Gene: ANGPT1 (angiopoietin 1)  Homo sapiens Symbol: ANGPT1 Name: angiopoietin 1 Description: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010] Type: protein-coding RefSeq Status: REVIEWED Also known as: AGP1; AGPT; ANG-1; ANG1; angiopoietin-1; OTTHUMP00000227592; OTTHUMP00000227599; OTTHUMP00000227600; OTTHUMP00000227626 Orthologs: Mus musculus : Angpt1 (angiopoietin 1)  MGI Rattus norvegicus : Angpt1 (angiopoietin 1) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 8 108,537,955 - 108,786,101 - NCBI Human Genome Assembly HuRef 8 103,581,813 - 103,830,178 - NCBI Human Genome Assembly GRCh37 8 108,261,710 - 108,510,254 - NCBI Human Genome Assembly Build 36 8 108,330,886 - 108,579,430 - NCBI Human Cytogenetic Map 8 q23.1   NCBI Human Genome Assembly 8 108,330,885 - 108,579,430   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Brain Ischemia   IPM   1643339   RGD   Carcinoma in Situ   ISS RGD:628896 1626167 associated with Mammary Neoplasms, Animal;mRNA:increased expression:mammary gland RGD   Carcinoma, Renal Cell Severity IEP   1643335 mRNA:altered expression:kidney RGD   Carcinoma, Transitional Cell Disease_progression IEP   2293863   RGD   Diabetes Mellitus, Experimental   ISS RGD:628896 2313817 protein:increased expression:retina RGD   Diabetes Mellitus, Experimental   ISS RGD:628896 1626163   RGD   Diabetic Retinopathy   IPM   2313818 associated with Diabetes Mellitus, Experimental RGD   Endometrial Neoplasms   IEP   2293852 protein:increased expression:endometrium epithelium RGD   Glioma   TAS   1578345   RGD   Hypertension   IEP   1626157 protein:increased expression:plasma, platelet RGD   Hypertension   IPM   2316068   RGD   Hypertension, Pulmonary   ISS   1578336   RGD   Hypertension, Pulmonary   ISS RGD:628896 2316069 protein:decreased expression:pulmonary artery RGD   Liver Cirrhosis, Experimental Disease_progression ISS RGD:628896 1643338 protein:increased expression:liver RGD   Myocardial Infarction   ISS RGD:628896 1626168 mRNA, protein:decreased expression:myocardium RGD   Neoplasm Invasiveness   ISS RGD:628896 1626167 associated with Mammary Neoplasms, Animal;mRNA:increased expression:mammary gland RGD   Nephrosis   ISS RGD:628896 1626164 mRNA, protein:decreased expression:glomerulus RGD   Ovarian Neoplasms   IEP   2293864 mRNA:decreased expression:ovary RGD   Prostatic Neoplasms   IEP   1643336 protein:increased expression:prostate gland RGD   Reperfusion Injury   IPM   2316041   RGD   Shock, Hemorrhagic   IPM   2316067   RGD   Stomach Ulcer   ISS RGD:628896 1601496 protein:increased expression:stomach RGD   Stroke   ISS RGD:628896 1626162   RGD   Stroke   ISS   704373   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) 17beta-estradiol decreases expression EXP   6480464 Estradiol results in decreased expression of ANGPT1 mRNA CTD PMID:16705744 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1551549 6480464 Tetrachlorodibenzodioxin results in decreased expression of ANGPT1 mRNA CTD PMID:16120747 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO RGD:628896 6480464 Puromycin Aminonucleoside results in increased expression of ANGPT1 mRNA CTD PMID:17667850 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ANGPT1 mRNA CTD PMID:16997883 5-fluorouracil multiple interactions EXP   6480464 ANGPT1 protein promotes the reaction [Fluorouracil results in increased expression of IFNA1 protein] CTD PMID:17786339 5-fluorouracil increases expression EXP   6480464 Fluorouracil results in increased expression of ANGPT1 protein CTD PMID:17786339 8-bromo-3',5'-cyclic AMP multiple interactions EXP   6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ANGPT1 mRNA CTD PMID:16997883 aflatoxin B1 affects expression EXP   6480464 Aflatoxin B1 affects the expression of ANGPT1 protein CTD PMID:20106945 aflatoxin B1 decreases expression EXP   6480464 Aflatoxin B1 results in decreased expression of ANGPT1 mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of ANGPT1 mRNA CTD PMID:21934132 ammonium chloride affects expression ISO RGD:628896 6480464 Ammonium Chloride affects the expression of ANGPT1 mRNA CTD PMID:16483693 arsenic atom decreases expression ISO RGD:1551549 6480464 Arsenic results in decreased expression of ANGPT1 mRNA CTD PMID:19654921 benzo[a]pyrene decreases expression ISO RGD:1551549 6480464 Benzo(a)pyrene results in decreased expression of ANGPT1 mRNA CTD PMID:22228805 cadmium dichloride increases expression EXP   6480464 Cadmium Chloride results in increased expression of ANGPT1 mRNA CTD PMID:12160620 capsaicin increases expression EXP   6480464 Capsaicin results in increased expression of ANGPT1 mRNA CTD PMID:21310942 chloroprene increases expression ISO RGD:628896 6480464 Chloroprene results in increased expression of ANGPT1 mRNA CTD PMID:23125180 cyclophosphamide increases expression EXP   6480464 Cyclophosphamide results in increased expression of ANGPT1 mRNA CTD PMID:17403535 cyclosporin A decreases expression EXP   6480464 Cyclosporine results in decreased expression of ANGPT1 mRNA CTD PMID:20106945 daunorubicin decreases expression ISO RGD:628896 6480464 Daunorubicin results in decreased expression of ANGPT1 mRNA; more ... CTD PMID:16626513 dexamethasone multiple interactions EXP   6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ANGPT1 mRNA CTD PMID:16997883 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of ANGPT1 mRNA CTD PMID:20458559 dioxygen increases expression ISO RGD:1551549 6480464 Oxygen deficiency results in increased expression of ANGPT1 mRNA CTD PMID:20412331 dioxygen multiple interactions ISO RGD:1551549 6480464 ARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of ANGPT1 mRNA] CTD PMID:20412331 doxorubicin multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein results in decreased susceptibility to Doxorubicin]; more ... CTD PMID:15763944 doxorubicin decreases response to substance EXP   6480464 ANGPT1 protein results in decreased susceptibility to Doxorubicin CTD PMID:15763944 elemental selenium decreases expression EXP   6480464 Selenium results in decreased expression of ANGPT1 mRNA CTD PMID:19244175 genistein decreases expression EXP   6480464 Genistein results in decreased expression of ANGPT1 mRNA CTD PMID:16705744 genistein increases expression ISO RGD:1551549 6480464 