Braf (B-Raf proto-oncogene, serine/threonine kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Braf (B-Raf proto-oncogene, serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Braf
Name: B-Raf proto-oncogene, serine/threonine kinase
RGD ID: 619908
Description: Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of ERK1 and ERK2 cascade; and response to cAMP. Is active in postsynapse. Used to study bile duct adenoma; cholangiocarcinoma; intrahepatic cholangiocarcinoma; and papillary thyroid carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-Raf; serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8469,329,772 - 69,476,931 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl469,342,813 - 69,476,931 (-)EnsemblGRCr8
mRatBN7.2468,375,484 - 68,510,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)EnsemblmRatBN7.2
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)Ensemblrn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera463,383,337 - 63,515,499 (-)NCBICelera
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Cytogenetic Map4q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adrenocortical carcinoma  (ISO)
ameloblastoma  (ISO)
Aortic Aneurysm, Giant Congenital  (ISO)
arteriovenous malformations of the brain  (ISO)
ataxia telangiectasia  (ISO)
autosomal recessive Alport syndrome  (ISO)
bile duct adenoma  (IAGP)
Breast Neoplasms  (ISO)
cancer  (ISO)
Carcinogenesis  (ISO)
cardiofaciocutaneous syndrome  (ISO,ISS)
cardiofaciocutaneous syndrome 1  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (IAGP)
colon carcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniopharyngioma  (ISO)
Dandy-Walker syndrome  (ISO)
Desbuquois dysplasia  (ISO)
Developmental Disabilities  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
dysembryoplastic neuroepithelial tumor  (ISO)
dysplastic nevus syndrome  (ISO)
endometrial carcinoma  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
familial melanoma  (ISO)
Follicular Thyroid Cancer  (ISO)
gallbladder cancer  (ISO)
ganglioglioma  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
germinoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (IAGP)
Kidney Neoplasms  (ISO)
Langerhans-cell histiocytosis  (ISS)
Liver Metastasis  (IAGP)
Liver Neoplasms  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mandibular Neoplasms  (ISO)
melanoma  (ISO,ISS)
Microsatellite Instability  (ISO)
multiple myeloma  (ISO)
myoepithelioma  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
Nevus  (ISO)
newborn respiratory distress syndrome  (ISO)
non-Hodgkin lymphoma  (ISO)
Nonseminomatous Germ Cell Tumor  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 7  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 3  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic acinar cell adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
papillary renal cell carcinoma  (ISO)
papillary thyroid carcinoma  (IMP,ISO,ISS)
PHACE Association  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Premature Birth  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate adenocarcinoma  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Romano-Ward Syndrome  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
tethered spinal cord syndrome  (ISO)
tetralogy of Fallot  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular Malformations  (ISO)
ventricular septal defect  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
ABT-737  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ascofuranone  (ISO)
benzo[a]pyrene  (ISO)
betulin  (ISO)
Biflorin  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobimetinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dabrafenib  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
famotidine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
icariside II  (ISO)
isotretinoin  (ISO)
ketamine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
maneb  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
Morindone  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Pentoxifylline  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirarubicin  (EXP)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium cyanide  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rutin  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (ISO)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (ISO)
CD4-positive, alpha-beta T cell differentiation  (ISO)
cell differentiation  (ISO)
cellular response to calcium ion  (ISO)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to xenobiotic stimulus  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
establishment of protein localization to membrane  (ISO)
face development  (ISO)
head morphogenesis  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (IBA,ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of neuron apoptotic process  (IMP,ISO)
negative regulation of synaptic vesicle exocytosis  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of D-glucose transmembrane transport  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive T cell selection  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
protein phosphorylation  (IDA,IMP)
regulation of axon regeneration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of T cell differentiation  (ISO)
response to cAMP  (IMP)
response to peptide hormone  (IMP)
signal transduction  (IEA)
somatic stem cell population maintenance  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
visual learning  (ISO)

Cellular Component
cell body  (ISO)
cytoplasm  (IBA,ISO)
cytosol  (IBA,ISO)
glutamatergic synapse  (ISO)
mitochondrion  (IBA,ISO)
neuron projection  (ISO)
plasma membrane  (IBA,ISO)
postsynapse  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Tumour mutation status and sites of metastasis in patients with cutaneous melanoma. Adler NR, etal., Br J Cancer. 2017 Sep 26;117(7):1026-1035. doi: 10.1038/bjc.2017.254. Epub 2017 Aug 8.
2. KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling. Appleman VA, etal., Mol Cancer Res. 2012 Sep;10(9):1228-39. doi: 10.1158/1541-7786.MCR-12-0340-T. Epub 2012 Aug 7.
3. Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074. Chen HM, etal., J Neurochem. 2008 May;105(4):1300-12. Epub 2008 Jan 10.
4. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Chmielecki J, etal., Cancer Discov. 2014 Dec;4(12):1398-405. doi: 10.1158/2159-8290.CD-14-0617. Epub 2014 Sep 29.
5. A central role for RAF¿MEK¿ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Collisson EA, etal., Cancer Discov. 2012 Aug;2(8):685-93. doi: 10.1158/2159-8290.CD-11-0347. Epub 2012 May 24.
6. Clonal architectures and driver mutations in metastatic melanomas. Ding L, etal., PLoS One. 2014 Nov 13;9(11):e111153. doi: 10.1371/journal.pone.0111153. eCollection 2014.
7. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. Estep AL, etal., PLoS ONE. 2007 Dec 5;2(12):e1279.
8. BRAF mutation in endometrial carcinoma and hyperplasia: correlation with KRAS and p53 mutations and mismatch repair protein expression. Feng YZ, etal., Clin Cancer Res. 2005 Sep 1;11(17):6133-8.
9. Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases. Frankel TL, etal., Cancer. 2017 Feb 15;123(4):568-575. doi: 10.1002/cncr.30351. Epub 2016 Oct 13.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
13. Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Hoeflich KP, etal., Cancer Res. 2006 Jan 15;66(2):999-1006.
14. Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. Honecker F, etal., J Clin Oncol. 2009 May 1;27(13):2129-36. Epub 2009 Mar 16.
15. New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Inoue S, etal., Hum Mol Genet. 2014 Dec 15;23(24):6553-66. doi: 10.1093/hmg/ddu376. Epub 2014 Jul 17.
16. CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity. James J, etal., Mol Cancer Ther. 2012 Apr;11(4):930-41. doi: 10.1158/1535-7163.MCT-11-0645. Epub 2012 Feb 7.
17. BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. Jeong JH, etal., PLoS One. 2008;3(12):e3949. Epub 2008 Dec 16.
18. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. Karbowniczek M, etal., J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.
19. DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Kelly PA and Rahmani Z, Mol Biol Cell. 2005 Aug;16(8):3562-73. Epub 2005 May 25.
20. R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade. Kimmelman AC, etal., Mol Cell Biol. 2002 Aug;22(16):5946-61.
21. An Animal Model Further Uncovers the Role of Mutant BrafV600E during Papillary Thyroid Cancer Development. Koelsch B, etal., Am J Pathol. 2020 Mar;190(3):702-710. doi: 10.1016/j.ajpath.2019.11.006. Epub 2020 Jan 14.
22. BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas. Lee D, etal., J Surg Oncol. 2015 Mar;111(3):359-64. doi: 10.1002/jso.23822. Epub 2014 Oct 24.
23. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. McCubrey JA, etal., Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Immunohistochemical localization of raf protein kinase in dendritic spines and spine apparatuses of the rat cerebral cortex. Mihály A, etal., Brain Res. 1991 May 3;547(2):309-14. doi: 10.1016/0006-8993(91)90976-3.
26. Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain. Morice C, etal., Eur J Neurosci. 1999 Jun;11(6):1995-2006.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Niihori T, etal., Nat Genet. 2006 Mar;38(3):294-6. Epub 2006 Feb 12.
29. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Nucera C, etal., Oncologist. 2011;16(3):296-309. doi: 10.1634/theoncologist.2010-0317. Epub 2011 Feb 25.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. The T1796A mutation of the BRAF gene is absent in Spitz nevi. Palmedo G, etal., J Cutan Pathol. 2004 Mar;31(3):266-70.
32. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
33. Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis. Passiglia F, etal., Crit Rev Oncol Hematol. 2016 Mar;99:150-7. doi: 10.1016/j.critrevonc.2015.12.015. Epub 2016 Jan 2.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
37. Prognostic and predictive values of oncogenic BRAF, NRAS, c-KIT and MITF in cutaneous and mucous melanoma. Pracht M, etal., J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1530-8. doi: 10.1111/jdv.12910. Epub 2015 Jan 26.
38. BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. Preto A, et al., J Pathol. 2008 Feb;214(3):320-7.
39. BRAF V600E mutational status in bile duct adenomas and hamartomas. Pujals A, etal., Histopathology. 2015 Oct;67(4):562-7. doi: 10.1111/his.12674. Epub 2015 Mar 31.
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome. Robertson S, etal., Hum Pathol. 2013 Dec;44(12):2768-73. doi: 10.1016/j.humpath.2013.07.026. Epub 2013 Oct 15.
44. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
45. Regulation and role of Raf-1/B-Raf heterodimerization. Rushworth LK, etal., Mol Cell Biol. 2006 Mar;26(6):2262-72.
46. Mutational analysis and clinical correlation of metastatic colorectal cancer. Russo AL, etal., Cancer. 2014 May 15;120(10):1482-90. doi: 10.1002/cncr.28599. Epub 2014 Feb 5.
47. BRAF mutations are also associated with neurocutaneous melanocytosis and large/giant congenital melanocytic nevi. Salgado CM, etal., Pediatr Dev Pathol. 2015 Jan-Feb;18(1):1-9. doi: 10.2350/14-10-1566-OA.1. Epub 2014 Dec 9.
48. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
49. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
50. B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis. Sobczak I, etal., Oncogene. 2008 Aug 14;27(35):4779-87. doi: 10.1038/onc.2008.128. Epub 2008 May 19.
51. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Tannapfel A, etal., Gut. 2003 May;52(5):706-12.
52. BRAF mutation is a prognostic biomarker for colorectal liver metastasectomy. Teng HW, etal., J Surg Oncol. 2012 Aug 1;106(2):123-9. doi: 10.1002/jso.23063. Epub 2012 Feb 13.
53. In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval. Ulisse S, etal., Clin Endocrinol (Oxf). 2012 Nov;77(5):780-6. doi: 10.1111/j.1365-2265.2012.04465.x.
54. Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability. Umeda Y, etal., J Hepatobiliary Pancreat Sci. 2013 Feb;20(2):223-33. doi: 10.1007/s00534-012-0531-9.
55. Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Urosevic J, etal., Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5015-20. doi: 10.1073/pnas.1016933108. Epub 2011 Mar 7.
56. v-Raf murine sarcoma viral oncogene mutation status in serous borderline ovarian tumors and the effect on clinical behavior. Verbruggen MB, etal., Int J Gynecol Cancer. 2009 Dec;19(9):1560-3.
57. Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin. Vuchak LA, etal., Mol Pharmacol. 2009 Nov;76(5):1123-9. Epub 2009 Aug 31.
58. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
59. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
60. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Yu J, etal., Neurology. 2009 Nov 10;73(19):1526-31. doi: 10.1212/WNL.0b013e3181c0664a. Epub 2009 Sep 30.
