Rps6 (ribosomal protein S6) - Rat Genome Database

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Gene: Rps6 (ribosomal protein S6) Rattus norvegicus
Analyze
Symbol: Rps6
Name: ribosomal protein S6
RGD ID: 3602
Description: Enables mRNA binding activity. A structural constituent of ribosome. Involved in several processes, including cellular response to ethanol; negative regulation of bicellular tight junction assembly; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Is active in GABA-ergic synapse; presynapse; and ribosome. Used to study transient cerebral ischemia. Biomarker of vascular dementia. Orthologous to human RPS6 (ribosomal protein S6); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; insulin signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 40S ribosomal protein S6; 40S ribosomal protein S6-like; LOC100911372; small ribosomal subunit protein eS6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Rps6-ps10  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85106,417,680 - 106,420,540 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5106,417,680 - 106,420,566 (-)EnsemblGRCr8
mRatBN7.25101,371,716 - 101,374,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5101,371,136 - 101,374,602 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl566,681,075 - 66,681,919 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5103,752,605 - 103,755,465 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05105,543,160 - 105,546,020 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05105,576,526 - 105,579,388 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05105,197,821 - 105,200,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,197,857 - 105,200,148 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl5105,209,846 - 105,212,173 (-)Ensemblrn6Rnor6.0
Rnor_5.05109,184,689 - 109,187,549 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45106,165,612 - 106,168,472 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5101,709,190 - 101,712,050 (+)NCBICelera
Cytogenetic Map5q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
alpha-Zearalanol  (EXP)
Alpinetin  (ISO)
amino acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (EXP)
amphibole asbestos  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
avobenzone  (ISO)
AZD4547  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
Betanin  (ISO)
bicalutamide  (ISO)
biguanides  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calyculin A  (ISO)
camostat  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capivasertib  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysophanol  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cobimetinib  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP)
dactolisib  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dimethyl sulfoxide  (ISO)
Dinitramine  (ISO)
dioxygen  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
everolimus  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Gingerenone A  (EXP,ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP)
glutathione  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
Ku-0063794  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
lipopolysaccharide  (ISO)
lonidamine  (ISO)
loratadine  (ISO)
LY294002  (ISO)
mechlorethamine  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
mycophenolic acid  (ISO)
N(6)-butyryl-cAMP  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
omipalisib  (ISO)
orlistat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
pentetrazol  (EXP)
perfluorooctanoic acid  (EXP,ISO)
PHA-665752  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
pyrvinium  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sapanisertib  (ISO)
SB 431542  (ISO)
silmitasertib  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tanespimycin  (ISO)
Temsirolimus  (ISO)
Terfenadine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
topiramate  (EXP)
torin 1  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
vandetanib  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The primary structure of rat ribosomal protein S6. Chan YL and Wool IG, J Biol Chem 1988 Feb 25;263(6):2891-6.
2. Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury. Chuang YC, etal., Int J Mol Sci. 2015 Nov 4;16(11):26406-16. doi: 10.3390/ijms161125963.
3. Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model. Chung JH, etal., BMC Genomics. 2011 Oct 20;12:520. doi: 10.1186/1471-2164-12-520.
4. The isolation of eukaryotic ribosomal proteins. The purification and characterization of the 40 S ribosomal subunit proteins S2, S3, S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28. Collatz E, etal., J Biol Chem. 1976 Aug 10;251(15):4666-72.
5. Two-dimensional electrophoretic analysis of ribosomal proteins from chronically injured liver. Gressner AM J Clin Chem Clin Biochem. 1979 Aug;17(8):541-5.
6. The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene? Lecomte F, etal., Somat Cell Mol Genet 1995 Nov;21(6):443-50.
7. Electron microscopic investigations on the location of rat liver ribosomal proteins S3a, S5, S6, S7 and S9 by means of antibody labeling. Lutsch G, etal., Biomed Biochim Acta. 1983;42(6):705-23.
8. Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin. Marion MJ and Marion C, FEBS Lett. 1988 May 23;232(2):281-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle. Miranda L, etal., Pflugers Arch. 2008 Mar;455(6):1129-40. Epub 2007 Oct 24.
11. rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9. Mok KW, etal., J Cell Sci. 2014 Nov 15;127(Pt 22):4870-82. doi: 10.1242/jcs.152231. Epub 2014 Sep 12.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. Peng J, etal., J Biol Chem. 2004 May 14;279(20):21003-11. doi: 10.1074/jbc.M400103200. Epub 2004 Mar 12.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Continuous ethanol exposure inhibits agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein in cultured rat astrocytes. Smith TL and Eaton MC, Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):145-8.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Ribosomal proteins cross-linked to natural mRNA by UV irradiation of rat liver polysomes. Takahashi Y and Ogata K, J Biochem. 1981 Nov;90(5):1549-52.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
22. Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release. Younts TJ, etal., Neuron. 2016 Oct 19;92(2):479-492. doi: 10.1016/j.neuron.2016.09.040.
