GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Braf | decreases activity | EXP | | 6480464 | CTD | sorafenib results in decreased activity of BRAF protein | PMID:17341847 | Braf | decreases activity | ISO | BRAF (Homo sapiens) | 6480464 | CTD | sorafenib results in decreased activity of BRAF protein; sorafenib results in decreased activity of BRAF protein mutant form | PMID:17341847 PMID:17664273 PMID:20823850 | Braf | multiple interactions | ISO | BRAF (Homo sapiens) | 6480464 | CTD | Sorafenib inhibits the reaction [BRAF protein mutant form results in increased phosphorylation of MAPK1 protein]; Sorafenib inhibits the reaction [BRAF protein mutant form results in increased phosphorylation of MAPK3 protein] | PMID:17664273 | |
Go Back to source page | Continue to Ontology report |