Additional References at PubMed
PMID:9207797   PMID:9679960   PMID:9837904   PMID:10704835   PMID:10854065   PMID:11698596   PMID:12194967   PMID:12650640   PMID:15199148   PMID:15736129   PMID:15782137   PMID:15784729  
PMID:15886202   PMID:16116448   PMID:16157584   PMID:16342120   PMID:16818623   PMID:16858395   PMID:16980614   PMID:17380122   PMID:17563371   PMID:18228248   PMID:18567582   PMID:18952847  
PMID:19667065   PMID:19727074   PMID:21203559   PMID:22065586   PMID:22169110   PMID:22510884   PMID:22628551   PMID:22891351   PMID:22892241   PMID:23010278   PMID:23022482   PMID:23334952  
PMID:23616533   PMID:24492844   PMID:24733831   PMID:25155755   PMID:25437913   PMID:26333016   PMID:27658714   PMID:29225069   PMID:29433126   PMID:35147166  


Genomics

Comparative Map Data
Braf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8469,329,772 - 69,476,931 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl469,342,813 - 69,476,931 (-)EnsemblGRCr8
mRatBN7.2468,375,484 - 68,510,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)EnsemblmRatBN7.2
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)Ensemblrn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera463,383,337 - 63,515,499 (-)NCBICelera
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Cytogenetic Map4q23NCBI
BRAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387140,713,328 - 140,924,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7140,719,327 - 140,924,976 (-)Ensemblhg38GRCh38
GRCh377140,413,128 - 140,624,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367140,080,751 - 140,271,033 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347139,887,462 - 140,077,748NCBI
Celera7135,155,867 - 135,346,614 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7134,729,459 - 134,920,529 (-)NCBIHuRef
CHM1_17140,368,045 - 140,559,148 (-)NCBICHM1_1
T2T-CHM13v2.07142,027,505 - 142,239,131 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27139,771,989 - 139,962,886 (-)NCBI
Braf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39639,580,171 - 39,702,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl639,580,171 - 39,702,397 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38639,603,231 - 39,725,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)Ensemblmm10GRCm38
MGSCv37639,553,236 - 39,675,462 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36639,557,807 - 39,675,462 (-)NCBIMGSCv36mm8
Celera639,588,093 - 39,710,723 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.43NCBI
Braf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554942,566,744 - 2,711,358 (+)Ensembl
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBIChiLan1.0ChiLan1.0
BRAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26177,509,195 - 177,712,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1729,523,822 - 29,723,049 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17145,124,291 - 145,327,115 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)EnsemblpanPan2panpan1.1
BRAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1168,222,909 - 8,318,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl168,222,907 - 8,317,906 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha168,989,501 - 9,160,850 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0168,065,738 - 8,237,942 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl168,065,737 - 8,239,141 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1168,017,140 - 8,188,930 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,861,588 - 8,033,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,929,505 - 8,101,841 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Braf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511814,385,958 - 14,495,443 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365924,737,011 - 4,834,664 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365924,728,371 - 4,833,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,957,991 - 9,132,553 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1188,957,963 - 9,132,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,522,257 - 9,636,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRAF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121109,495,525 - 109,690,261 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660726,137,051 - 6,336,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Braf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476520,773,885 - 20,951,736 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476520,766,368 - 20,951,560 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Braf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16100,057,507 - 100,188,855 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Braf
615 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:36
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000014604
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46796011273752811Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
AW529263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2468,494,111 - 68,494,314 (+)MAPPERmRatBN7.2
Rnor_6.0467,504,571 - 67,504,773NCBIRnor6.0
Rnor_5.0467,311,711 - 67,311,913UniSTSRnor5.0
RGSC_v3.4467,227,180 - 67,227,382UniSTSRGSC3.4
Celera463,498,578 - 63,498,780UniSTS
RH 3.4 Map4407.4UniSTS
Cytogenetic Map4q21-q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001070228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_231692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF352172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014604   ⟹   ENSRNOP00000014604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl469,355,844 - 69,440,866 (-)Ensembl
mRatBN7.2 Ensembl468,388,299 - 68,474,089 (-)Ensembl
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100954   ⟹   ENSRNOP00000091382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl469,345,458 - 69,476,931 (-)Ensembl
