RGD Reference Report - Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release. - Rat Genome Database

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Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release.

Authors: Younts, Thomas J  Monday, Hannah R  Dudok, Barna  Klein, Matthew E  Jordan, Bryen A  Katona, István  Castillo, Pablo E 
Citation: Younts TJ, etal., Neuron. 2016 Oct 19;92(2):479-492. doi: 10.1016/j.neuron.2016.09.040.
RGD ID: 155230753
Pubmed: PMID:27764673   (View Abstract at PubMed)
PMCID: PMC5119541   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2016.09.040   (Journal Full-text)

Long-term changes of neurotransmitter release are critical for proper brain function. However, the molecular mechanisms underlying these changes are poorly understood. While protein synthesis is crucial for the consolidation of postsynaptic plasticity, whether and how protein synthesis regulates presynaptic plasticity in the mature mammalian brain remain unclear. Here, using paired whole-cell recordings in rodent hippocampal slices, we report that presynaptic protein synthesis is required for long-term, but not short-term, plasticity of GABA release from type 1 cannabinoid receptor (CB1)-expressing axons. This long-term depression of inhibitory transmission (iLTD) involves cap-dependent protein synthesis in presynaptic interneuron axons, but not somata. Translation is required during the induction, but not maintenance, of iLTD. Mechanistically, CB1 activation enhances protein synthesis via the mTOR pathway. Furthermore, using super-resolution STORM microscopy, we revealed eukaryotic ribosomes in CB1-expressing axon terminals. These findings suggest that presynaptic local protein synthesis controls neurotransmitter release during long-term plasticity in the mature mammalian brain.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rps6RatGABA-ergic synapse is_active_inIDA PMID:27764673SynGO 
Rps6Ratpresynapse is_active_inIDA PMID:27764673SynGO 
Rps6Ratribosome is_active_inIDA PMID:27764673SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Rps6  (ribosomal protein S6)


Additional Information