Genistein results in increased expression of ANGPT1 mRNA CTD PMID:21048042 hydrogen peroxide affects expression EXP   6480464 Hydrogen Peroxide affects the expression of ANGPT1 mRNA CTD PMID:20044591 iloprost multiple interactions EXP   6480464 tyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT1 mRNA] CTD PMID:16373414 iloprost increases expression EXP   6480464 Iloprost results in increased expression of ANGPT1 mRNA CTD PMID:16373414 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; more ... CTD PMID:15763944 methoxychlor increases expression ISO RGD:628896 6480464 Methoxychlor results in increased expression of ANGPT1 protein CTD PMID:15503810 N-acetyl-L-cysteine decreases secretion EXP   6480464 Acetylcysteine results in decreased secretion of ANGPT1 protein CTD PMID:19622383 N-nitrosodiethylamine increases expression ISO RGD:628896 6480464 Diethylnitrosamine results in increased expression of ANGPT1 mRNA CTD PMID:17034775 N-nitrosodiethylamine multiple interactions ISO RGD:628896 6480464 Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT1 mRNA] CTD PMID:17034775 nicotinic acid increases expression ISO RGD:628896 6480464 Niacin results in increased expression of ANGPT1 mRNA CTD PMID:17557352 nicotinic acid increases expression ISO RGD:1551549 6480464 Niacin results in increased expression of ANGPT1 mRNA CTD PMID:17557352 ochratoxin A increases expression ISO RGD:628896 6480464 ochratoxin A results in increased expression of ANGPT1 mRNA CTD PMID:23358140 ozone decreases expression ISO RGD:1551549 6480464 Ozone results in decreased expression of ANGPT1 mRNA CTD PMID:17460151 ozone increases expression ISO RGD:1551549 6480464 Ozone results in increased expression of ANGPT1 mRNA CTD PMID:21543283 PD123319 multiple interactions ISO RGD:628896 6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA] CTD PMID:14638905 phenylephrine multiple interactions ISO RGD:1551549 6480464 ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; more ... CTD PMID:18502941 phenylephrine increases expression ISO RGD:1551549 6480464 Phenylephrine results in increased expression of ANGPT1 mRNA; more ... CTD PMID:18502941 poly(vinyl chloride) decreases expression EXP   6480464 Polyvinyl Chloride results in decreased expression of ANGPT1 mRNA CTD PMID:12809767 roxarsone decreases expression EXP   6480464 Roxarsone results in decreased expression of ANGPT1 mRNA CTD PMID:18414637 selenium atom decreases expression EXP   6480464 Selenium results in decreased expression of ANGPT1 mRNA CTD PMID:19244175 sildenafil increases expression ISO RGD:628896 6480464 sildenafil results in increased expression of ANGPT1 mRNA; more ... CTD PMID:18373738 simvastatin increases expression ISO RGD:628896 6480464 Simvastatin results in increased expression of ANGPT1; more ... CTD PMID:18544044 streptozocin increases expression ISO RGD:628896 6480464 Streptozocin results in increased expression of ANGPT1 protein; more ... CTD PMID:15643138 streptozocin decreases expression ISO RGD:628896 6480464 Streptozocin results in decreased expression of ANGPT1 mRNA CTD PMID:19958114 testosterone enanthate affects expression EXP   6480464 testosterone enanthate affects the expression of ANGPT1 mRNA CTD PMID:17440010 tetrachloromethane decreases expression ISO RGD:1551549 6480464 Carbon Tetrachloride results in decreased expression of ANGPT1 mRNA CTD PMID:17484886 tetrachloromethane increases expression ISO RGD:628896 6480464 Carbon Tetrachloride results in increased expression of ANGPT1 mRNA; more ... CTD PMID:15135347 valsartan multiple interactions ISO RGD:628896 6480464 valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; more ... CTD PMID:14638905 vancomycin increases expression ISO RGD:1551549 6480464 Vancomycin results in increased expression of ANGPT1 mRNA CTD PMID:18930951 zinc atom decreases expression ISO RGD:1551549 6480464 Zinc deficiency results in decreased expression of ANGPT1 mRNA CTD PMID:20857495 zinc(0) decreases expression ISO RGD:1551549 6480464 Zinc deficiency results in decreased expression of ANGPT1 mRNA CTD PMID:20857495 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activation of transmembrane receptor protein tyrosine kinase activity   IDA   2290271 PMID:19424712 UniProtKB PMID:19424712 angiogenesis   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 blood coagulation   TAS   2290271 Reactome:REACT_604 Reactome Reactome:REACT_604 cell differentiation   IEA UniProtKB-KW:KW-0221 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 cell-substrate adhesion   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 glomerulus vasculature development   ISS UniProtKB:O35460 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 glomerulus vasculature development   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 hemopoiesis   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 heparin biosynthetic process   IDA   2290271 PMID:19297368 UniProtKB PMID:19297368 in utero embryonic development   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 leukocyte migration   TAS   2290271 Reactome:REACT_12051 Reactome Reactome:REACT_12051 negative regulation of apoptotic process   IDA   2290271 PMID:10218485 UniProtKB PMID:10218485 negative regulation of apoptotic process   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of apoptotic process   IDA   2290271 PMID:12958144 UniProtKB PMID:12958144 negative regulation of cell adhesion   IDA   2290271 PMID:19674970 UniProtKB PMID:19674970 negative regulation of endothelial cell apoptotic process   IDA   2290271 PMID:19674970 UniProtKB PMID:19674970 negative regulation of vascular permeability   IDA   2290271 PMID:14978158 UniProtKB PMID:14978158 negative regulation of vascular permeability   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of vascular permeability   IDA   2290271 PMID:19297368 UniProtKB PMID:19297368 positive chemotaxis   IDA   2290271 PMID:9660821 UniProtKB PMID:9660821 positive regulation of blood vessel endothelial cell migration   IDA   2290271 PMID:9660821 UniProtKB PMID:9660821 positive regulation of cell adhesion   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of endothelial cell migration   IDA   2290271 PMID:12958144 UniProtKB PMID:12958144 positive regulation of ERK1 and ERK2 cascade   