PAK1 (p21 (RAC1) activated kinase 1) - Rat Genome Database

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Gene: PAK1 (p21 (RAC1) activated kinase 1) Chlorocebus sabaeus
Analyze
Symbol: PAK1
Name: p21 (RAC1) activated kinase 1
RGD ID: 18667733
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); amygdala development (ortholog); cell migration (ortholog); PARTICIPATES IN adenosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); GABA-ergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase PAK 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,530,037 - 68,679,413 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl168,529,571 - 68,617,092 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604357,091,179 - 57,240,461 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
amygdala development  (ISO)
branching morphogenesis of an epithelial tube  (IEA)
cell migration  (IEA,ISO)
cellular response to insulin stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cerebellum development  (ISO)
chromatin remodeling  (IEA)
dendrite development  (ISO)
dendritic spine development  (ISO)
DNA damage response  (IEA)
establishment of cell polarity  (ISO)
gamma-aminobutyric acid secretion, neurotransmission  (ISO)
glutamate secretion, neurotransmission  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
intracellular signal transduction  (IEA)
MAPK cascade  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cell proliferation involved in contact inhibition  (IEA)
neuromuscular junction development  (ISO)
neuron projection morphogenesis  (ISO)
observational learning  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of fibroblast migration  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA)
positive regulation of microtubule nucleation  (IEA)
positive regulation of microtubule polymerization  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of stress fiber assembly  (IEA)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein autophosphorylation  (ISO)
protein localization to cytoplasmic stress granule  (IEA)
protein phosphorylation  (ISO)
receptor clustering  (ISO)
regulation of actin cytoskeleton organization  (IEA,ISO)
regulation of axonogenesis  (IEA)
regulation of gene expression  (ISO)
regulation of long-term synaptic potentiation  (ISO)
regulation of MAPK cascade  (IEA,ISO)
regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (ISO)
response to hypoxia  (ISO)
transmission of nerve impulse  (ISO)
wound healing  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,530,037 - 68,679,413 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl168,529,571 - 68,617,092 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604357,091,179 - 57,240,461 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,322,017 - 77,530,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,322,017 - 77,474,635 (-)EnsemblGRCh38hg38GRCh38
GRCh371177,033,062 - 77,185,139 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,710,708 - 76,862,581 (-)NCBINCBI36Build 36hg18NCBI36
Build 341176,710,708 - 76,862,581NCBI
Celera1174,340,698 - 74,492,467 (-)NCBICelera
Cytogenetic Map11q13.5-q14.1NCBI
HuRef1173,331,052 - 73,483,383 (-)NCBIHuRef
CHM1_11176,916,194 - 77,068,127 (-)NCBICHM1_1
T2T-CHM13v2.01177,254,590 - 77,463,028 (-)NCBIT2T-CHM13v2.0
Pak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,437,748 - 97,561,588 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,437,748 - 97,561,588 (+)EnsemblGRCm39 Ensembl
GRCm38797,788,541 - 97,912,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,788,541 - 97,912,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv377104,991,449 - 105,060,891 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36797,718,162 - 97,786,524 (+)NCBIMGSCv36mm8
Celera798,163,397 - 98,233,432 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
Pak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,522,399 - 161,637,623 (+)NCBIGRCr8
mRatBN7.21152,111,172 - 152,226,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,111,188 - 152,226,383 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,098,178 - 160,212,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,278,365 - 167,392,536 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,151,847 - 160,266,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,768,156 - 162,883,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,768,156 - 162,883,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,974,734 - 169,090,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,057,622 - 155,174,714 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11155,136,027 - 155,253,120 (+)NCBI
Celera1150,203,043 - 150,317,598 (+)NCBICelera
Cytogenetic Map1q32NCBI
Pak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541414,365,157 - 14,450,611 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541414,365,325 - 14,447,470 (+)NCBIChiLan1.0ChiLan1.0
PAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2978,241,183 - 78,393,005 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,289,592 - 79,441,441 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,372,577 - 72,524,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,014,744 - 76,166,503 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,015,998 - 76,104,197 (-)Ensemblpanpan1.1panPan2
PAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12121,341,530 - 21,409,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2121,265,484 - 21,408,416 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2121,157,810 - 21,301,590 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02121,465,428 - 21,609,203 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2121,463,819 - 21,609,213 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12121,241,163 - 21,385,037 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02121,457,239 - 21,600,991 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02121,380,679 - 21,525,504 (+)NCBIUU_Cfam_GSD_1.0
Pak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494764,401,523 - 64,536,045 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,001,014 - 6,086,614 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,001,126 - 6,135,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl911,830,095 - 12,020,415 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1911,830,095 - 11,973,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,979,543 - 13,123,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624863439,541 - 525,918 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624863442,465 - 609,159 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 60
Low 20
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000001854   ⟹   ENSCSAP00000000190
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl168,529,571 - 68,617,092 (-)Ensembl
RefSeq Acc Id: XM_008020237   ⟹   XP_008018428
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1168,530,037 - 68,617,091 (-)NCBI
Vero_WHO_p1.0NW_02366604357,153,513 - 57,240,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020238   ⟹   XP_008018429
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1168,530,038 - 68,678,908 (-)NCBI
Vero_WHO_p1.0NW_02366604357,091,606 - 57,240,459 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020240   ⟹   XP_008018431
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1168,530,037 - 68,617,091 (-)NCBI
Vero_WHO_p1.0NW_02366604357,153,465 - 57,240,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020241   ⟹   XP_008018432
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1168,530,038 - 68,678,908 (-)NCBI
Vero_WHO_p1.0NW_02366604357,091,611 - 57,240,459 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020244   ⟹   XP_008018435
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1168,530,037 - 68,617,090 (-)NCBI
Vero_WHO_p1.0NW_02366604357,153,514 - 57,240,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020245   ⟹   XP_008018436
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1168,530,037 - 68,617,088 (-)NCBI
Vero_WHO_p1.0NW_02366604357,153,517 - 57,240,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008020246   ⟹   XP_008018437
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1168,530,038 - 68,679,413 (-)NCBI
Vero_WHO_p1.0NW_02366604357,091,179 - 57,240,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038005437   ⟹   XP_037861365
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604357,091,587 - 57,240,459 (+)NCBI
RefSeq Acc Id: XM_038005438   ⟹   XP_037861366
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604357,153,559 - 57,240,453 (+)NCBI
RefSeq Acc Id: XM_038005439   ⟹   XP_037861367
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604357,091,179 - 57,240,453 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008018431   ⟸   XM_008020240
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008018428   ⟸   XM_008020237
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008018435   ⟸   XM_008020244
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008018436   ⟸   XM_008020245
- Peptide Label: isoform X3
- UniProtKB: A0A0D9QV01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008018437   ⟸   XM_008020246
- Peptide Label: isoform X3
- UniProtKB: A0A0D9QV01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008018432   ⟸   XM_008020241
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008018429   ⟸   XM_008020238
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000000190   ⟸   ENSCSAT00000001854
RefSeq Acc Id: XP_037861367   ⟸   XM_038005439
- Peptide Label: isoform X3
- UniProtKB: A0A0D9QV01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037861365   ⟸   XM_038005437
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037861366   ⟸   XM_038005438
- Peptide Label: isoform X3
- UniProtKB: A0A0D9QV01 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001854.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.810.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PAK_BD UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PAK1 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PAK 1 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TAO UniProtKB/TrEMBL
Pfam PBD UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE CRIB UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART PBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QV01 ENTREZGENE, UniProtKB/TrEMBL