Braf (B-Raf proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Braf (B-Raf proto-oncogene, serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Braf
Name: B-Raf proto-oncogene, serine/threonine kinase
RGD ID: 619908
Description: Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of ERK1 and ERK2 cascade; and response to cAMP. Predicted to be located in several cellular components, including cell body; intracellular membrane-bounded organelle; and neuron projection. Predicted to be active in cytosol; mitochondrion; and plasma membrane. Used to study bile duct adenoma; cholangiocarcinoma; intrahepatic cholangiocarcinoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-Raf; serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8469,329,772 - 69,476,931 (-)NCBIGRCr8
mRatBN7.2468,375,484 - 68,510,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Celera463,383,337 - 63,515,499 (-)NCBICelera
Cytogenetic Map4q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenocortical carcinoma  (ISO)
ameloblastoma  (ISO)
Aortic Aneurysm, Giant Congenital  (ISO)
arteriovenous malformations of the brain  (ISO)
ataxia telangiectasia  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bile duct adenoma  (IAGP)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
cancer  (ISO)
Carcinogenesis  (ISO)
cardiofaciocutaneous syndrome  (ISO,ISS)
cardiofaciocutaneous syndrome 1  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (IAGP)
chronic lymphocytic leukemia  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myeloid leukemia  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniopharyngioma  (ISO)
Dandy-Walker syndrome  (ISO)
Developmental Disabilities  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
dysembryoplastic neuroepithelial tumor  (ISO)
dysplastic nevus syndrome  (ISO)
endometrial carcinoma  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
familial melanoma  (ISO)
Follicular Thyroid Cancer  (ISO)
gallbladder cancer  (ISO)
ganglioglioma  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
germinoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (IAGP)
Kidney Neoplasms  (ISO)
Langerhans-cell histiocytosis  (ISS)
Liver Metastasis  (IAGP)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mandibular Neoplasms  (ISO)
melanoma  (ISO,ISS)
Microsatellite Instability  (ISO)
multiple myeloma  (ISO)
myoepithelioma  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
Nevus  (ISO)
newborn respiratory distress syndrome  (ISO)
non-Hodgkin lymphoma  (ISO)
Nonseminomatous Germ Cell Tumor  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 7  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 3  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic acinar cell adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
PHACE Association  (ISO)
plasma cell neoplasm  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Premature Birth  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate adenocarcinoma  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
tethered spinal cord syndrome  (ISO)
thyroid gland papillary carcinoma  (IMP,ISO,ISS)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
uterine cancer  (ISO)
Vascular Malformations  (ISO)
ventricular septal defect  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
ABT-737  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
betulin  (ISO)
Biflorin  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobimetinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dabrafenib  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
famotidine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
icariside II  (ISO)
isotretinoin  (ISO)
ketamine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
maneb  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Pentoxifylline  (EXP)
phenobarbital  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium cyanide  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rutin  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (EXP,ISO)
succimer  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (ISO)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (ISO)
CD4-positive, alpha-beta T cell differentiation  (ISO)
cell differentiation  (ISO)
cellular response to calcium ion  (ISO)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to xenobiotic stimulus  (ISO)
endothelial cell apoptotic process  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of protein localization to membrane  (ISO)
face development  (ISO)
head morphogenesis  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (IBA,ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of neuron apoptotic process  (IMP,ISO)
negative regulation of synaptic vesicle exocytosis  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive T cell selection  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
protein phosphorylation  (IDA,IMP)
Ras protein signal transduction  (IEA)
regulation of axon regeneration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of T cell differentiation  (ISO)
response to cAMP  (IMP)
response to peptide hormone  (IMP)
somatic stem cell population maintenance  (ISO)
stress fiber assembly  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
synaptic vesicle exocytosis  (ISO)
T cell differentiation in thymus  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trehalose metabolism in response to stress  (ISO)
visual learning  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tumour mutation status and sites of metastasis in patients with cutaneous melanoma. Adler NR, etal., Br J Cancer. 2017 Sep 26;117(7):1026-1035. doi: 10.1038/bjc.2017.254. Epub 2017 Aug 8.
2. KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling. Appleman VA, etal., Mol Cancer Res. 2012 Sep;10(9):1228-39. doi: 10.1158/1541-7786.MCR-12-0340-T. Epub 2012 Aug 7.
3. Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074. Chen HM, etal., J Neurochem. 2008 May;105(4):1300-12. Epub 2008 Jan 10.
4. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Chmielecki J, etal., Cancer Discov. 2014 Dec;4(12):1398-405. doi: 10.1158/2159-8290.CD-14-0617. Epub 2014 Sep 29.