IDA   2290271 PMID:18425120 UniProtKB PMID:18425120 positive regulation of ERK1 and ERK2 cascade   IDA   2290271 PMID:19615361 UniProtKB PMID:19615361 positive regulation of peptidyl-serine phosphorylation   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of peptidyl-tyrosine phosphorylation   IDA   2290271 PMID:15851516 UniProtKB PMID:15851516 positive regulation of peptidyl-tyrosine phosphorylation   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of peptidyl-tyrosine phosphorylation   IDA   2290271 PMID:19689429 UniProtKB PMID:19689429 positive regulation of phosphatidylinositol 3-kinase cascade   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of protein kinase B signaling cascade   IDA   2290271 PMID:18425120 UniProtKB PMID:18425120 positive regulation of protein kinase B signaling cascade   IDA   2290271 PMID:19615361 UniProtKB PMID:19615361 positive regulation of protein ubiquitination   IDA   2290271 PMID:19689429 UniProtKB PMID:19689429 positive regulation of receptor internalization   IDA   2290271 PMID:19424712 UniProtKB PMID:19424712 protein localization to cell surface   IDA   2290271 PMID:19615361 UniProtKB PMID:19615361 regulation of endothelial cell proliferation NOT IDA   2290271 PMID:8980223 UniProtKB PMID:8980223 regulation of satellite cell proliferation   IDA   2290271 PMID:19733541 UniProtKB PMID:19733541 sprouting angiogenesis   IDA   2290271 PMID:10218485 UniProtKB PMID:10218485 sprouting angiogenesis   IDA   2290271 PMID:9560344 UniProtKB PMID:9560344 Tie signaling pathway   IDA   2290271 PMID:19689429 UniProtKB PMID:19689429 Tie signaling pathway   IDA   2290271 PMID:19922791 UniProtKB PMID:19922791 transmembrane receptor protein tyrosine kinase signaling pathway   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular region   TAS   2290271 Reactome:REACT_12409 Reactome Reactome:REACT_12409 extracellular region   TAS   2290271 Reactome:REACT_16914 Reactome Reactome:REACT_16914 extracellular region   TAS   2290271 Reactome:REACT_16906 Reactome Reactome:REACT_16906 extracellular region   TAS   2290271 Reactome:REACT_16885 Reactome Reactome:REACT_16885 extracellular region   TAS   2290271 Reactome:REACT_12575 Reactome Reactome:REACT_12575 extracellular region   TAS   2290271 Reactome:REACT_12523 Reactome Reactome:REACT_12523 extracellular region   TAS   2290271 Reactome:REACT_12516 Reactome Reactome:REACT_12516 extracellular region   TAS   2290271 Reactome:REACT_12511 Reactome Reactome:REACT_12511 extracellular region   TAS   2290271 Reactome:REACT_12504 Reactome Reactome:REACT_12504 extracellular region   TAS   2290271 Reactome:REACT_12475 Reactome Reactome:REACT_12475 extracellular region   TAS   2290271 Reactome:REACT_12431 Reactome Reactome:REACT_12431 extracellular space   IDA   2290271 PMID:10218485 UniProtKB PMID:10218485 extracellular space   IDA   2290271 PMID:8980223 UniProtKB PMID:8980223 membrane raft   IDA   2290271 PMID:19615361 UniProtKB PMID:19615361 microvillus   IDA   2290271 PMID:19424712 UniProtKB PMID:19424712 plasma membrane   IDA   2290271 PMID:19424712 UniProtKB PMID:19424712 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) receptor binding   IEA Ensembl:ENSMUSP00000022921 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 receptor tyrosine kinase binding   IPI UniProtKB:Q02763 2290271 PMID:19922791 UniProtKB PMID:19922791 receptor tyrosine kinase binding   IPI UniProtKB:Q02763 2290271 PMID:8980223 UniProtKB PMID:8980223 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) angiopoietin signaling pathway   ISS   1578337   RGD   rheumatoid arthritis pathway   IEA RGD:733136 6907045   KEGG hsa:05323 External Database Links KEGG Pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Rheumatoid arthritis Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling (PID:200079) SHP2 signaling (PID:200083) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal liver regeneration   IEA   704403   RGD   Disease Annotations Brain Ischemia  (IPM) Carcinoma in Situ  (ISS) Carcinoma, Renal Cell  (IEP) Carcinoma, Transitional Cell  (IEP) Diabetes Mellitus, Experimental  (ISS) Diabetic Retinopathy  (IPM) Endometrial Neoplasms  (IEP) Glioma  (TAS) Hypertension  (IEP,IPM) Hypertension, Pulmonary  (ISS) Liver Cirrhosis, Experimental  (ISS) Myocardial Infarction  (ISS) Neoplasm Invasiveness  (ISS) Nephrosis  (ISS) Ovarian Neoplasms  (IEP) Prostatic Neoplasms  (IEP) Reperfusion Injury  (IPM) Shock, Hemorrhagic  (IPM) Stomach Ulcer  (ISS) Stroke  (ISS) Gene-Chemical Interaction Annotations 17beta-estradiol  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO) 3-isobutyl-1-methyl-7H-xanthine  (EXP) 5-fluorouracil  (EXP) 8-bromo-3',5'-cyclic AMP  (EXP) aflatoxin B1  (EXP) all-trans-retinoic acid  (EXP) ammonium chloride  (ISO) arsenic atom  (ISO) benzo[a]pyrene  (ISO) cadmium dichloride  (EXP) capsaicin  (EXP) chloroprene  (ISO) cyclophosphamide  (EXP) cyclosporin A  (EXP) daunorubicin  (ISO) dexamethasone  (EXP) diarsenic trioxide  (EXP) dioxygen  (ISO) doxorubicin  (EXP) elemental selenium  (EXP) genistein  (EXP,ISO) hydrogen peroxide  (EXP) iloprost  (EXP) LY294002  (EXP) methoxychlor  (ISO) N-acetyl-L-cysteine  (EXP) N-nitrosodiethylamine  (ISO) nicotinic acid  (ISO) ochratoxin A  (ISO) ozone  (ISO) PD123319  (ISO) phenylephrine  (ISO) poly(vinyl chloride)  (EXP) roxarsone  (EXP) selenium atom  (EXP) sildenafil  (ISO) simvastatin  (ISO) streptozocin  (ISO) testosterone enanthate  (EXP) tetrachloromethane  (ISO) valsartan  (ISO) vancomycin  (ISO) zinc atom  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process activation of transmembrane receptor protein tyrosine kinase activity  (IDA) angiogenesis  (IEA) blood coagulation  (TAS) cell differentiation  (IEA) cell-substrate adhesion  (IEA) glomerulus vasculature development  (IEA,ISS) hemopoiesis  (IEA) heparin biosynthetic process  (IDA) in utero embryonic development  (IEA) leukocyte migration  (TAS) negative regulation of apoptotic process  (IDA,IEA) negative regulation of cell adhesion  (IDA) negative regulation of endothelial cell apoptotic process  (IDA) negative regulation of vascular permeability  (IDA,IEA) positive chemotaxis  (IDA) positive regulation of blood vessel endothelial cell migration  (IDA) positive regulation of cell adhesion  (IEA) positive regulation of endothelial cell migration  (IDA) positive regulation of ERK1 and ERK2 cascade  (IDA) positive regulation of peptidyl-serine phosphorylation  (IEA) positive regulation of peptidyl-tyrosine phosphorylation  (IDA,IEA) positive regulation of phosphatidylinositol 3-kinase cascade  (IEA) positive regulation of protein kinase B signaling cascade  (IDA) positive regulation of protein ubiquitination  (IDA) positive regulation of receptor internalization  (IDA) protein localization to cell surface  (IDA) regulation of endothelial cell proliferation  (IDA) regulation of satellite cell proliferation  (IDA) sprouting angiogenesis  (IDA) Tie signaling pathway  (IDA) transmembrane receptor protein tyrosine kinase signaling pathway  (IEA) Cellular Component extracellular region  (TAS) extracellular space  (IDA) membrane raft  (IDA) microvillus  (IDA) plasma membrane  (IDA) Molecular Function receptor binding  (IEA) receptor tyrosine kinase binding  (IPI) Molecular Pathway Annotations angiopoietin signaling pathway  (ISS) rheumatoid arthritis pathway  (IEA) External Database Links KEGG Pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Rheumatoid arthritis Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling (PID:200079) SHP2 signaling (PID:200083) Phenotype Annotations abnormal liver regeneration  (IEA) References - curated 1. Baldewijns MM, etal., Br J Cancer. 2007 Jun 18;96(12):1888-95. Epub 2007 May 15. 2. Buschhorn HM, etal., Prostate. 2005 Sep 1;64(4):341-6. 3. Childs EW, etal., Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2285-95. Epub 2008 Mar 14. 4. Chu D, etal., Ann Thorac Surg. 2004 Feb;77(2):449-56; discussion 456-7. 5. GOA_HUMAN data from the GO Consortium 6. Hammes HP, etal., Diabetes. 2004 Apr;53(4):1104-10. 7. Hata K, etal., Oncology. 2002;62(4):340-8. 8. Joussen AM, etal., Am J Pathol. 2002 May;160(5):1683-93. 9. Kim JW, etal., Lab Invest. 2000 Apr;80(4):587-94. 10. Kosacka J, etal., Cell Tissue Res. 2005 Apr;320(1):11-9. Epub 2005 Feb 16. 11. Kraizer Y, etal., Biochem Biophys Res Commun 2001 Sep 14;287(1):209-15. 12. Lee JS, etal., Cardiovasc Res. 2008 Jun 1;78(3):572-80. Epub 2008 Feb 19. 13. Lu YH, etal., Acta Pharmacol Sin. 2006 May;27(5):579-87. 14. Nadar S, etal., Am J Hypertens. 2006 Sep;19(9):970-7; discussion 978. 15. Onda T, etal., J Cereb Blood Flow Metab. 2007 Jul 18;. 16. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 17. Quentin T, etal., Anticancer Res. 2004 Sep-Oct;24(5A):2745-56. 18. Reiss Y, etal., Brain Pathol. 2005 Oct;15(4):311-7. 19. RGD automated import pipeline for gene-chemical interactions 20. Saito M, etal., Pathol Int. 2007 Mar;57(3):140-7. 21. Sandhu R, etal., Cardiovasc Res. 2004 Oct 1;64(1):115-24. 22. Shin HY, etal., J Neurosci Res. 2009 Nov 2. 23. Tugues S, etal., Hepatology. 2007 Dec;46(6):1919-26. 24. Wang MM, etal., Exp Neurol 2002 Feb;173(2):283-8. 25. Wen CY, etal., J Gastroenterol. 2003;38(5):431-5. 26. Wurmbach JH, etal., Anticancer Res. 2000 Nov-Dec;20(6D):5217-20. 27. Yamamoto A, etal., Respiration. 2008;75(3):328-38. Epub 2007 Dec 10. 28. Yan M, etal., Pathobiology. 2004;71(5):253-60. 29. Yang YB, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):93-6, 104. 30. Zacharek A, etal., J Cereb Blood Flow Metab. 2007 Mar 14;. References - uncurated PubMed 10051567   10218485   10343124   10514510   10706866   10766762   10854239   10944458   11165944   11729102   11776343   11827452   11856872   11870550   11891175   11967990   12168954   12213874   12239588   12243755   12402160   12427764   12477932   12612904   12649156   12717391   12810673   12816861   12890486   12958144   12958167   14561809   14597243   14665640   14672554   14715662   14749497   14978158   14991531   15001532   15019820   15094228   15161644   15198927   15213103   15242771   15284220   15381091   15453096   15498854   15542434   15562207   15692086   15694363   15746084   15769741   15781448   15823283   15851516   15892598   16000309   16020388   16049136   16229183   16354591   16547766   16614513   16645159   16690881   16723371   16803467   16830384   16917117   16956819   17039426   17168735   17322632   17341311   17466926   17525262   17558601   17562701   17603084   17724803   17728252   17785951   17803352   17943167   18035072   18080866   18092380   18199826   18269030   18310225   18326231   18330951   18382887   18425120   18664247   18675456   18807212   18823985   18991494   18996102   19010534   19028450   19082480   19082594   19086654   19127216   19148554   19223473   19297368   19300530   19301945   19322669   19339077   19351722   19424712   19476937   19478794   19487284   19543148   19567053   19615361   19674970   19689429   19733541   19815705   19875484   19916173   19919521   19922791   19954476   20036815   20056911   20072144   20098680   20099495   20185425   20208992   20346360   20378606   20471887   20554518   20602615   20629092   20696814   20863203   21042788   21140268   21168819   21179479   21212269   21273558   21300047   21380565   21400522   21660578   21672190   21710361   21778249   21849906   21858121   21878936   21884468   21885850   21905000   21905955   21906428   21948244   21963094   22000910   22015631   22033412   22095586   22143796   22205728   22229541   22235284   22334788   22391155   22449617   22483377   22496856   22583143   22642477   22867989   22901561   22949515   23024612   23190105   23288163   7584026   7584028   7642106   8980223   8980224   9204896   9525952   9545648   9560344   9660821   9723709 RGD Disease Portals ANGPT1 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data ANGPT1   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 8 108,537,955 - 108,786,101 - NCBI Human Genome Assembly HuRef 8 103,581,813 - 103,830,178 - NCBI Human Genome Assembly GRCh37 8 108,261,710 - 108,510,254 - NCBI Human Genome Assembly Build 36 8 108,330,886 - 108,579,430 - NCBI Human Cytogenetic Map 8 q23.1   NCBI Human Genome Assembly 8 108,330,885 - 108,579,430   NCBI Angpt1   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 15 42,424,723 - 42,676,795 - NCBI Mouse cM Map 15 16.69   NCBI Mouse Celera Assembly 15 42,923,801 - 43,172,633 - NCBI Mouse Genome Assembly Build 37 15 42,256,269 - 42,508,341 - NCBI Mouse Genome Assembly Build 