Pak1 (p21 (RAC1) activated kinase 1) - Rat Genome Database

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Gene: Pak1 (p21 (RAC1) activated kinase 1) Rattus norvegicus
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Symbol: Pak1
Name: p21 (RAC1) activated kinase 1
RGD ID: 3250
Description: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of cell growth. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PARTICIPATES IN adenosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; 1-octadec-9-enoylglycero-3-phosphate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-PAK; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p68-PAK; PAK-1; protein kinase MUK2; serine/threonine-protein kinase PAK 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,522,399 - 161,637,623 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1161,491,847 - 161,637,612 (+)EnsemblGRCr8
mRatBN7.21152,111,172 - 152,226,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,111,188 - 152,226,383 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,098,178 - 160,212,347 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,278,365 - 167,392,536 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,151,847 - 160,266,019 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,768,156 - 162,883,356 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,768,156 - 162,883,355 (+)Ensemblrn6Rnor6.0
Rnor_5.01168,974,734 - 169,090,326 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41155,057,622 - 155,174,714 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1150,203,043 - 150,317,598 (+)NCBICelera
RGSC_v3.11155,136,027 - 155,253,120 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP)
axitinib  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
caffeine  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
diallyl disulfide  (ISO)
dibenziodolium  (EXP)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulfates  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO,ISS)
amygdala development  (ISO)
apoptotic process  (IEA)
branching morphogenesis of an epithelial tube  (IEA,ISO,ISS)
cell migration  (IBA,ISO)
cellular response to insulin stimulus  (IDA)
cellular response to starvation  (IBA)
cerebellum development  (IEP)
chromatin remodeling  (IEA,ISO,ISS)
dendrite development  (ISO)
dendritic spine development  (ISO)
DNA damage response  (IEA,ISO,ISS)
establishment of cell polarity  (IMP)
exocytosis  (IEA)
gamma-aminobutyric acid secretion, neurotransmission  (ISO)
glutamate secretion, neurotransmission  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,TAS)
MAPK cascade  (IEA,ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of cell proliferation involved in contact inhibition  (IEA,ISO,ISS)
neuromuscular junction development  (ISO)
neuron projection morphogenesis  (IMP)
observational learning  (ISO)
positive regulation of axon extension  (IMP)
positive regulation of cell migration  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of fibroblast migration  (IDA)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of microtubule nucleation  (IEA,ISO,ISS)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of protein targeting to membrane  (IMP)
positive regulation of stress fiber assembly  (IEA,ISO,ISS)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
protein autophosphorylation  (IDA)
protein localization to cytoplasmic stress granule  (IEA,ISO,ISS)
protein phosphorylation  (IDA)
receptor clustering  (ISO)
regulation of actin cytoskeleton organization  (IBA,IMP)
regulation of axonogenesis  (IBA)
regulation of gene expression  (ISO)
regulation of long-term synaptic potentiation  (ISO)
regulation of MAPK cascade  (IBA,ISO)
regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (ISO)
response to hypoxia  (IDA)
small GTPase-mediated signal transduction  (TAS)
transmission of nerve impulse  (ISO)
wound healing  (IEA,ISO,ISS)

Cellular Component
actin filament  (IEA,ISO)
axon  (IDA,ISO)
cell projection  (IEA)
cell-cell junction  (IEA,ISO,ISS)
centrosome  (IEA)
chromosome  (IEA)
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
dendrite  (IDA,ISO)
focal adhesion  (IEA)
GABA-ergic synapse  (ISO)
glutamatergic synapse  (ISO)
growth cone  (ISO)
intercalated disc  (IDA)
lamellipodium  (IDA,IEA)
nuclear membrane  (IDA)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (ISO)
organelle  (IEA)
plasma membrane  (IEA,ISO,ISS)
postsynaptic density  (ISO)
presynapse  (IEA)
protein-containing complex  (IEA,ISO)
ruffle  (IDA,IEA,ISO,ISS)
ruffle membrane  (IEA)
Z disc  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour. Baudry D, etal., Oncogene. 2002 Aug 15;21(36):5566-73.
2. Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Bostner J, etal., Oncogene. 2007 Oct 25;26(49):6997-7005. Epub 2007 May 7.
3. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Brown JL, etal., Curr Biol. 1996 May 1;6(5):598-605.
4. Activation of p21-activated protein kinase alpha (alpha PAK) by hyperosmotic shock in neonatal ventricular myocytes. Clerk A and Sugden PH, FEBS Lett. 1997 Feb 10;403(1):23-5.
5. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. Daniels RH, etal., EMBO J. 1998 Feb 2;17(3):754-64.
