RPS6 (ribosomal protein S6) - Rat Genome Database

Name: RPS6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: RPS6 (ribosomal protein S6) Pan paniscus

Analyze

Symbol:

RPS6

Name:

ribosomal protein S6

RGD ID:

11769560

Description:

ENCODES a protein that exhibits mRNA binding (ortholog); protein kinase binding (ortholog); structural constituent of ribosome (ortholog); INVOLVED IN activation-induced cell death of T cells (ortholog); cellular response to ethanol (ortholog); cytoplasmic translation (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Disease Progression (ortholog); Experimental Autoimmune Myocarditis (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); cytoplasmic ribonucleoprotein granule (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

40S ribosomal protein S6; LOC100972194; small ribosomal subunit protein eS6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RPS6 (ribosomal protein S6)	NCBI	Ortholog
Mus musculus (house mouse):	Rps6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Rps6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rps6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RPS6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rps6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RPS6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RPS6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rps6 (ribosomal protein S6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	105,135,133 - 105,170,654 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	105,141,077 - 105,176,598 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	19,185,455 - 19,189,504 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	19,674,380 - 19,678,397 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	19,674,380 - 19,677,722 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Disease Progression (ISO)

Experimental Autoimmune Myocarditis (ISO)

Hemimegalencephaly (ISO)

hepatocellular carcinoma (ISO)

Liver Failure (ISO)

Stomach Neoplasms (ISO)

Temporomandibular Joint Osteoarthritis (ISO)

transient cerebral ischemia (ISO)

vascular dementia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Cellular Component

cell body (ISO)

cytoplasm (ISO)

cytoplasmic ribonucleoprotein granule (ISO)

cytosol (ISO)

cytosolic ribosome (ISO)

cytosolic small ribosomal subunit (ISO)

dendrite (ISO)

endoplasmic reticulum (ISO)

GABA-ergic synapse (ISO)

nucleolus (ISO)

nucleus (ISO)

perinuclear region of cytoplasm (ISO)

presynapse (ISO)

ribonucleoprotein complex (IEA)

ribosome (IEA,ISO)

small ribosomal subunit (ISO)

small-subunit processome (ISO)

Molecular Function

mRNA binding (ISO)

protein binding (ISO)

protein kinase binding (ISO)

structural constituent of ribosome (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (ISO)

translation pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RPS6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	105,135,133 - 105,170,654 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	105,141,077 - 105,176,598 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	19,185,455 - 19,189,504 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	19,674,380 - 19,678,397 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	19,674,380 - 19,677,722 (-)	Ensembl	panpan1.1		panPan2

RPS6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	19,375,715 - 19,380,236 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	19,375,715 - 19,380,236 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	19,375,713 - 19,380,234 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	19,366,254 - 19,370,235 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	19,366,253 - 19,370,235	NCBI
Celera	9	19,302,350 - 19,306,331 (-)	NCBI		Celera
Cytogenetic Map	9	p22.1	NCBI
HuRef	9	19,337,814 - 19,341,795 (-)	NCBI		HuRef
CHM1_1	9	19,376,051 - 19,380,032 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	19,388,517 - 19,393,023 (-)	NCBI		T2T-CHM13v2.0

Rps6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	86,772,336 - 86,775,604 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	86,772,897 - 86,775,649 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	86,854,099 - 86,857,367 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	86,854,660 - 86,857,412 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	86,500,003 - 86,503,271 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	86,325,893 - 86,328,588 (-)	NCBI		MGSCv36	mm8
Celera	4	85,374,929 - 85,378,195 (-)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	40.69	NCBI

Rps6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	106,417,680 - 106,420,540 (-)	NCBI		GRCr8
mRatBN7.2	5	101,371,716 - 101,374,576 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	66,681,075 - 66,681,919 (+)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	5	101,371,136 - 101,374,602 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	103,752,605 - 103,755,465 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	105,543,160 - 105,546,020 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	105,576,526 - 105,579,388 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	105,197,821 - 105,200,681 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	105,197,857 - 105,200,148 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	5	105,209,846 - 105,212,173 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	109,184,689 - 109,187,549 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	106,165,612 - 106,168,472 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	101,709,190 - 101,712,050 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

Rps6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	21,744,082 - 21,746,626 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955434	21,744,045 - 21,745,646 (-)	NCBI	ChiLan1.0	ChiLan1.0