36.1 15 42,256,269 - 42,508,341 - NCBI Mouse Cytogenetic Map 15 B3.1   NCBI Angpt1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 7 q31   NCBI RGSC Genome Assembly v5.0 7 81,368,928 - 81,618,369 - NCBI RGSC Genome Assembly v3.4 7 78,195,504 - 78,451,471 - NCBI Rat Celera Assembly 7 70,543,119 - 70,792,915 - NCBI Position Markers D8S383   Map Chr Position Strand Source Human Genome Assembly HuRef 8 103,702,306 - 103,702,617   UniSTS Human Genome Assembly GRCh37 8 108,382,324 - 108,382,667   UniSTS Human Celera Assembly 8 104,568,604 - 104,568,938   RGD Human Genome Assembly Build 36 8 108,451,500 - 108,451,843   RGD Marshfield Human Genetic Map 8 120.29   RGD Marshfield Human Genetic Map 8 120.29   UniSTS RH17369   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 8 445.99   UniSTS Human Genome Assembly HuRef 8 103,582,050 - 103,582,291   UniSTS Human Genome Assembly GRCh37 8 108,261,947 - 108,262,188   UniSTS Human Celera Assembly 8 104,448,750 - 104,448,991   RGD Human Genome Assembly Build 36 8 108,331,123 - 108,331,364   RGD Human Cytogenetic Map 8 q23.1   UniSTS RH121046   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 8 52917.0   UniSTS Human Genome Assembly HuRef 8 103,619,242 - 103,619,532   UniSTS Human Genome Assembly GRCh37 8 108,299,137 - 108,299,427   UniSTS Human Celera Assembly 8 104,485,939 - 104,486,229   RGD Human Genome Assembly Build 36 8 108,368,313 - 108,368,603   RGD Human Cytogenetic Map 8 q23.1   UniSTS RH25244   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 8 445.99   UniSTS Human Genome Assembly HuRef 8 103,582,466 - 103,582,602   UniSTS Human Genome Assembly GRCh37 8 108,262,363 - 108,262,499   UniSTS Human Celera Assembly 8 104,449,166 - 104,449,302   RGD Human Genome Assembly Build 36 8 108,331,539 - 108,331,675   RGD Human Cytogenetic Map 8 q23.1   UniSTS ANGPT1__4215   Map Chr Position Strand Source Human Genome Assembly HuRef 8 103,581,705 - 103,582,512   UniSTS Human Genome Assembly GRCh37 8 108,261,602 - 108,262,409   UniSTS Human Celera Assembly 8 104,448,405 - 104,449,212   RGD Human Genome Assembly Build 36 8 108,330,778 - 108,331,585   RGD D11S3114   Map Chr Position Strand Source Human Cytogenetic Map 9 q34.13   UniSTS Human Cytogenetic Map 15 q13   UniSTS Human Cytogenetic Map 3 p22-p21.3   UniSTS Human Cytogenetic Map 1 q32.1   UniSTS Human Cytogenetic Map 7 p14.1   UniSTS Human Cytogenetic Map 2 q22.3   UniSTS Human Cytogenetic Map 3 p24.3   UniSTS Human Cytogenetic Map 17 q25.3   UniSTS Human Cytogenetic Map 7 q31.1   UniSTS Human Cytogenetic Map 7 q21.11   UniSTS Human Cytogenetic Map 5 q31   UniSTS Human Cytogenetic Map 22 q13.33   UniSTS Human Cytogenetic Map 8 q22.3   UniSTS Human Cytogenetic Map 2 p25.1   UniSTS Human Cytogenetic Map 3 q22-q24   UniSTS Human Cytogenetic Map 5 q23.3-q31.1   UniSTS Human Cytogenetic Map 8 p21.3   UniSTS Human Cytogenetic Map 14 q32.3   UniSTS Human Cytogenetic Map 7 q11.23   UniSTS Human Cytogenetic Map 7 q32   UniSTS Human Cytogenetic Map 17 q11   UniSTS Human Cytogenetic Map 1 q21-q23   UniSTS Human Cytogenetic Map 12 q13.13   UniSTS Human Cytogenetic Map 17 p12-p11.2   UniSTS Human Cytogenetic Map 6 p21.1   UniSTS Human Cytogenetic Map X p22.2   UniSTS Human Cytogenetic Map 19 p13.11   UniSTS Human Cytogenetic Map 19 p13.2   UniSTS Human Cytogenetic Map 16 q24.3   UniSTS Human Cytogenetic Map 9 q34.3   UniSTS Human Cytogenetic Map 19 q13.33   UniSTS Human Cytogenetic Map 2 q32.3   UniSTS Human Cytogenetic Map 1 q25.1   UniSTS Human Cytogenetic Map 10 p15.3   UniSTS Human Cytogenetic Map 12 q12   UniSTS Human Cytogenetic Map 12 q24.31   UniSTS Human Cytogenetic Map 15 q15   UniSTS Human Cytogenetic Map 22 q11.23   UniSTS Human Cytogenetic Map 17 q25   UniSTS Human Cytogenetic Map 16 q22.1   UniSTS Human Cytogenetic Map 19 p13.3   UniSTS Human Cytogenetic Map 5 q23.3   UniSTS Human Cytogenetic Map 15 q15.1   UniSTS Human Cytogenetic Map 3 q27.2   UniSTS Human Cytogenetic Map 20 q13.12   UniSTS Human Cytogenetic Map X p11.23   UniSTS Human Cytogenetic Map 16 q13   UniSTS Human Cytogenetic Map 19 q13.3   UniSTS Human Cytogenetic Map 1 q32   UniSTS Human Cytogenetic Map 6 q25.3   UniSTS Human Cytogenetic Map 1 p36.2   UniSTS Human Cytogenetic Map 15 q11.2-q21.3   UniSTS Human Cytogenetic Map 14 q24.3   UniSTS Human Cytogenetic Map 19 p13   UniSTS Human Cytogenetic Map 1 p35.1   UniSTS Human Cytogenetic Map 17 q11.2   UniSTS Human Cytogenetic Map 12 q13.2   UniSTS Human Cytogenetic Map 22 q13.1   UniSTS Human Cytogenetic Map 11 p15   UniSTS Human Cytogenetic Map 8 q24.13   UniSTS Human Cytogenetic Map 1 q41   UniSTS Human Cytogenetic Map 19 q13.12   UniSTS Human Cytogenetic Map 17 q12   UniSTS Human Cytogenetic Map 12 p12.1   UniSTS Human Cytogenetic Map 15 q25.2   UniSTS Human Cytogenetic Map 2 p13.1   UniSTS Human Cytogenetic Map 1 p36.13   UniSTS Human Cytogenetic Map 2 q12.1   UniSTS Human Cytogenetic Map 11 q23.3   UniSTS Human Cytogenetic Map X p11.3   UniSTS Human Cytogenetic Map 17 p13   UniSTS Human Cytogenetic Map 20 q13.13   UniSTS Human Cytogenetic Map 4 q12   UniSTS Human Cytogenetic Map 16 q24   UniSTS Human Cytogenetic Map 17 p13.1   UniSTS Human Cytogenetic Map 10 q23.1   UniSTS Human Cytogenetic Map 1 q44   UniSTS Human Cytogenetic Map 3 p21.31   UniSTS Human Cytogenetic Map 17 p13.2   UniSTS Human Cytogenetic Map 9 q33.3   UniSTS Human Cytogenetic Map 2 p11.2   UniSTS Human Cytogenetic Map 22 q12.1   UniSTS Human Cytogenetic Map 17 q22.2   UniSTS Human Cytogenetic Map 1 p36.33   UniSTS Human Cytogenetic Map 10 q11.1   UniSTS Human Cytogenetic Map 19 q12   UniSTS Human Cytogenetic Map 11 q14.2   UniSTS Human Cytogenetic Map 1 q23.1   UniSTS Human Cytogenetic Map 11 p15.4   UniSTS Human Cytogenetic Map 18 q12.1-q21.1   UniSTS Human Cytogenetic Map 2 q37   UniSTS Human Cytogenetic Map 20 q11.21   UniSTS Human Cytogenetic Map 6 p21.32   UniSTS Human Cytogenetic Map 10 q26.3   UniSTS Human Cytogenetic Map 7 q22.1   UniSTS Human Cytogenetic Map 14 q12   UniSTS Human Cytogenetic Map 8 p11.22   UniSTS Human Cytogenetic Map 19 q13.32   UniSTS Human Cytogenetic Map 17 q21.31   UniSTS Human Cytogenetic Map 17 q21   UniSTS Human Cytogenetic Map 2 q21.3   UniSTS Human Cytogenetic Map 2 q21.1   UniSTS Human Cytogenetic Map 6 q27   UniSTS Human Cytogenetic