RGD Reference Report - Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. - Rat Genome Database

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Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen.

Authors: Ye, F  Florian, M  Magder, SA  Hussain, SN 
Citation: Ye F, etal., Steroids 2002 Mar;67(3-4):305-10.
RGD ID: 631873
Pubmed: PMID:11856554   (View Abstract at PubMed)

Estrogen promotes endothelial cell proliferation and survival in the vasculture of non-reproductive organs. The main mechanisms through which estrogen exerts its effects on endothelial cells remain unknown. Angiopoietins are newly described modulators of endothelial cell survival and they exert their effects through the activation of endothelial cell-specific Tie-2 receptors. In this study, we evaluated whether estrogen modulates the activity and expression of Tie-2 receptors, Ang-1 and its endogenous antagonist; angiopoietins-2 (Ang-2) in non-reproductive organs. Using RT-PCR, we found that daily administration of 17-beta-estradiol for 8 days in ovariectomized rats results in a significant reduction in tissue Ang-1 mRNA expression. By comparison, estrogen therapy produced a significant increase in Ang-2 mRNA in estrogen-treated rats with heart, kidney and lung Ang-2 mRNA levels reaching 169%, 152% and 224% of those of oil-treated animals, respectively. We also observed that tyrosine phosphorylation of Tie-2 receptors is significantly attenuated in ovariectomized rats treated with 17-beta-estradiol. Our results suggest that the effects of estrogen on the vasculature of non-reproductive organs require the inhibition of angiopoietin-1-Tie-2 receptor pathway and that this inhibition is achieved through simultaneous down-regulation of Ang-1 and Tie-2 expression and elevation in Ang-2 expression.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to estrogen  IDA 631873 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tek  (TEK receptor tyrosine kinase)

Objects referenced in this article
Gene Angpt1 angiopoietin 1 Rattus norvegicus
Gene Angpt2 angiopoietin 2 Rattus norvegicus

Additional Information