5. A central role for RAF¿MEK¿ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Collisson EA, etal., Cancer Discov. 2012 Aug;2(8):685-93. doi: 10.1158/2159-8290.CD-11-0347. Epub 2012 May 24.
6. Clonal architectures and driver mutations in metastatic melanomas. Ding L, etal., PLoS One. 2014 Nov 13;9(11):e111153. doi: 10.1371/journal.pone.0111153. eCollection 2014.
7. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. Estep AL, etal., PLoS ONE. 2007 Dec 5;2(12):e1279.
8. BRAF mutation in endometrial carcinoma and hyperplasia: correlation with KRAS and p53 mutations and mismatch repair protein expression. Feng YZ, etal., Clin Cancer Res. 2005 Sep 1;11(17):6133-8.
9. Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases. Frankel TL, etal., Cancer. 2017 Feb 15;123(4):568-575. doi: 10.1002/cncr.30351. Epub 2016 Oct 13.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
13. Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Hoeflich KP, etal., Cancer Res. 2006 Jan 15;66(2):999-1006.
14. Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. Honecker F, etal., J Clin Oncol. 2009 May 1;27(13):2129-36. Epub 2009 Mar 16.
15. New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Inoue S, etal., Hum Mol Genet. 2014 Dec 15;23(24):6553-66. doi: 10.1093/hmg/ddu376. Epub 2014 Jul 17.
16. CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity. James J, etal., Mol Cancer Ther. 2012 Apr;11(4):930-41. doi: 10.1158/1535-7163.MCT-11-0645. Epub 2012 Feb 7.
17. BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. Jeong JH, etal., PLoS One. 2008;3(12):e3949. Epub 2008 Dec 16.
18. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. Karbowniczek M, etal., J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.
19. DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Kelly PA and Rahmani Z, Mol Biol Cell. 2005 Aug;16(8):3562-73. Epub 2005 May 25.
20. R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade. Kimmelman AC, etal., Mol Cell Biol. 2002 Aug;22(16):5946-61.
21. An Animal Model Further Uncovers the Role of Mutant BrafV600E during Papillary Thyroid Cancer Development. Koelsch B, etal., Am J Pathol. 2020 Mar;190(3):702-710. doi: 10.1016/j.ajpath.2019.11.006. Epub 2020 Jan 14.
22. BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas. Lee D, etal., J Surg Oncol. 2015 Mar;111(3):359-64. doi: 10.1002/jso.23822. Epub 2014 Oct 24.
23. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. McCubrey JA, etal., Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain. Morice C, etal., Eur J Neurosci. 1999 Jun;11(6):1995-2006.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Niihori T, etal., Nat Genet. 2006 Mar;38(3):294-6. Epub 2006 Feb 12.
28. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Nucera C, etal., Oncologist. 2011;16(3):296-309. doi: 10.1634/theoncologist.2010-0317. Epub 2011 Feb 25.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. The T1796A mutation of the BRAF gene is absent in Spitz nevi. Palmedo G, etal., J Cutan Pathol. 2004 Mar;31(3):266-70.
31. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
32. Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis. Passiglia F, etal., Crit Rev Oncol Hematol. 2016 Mar;99:150-7. doi: 10.1016/j.critrevonc.2015.12.015. Epub 2016 Jan 2.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
36. Prognostic and predictive values of oncogenic BRAF, NRAS, c-KIT and MITF in cutaneous and mucous melanoma. Pracht M, etal., J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1530-8. doi: 10.1111/jdv.12910. Epub 2015 Jan 26.
37. BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. Preto A, et al., J Pathol. 2008 Feb;214(3):320-7.
38. BRAF V600E mutational status in bile duct adenomas and hamartomas. Pujals A, etal., Histopathology. 2015 Oct;67(4):562-7. doi: 10.1111/his.12674. Epub 2015 Mar 31.
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome. Robertson S, etal., Hum Pathol. 2013 Dec;44(12):2768-73. doi: 10.1016/j.humpath.2013.07.026. Epub 2013 Oct 15.
43. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
44. Regulation and role of Raf-1/B-Raf heterodimerization. Rushworth LK, etal., Mol Cell Biol. 2006 Mar;26(6):2262-72.
45. Mutational analysis and clinical correlation of metastatic colorectal cancer. Russo AL, etal., Cancer. 2014 May 15;120(10):1482-90. doi: 10.1002/cncr.28599. Epub 2014 Feb 5.
46. BRAF mutations are also associated with neurocutaneous melanocytosis and large/giant congenital melanocytic nevi. Salgado CM, etal., Pediatr Dev Pathol. 2015 Jan-Feb;18(1):1-9. doi: 10.2350/14-10-1566-OA.1. Epub 2014 Dec 9.
47. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
48. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
49. B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis. Sobczak I, etal., Oncogene. 2008 Aug 14;27(35):4779-87. doi: 10.1038/onc.2008.128. Epub 2008 May 19.
50. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Tannapfel A, etal., Gut. 2003 May;52(5):706-12.
51. BRAF mutation is a prognostic biomarker for colorectal liver metastasectomy. Teng HW, etal., J Surg Oncol. 2012 Aug 1;106(2):123-9. doi: 10.1002/jso.23063. Epub 2012 Feb 13.
52. In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval. Ulisse S, etal., Clin Endocrinol (Oxf). 2012 Nov;77(5):780-6. doi: 10.1111/j.1365-2265.2012.04465.x.
53. Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability. Umeda Y, etal., J Hepatobiliary Pancreat Sci. 2013 Feb;20(2):223-33. doi: 10.1007/s00534-012-0531-9.
54. Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Urosevic J, etal., Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5015-20. doi: 10.1073/pnas.1016933108. Epub 2011 Mar 7.
55. v-Raf murine sarcoma viral oncogene mutation status in serous borderline ovarian tumors and the effect on clinical behavior. Verbruggen MB, etal., Int J Gynecol Cancer. 2009 Dec;19(9):1560-3.
56. Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin. Vuchak LA, etal., Mol Pharmacol. 2009 Nov;76(5):1123-9. Epub 2009 Aug 31.
57. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
58. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
59. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Yu J, etal., Neurology. 2009 Nov 10;73(19):1526-31. doi: 10.1212/WNL.0b013e3181c0664a. Epub 2009 Sep 30.
Additional References at PubMed
PMID:9207797   PMID:9679960   PMID:9837904   PMID:10704835   PMID:10854065   PMID:11698596   PMID:12194967   PMID:12650640   PMID:15199148   PMID:15736129   PMID:15782137   PMID:15784729  
PMID:15886202   PMID:16116448   PMID:16157584   PMID:16342120   PMID:16818623   PMID:16858395   PMID:16980614   PMID:17380122   PMID:17563371   PMID:18228248   PMID:18567582   PMID:18952847  
PMID:19667065   PMID:19727074   PMID:21203559   PMID:22065586   PMID:22169110   PMID:22510884   PMID:22628551   PMID:22891351   PMID:22892241   PMID:23010278   PMID:23022482   PMID:23334952  
PMID:23616533   PMID:24492844   PMID:24733831   PMID:25155755   PMID:25437913   PMID:26333016   PMID:27658714   PMID:29225069   PMID:29433126   PMID:35147166  


Genomics

Comparative Map Data
Braf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8469,329,772 - 69,476,931 (-)NCBIGRCr8
mRatBN7.2468,375,484 - 68,510,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Celera463,383,337 - 63,515,499 (-)NCBICelera
Cytogenetic Map4q23NCBI
BRAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387140,713,328 - 140,924,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7140,719,327 - 140,924,929 (-)EnsemblGRCh38hg38GRCh38
GRCh377140,413,128 - 140,624,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367140,080,751 - 140,271,033 (-)NCBINCBI36Build 36hg18NCBI36
Build 347139,887,462 - 140,077,748NCBI
Celera7135,155,867 - 135,346,614 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7134,729,459 - 134,920,529 (-)NCBIHuRef
CHM1_17140,368,045 - 140,559,148 (-)NCBICHM1_1
T2T-CHM13v2.07142,027,505 - 142,239,131 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27139,771,989 - 139,962,886 (-)NCBI
Braf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39639,580,171 - 39,702,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl639,580,171 - 39,702,397 (-)EnsemblGRCm39 Ensembl
GRCm38639,603,231 - 39,725,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv37639,553,236 - 39,675,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36639,557,807 - 39,675,462 (-)NCBIMGSCv36mm8
Celera639,588,093 - 39,710,723 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.43NCBI
Braf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBIChiLan1.0ChiLan1.0
BRAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26177,509,195 - 177,712,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1729,523,822 - 29,723,049 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17145,124,291 - 145,327,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)Ensemblpanpan1.1panPan2
BRAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1168,222,909 - 8,318,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl168,222,907 - 8,317,906 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,989,501 - 9,160,850 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0168,065,738 - 8,237,942 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl168,065,737 - 8,239,141 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1168,017,140 - 8,188,930 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,861,588 - 8,033,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,929,505 - 8,101,841 (+)NCBIUU_Cfam_GSD_1.0
Braf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511814,385,958 - 14,495,443 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365924,737,011 - 4,834,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365924,728,371 - 4,833,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,957,991 - 9,132,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,957,963 - 9,132,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,522,257 - 9,636,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRAF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121109,495,525 - 109,690,261 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660726,137,051 - 6,336,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Braf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476520,773,885 - 20,951,736 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476520,766,368 - 20,951,560 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Braf
579 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:36