Map 2 q33.1   UniSTS Human Cytogenetic Map 9 q21.12   UniSTS Human Cytogenetic Map 7 p22.2   UniSTS Human Cytogenetic Map 20 p13   UniSTS Human Cytogenetic Map 17 q25.1   UniSTS Human Cytogenetic Map 10 q24.31   UniSTS Human Cytogenetic Map 15 q22.31   UniSTS Human Cytogenetic Map 11 q12.3   UniSTS Human Cytogenetic Map 2 q31.1   UniSTS Human Cytogenetic Map 1 p36.21   UniSTS Human Cytogenetic Map 1 p31.1   UniSTS Human Cytogenetic Map 1 p36.11   UniSTS Human Cytogenetic Map 1 p32.3   UniSTS Human Cytogenetic Map 3 q13.31   UniSTS Human Cytogenetic Map 6 q13   UniSTS Human Cytogenetic Map 1 q21   UniSTS Human Cytogenetic Map 3 q21.3   UniSTS Human Cytogenetic Map 19 q13.4   UniSTS Human Cytogenetic Map 12 q23.2   UniSTS Human Cytogenetic Map 1 q21.3   UniSTS Human Cytogenetic Map 1 q22   UniSTS Human Cytogenetic Map 1 p36   UniSTS Human Cytogenetic Map 4 p14   UniSTS Human Cytogenetic Map 19 p12   UniSTS Human Cytogenetic Map 22 q11.21   UniSTS Human Cytogenetic Map 7 q22   UniSTS Human Cytogenetic Map 16 q22   UniSTS Human Cytogenetic Map 2 q11.2   UniSTS Human Cytogenetic Map 19 p13.1-p12   UniSTS Human Cytogenetic Map 16 p13.3   UniSTS Human Cytogenetic Map 2 p22.1   UniSTS Human Cytogenetic Map 1 p34.3   UniSTS Human Cytogenetic Map 5 q23.1   UniSTS Human Cytogenetic Map 8 q24.3   UniSTS Human Cytogenetic Map 1 q25   UniSTS Human Cytogenetic Map 1 q21.2   UniSTS Human Cytogenetic Map 12 q22   UniSTS Human Cytogenetic Map 21 q22.3   UniSTS Human Cytogenetic Map 21 q22.11   UniSTS Human Cytogenetic Map 3 q23   UniSTS Human Cytogenetic Map 6 p21.3   UniSTS Human Cytogenetic Map 2 q12.3   UniSTS Human Cytogenetic Map 12 p13.31   UniSTS Human Cytogenetic Map 8 p11.2   UniSTS Human Cytogenetic Map 7 q21.1   UniSTS Human Cytogenetic Map 19 q13.43   UniSTS Human Cytogenetic Map 2 q35   UniSTS Human Cytogenetic Map 5 q35.3   UniSTS Human Cytogenetic Map 5 p13   UniSTS Human Cytogenetic Map 22 q11.2   UniSTS Human Cytogenetic Map 5 p12   UniSTS Human Cytogenetic Map 1 p34.2   UniSTS Human Cytogenetic Map 12 q21.1   UniSTS Human Cytogenetic Map 16 q12   UniSTS Human Cytogenetic Map 2 q37.1   UniSTS Human Cytogenetic Map 7 p14.3   UniSTS Human Cytogenetic Map X q13.2   UniSTS Human Cytogenetic Map 18 p11.21   UniSTS Human Cytogenetic Map 17 p13.3   UniSTS Human Cytogenetic Map 14 q24   UniSTS Human Cytogenetic Map 15 q24.1   UniSTS Human Cytogenetic Map 7 p22.3   UniSTS Human Cytogenetic Map 22 q13.2   UniSTS Human Cytogenetic Map 2 p21   UniSTS Human Cytogenetic Map 22 q11.1   UniSTS Human Cytogenetic Map 22 q13   UniSTS Human Cytogenetic Map 11 q13.1-q13.2   UniSTS Human Cytogenetic Map 7 p22   UniSTS Human Cytogenetic Map 1 p32-p31   UniSTS Human Cytogenetic Map 19 q13.1   UniSTS Human Cytogenetic Map 11 q13   UniSTS Human Cytogenetic Map 7 q21-q22   UniSTS Human Cytogenetic Map 11 p15.5   UniSTS Human Cytogenetic Map 12 p13.1   UniSTS Human Cytogenetic Map 8 p22   UniSTS Human Cytogenetic Map 3 q25.33   UniSTS Human Cytogenetic Map 10 q23.31   UniSTS Human Cytogenetic Map 1 p13.3   UniSTS Human Cytogenetic Map 20 q13.3   UniSTS Human Cytogenetic Map 17 q23.2   UniSTS Human Cytogenetic Map 14 q24.1   UniSTS Human Cytogenetic Map 1 p36.32   UniSTS Human Cytogenetic Map 10 q24.32   UniSTS Human Cytogenetic Map 2 q33.2   UniSTS Human Cytogenetic Map 1 p35-p34.3   UniSTS Human Cytogenetic Map 7 p11.2   UniSTS Human Cytogenetic Map 5 q35.2   UniSTS Human Cytogenetic Map 10 q22.3   UniSTS Human Cytogenetic Map 2 p13.3   UniSTS Human Cytogenetic Map 3 q12.3   UniSTS Human Cytogenetic Map 12 q   UniSTS Human Cytogenetic Map 12 p12.2-p11.2   UniSTS Human Cytogenetic Map 2 p23.3   UniSTS Human Cytogenetic Map 2 q14.3   UniSTS Human Cytogenetic Map 7 p13   UniSTS Human Cytogenetic Map 11 p15.3   UniSTS Human Cytogenetic Map 1 p36.11-p34.2   UniSTS Human Cytogenetic Map 4 q35.1   UniSTS Human Cytogenetic Map 6 q22.31   UniSTS Human Cytogenetic Map 11 q13.1   UniSTS Human Cytogenetic Map 16 q22.2   UniSTS Human Cytogenetic Map 11 q22.3   UniSTS Human Cytogenetic Map 10 p14   UniSTS Human Cytogenetic Map 8 q22.1   UniSTS Human Cytogenetic Map 6 q21   UniSTS Human Cytogenetic Map 4 p16.1   UniSTS Human Cytogenetic Map 20 p11.23   UniSTS Human Cytogenetic Map 3 q22.3   UniSTS Human Cytogenetic Map 3 q27.3   UniSTS Human Cytogenetic Map 22 q12.2   UniSTS Human Cytogenetic Map 14 q32.11   UniSTS Human Cytogenetic Map 15 q14   UniSTS Human Cytogenetic Map 5 q31.3   UniSTS Human Cytogenetic Map 11 q14   UniSTS Human Cytogenetic Map 15 q21   UniSTS Human Cytogenetic Map 3 q27.1   UniSTS Human Cytogenetic Map 3 p14.3   UniSTS Human Cytogenetic Map 12 p13.2   UniSTS Human Cytogenetic Map 6 p21.2   UniSTS Human Cytogenetic Map 10 q11.1-q24   UniSTS Human Cytogenetic Map 1 p36.31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS Human Cytogenetic Map X p11.22   UniSTS Human Cytogenetic Map 10 p15.1   UniSTS Human Cytogenetic Map X q24   UniSTS Human Cytogenetic Map 7 p22.1   UniSTS Human Cytogenetic Map 14 q31.1   UniSTS Human Cytogenetic Map 19 q13.2   UniSTS Human Cytogenetic Map X q21.1   UniSTS Human Cytogenetic Map 15 q22   UniSTS Human Cytogenetic Map 6 p25   UniSTS Human Cytogenetic Map 16 p11.2   UniSTS Human Cytogenetic Map X q12-q13   UniSTS Human Cytogenetic Map 12 q13.3   UniSTS Human Cytogenetic Map 9 q34.11   UniSTS Human Cytogenetic Map 7 q31   UniSTS Human Cytogenetic Map 7 q31.1-q31.3   UniSTS Human Cytogenetic Map 11 q13.4   UniSTS Human Cytogenetic Map 7 q34   UniSTS Human Cytogenetic Map X q13.1-q21.1   UniSTS Human Cytogenetic Map 20 pter-q12   UniSTS Human Cytogenetic Map 14 q32.31   UniSTS Human Cytogenetic Map 12 q13.11-q14.3   UniSTS Human Cytogenetic Map 2 q32.1   UniSTS Human Cytogenetic Map 15 q21-q22   UniSTS Human Cytogenetic Map 19 q13   UniSTS Human Cytogenetic Map 20 q11.22-q11.23   UniSTS Human Cytogenetic Map 10 q23   UniSTS Human Cytogenetic Map 17 p11.2   UniSTS Human Cytogenetic Map 11 p11.2   UniSTS Human Cytogenetic Map 4 q21.22   UniSTS Human Cytogenetic Map 13 q14.2   UniSTS Human Cytogenetic Map 1 q21.2-q21.3   UniSTS Human Cytogenetic Map 9 p24.1   UniSTS Human Cytogenetic Map 15 q15.3   UniSTS Human Cytogenetic Map 3 q13.33   UniSTS Human Cytogenetic Map 8 q11.2   UniSTS Human Cytogenetic Map X q12   UniSTS Human Cytogenetic Map 1 q41-q42.2   