6. A FOXO-Pak1 transcriptional pathway controls neuronal polarity. de la Torre-Ubieta L, etal., Genes Dev. 2010 Apr 15;24(8):799-813. doi: 10.1101/gad.1880510.
7. Novel role of proline-rich nonreceptor tyrosine kinase 2 in vascular wall remodeling after balloon injury. Gadepalli R, etal., Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2652-61. doi: 10.1161/ATVBAHA.112.253112. Epub 2012 Aug 23.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK). Goto H, etal., Genes Cells. 2002 Feb;7(2):91-7.
10. Scaffolding function of PAK in the PDK1-Akt pathway. Higuchi M, etal., Nat Cell Biol. 2008 Nov;10(11):1356-64. doi: 10.1038/ncb1795. Epub 2008 Oct 19.
11. p21-activated kinase 1 participates in vascular remodeling in vitro and in vivo. Hinoki A, etal., Hypertension. 2010 Jan;55(1):161-5. doi: 10.1161/HYPERTENSIONAHA.109.143057. Epub 2009 Nov 9.
12. Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Hirai S, etal., Oncogene 1996 Feb 1;12(3):641-50.
13. Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. Holm C, etal., J Natl Cancer Inst. 2006 May 17;98(10):671-80.
14. Localized activation of p21-activated kinase controls neuronal polarity and morphology. Jacobs T, etal., J Neurosci. 2007 Aug 8;27(32):8604-15.
15. Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Ke Y, etal., Circ Res. 2004 Feb 6;94(2):194-200. Epub 2003 Dec 11.
16. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
17. Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Liu W, etal., Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14.
18. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. Ma QL, etal., J Biol Chem. 2008 May 16;283(20):14132-43. Epub 2008 Mar 17.
19. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Manser E, etal., Mol Cell 1998 Jan;1(2):183-92.
20. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Manser E, etal., Nature 1994 Jan 6;367(6458):40-6.
21. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. Mao K, etal., J Mol Cell Cardiol. 2008 Feb;44(2):429-34. Epub 2007 Dec 3.
22. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. Martin GA, etal., EMBO J 1995 May 1;14(9):1970-8.
23. Analysis of gene amplification and prognostic markers in ovarian cancer using comparative genomic hybridization for microarrays and immunohistochemical analysis for tissue microarrays. Mayr D, etal., Am J Clin Pathol. 2006 Jul;126(1):101-9.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion. Mitsios N, etal., BMC Neurosci. 2007 Nov 12;8:93.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. O'Sullivan GC, etal., Int J Cancer. 2007 Nov 1;121(9):1930-40.
28. A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway. Osada S, etal., FEBS Lett 1997 Mar 10;404(2-3):227-33.
29. YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Osada S, etal., Oncogene 1997 May 1;14(17):2047-57.
30. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. Park E, etal., J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7.
31. Dissecting activation of the PAK1 kinase at protrusions in living cells. Parrini MC, etal., J Biol Chem. 2009 Sep 4;284(36):24133-43. doi: 10.1074/jbc.M109.015271. Epub 2009 Jul 1.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Abnormalities of the Duo/Ras-related C3 botulinum toxin substrate 1/p21-activated kinase 1 pathway drive myosin light chain phosphorylation in frontal cortex in schizophrenia. Rubio MD, etal., Biol Psychiatry. 2012 May 15;71(10):906-14. doi: 10.1016/j.biopsych.2012.02.006. Epub 2012 Mar 27.
39. Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. Sakurada K, etal., J Biol Chem 2002 Nov 22;277(47):45473-9.
40. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
41. Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells. Schmitz U, etal., Biochem Biophys Res Commun. 2002 Mar 1;291(3):687-91.
42. Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes. Seko Y, etal., Biochem Biophys Res Commun. 1997 Oct 29;239(3):840-4.
43. Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. Shekarabi M, etal., J Neurosci. 2005 Mar 23;25(12):3132-41.
44. Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. Sundberg-Smith LJ, etal., J Biol Chem. 2005 Jan 21;280(3):2055-64. Epub 2004 Nov 12.
45. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
46. Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation. Toriyama M, etal., Curr Biol. 2013 Mar 18;23(6):529-34. doi: 10.1016/j.cub.2013.02.017. Epub 2013 Feb 28.
47. Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase. Tsakiridis T, etal., J Biol Chem. 1996 Aug 16;271(33):19664-7.
48. Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells. Tunduguru R, etal., Biochem Pharmacol. 2014 Nov 15;92(2):380-8. doi: 10.1016/j.bcp.2014.08.033. Epub 2014 Sep 6.