23. Effects of electroacupuncture on the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of rats with vascular dementia. Zhu Y, etal., Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009.
Additional References at PubMed
PMID:2106518   PMID:2334893   PMID:8590812   PMID:8706699   PMID:10856218   PMID:12388085   PMID:14681305   PMID:14993145   PMID:14993219   PMID:15121898   PMID:15489334   PMID:15590835  
PMID:15883184   PMID:16166381   PMID:16286931   PMID:16357222   PMID:16428328   PMID:16854843   PMID:17000767   PMID:17182729   PMID:18362888   PMID:18697920   PMID:18809582   PMID:19946888  
PMID:21418524   PMID:21630459   PMID:21700703   PMID:22022532   PMID:22658674   PMID:22948214   PMID:23285266   PMID:23500592   PMID:24508636   PMID:24625528   PMID:27194793   PMID:30053369  
PMID:31112404   PMID:31157869   PMID:35352799  


Genomics

Comparative Map Data
Rps6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85106,417,680 - 106,420,540 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5106,417,680 - 106,420,566 (-)EnsemblGRCr8
mRatBN7.25101,371,716 - 101,374,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5101,371,136 - 101,374,602 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl566,681,075 - 66,681,919 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5103,752,605 - 103,755,465 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05105,543,160 - 105,546,020 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05105,576,526 - 105,579,388 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05105,197,821 - 105,200,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,197,857 - 105,200,148 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl5105,209,846 - 105,212,173 (-)Ensemblrn6Rnor6.0
Rnor_5.05109,184,689 - 109,187,549 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45106,165,612 - 106,168,472 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5101,709,190 - 101,712,050 (+)NCBICelera
Cytogenetic Map5q32NCBI
RPS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38919,375,715 - 19,380,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl919,375,715 - 19,380,282 (-)Ensemblhg38GRCh38
GRCh37919,375,713 - 19,380,234 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36919,366,254 - 19,370,235 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34919,366,253 - 19,370,235NCBI
Celera919,302,350 - 19,306,331 (-)NCBICelera
Cytogenetic Map9p22.1NCBI
HuRef919,337,814 - 19,341,795 (-)NCBIHuRef
CHM1_1919,376,051 - 19,380,032 (-)NCBICHM1_1
T2T-CHM13v2.0919,388,517 - 19,393,023 (-)NCBIT2T-CHM13v2.0
Rps6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39486,772,336 - 86,775,604 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl486,772,897 - 86,775,649 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38486,854,099 - 86,857,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl486,854,660 - 86,857,412 (-)Ensemblmm10GRCm38
MGSCv37486,500,003 - 86,503,271 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36486,325,893 - 86,328,588 (-)NCBIMGSCv36mm8
Celera485,374,929 - 85,378,195 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map440.69NCBI
Rps6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543421,744,082 - 21,746,626 (-)Ensembl
ChiLan1.0NW_00495543421,744,045 - 21,745,646 (-)NCBIChiLan1.0ChiLan1.0
RPS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211105,135,133 - 105,170,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19105,141,077 - 105,176,598 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0919,185,455 - 19,189,504 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1919,674,380 - 19,678,397 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl919,674,380 - 19,677,722 (-)EnsemblpanPan2panpan1.1
RPS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11139,161,422 - 39,165,148 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1139,161,422 - 39,165,148 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1137,819,139 - 37,822,865 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01140,094,843 - 40,098,569 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1140,094,843 - 40,098,569 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11138,787,210 - 38,790,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01138,584,732 - 38,588,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01139,218,708 - 39,222,435 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rps6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947153,583,479 - 153,586,550 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366521,253,025 - 1,255,906 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366521,252,986 - 1,255,987 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1203,444,450 - 203,451,468 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11203,444,360 - 203,447,643 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,094,866 - 227,098,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11260,353,800 - 60,357,797 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1260,353,817 - 60,357,759 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603848,467,090 - 48,471,105 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473623,328,002 - 23,336,140 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473623,332,556 - 23,336,234 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rps6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1167,163,112 - 67,166,026 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rps6