UniSTS Human Cytogenetic Map 11 q22-q23   UniSTS Human Cytogenetic Map 12 q23-q24.1   UniSTS Human Cytogenetic Map 1 p36.3   UniSTS Human Cytogenetic Map 1 p33   UniSTS Human Cytogenetic Map 6 p12.3   UniSTS Human Cytogenetic Map 1 q43   UniSTS Human Cytogenetic Map 15 q26.3   UniSTS Human Cytogenetic Map 15 q13.1   UniSTS Human Cytogenetic Map X q13.1   UniSTS Human Cytogenetic Map 10 q11.21   UniSTS Human Cytogenetic Map 17 q23.3   UniSTS Human Cytogenetic Map 3 p21   UniSTS Human Cytogenetic Map 15 q11-q13   UniSTS Human Cytogenetic Map 13 q12-q14   UniSTS Human Cytogenetic Map 18 q21.1   UniSTS Human Cytogenetic Map 9 p23   UniSTS Human Cytogenetic Map 7 p12.3   UniSTS Human Cytogenetic Map 3 p25.3   UniSTS Human Cytogenetic Map 2 q37.2   UniSTS Human Cytogenetic Map 2 p14   UniSTS Human Cytogenetic Map 10 q11.22   UniSTS Human Cytogenetic Map 1 p21.2   UniSTS Human Cytogenetic Map 3 p22.1   UniSTS Human Cytogenetic Map 19 q13.42   UniSTS Human Cytogenetic Map 19 q13.31   UniSTS Human Cytogenetic Map 14 q32.2   UniSTS Human Cytogenetic Map 17 q21.2   UniSTS Human Cytogenetic Map 13 q32.2   UniSTS Human Cytogenetic Map 14 q23.1   UniSTS Human Cytogenetic Map 5 q11.2   UniSTS Human Cytogenetic Map 2 q24.1   UniSTS Human Cytogenetic Map 7 q32.1   UniSTS Human Cytogenetic Map 19 p13.1   UniSTS Human Cytogenetic Map 5 q31.1   UniSTS Human Cytogenetic Map 8 p12-p11   UniSTS Human Cytogenetic Map 1 q31-q32   UniSTS Human Cytogenetic Map 6 q24.1   UniSTS Human Cytogenetic Map 10 q24   UniSTS Human Cytogenetic Map X q28   UniSTS Human Cytogenetic Map 15 q26.1   UniSTS Human Cytogenetic Map 10 q26.11   UniSTS Human Cytogenetic Map 8 p21.1   UniSTS Human Cytogenetic Map 7 p15.3   UniSTS Human Cytogenetic Map 7 p21.1   UniSTS Human Cytogenetic Map 4 q21.1   UniSTS Human Cytogenetic Map 15 q11.2   UniSTS Human Cytogenetic Map 13 q32.3   UniSTS Human Cytogenetic Map X q25   UniSTS Human Cytogenetic Map 12 q24.33   UniSTS Human Cytogenetic Map 14 q23.2   UniSTS Human Cytogenetic Map 2 q24.2   UniSTS Human Cytogenetic Map 16 p12.2   UniSTS Human Cytogenetic Map 15 q21.2   UniSTS Human Cytogenetic Map 3 p26.1-p25.1   UniSTS Human Cytogenetic Map 3 q13.2   UniSTS Human Cytogenetic Map 4 p15.2   UniSTS Human Cytogenetic Map 17 q24-q25   UniSTS Human Cytogenetic Map 5 q12.1   UniSTS Human Cytogenetic Map 5 q15   UniSTS Human Cytogenetic Map 17 q22   UniSTS Human Cytogenetic Map 17 q21.1   UniSTS Human Cytogenetic Map 8 q23.1   UniSTS Human Cytogenetic Map 10 p12.31   UniSTS Human Cytogenetic Map 2 q33.3   UniSTS Human Cytogenetic Map X q21   UniSTS Human Cytogenetic Map 6 p12   UniSTS Human Cytogenetic Map 2 p15-p13   UniSTS Human Cytogenetic Map 19 q   UniSTS Human Cytogenetic Map 20 p11   UniSTS Human Cytogenetic Map 22 q12.3-q13.1   UniSTS Human Cytogenetic Map 1 q25.2   UniSTS Human Cytogenetic Map 10 q21.3   UniSTS Human Cytogenetic Map 3 p21.1-p14.3   UniSTS Human Cytogenetic Map 6 p12.1   UniSTS Human Cytogenetic Map 14 q23.3   UniSTS Human Cytogenetic Map 4 p16.3   UniSTS Human Cytogenetic Map 6 q16.1   UniSTS Human Cytogenetic Map 5 p13.1   UniSTS Human Cytogenetic Map 9 q21.11   UniSTS Human Cytogenetic Map 8 q12   UniSTS Human Cytogenetic Map 1 q24.2   UniSTS Human Cytogenetic Map 2 q34   UniSTS Human Cytogenetic Map 8 p11.23   UniSTS Human Cytogenetic Map 14 q21.2   UniSTS Human Cytogenetic Map 7 q35   UniSTS Human Cytogenetic Map 5 p13.3   UniSTS Human Cytogenetic Map 1 q42.3   UniSTS Human Cytogenetic Map 1 q22-q23   UniSTS Human Cytogenetic Map 6 p21.31   UniSTS Human Cytogenetic Map 4 q21   UniSTS Human Cytogenetic Map 10 p13   UniSTS Human Cytogenetic Map 5 q13   UniSTS Human Cytogenetic Map 4 q13.3   UniSTS Human Cytogenetic Map 9 q34.1   UniSTS Human Cytogenetic Map 5 q13.2   UniSTS Human Cytogenetic Map 17 p12   UniSTS Human Cytogenetic Map 9 q22.1-q22.2   UniSTS Human Cytogenetic Map 18 q12.1   UniSTS Human Cytogenetic Map 13 q14.11   UniSTS Human Cytogenetic Map 7 q21.2   UniSTS Human Cytogenetic Map 9 p22.3   UniSTS Human Cytogenetic Map 8 q21.11   UniSTS Human Cytogenetic Map 6 p22.3   UniSTS Human Cytogenetic Map 5 q32   UniSTS Human Cytogenetic Map 4 p12   UniSTS Human Cytogenetic Map 2 q13   UniSTS Human Cytogenetic Map 21 q11.2   UniSTS Human Cytogenetic Map 1 p34.1   UniSTS Human Cytogenetic Map 19 q11   UniSTS Human Cytogenetic Map 8 p21.2   UniSTS Human Cytogenetic Map 15 q26.2   UniSTS Human Cytogenetic Map 14 q22.1   UniSTS Human Cytogenetic Map 11 p15.1   UniSTS Human Cytogenetic Map 10 q25.3   UniSTS Human Cytogenetic Map 20 q11.23   UniSTS Human Cytogenetic Map 12 q13.11   UniSTS Human Cytogenetic Map 11 q13.2   UniSTS Human Cytogenetic Map 5 p13.2   UniSTS Human Cytogenetic Map 16 q24.1   UniSTS Human Cytogenetic Map 9 q32   UniSTS Human Cytogenetic Map 2 q36.1   UniSTS Human Cytogenetic Map 1 q42.13   UniSTS Human Cytogenetic Map 1 q21.1   UniSTS Human Cytogenetic Map 17 q21.32   UniSTS Human Cytogenetic Map 16 q23.1   UniSTS Human Cytogenetic Map 3 q25.1   UniSTS Human Cytogenetic Map 1 p22.2   UniSTS Human Cytogenetic Map 1 p32.2-p32.1   UniSTS Human Cytogenetic Map 15 q24   UniSTS Human Cytogenetic Map X p21.1   UniSTS Human Cytogenetic Map 12 q14.3   UniSTS Human Cytogenetic Map 7 q36   UniSTS Human Cytogenetic Map 9 q34   UniSTS Human Cytogenetic Map 11 q22   UniSTS Human Cytogenetic Map 5 p15.3   UniSTS Human Cytogenetic Map 7 q11.21   UniSTS Human Cytogenetic Map 20 q13.3-qter   UniSTS Human Cytogenetic Map 13 q13.1   UniSTS Human Cytogenetic Map 1 p33-p32   UniSTS Human Cytogenetic Map 21 q22.2   UniSTS Human Cytogenetic Map 3 q13.13-q13.2   UniSTS Human Cytogenetic Map 3 p21.3   UniSTS Human Cytogenetic Map 12 p11.21   UniSTS Human Cytogenetic Map 7 q   UniSTS Human Cytogenetic Map 11 q13.5   UniSTS Human Cytogenetic Map 4 q32   UniSTS Human Cytogenetic Map 9 q22.33   UniSTS Human Cytogenetic Map 5 q35.1   UniSTS Human Cytogenetic Map 9 p13.3   UniSTS Human Cytogenetic Map 13 q14.13   UniSTS Human Cytogenetic Map 10 p12.1   UniSTS Human Cytogenetic Map 20 q13.33   UniSTS Human Cytogenetic Map 19 p13.13   UniSTS Human Cytogenetic Map 4 q13.2   UniSTS Human Cytogenetic Map 4 q31.23   UniSTS Human Cytogenetic Map 7 q36.3   UniSTS Human Cytogenetic Map 14 q24.2   UniSTS Angpt1   Map Chr Position Strand Source Human Genome Assembly