49. A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis. Wang D, etal., Circ Res. 2009 May 8;104(9):1066-75. doi: 10.1161/CIRCRESAHA.109.196691. Epub 2009 Apr 9.
50. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
51. Zhonghua zhong liu za zhi [Chinese journal of oncology] Xie D, etal., Zhonghua Zhong Liu Za Zhi. 2006 Dec;28(12):911-4.
52. MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1. Zhan MN, etal., Cell Death Dis. 2017 Jan 5;8(1):e2529. doi: 10.1038/cddis.2016.440.
53. Genomewide analysis of DNA methylation in rat lungs with lipopolysaccharideinduced acute lung injury. Zhang XQ, etal., Mol Med Rep. 2013 May;7(5):1417-24. doi: 10.3892/mmr.2013.1405. Epub 2013 Mar 28.
54. [The clinico-pathological significance of protein expression of PAK1 in bladder transitional cell carcinoma] Zhang YH, etal., Zhonghua Yi Xue Za Zhi. 2007 Oct 16;87(38):2710-3.
55. Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1. Zhao H, etal., J Neuroinflammation. 2011 Nov 14;8:159. doi: 10.1186/1742-2094-8-159.
Additional References at PubMed
PMID:7559638   PMID:7592896   PMID:9032240   PMID:9395435   PMID:9418861   PMID:9601050   PMID:9852149   PMID:10075701   PMID:10559936   PMID:10802735   PMID:11278486   PMID:11604394  
PMID:11864573   PMID:11950598   PMID:12165471   PMID:12189148   PMID:12213441   PMID:12692179   PMID:12876277   PMID:12912914   PMID:12950086   PMID:14580336   PMID:14707132   PMID:15182717  
PMID:15721239   PMID:15944209   PMID:16278681   PMID:16396499   PMID:17060906   PMID:17114649   PMID:17224451   PMID:17389360   PMID:17724026   PMID:17726028   PMID:18006851   PMID:18481281  
PMID:18515110   PMID:18586681   PMID:18721488   PMID:19667065   PMID:19850129   PMID:20457839   PMID:22022532   PMID:22153498   PMID:23260667   PMID:23333386   PMID:23509247   PMID:23528453  
PMID:23633677   PMID:24859002   PMID:25198505   PMID:25242307   PMID:25766321   PMID:26255026   PMID:26483344   PMID:26670864   PMID:26700000   PMID:27121078   PMID:27296803   PMID:27583434  
PMID:27917469   PMID:28408623   PMID:28972183   PMID:31587871   PMID:31868209   PMID:36938611  


Genomics

Comparative Map Data
Pak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,522,399 - 161,637,623 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1161,491,847 - 161,637,612 (+)EnsemblGRCr8
mRatBN7.21152,111,172 - 152,226,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,111,188 - 152,226,383 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,098,178 - 160,212,347 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,278,365 - 167,392,536 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,151,847 - 160,266,019 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,768,156 - 162,883,356 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,768,156 - 162,883,355 (+)Ensemblrn6Rnor6.0
Rnor_5.01168,974,734 - 169,090,326 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41155,057,622 - 155,174,714 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1150,203,043 - 150,317,598 (+)NCBICelera
RGSC_v3.11155,136,027 - 155,253,120 (+)NCBI
Cytogenetic Map1q32NCBI
PAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,322,017 - 77,530,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,321,548 - 77,474,635 (-)Ensemblhg38GRCh38
GRCh371177,033,062 - 77,185,139 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,710,708 - 76,862,581 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341176,710,708 - 76,862,581NCBI
Celera1174,340,698 - 74,492,467 (-)NCBICelera
Cytogenetic Map11q13.5-q14.1NCBI
HuRef1173,331,052 - 73,483,383 (-)NCBIHuRef
CHM1_11176,916,194 - 77,068,127 (-)NCBICHM1_1
T2T-CHM13v2.01177,254,590 - 77,463,028 (-)NCBIT2T-CHM13v2.0
Pak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,437,748 - 97,561,588 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,437,748 - 97,561,588 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38797,788,541 - 97,912,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,788,541 - 97,912,381 (+)Ensemblmm10GRCm38
MGSCv377104,991,449 - 105,060,891 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36797,718,162 - 97,786,524 (+)NCBIMGSCv36mm8
Celera798,163,397 - 98,233,432 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
Pak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541414,365,157 - 14,450,611 (+)Ensembl
ChiLan1.0NW_00495541414,365,325 - 14,447,470 (+)NCBIChiLan1.0ChiLan1.0
PAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2978,241,183 - 78,393,005 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,289,592 - 79,441,441 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,372,577 - 72,524,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,014,744 - 76,166,503 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,015,998 - 76,104,197 (-)EnsemblpanPan2panpan1.1
PAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12121,341,530 - 21,409,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2121,265,484 - 21,408,416 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2121,157,810 - 21,301,590 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02121,465,428 - 21,609,203 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2121,463,819 - 21,609,213 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12121,241,163 - 21,385,037 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02121,457,239 - 21,600,991 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02121,380,679 - 21,525,504 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494764,401,523 - 64,536,045 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,001,014 - 6,086,614 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,001,126 - 6,135,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl911,830,095 - 12,020,415 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1911,830,095 - 11,973,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,979,543 - 13,123,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,530,037 - 68,679,413 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl168,529,571 - 68,617,092 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604357,091,179 - 57,240,461 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624863439,541 - 525,918 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624863442,465 - 609,159 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pak1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1296,140,639 - 96,218,182 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pak1
1040 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000049321
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
AI072234  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81251,733,586 - 251,733,790 (+)Marker Load Pipeline
mRatBN7.21152,225,115 - 152,225,321 (+)MAPPERmRatBN7.2
Rnor_6.01162,882,082 - 162,882,287NCBIRnor6.0
Rnor_5.01169,089,052 - 169,089,257UniSTSRnor5.0
RGSC_v3.41155,174,111 - 155,174,316UniSTSRGSC3.4
Celera1150,316,995 - 150,317,200UniSTS
RH 3.4 Map11166.1UniSTS
Cytogenetic Map1q32UniSTS
PMC140666P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21152,203,571 - 152,203,651 (+)MAPPERmRatBN7.2
Rnor_6.01162,860,538 - 162,860,617NCBIRnor6.0
Rnor_5.01169,067,508 - 169,067,587UniSTSRnor5.0
RGSC_v3.41155,152,567 - 155,152,646UniSTSRGSC3.4
Celera1150,295,462 - 150,295,541UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000049321   ⟹   ENSRNOP00000045832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1161,491,847 - 161,637,612 (+)Ensembl
mRatBN7.2 Ensembl1152,111,188 - 152,226,383 (+)Ensembl
Rnor_6.0 Ensembl1162,768,156 - 162,882,685 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091952   ⟹   ENSRNOP00000073036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1161,491,847 - 161,637,612 (+)Ensembl
mRatBN7.2 Ensembl1152,111,188 - 152,226,383 (+)Ensembl
Rnor_6.0 Ensembl1162,817,611 - 162,883,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104124   ⟹   ENSRNOP00000085225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1152,111,762 - 152,225,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108538   ⟹   ENSRNOP00000095378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1161,491,847 - 161,637,612 (+)Ensembl
mRatBN7.2 Ensembl1152,111,188 - 152,226,383 (+)Ensembl
RefSeq Acc Id: NM_017198   ⟹   NP_058894
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,522,450 - 161,636,952 (+)NCBI
mRatBN7.21152,111,210 - 152,225,719 (+)NCBI
Rnor_6.01162,768,156 - 162,882,685 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
RGSC_v3.41155,057,622 - 155,174,714 (+)RGD
Celera1150,203,043 - 150,317,598 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229752   ⟹   XP_006229814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,571,780 - 161,637,623 (+)NCBI
mRatBN7.21152,160,621 - 152,226,390 (+)NCBI
Rnor_6.01162,817,582 - 162,883,356 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229753   ⟹   XP_006229815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,571,848 - 161,637,623 (+)NCBI
mRatBN7.21152,160,620 - 152,226,390 (+)NCBI
Rnor_6.01162,817,582 - 162,883,356 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229754   ⟹   XP_006229816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,554,535 - 161,637,623 (+)NCBI
mRatBN7.21152,143,335 - 152,226,390 (+)NCBI
Rnor_6.01162,800,097 - 162,883,356 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109396   ⟹   XP_038965324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,522,412 - 161,637,623 (+)NCBI
mRatBN7.21152,111,172 - 152,226,390 (+)NCBI
RefSeq Acc Id: XM_063287516   ⟹   XP_063143586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,522,399 - 161,637,623 (+)NCBI
RefSeq Acc Id: XM_063287517   ⟹   XP_063143587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,522,412 - 161,637,623 (+)NCBI
