RGD Reference Report - The role of angiopoietins during angiogenesis in gliomas. - Rat Genome Database

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The role of angiopoietins during angiogenesis in gliomas.

Authors: Reiss, Y  Machein, MR  Plate, KH 
Citation: Reiss Y, etal., Brain Pathol. 2005 Oct;15(4):311-7.
RGD ID: 1578345
Pubmed: PMID:16389943   (View Abstract at PubMed)
PMCID: PMC8095963   (View Article at PubMed Central)

The formation of new blood vessels plays an important role in human disease development and progression. For instance, it is well established that the growth of most cancers critically depends on the supply of nutrition and oxygen by newly recruited blood vessels. Similarly, malignant gliomas, the most common primary brain tumors occurring in humans are highly dependent on angiogenesis. In recent years, there has been tremendous effort to uncover the molecular mechanisms that drive blood vessel growth in adult tissues, especially during cancer progression. Vascular endothelial growth factor (VEGF) and other morphogens, such as angiopoietins and ephrins have been shown to be critically involved in the formation of new blood vessels during both developmental and pathological angiogenesis as evidenced by genetic studies in mice. In this review, we focus on angiopoietins, a family of growth factor ligands binding to Tie tyrosine kinase receptors with emphasis on their functional consequences during the growth and progression of experimental tumors and malignant human gliomas.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
high grade glioma  TAS 1578345 RGD 

Objects Annotated

Genes (Homo sapiens)
ANGPT1  (angiopoietin 1)

Objects referenced in this article
Gene TEK TEK receptor tyrosine kinase Homo sapiens
Gene Angpt1 angiopoietin 1 Mus musculus
Gene Tek TEK receptor tyrosine kinase Mus musculus
Gene Angpt1 angiopoietin 1 Rattus norvegicus
Gene Tek TEK receptor tyrosine kinase Rattus norvegicus

Additional Information