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111433   ⟹   ENSRNOP00000096915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl469,345,458 - 69,476,931 (-)Ensembl
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113323   ⟹   ENSRNOP00000092085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl469,342,813 - 69,476,931 (-)Ensembl
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122584   ⟹   ENSRNOP00000099453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl469,345,458 - 69,476,931 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146376   ⟹   ENSRNOP00000111883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl469,345,458 - 69,476,931 (-)Ensembl
RefSeq Acc Id: NM_001427466   ⟹   NP_001414395
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,931 (-)NCBI
RefSeq Acc Id: XM_006236357   ⟹   XP_006236419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
mRatBN7.2468,378,673 - 68,510,646 (-)NCBI
Rnor_6.0467,389,331 - 67,520,549 (-)NCBI
Rnor_5.0467,196,477 - 67,327,649 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285396   ⟹   XP_063141466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
RefSeq Acc Id: XM_063285397   ⟹   XP_063141467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
RefSeq Acc Id: XM_063285398   ⟹   XP_063141468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
RefSeq Acc Id: XM_231692   ⟹   XP_231692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
mRatBN7.2468,378,673 - 68,510,649 (-)NCBI
Rnor_6.0467,389,331 - 67,520,549 (-)NCBI
Rnor_5.0467,196,477 - 67,327,649 (-)NCBI
RGSC_v3.4467,117,759 - 67,243,058 (-)RGD
Sequence:
RefSeq Acc Id: XR_010065581
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065582
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,329,772 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065583
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065584
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,329,772 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065585
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,329,772 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065586
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065587
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065588
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065589
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065590
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,357,549 - 69,476,779 (-)NCBI
RefSeq Acc Id: XP_231692   ⟸   XM_231692
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ATH0 (UniProtKB/TrEMBL),   A0A8I6AFV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236419   ⟸   XM_006236357
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AFV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014604   ⟸   ENSRNOT00000014604
Ensembl Acc Id: ENSRNOP00000092085   ⟸   ENSRNOT00000113323
Ensembl Acc Id: ENSRNOP00000096915   ⟸   ENSRNOT00000111433
Ensembl Acc Id: ENSRNOP00000091382   ⟸   ENSRNOT00000100954
RefSeq Acc Id: NP_001414395   ⟸   NM_001427466
- UniProtKB: A0A8I6AFV6 (UniProtKB/TrEMBL),   A0A8I6ADL5 (UniProtKB/TrEMBL),   A6IEW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141468   ⟸   XM_063285398
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AFV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141467   ⟸   XM_063285397
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AFV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141466   ⟸   XM_063285396
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AFV6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111883   ⟸   ENSRNOT00000146376
Ensembl Acc Id: ENSRNOP00000099453   ⟸   ENSRNOT00000122584
Protein Domains
Phorbol-ester/DAG-type   Protein kinase   RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9C3-F1-model_v2 AlphaFold F1M9C3 1-712 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619908 AgrOrtholog
BioCyc Gene G2FUF-45181 BioCyc
Ensembl Genes ENSRNOG00000010957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014604 ENTREZGENE
  ENSRNOT00000014604.9 UniProtKB/TrEMBL
  ENSRNOT00000100954 ENTREZGENE
  ENSRNOT00000100954.2 UniProtKB/TrEMBL
  ENSRNOT00000111433 ENTREZGENE
  ENSRNOT00000111433.2 UniProtKB/TrEMBL
  ENSRNOT00000113323 ENTREZGENE
  ENSRNOT00000113323.2 UniProtKB/TrEMBL
  ENSRNOT00000122584 ENTREZGENE
  ENSRNOT00000122584.1 UniProtKB/TrEMBL
  ENSRNOT00000146376 ENTREZGENE
  ENSRNOT00000146376.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Raf-like_ras-bd UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser/Thr_Kinases-Pseudokinases UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
NCBI Gene 114486 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE B-RAF UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
PhenoGen Braf PhenoGen
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010957 RatGTEx
SMART RBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8I6ADL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATH0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDY4_RAT UniProtKB/TrEMBL
  A0ABK0M8N1_RAT UniProtKB/TrEMBL
  A6IEW0 ENTREZGENE, UniProtKB/TrEMBL
  F1M9C3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Braf  B-Raf proto-oncogene, serine/threonine kinase  Braf  v-raf murine sarcoma viral oncogene homolog B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Braf  v-raf murine sarcoma viral oncogene homolog B  Braf  v-raf murine sarcoma viral oncogene homolog B1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Braf  v-raf murine sarcoma viral oncogene homolog B1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Braf        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutated in human choroidal melanoma 634639
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557