Mbp (myelin basic protein) - Rat Genome Database

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Gene: Mbp (myelin basic protein) Rattus norvegicus
Analyze
Symbol: Mbp
Name: myelin basic protein
RGD ID: 3054
Description: A structural constituent of myelin sheath. Involved in several processes, including negative regulation of axonogenesis; response to progesterone; and response to tumor necrosis factor. Located in cell surface and compact myelin. Used to study demyelinating disease. Biomarker of Huntington's disease; brain disease (multiple); diabetic neuropathy; hypothyroidism; and schizophrenia. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein); INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; (S)-nicotine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Golli-Mbp; MBP S; Mbps; myelin basic protein Golli-mbp; myelin basic protein S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mbpmd  
Genetic Models: LE-Mbpmd
Is Marker For: Strains:   LE-Mbpmd  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81878,130,652 - 78,241,174 (+)NCBIGRCr8
mRatBN7.21875,855,878 - 75,966,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1875,855,878 - 75,966,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1877,957,063 - 78,067,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01878,627,339 - 78,737,995 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01876,475,022 - 76,586,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01879,326,738 - 79,437,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1879,326,738 - 79,437,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01878,385,304 - 78,504,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41878,943,608 - 79,057,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11879,098,861 - 79,130,602 (+)NCBI
Celera1874,493,165 - 74,602,969 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-20-hydroxypregn-4-en-3-one  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17beta-estradiol  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (EXP)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-palmitoylglycerol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
agmatine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brucine  (EXP)
butanal  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbofuran  (EXP)
carbon monoxide  (ISO)
casticin  (ISO)
chloroacetic acid  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diethyldithiocarbamic acid  (EXP)
diiodine  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethylenediaminetetraacetic acid  (EXP)
etoposide  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glyburide  (EXP)
glycerol  (EXP)
glyphosate  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lidocaine  (EXP)
linagliptin  (ISO)
lovastatin  (EXP)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
neocuproine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
quetiapine fumarate  (ISO)
rifampicin  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
scopolamine  (ISO)
selenic acid  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
tamibarotene  (EXP)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
trimethylamine N-oxide  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Y-27632  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Association between maternal periapical lesions and brain inflammation in rat pups. Bain JL, etal., Arch Oral Biol. 2013 Mar;58(3):266-71. doi: 10.1016/j.archoralbio.2012.11.007. Epub 2012 Dec 12.
2. Selective effect of hypothyroidism on expression of myelin markers during development. Barradas PC, etal., J Neurosci Res. 2001 Oct 15;66(2):254-61. doi: 10.1002/jnr.1218.
3. Microstructural changes observed with DKI in a transgenic Huntington rat model: evidence for abnormal neurodevelopment. Blockx I, etal., Neuroimage. 2012 Jan 16;59(2):957-67. doi: 10.1016/j.neuroimage.2011.08.062. Epub 2011 Aug 30.
4. DNA length polymorphism 5' to the myelin basic protein gene is associated with multiple sclerosis. Boylan KB, etal., Ann Neurol 1990 Mar;27(3):291-7.
5. Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2',3'-cyclic nucleotide 3'-phosphodiesterase in the CNS of adult rats. Brunner C, etal., J Neurochem 1989 Jan;52(1):296-304.
6. Phosphatidylinositol-3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes. Clark RE Jr, etal., J Neurochem 2002 Nov;83(3):565-73.
7. Familial dysmyelination in a Long Evans rat mutant. Delaney KH, etal., Lab Anim Sci 1995 Oct;45(5):547-53.
8. Protective effects of pentoxifylline on lipopolysaccharide-induced white matter injury in a rat model of periventricular leukomalasia. Dilek M, etal., J Matern Fetal Neonatal Med. 2013 Jul 23.
9. Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats. Eftekharpour E, etal., Exp Neurol 2005 Jun;193(2):334-49.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum. Ghoumari AM, etal., J Neurochem. 2003 Aug;86(4):848-59.
12. Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPa (signal regulatory protein-a) on phagocytes. Gitik M, etal., J Neuroinflammation. 2011 Mar 15;8:24. doi: 10.1186/1742-2094-8-24.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Myelin-associated oligodendrocytic basic protein mRNAs reside at different subcellular locations. Gould RM, etal., J Neurochem 1999 Nov;73(5):1913-24.
15. Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain. Gregersen R, etal., Exp Brain Res. 2001 Jun;138(3):384-92.
16. Evaluation of a rat model of experimental autoimmune encephalomyelitis with human MBP as antigen. Guo L, etal., Cell Mol Immunol. 2004 Oct;1(5):387-91.
17. Thyroxin Treatment Protects Against White Matter Injury in The Immature Brain via Brain-Derived Neurotrophic Factor. Hung PL, etal., Stroke. 2013 Aug;44(8):2275-83. doi: 10.1161/STROKEAHA.113.001552. Epub 2013 May 28.
