RGD Reference Report - [The expression and significance of the angiopoietin-1 in the kidney of diabetic rats] - Rat Genome Database

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[The expression and significance of the angiopoietin-1 in the kidney of diabetic rats]

Authors: Yang, YB  Chen, ZJ  Liu, F  Huang, SM 
Citation: Yang YB, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):93-6, 104.
RGD ID: 1626163
Pubmed: PMID:17294737   (View Abstract at PubMed)

OBJECTIVE: To explore the expression and significance of angiopoietin-1 (Ang-1) in the renal tissue of diabetic rats. METHODS: The SD rats were divided into the diabetic and control groups. The diabetic group was treated by streptozotocin. The expression of Ang-1 in renal tissue was detected by RT-PCR and immunohisochemistry at 2, 4, 8, 12, 16, 20 and 24 weeks. The level of Ang-1 was quantified by computer image analysis. The relationship between Ang-1 and the index of renal damage including renal/body weight, urinary protein excretion, glomerular volume, and glomerular area was analyzed. RESULTS: Ang-1 mRNA in diabetic renal tissue was significantly upregulated at 4 and 8 weeks, compared with diabetic group at other time points or control group at the same time points, and then downregulated gradually after 12 weeks. The level of Ang-1 mRNA decreased significantly as compared with control group at 24 week. Ang-1 was outstandingly expressed in glomeruli. From 4-week to 24-week, the number of Ang-1 staining in diabetic glomeruli increased significantly as compared with control group, being maximal at 4 and 8 weeks, and subsequently decreased after 12 week. Ang-1 level was correlated with renal/body weight, glomerular volume, glomerular area, and urine protein excretion, respectively. CONCLUSION: The change of Ang-1, which is early upregulation and late downregulation, exists in diabetic renal tissue. The unusual expression of Ang-1 is partly connected with the renal changes of diabetic rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOAngpt1 (Rattus norvegicus)1626163; 1626163 RGD 
Experimental Diabetes Mellitus  IEP 1626163 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Angpt1  (angiopoietin 1)

Genes (Mus musculus)
Angpt1  (angiopoietin 1)

Genes (Homo sapiens)
ANGPT1  (angiopoietin 1)


Additional Information