RefSeq Acc Id: XM_063287520   ⟹   XP_063143590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,554,565 - 161,637,623 (+)NCBI
RefSeq Acc Id: XM_063287524   ⟹   XP_063143594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,554,565 - 161,637,623 (+)NCBI
RefSeq Acc Id: NP_058894   ⟸   NM_017198
- UniProtKB: Q62934 (UniProtKB/Swiss-Prot),   P35465 (UniProtKB/Swiss-Prot),   A6I6C0 (UniProtKB/TrEMBL),   A0A8L2QLX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229816   ⟸   XM_006229754
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006229814   ⟸   XM_006229752
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006229815   ⟸   XM_006229753
- Peptide Label: isoform X1
- UniProtKB: Q62934 (UniProtKB/Swiss-Prot),   P35465 (UniProtKB/Swiss-Prot),   A6I6C0 (UniProtKB/TrEMBL),   A0A8L2QLX9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045832   ⟸   ENSRNOT00000049321
Ensembl Acc Id: ENSRNOP00000073036   ⟸   ENSRNOT00000091952
RefSeq Acc Id: XP_038965324   ⟸   XM_039109396
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000085225   ⟸   ENSRNOT00000104124
Ensembl Acc Id: ENSRNOP00000095378   ⟸   ENSRNOT00000108538
RefSeq Acc Id: XP_063143586   ⟸   XM_063287516
- Peptide Label: isoform X1
- UniProtKB: Q62934 (UniProtKB/Swiss-Prot),   P35465 (UniProtKB/Swiss-Prot),   A0A8L2QLX9 (UniProtKB/TrEMBL),   A6I6C0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143587   ⟸   XM_063287517
- Peptide Label: isoform X1
- UniProtKB: Q62934 (UniProtKB/Swiss-Prot),   P35465 (UniProtKB/Swiss-Prot),   A0A8L2QLX9 (UniProtKB/TrEMBL),   A6I6C0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143590   ⟸   XM_063287520
- Peptide Label: isoform X1
- UniProtKB: Q62934 (UniProtKB/Swiss-Prot),   P35465 (UniProtKB/Swiss-Prot),   A0A8L2QLX9 (UniProtKB/TrEMBL),   A6I6C0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143594   ⟸   XM_063287524
- Peptide Label: isoform X1
- UniProtKB: Q62934 (UniProtKB/Swiss-Prot),   P35465 (UniProtKB/Swiss-Prot),   A0A8L2QLX9 (UniProtKB/TrEMBL),   A6I6C0 (UniProtKB/TrEMBL)
Protein Domains
CRIB   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35465-F1-model_v2 AlphaFold P35465 1-544 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690212
Promoter ID:EPDNEW_R737
Type:initiation region
Name:Pak1_1
Description:p21 activated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R738  EPDNEW_R739  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,768,136 - 162,768,196EPDNEW
RGD ID:13690213
Promoter ID:EPDNEW_R738
Type:initiation region
Name:Pak1_3
Description:p21 activated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R737  EPDNEW_R739  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,768,405 - 162,768,465EPDNEW
RGD ID:13690219
Promoter ID:EPDNEW_R739
Type:initiation region
Name:Pak1_2
Description:p21 activated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R737  EPDNEW_R738  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,817,625 - 162,817,685EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3250 AgrOrtholog
BioCyc Gene G2FUF-58435 BioCyc
Ensembl Genes ENSRNOG00000029784 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091952 ENTREZGENE
  ENSRNOT00000091952.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CRIB_dom UniProtKB/Swiss-Prot
  CRIB_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PAK3-like UniProtKB/Swiss-Prot
  PAK_BD UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:29431 UniProtKB/Swiss-Prot
NCBI Gene 29431 ENTREZGENE
PANTHER NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED UniProtKB/Swiss-Prot
Pfam PBD UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Pak1 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029784 RatGTEx
SMART PBD UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC219838
UniProt A0A8I6ATD5_RAT UniProtKB/TrEMBL
  A0A8L2QLX9 ENTREZGENE, UniProtKB/TrEMBL
  A6I6C0 ENTREZGENE, UniProtKB/TrEMBL
  A6I6C1_RAT UniProtKB/TrEMBL
  P35465 ENTREZGENE, UniProtKB/Swiss-Prot
  Q62934 ENTREZGENE
UniProt Secondary Q62934 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Pak1  p21 (RAC1) activated kinase 1  Pak1  p21 protein (Cdc42/Rac)-activated kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-27 Pak1  p21 protein (Cdc42/Rac)-activated kinase 1  Pak1  p21 (CDKN1A)-activated kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pak1  p21 (CDKN1A)-activated kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function phosphorylates protein serine/threonine residues 61685
gene_function phosphorylates protein serine/threonine residues 70317
gene_product mitogen activated protein kinase kinase kinase family member 61685
gene_product mitogen activated protein kinase kinase kinase family member 70317
gene_protein 67 kDa 61685
gene_protein 67 kDa 70317
gene_regulation activated by receptor tyrosine kinases and trimeric G protein-linked receptors 70317