18. Myelin basic protein as a binding partner and calmodulin adaptor for the BKCa channel. Kim H, etal., Proteomics. 2007 Aug;7(15):2591-602.
19. [Relationship between anti-myelin basic protein antibody and myelinoclasis in rat brain stem after brain trauma]. Li W, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jun;28(6):1028-30.
20. Alterations of myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Lin KY, etal., Vet Parasitol. 2010 Jul 15;171(1-2):74-80. doi: 10.1016/j.vetpar.2010.03.019. Epub 2010 Mar 30.
21. Autoantibodies to neuron-specific proteins S100, GFAP, MBP and NGF in the serum of rats with streptozotocin-induced diabetes. Lotosh NG, etal., Bull Exp Biol Med. 2013 May;155(1):48-51.
22. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Majava V, etal., Amino Acids. 2010 Jun;39(1):59-71. doi: 10.1007/s00726-009-0364-2. Epub 2009 Oct 24.
23. Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein. Matheus L and Blair GE, Biochim Biophys Acta 2003 Oct 20;1630(1):47-53.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Insertion of a retrotransposon in Mbp disrupts mRNA splicing and myelination in a new mutant rat. O'Connor LT, etal., J Neurosci 1999 May 1;19(9):3404-13.
27. Perturbation of myelin basic protein (Mbp) splice variant expression in developing rat cerebellum following perinatal exposure to methylmercury. Padhi BK and Pelletier G, Toxicol Lett. 2012 Sep 18;213(3):374-80. doi: 10.1016/j.toxlet.2012.07.011. Epub 2012 Jul 24.
28. Exacerbation of experimental autoimmune encephalomyelitis in rodents infected with murine gammaherpesvirus-68. Peacock JW, etal., Eur J Immunol. 2003 Jul;33(7):1849-58. doi: 10.1002/eji.200323148.
29. Characterization of the optic nerve and retinal ganglion cell layer in the dysmyelinated adult Long Evans Shaker rat: evidence for axonal sprouting. Phokeo V, etal., J Comp Neurol 2002 Sep 23;451(3):213-24.
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Roach A, etal., Cell 1983 Oct;34(3):799-806.
33. Acute urinary retention due to benign inflammatory nervous diseases. Sakakibara R, etal., J Neurol. 2006 Aug;253(8):1103-10. Epub 2006 May 6.
34. Cloned proteolipid protein and myelin basic protein cDNA. Transcription of the two genes during myelination. Schaich M, etal., Biol Chem Hoppe Seyler 1986 Aug;367(8):825-34.
35. Beneficial effect of TNF-alpha inhibition on diabetic peripheral neuropathy. Shi X, etal., J Neuroinflammation. 2013 Jun 4;10:69. doi: 10.1186/1742-2094-10-69.
36. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Swanborg RH Clin Immunol Immunopathol 1995 Oct;77(1):4-13.
37. Maternal omega-3 fatty acid supplementation protects against lipopolysaccharide-induced white matter injury in the neonatal rat brain. Tuzun F, etal., J Matern Fetal Neonatal Med. 2012 Jun;25(6):849-54. doi: 10.3109/14767058.2011.587917. Epub 2011 Sep 6.
38. Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Wang W, etal., Neurol Res. 2012 Dec;34(10):1007-15. doi: 10.1179/1743132812Y.0000000106.
39. Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS. Xie F, etal., Int J Mol Med. 2013 Sep 11. doi: 10.3892/ijmm.2013.1486.
40. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
41. Altered hippocampal myelinated fiber integrity in a lithium-pilocarpine model of temporal lobe epilepsy: a histopathological and stereological investigation. Ye Y, etal., Brain Res. 2013 Jul 19;1522:76-87. doi: 10.1016/j.brainres.2013.05.026. Epub 2013 May 28.
42. Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia. Zhang R, etal., Brain Res. 2012 Aug 21;1469:136-43. doi: 10.1016/j.brainres.2012.06.003. Epub 2012 Jun 29.
43. Downregulation of microRNA-199a-5p alleviated lidocaine-induced sensory dysfunction and spinal cord myelin lesions in a rat model. Zhang Z, etal., Toxicol Lett. 2021 Jan 1;336:1-10. doi: 10.1016/j.toxlet.2020.11.001. Epub 2020 Nov 6.