HuRef 8 103,829,658 - 103,829,842   UniSTS Human Genome Assembly GRCh37 8 108,509,734 - 108,509,918   UniSTS Human Celera Assembly 8 104,696,004 - 104,696,188   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1357356 BW59_H Body weight QTL 59 (human) 2 .001 Body weight BMI before exercise training 8 76978225 135242593 Human 1357358 COHEN2_H Cohen syndrome QTL 2 (human) 3.237 Cohen syndrome 8 93020370 123742452 Human 1357366 BW69_H Body weight QTL 69 (human) .0065 Body weight body mass index 8 94328946 120328946 Human 1559120 SCL27_H Serum cholesterol level QTL 27 (human) 1.97 .004 Lipid level HDL cholesterol 8 81039857 127346752 Human 2293473 PRSTS295_H Prostate tumor susceptibility QTL 295 (human) .009 Prostate tumor susceptibility 8 86189849 112189849 Human 2293451 PRSTS204_H Prostate tumor susceptibility QTL 204 (human) 1.87 Prostate tumor susceptibility 8 101387760 127387760 Human 2292808 PRSTS6_H Prostate tumor susceptibility QTL 6 (human) Prostate tumor susceptibility early onset 8 94328946 120328946 Human 2315771 GLUCO144_H Glucose level QTL 144 (human) 1.73 .00421 Glucose level 8 93103268 119103268 Human 2302753 MAMTS17_H Mammary tumor susceptibility QTL 17 (human) .045 Mammary tumor susceptibility 8 105456227 131456227 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_029405 (Get FASTA) Search GEO for Microarray Profiles   NM_001146 (Get FASTA) Search GEO for Microarray Profiles   NM_001199859 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AB084454 (Get FASTA) Search GEO for Microarray Profiles   ABBA01037696 (Get FASTA) Search GEO for Microarray Profiles   AC091010 (Get FASTA) Search GEO for Microarray Profiles   AK300319 (Get FASTA) Search GEO for Microarray Profiles   AK304717 (Get FASTA) Search GEO for Microarray Profiles   AL700429 (Get FASTA) Search GEO for Microarray Profiles   AMYH01018954 (Get FASTA) Search GEO for Microarray Profiles   AMYH01018955 (Get FASTA) Search GEO for Microarray Profiles   AP000428 (Get FASTA) Search GEO for Microarray Profiles   AP003480 (Get FASTA) Search GEO for Microarray Profiles   AW069541 (Get FASTA) Search GEO for Microarray Profiles   AY055342 (Get FASTA) Search GEO for Microarray Profiles   AY121504 (Get FASTA) Search GEO for Microarray Profiles   AY124380 (Get FASTA) Search GEO for Microarray Profiles   BC029406 (Get FASTA) Search GEO for Microarray Profiles   BC152411 (Get FASTA) Search GEO for Microarray Profiles   BC152419 (Get FASTA) Search GEO for Microarray Profiles   BX648814 (Get FASTA) Search GEO for Microarray Profiles   CH471060 (Get FASTA) Search GEO for Microarray Profiles   CX867178 (Get FASTA) Search GEO for Microarray Profiles   D13628 (Get FASTA) Search GEO for Microarray Profiles   U83508 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_001199859 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001186788 Peptide Label: isoform 2 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 8 108,537,955 - 108,786,101 - NCBI Human Genome Assembly HuRef 8 103,581,813 - 103,830,178 - ENTREZGENE Human Genome Assembly GRCh37 8 108,261,710 - 108,510,254 - ENTREZGENE RefSeq Acc Id: NM_001146 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001137 Peptide Label: isoform 1 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 8 108,537,955 - 108,786,101 - NCBI Human Genome Assembly HuRef 8 103,581,813 - 103,830,178 - ENTREZGENE Human Genome Assembly GRCh37 8 108,261,710 - 108,510,254 - ENTREZGENE Human Genome Assembly Build 36 8 108,330,886 - 108,579,430 - NCBI Archive Protein Sequences Protein RefSeqs NP_001137 (Get FASTA)   NP_001186788 (Get FASTA) GenBank Protein AAB50557 (Get FASTA)   AAH29406 (Get FASTA)   AAI52412 (Get FASTA)   AAI52420 (Get FASTA)   AAI66662 (Get FASTA)   AAL59669 (Get FASTA)   AAM81745 (Get FASTA)   AAM92271 (Get FASTA)   ACE86690 (Get FASTA)   ACE87374 (Get FASTA)   BAA02793 (Get FASTA)   BAB91325 (Get FASTA)   BAG62071 (Get FASTA)   BAG65481 (Get FASTA)   CAI45984 (Get FASTA)   EAW91909 (Get FASTA)   EAW91910 (Get FASTA)   EAW91911 (Get FASTA)   EAW91912 (Get FASTA)   Q15389 (Get FASTA) Promoters RGD ID: 7211631 Promoter ID: EPDNEW_H11562 Type: initiation region Name: ANGPT1_1 Description: angiopoietin 1 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Human Genome Assembly Build 36 8 108,510,231 - 108,510,291   EPDNEW RGD ID: 6806488 Promoter ID: HG_KWN:61910 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: NB4 Transcripts: ENST00000297450,   UC003YMO.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 8 108,578,686 - 108,579,337 - MPROMDB Additional Information External Database Links Database Acc Id Source(s) COSMIC ANGPT1 COSMIC Ensembl Genes ENSG00000154188 ENTREZGENE Ensembl Protein ENSP00000297450 ENTREZGENE   ENSP00000428340 ENTREZGENE Ensembl Transcript ENST00000297450 ENTREZGENE   ENST00000517746 ENTREZGENE Entrez Gene 284 ENTREZGENE Gene3D-CATH Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot   Fibrinogen_a/b/g_C_2 UniProtKB/Swiss-Prot Germonline ENSG00000154188 HGNC ID 484 ENTREZGENE HomoloGene Group ID 37447 ENTREZGENE HPRD ID 03392 ENTREZGENE InterPro Fibrinogen_a/b/g_C UniProtKB/Swiss-Prot   Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot   Fibrinogen_a/b/g_C_2 UniProtKB/Swiss-Prot   Fibrinogen_CS UniProtKB/Swiss-Prot IPI IPI00016677 UniProtKB/Swiss-Prot   IPI00976582 UniProtKB/TrEMBL   IPI01011803 UniProtKB/TrEMBL   IPI01013211 UniProtKB/TrEMBL KEGG Report hsa:284 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 601667 OMIM Pfam Fibrinogen_C UniProtKB/Swiss-Prot PharmGKB PA24791 PharmGKB PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot   FIBRINOGEN_C_2 UniProtKB/Swiss-Prot SMART FBG UniProtKB/Swiss-Prot Superfamily-SCOP Fibrinogen_a/b/g_C UniProtKB/Swiss-Prot UniGene Hs.369675 ENTREZGENE UniProt ANGP1_HUMAN UniProtKB/Swiss-Prot   B4DTQ9_HUMAN UniProtKB/TrEMBL   E5RFF4_HUMAN UniProtKB/TrEMBL   E7ERK4_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 ANGPT1  angiopoietin 1  ANGPT1  angiopoietin 1  Symbol and/or name change 39860 APPROVED 2011-07-27 ANGPT1  angiopoietin 1  ANGPT1  angiopoietin 1  Symbol and/or name change 39860 APPROVED

More on ANGPT1 Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 733136 Created: 2004-01-12 Species: Homo sapiens Last Modified: 2013-05-14 Status: ACTIVE