptide Label: precursor
- UniProtKB: Q8K4Q4 (UniProtKB/Swiss-Prot),   O35460 (UniProtKB/Swiss-Prot),   A6HR97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241671   ⟸   XM_006241609
- Peptide Label: isoform X1
- UniProtKB: Q8K4Q4 (UniProtKB/Swiss-Prot),   O35460 (UniProtKB/Swiss-Prot),   F1LSB2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007979   ⟸   ENSRNOT00000007979
RefSeq Acc Id: XP_063120422   ⟸   XM_063264352
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063120421   ⟸   XM_063264351
- Peptide Label: isoform X2
- UniProtKB: Q8K4Q4 (UniProtKB/Swiss-Prot),   O35460 (UniProtKB/Swiss-Prot)
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35460-F1-model_v2 AlphaFold O35460 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628896 AgrOrtholog
BioCyc Gene G2FUF-33504 BioCyc
Ensembl Genes ENSRNOG00000005854 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007979 ENTREZGENE
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot
InterPro FIB_ANG-like UniProtKB/Swiss-Prot
  Fibrinogen-like_C UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot
  Fibrinogen_CS UniProtKB/Swiss-Prot
KEGG Report rno:89807 UniProtKB/Swiss-Prot
NCBI Gene 89807 ENTREZGENE
PANTHER FIBRINOGEN ALPHA CHAIN UniProtKB/Swiss-Prot
  FIBRINOGEN ALPHA CHAIN UniProtKB/Swiss-Prot
Pfam ANG-1 UniProtKB/Swiss-Prot
  Fibrinogen_C UniProtKB/Swiss-Prot
PhenoGen Angpt1 PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005854 RatGTEx
SMART FBG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot
UniProt A6HR97 ENTREZGENE, UniProtKB/TrEMBL
  ANGP1_RAT UniProtKB/Swiss-Prot
  F1LSB2 ENTREZGENE, UniProtKB/TrEMBL
  O35460 ENTREZGENE
  Q8K4Q4 ENTREZGENE
UniProt Secondary Q8K4Q4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-02-23 Angpt1  angiopoietin 1  Agpt_predicted  angiopoietin (predicted)  Data merged from RGD:1308554 737654 APPROVED
2005-01-12 Agpt_predicted  angiopoietin (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Angpt1  angiopoietin 1      Symbol and Name updated 629477 APPROVED
2003-03-07 Angpt1  angiopoietin 1  Agpt1  angiopoietin 1  Data merged from RGD:621860 628472 PROVISIONAL
2003-02-27 Angpt1  angiopoietin 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Agpt1  angiopoietin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is downregulated post MCAO in SHRSP rat strain compared with SHR and WKY rat strains 1553895
gene_function binds and activates Tie2 receptor by inducing its tyrosine phosphorylation. implicated in endothelial developmental processes later and distinct from that of Vegf 724707
gene_process plays a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and mediates blood vessel maturation/stability; it may play an important role in the heart early development 724707