RGD Reference Report - Localized activation of p21-activated kinase controls neuronal polarity and morphology. - Rat Genome Database

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Localized activation of p21-activated kinase controls neuronal polarity and morphology.

Authors: Jacobs, T  Causeret, F  Nishimura, YV  Terao, M  Norman, A  Hoshino, M  Nikolic, M 
Citation: Jacobs T, etal., J Neurosci. 2007 Aug 8;27(32):8604-15.
RGD ID: 2299172
Pubmed: PMID:17687038   (View Abstract at PubMed)
PMCID: PMC2080820   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.0765-07.2007   (Journal Full-text)

In the developing forebrain, neuronal polarization is a stepwise and initially reversible process that underlies correct migration and axon specification. Many aspects of cytoskeletal changes that accompany polarization are currently molecularly undefined and thus poorly understood. Here we reveal that the p21-activated kinase (Pak1) is essential for the specification of an axon and dendrites. In hippocampal neurons, activation of Pak1 is spatially restricted to the immature axon despite its uniform presence in all neurites. Hyperactivation of Pak1 at the membrane of all neurites or loss of Pak1 expression disrupts both neuronal morphology and the distinction between an axon and dendrites. We reveal that Pak1 acts on polarity in a kinase-dependent manner, by affecting the F-actin and microtubule cytoskeleton at least in part through Rac1 and cofilin. Our data are the first to demonstrate the importance of localized Pak1 kinase activation for neuronal polarization and differentiation.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon  IDA 2299172 RGD 
dendrite  IDA 2299172 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pak1  (p21 (RAC1) activated kinase 1)


Additional Information