RGD Reference Report - Two-dimensional electrophoretic analysis of ribosomal proteins from chronically injured liver. - Rat Genome Database

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Two-dimensional electrophoretic analysis of ribosomal proteins from chronically injured liver.

Authors: Gressner, AM 
Citation: Gressner AM J Clin Chem Clin Biochem. 1979 Aug;17(8):541-5.
RGD ID: 11040911
Pubmed: PMID:501300   (View Abstract at PubMed)

Proteins of the small and large ribosomal subunit, isolated at various times from long-term thioacetamide-damaged rat livers, were analysed by two-dimensional polyacrylamide gel electrophoresis and compared with those from normal liver. Chronic hepatic injury induced a number of time-dependent changes of the structural proteins of the small subunit, whereas the proteins of the large subparticle were essentially unaffected. The most significant alterations were an anodical dislocation of protein S6, a strong diminution in the amounts of proteins S9 and S10 and the occurrence of 3 to 4 additional small subunit proteins. By autoradiographic studies it was established that the modifications of S6 were brought about by an enhanced phosphorylation of this protein, which was the earliest sign of a ribosomal alteration in injured liver tissue.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Liver Failure  ISORps6 (Rattus norvegicus) more ...11040911; 11040911; 11040911; 11040911; 11040911; 11040911 RGD 
Liver Failure  IEP 11040911; 11040911; 11040911 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rps10  (ribosomal protein S10)
Rps6  (ribosomal protein S6)
Rps9  (ribosomal protein S9)

Genes (Mus musculus)
Rps10  (ribosomal protein S10)
Rps6  (ribosomal protein S6)
Rps9  (ribosomal protein S9)

Genes (Homo sapiens)
RPS10  (ribosomal protein S10)
RPS6  (ribosomal protein S6)
RPS9  (ribosomal protein S9)


Additional Information