RPS6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	39,161,422 - 39,165,148 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	39,161,422 - 39,165,148 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	37,819,139 - 37,822,865 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	40,094,843 - 40,098,569 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	40,094,843 - 40,098,569 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	38,787,210 - 38,790,959 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	38,584,732 - 38,588,458 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	39,218,708 - 39,222,435 (-)	NCBI		UU_Cfam_GSD_1.0

Rps6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	153,583,479 - 153,586,550 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936652	1,253,025 - 1,255,906 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936652	1,252,986 - 1,255,987 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPS6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	203,444,450 - 203,451,468 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	203,444,360 - 203,447,643 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	227,094,866 - 227,098,139 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPS6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	60,353,800 - 60,357,797 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	60,353,817 - 60,357,759 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	48,467,090 - 48,471,105 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rps6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	23,328,002 - 23,336,140 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	23,332,556 - 23,336,234 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003822604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063594466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000052212 ⟹ ENSPPAP00000029363

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	19,674,380 - 19,677,722 (-)	Ensembl

RefSeq Acc Id:

XM_003822604 ⟹ XP_003822652

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	105,135,133 - 105,170,654 (+)	NCBI
NHGRI_mPanPan1	9	105,141,077 - 105,176,598 (+)	NCBI
Mhudiblu_PPA_v0	9	19,185,455 - 19,189,504 (-)	NCBI
PanPan1.1	9	19,674,380 - 19,678,397 (-)	NCBI

Sequence:

show sequence

TGCTCATCTCGCGAGAACTGAAAGAGCCTATGTGACCTGCGCTAAGCGGAAGTTAGCCCTCTTT
TCCGTGGCGCCTCGGAGGCGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCAC
TGGCTGCCAAAAACTCATTGAAGTGGACGATGAACGCAAACTTCGTACTTTTTATGAGAAGCGT
ATGGCCACAGAAGTTGCTGCTGACGCTCTGGGTGAAGAATGGAAGGGTTATGTGGTCCGAATCA
GTGGTGGGAACGACAAACAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCG
CCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAAA
TCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAG
GAGAGAAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGC
TAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCCGCCAGTATGTTGTAAGA
AAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGTCTTGTTA
CTCCACGTGTCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAA
TAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGGAGAAG
CGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGAGCTTCTACTTCTAAGTCTG
AATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCGGA

hide sequence

RefSeq Acc Id:

XM_063594466 ⟹ XP_063450536

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	105,163,150 - 105,170,654 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003822652	(Get FASTA)	NCBI Sequence Viewer
	XP_063450536	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000029363
	ENSPPAP00000029363.1

RefSeq Acc Id:

XP_003822652 ⟸ XM_003822604

- UniProtKB:

A0A2R9BJ29 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMK
QGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTT
VPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRI
ALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

hide sequence

RefSeq Acc Id:

ENSPPAP00000029363 ⟸ ENSPPAT00000052212

RefSeq Acc Id:

XP_063450536 ⟸ XM_063594466

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037670	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000052212.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.2650	UniProtKB/TrEMBL
InterPro	Ribosomal_S6_euk	UniProtKB/TrEMBL
	Ribosomal_S6e	UniProtKB/TrEMBL
	Ribosomal_S6e_CS	UniProtKB/TrEMBL
NCBI Gene	RPS6	ENTREZGENE
PANTHER	40S RIBOSOMAL PROTEIN S6	UniProtKB/TrEMBL
	PTHR11502	UniProtKB/TrEMBL
Pfam	Ribosomal_S6e	UniProtKB/TrEMBL
PIRSF	Ribosom_S6_euk	UniProtKB/TrEMBL
PROSITE	RIBOSOMAL_S6E	UniProtKB/TrEMBL
SMART	Ribosomal_S6e	UniProtKB/TrEMBL
UniProt	A0A2R9BJ29	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-13	RPS6	ribosomal protein S6	LOC100972194	40S ribosomal protein S6	Symbol and/or name change	5135510	APPROVED
2023-06-21	LOC100972194	40S ribosomal protein S6	RPS6	ribosomal protein S6	Symbol and/or name change	5135510	APPROVED
2020-07-01	RPS6	ribosomal protein S6	LOC100972194	40S ribosomal protein S6	Symbol and/or name change	5135510	APPROVED
2018-05-08	LOC100972194	40S ribosomal protein S6	RPS6	ribosomal protein S6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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