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000073270
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Hmgc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85106,420,042 - 106,420,210 (+)Marker Load Pipeline
mRatBN7.25101,374,078 - 101,374,246 (+)MAPPERmRatBN7.2
Rnor_6.05105,200,184 - 105,200,351NCBIRnor6.0
Rnor_6.05105,212,209 - 105,212,376NCBIRnor6.0
Rnor_5.05109,199,077 - 109,199,244UniSTSRnor5.0
Rnor_5.05109,187,052 - 109,187,219UniSTSRnor5.0
RGSC_v3.45106,167,975 - 106,168,142UniSTSRGSC3.4
RH 3.4 Map5737.5UniSTS
RH 3.4 Map5737.5RGD
Cytogenetic Map5q22-q23UniSTS
RH131255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,375,192 - 101,375,395 (+)MAPPERmRatBN7.2
Rnor_6.05105,213,323 - 105,213,525NCBIRnor6.0
Rnor_6.05105,201,298 - 105,201,500NCBIRnor6.0
Rnor_5.05109,200,191 - 109,200,393UniSTSRnor5.0
Rnor_5.05109,188,166 - 109,188,368UniSTSRnor5.0
RGSC_v3.45106,169,089 - 106,169,291UniSTSRGSC3.4
Celera5101,708,371 - 101,708,573UniSTS
RH 3.4 Map5741.1UniSTS
Cytogenetic Map5q22-q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 61 134 57 60 41 86 41 298 168 11 125 71 73 19 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC058149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010383   ⟹   ENSRNOP00000010383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5106,417,680 - 106,420,062 (-)Ensembl
mRatBN7.2 Ensembl5101,371,136 - 101,374,098 (-)Ensembl
Rnor_6.0 Ensembl5105,209,846 - 105,212,173 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073270   ⟹   ENSRNOP00000067572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5106,417,680 - 106,420,566 (-)Ensembl
mRatBN7.2 Ensembl5101,371,136 - 101,374,602 (-)Ensembl
Rnor_6.0 Ensembl5105,197,857 - 105,200,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096848   ⟹   ENSRNOP00000077015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl566,681,075 - 66,681,919 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104045   ⟹   ENSRNOP00000092962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,371,136 - 101,374,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107590   ⟹   ENSRNOP00000097987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5101,371,136 - 101,374,533 (-)Ensembl
RefSeq Acc Id: NM_017160   ⟹   NP_058856
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,417,680 - 106,420,540 (-)NCBI
mRatBN7.25101,371,716 - 101,374,576 (-)NCBI
Rnor_6.05105,197,821 - 105,200,681 (-)NCBI
Rnor_5.05109,184,689 - 109,187,549 (-)NCBI
RGSC_v3.45106,165,612 - 106,168,472 (-)RGD
Celera5101,709,190 - 101,712,050 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058856 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42079 (Get FASTA)   NCBI Sequence Viewer  
  AAH58149 (Get FASTA)   NCBI Sequence Viewer  
  EDL76012 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067572
  ENSRNOP00000067572.2
GenBank Protein P62755 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058856   ⟸   NM_017160
- UniProtKB: P62755 (UniProtKB/Swiss-Prot),   A6KRB6 (UniProtKB/TrEMBL),   M0RD75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067572   ⟸   ENSRNOT00000073270
Ensembl Acc Id: ENSRNOP00000010383   ⟸   ENSRNOT00000010383
Ensembl Acc Id: ENSRNOP00000092962   ⟸   ENSRNOT00000104045
Ensembl Acc Id: ENSRNOP00000077015   ⟸   ENSRNOT00000096848
Ensembl Acc Id: ENSRNOP00000097987   ⟸   ENSRNOT00000107590

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62755-F1-model_v2 AlphaFold P62755 1-249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3602 AgrOrtholog
BioCyc Gene G2FUF-40838 BioCyc
Ensembl Genes ENSRNOG00000007663 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000049025 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000073270 ENTREZGENE
  ENSRNOT00000073270.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.2650 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918741 IMAGE-MGC_LOAD
InterPro Ribosomal_S6_euk UniProtKB/Swiss-Prot
  Ribosomal_S6e UniProtKB/Swiss-Prot
  Ribosomal_S6e_CS UniProtKB/Swiss-Prot
KEGG Report rno:29304 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72867 IMAGE-MGC_LOAD
NCBI Gene 29304 ENTREZGENE
PANTHER PTHR11502 UniProtKB/Swiss-Prot
Pfam Ribosomal_S6e UniProtKB/Swiss-Prot
PhenoGen Rps6 PhenoGen
PIRSF Ribosom_S6_euk UniProtKB/Swiss-Prot
PROSITE RIBOSOMAL_S6E UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007663 RatGTEx
  ENSRNOG00000049025 RatGTEx
SMART Ribosomal_S6e UniProtKB/Swiss-Prot
TIGR TC204150
UniProt A0A0H2UHF7_RAT UniProtKB/TrEMBL
  A6KRB6 ENTREZGENE, UniProtKB/TrEMBL
  M0RD75 ENTREZGENE, UniProtKB/TrEMBL
  P62755 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P08227 UniProtKB/Swiss-Prot
  P10660 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rps6  ribosomal protein S6  LOC100911372  40S ribosomal protein S6-like  Data merged from RGD:6493116 737654 PROVISIONAL
2012-07-05 LOC100911372  40S ribosomal protein S6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Rps6  ribosomal protein S6      Name updated 70584 APPROVED