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000014604
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)46699318572752834Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)46699318572752834Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46699318572752834Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)46738666970362197Rat

Markers in Region
AW529263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2468,494,111 - 68,494,314 (+)MAPPERmRatBN7.2
Rnor_6.0467,504,571 - 67,504,773NCBIRnor6.0
Rnor_5.0467,311,711 - 67,311,913UniSTSRnor5.0
RGSC_v3.4467,227,180 - 67,227,382UniSTSRGSC3.4
Celera463,498,578 - 63,498,780UniSTS
RH 3.4 Map4407.4UniSTS
Cytogenetic Map4q21-q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 7 4 4 4 74 20 36 11
Low 3 31 50 37 15 37 8 11 15 5 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001070228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_231692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF352172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014604   ⟹   ENSRNOP00000014604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl468,388,299 - 68,474,089 (-)Ensembl
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100954   ⟹   ENSRNOP00000091382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111433   ⟹   ENSRNOP00000096915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113323   ⟹   ENSRNOP00000092085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)Ensembl
RefSeq Acc Id: NM_001427466   ⟹   NP_001414395
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,931 (-)NCBI
RefSeq Acc Id: XM_006236357   ⟹   XP_006236419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
mRatBN7.2468,378,673 - 68,510,646 (-)NCBI
Rnor_6.0467,389,331 - 67,520,549 (-)NCBI
Rnor_5.0467,196,477 - 67,327,649 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285396   ⟹   XP_063141466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
RefSeq Acc Id: XM_063285397   ⟹   XP_063141467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
RefSeq Acc Id: XM_063285398   ⟹   XP_063141468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
RefSeq Acc Id: XM_231692   ⟹   XP_231692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,345,458 - 69,476,779 (-)NCBI
mRatBN7.2468,378,673 - 68,510,649 (-)NCBI
Rnor_6.0467,389,331 - 67,520,549 (-)NCBI
Rnor_5.0467,196,477 - 67,327,649 (-)NCBI
RGSC_v3.4467,117,759 - 67,243,058 (-)RGD
Sequence:
RefSeq Acc Id: XR_010065581
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065582
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,329,772 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065583
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065584
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,329,772 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065585
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,329,772 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065586
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065587
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065588
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065589
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,332,992 - 69,476,779 (-)NCBI
RefSeq Acc Id: XR_010065590
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8469,357,549 - 69,476,779 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_231692   ⟸   XM_231692
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ATH0 (UniProtKB/TrEMBL),   A0A8I6AFV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236419   ⟸   XM_006236357
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AFV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014604   ⟸   ENSRNOT00000014604
RefSeq Acc Id: ENSRNOP00000092085   ⟸   ENSRNOT00000113323
RefSeq Acc Id: ENSRNOP00000096915   ⟸   ENSRNOT00000111433
RefSeq Acc Id: ENSRNOP00000091382   ⟸   ENSRNOT00000100954
RefSeq Acc Id: NP_001414395   ⟸   NM_001427466
- UniProtKB: A0A8I6AFV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141468   ⟸   XM_063285398
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063141467   ⟸   XM_063285397
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063141466   ⟸   XM_063285396
- Peptide Label: isoform X1
Protein Domains
Phorbol-ester/DAG-type   Protein kinase   RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9C3-F1-model_v2 AlphaFold F1M9C3 1-712 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619908 AgrOrtholog
BioCyc Gene G2FUF-45181 BioCyc
Ensembl Genes ENSRNOG00000010957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014604.8 UniProtKB/TrEMBL
  ENSRNOT00000100954.1 UniProtKB/TrEMBL
  ENSRNOT00000111433.1 UniProtKB/TrEMBL
  ENSRNOT00000113323.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Raf-like_ras-bd UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
NCBI Gene 114486 ENTREZGENE
PANTHER NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
PhenoGen Braf PhenoGen
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010957 RatGTEx
SMART RBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8I6ADL5_RAT UniProtKB/TrEMBL
  A0A8I6AFV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATH0 ENTREZGENE, UniProtKB/TrEMBL
  A6IEW0_RAT UniProtKB/TrEMBL
  F1M9C3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Braf  B-Raf proto-oncogene, serine/threonine kinase  Braf  v-raf murine sarcoma viral oncogene homolog B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Braf  v-raf murine sarcoma viral oncogene homolog B  Braf  v-raf murine sarcoma viral oncogene homolog B1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Braf  v-raf murine sarcoma viral oncogene homolog B1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Braf        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutated in human choroidal melanoma 634639
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557