Additional References at PubMed
PMID:1694232   PMID:4122324   PMID:4141893   PMID:7578863   PMID:7592896   PMID:8889548   PMID:8947489   PMID:9722539   PMID:11500922   PMID:12372841   PMID:12477932   PMID:12718855  
PMID:14614079   PMID:15695521   PMID:16405874   PMID:16421295   PMID:16723544   PMID:16773652   PMID:17329413   PMID:17634366   PMID:18821983   PMID:19026719   PMID:19178193   PMID:19211156  
PMID:19292454   PMID:20334434   PMID:20578039   PMID:20637745   PMID:20882567   PMID:21357748   PMID:21479584   PMID:21996274   PMID:22524708   PMID:22676642   PMID:22871113   PMID:22926577  
PMID:24101522   PMID:24321769   PMID:24524292   PMID:25003183   PMID:25282817   PMID:25512606   PMID:25847153   PMID:25931508   PMID:26002313   PMID:26670084   PMID:27230884   PMID:27346352  
PMID:29034508   PMID:29073112   PMID:29476059   PMID:29742816   PMID:30926549   PMID:31885393  


Genomics

Comparative Map Data
Mbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81878,130,652 - 78,241,174 (+)NCBIGRCr8
mRatBN7.21875,855,878 - 75,966,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1875,855,878 - 75,966,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1877,957,063 - 78,067,713 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01878,627,339 - 78,737,995 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01876,475,022 - 76,586,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01879,326,738 - 79,437,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1879,326,738 - 79,437,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01878,385,304 - 78,504,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41878,943,608 - 79,057,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11879,098,861 - 79,130,602 (+)NCBI
Celera1874,493,165 - 74,602,969 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
MBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381876,978,833 - 77,133,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1876,978,827 - 77,133,683 (-)EnsemblGRCh38hg38GRCh38
GRCh371874,690,789 - 74,844,739 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361872,819,777 - 72,973,762 (-)NCBINCBI36Build 36hg18NCBI36
Build 341872,820,710 - 72,857,962NCBI
Celera1871,507,828 - 71,661,692 (-)NCBICelera
Cytogenetic Map18q23NCBI
HuRef1871,371,431 - 71,525,606 (-)NCBIHuRef
CHM1_11874,686,498 - 74,841,139 (-)NCBICHM1_1
T2T-CHM13v2.01877,209,381 - 77,365,381 (-)NCBIT2T-CHM13v2.0
Mbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391882,492,883 - 82,603,762 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1882,493,271 - 82,603,762 (+)EnsemblGRCm39 Ensembl
GRCm381882,475,091 - 82,585,637 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1882,475,146 - 82,585,637 (+)EnsemblGRCm38mm10GRCm38
MGSCv371882,644,515 - 82,755,029 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361882,609,551 - 82,720,065 (+)NCBIMGSCv36mm8
Celera1883,548,320 - 83,655,575 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1855.84NCBI
Mbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540260,323,950 - 60,441,406 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540260,324,060 - 60,448,926 (-)NCBIChiLan1.0ChiLan1.0
MBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21794,522,267 - 94,651,329 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11880,214,890 - 80,343,953 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01870,369,882 - 70,526,693 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11873,628,537 - 73,781,956 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1873,629,522 - 73,755,351 (-)Ensemblpanpan1.1panPan2
MBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112,841,801 - 2,952,553 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12,846,589 - 2,951,860 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha13,844,963 - 3,959,816 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012,644,339 - 2,759,352 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12,644,344 - 2,759,352 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112,689,655 - 2,804,648 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012,640,084 - 2,755,067 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012,810,294 - 2,925,302 (+)NCBIUU_Cfam_GSD_1.0
Mbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494416,761,025 - 16,837,898 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366162,082,099 - 2,159,070 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366162,082,154 - 2,159,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1147,590,865 - 147,685,290 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11147,649,516 - 147,685,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1182,844,154 - 2,996,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl182,868,795 - 2,997,046 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606022,960,760 - 23,116,155 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248063,489,681 - 3,588,335 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248063,465,881 - 3,587,428 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mbp
833 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1452
Count of miRNA genes:250
Interacting mature miRNAs:309
Transcripts:ENSRNOT00000022280, ENSRNOT00000022303, ENSRNOT00000058295, ENSRNOT00000058296
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
634333Pia19Pristane induced arthritis QTL 193.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)187399714079532029Rat

Markers in Region
D18Chm78  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,869,336 - 75,869,542 (+)MAPPERmRatBN7.2
Rnor_6.01879,340,199 - 79,340,404NCBIRnor6.0
Rnor_5.01878,398,856 - 78,399,061UniSTSRnor5.0
RGSC_v3.41878,957,101 - 78,957,306UniSTSRGSC3.4
Celera1874,506,599 - 74,506,804UniSTS
Cytogenetic Map18qUniSTS
D18Chm77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,866,786 - 75,866,989 (+)MAPPERmRatBN7.2
Rnor_6.01879,337,649 - 79,337,851NCBIRnor6.0
Rnor_5.01878,396,306 - 78,396,508UniSTSRnor5.0
RGSC_v3.41878,954,551 - 78,954,753UniSTSRGSC3.4
Celera1874,504,049 - 74,504,251UniSTS
Cytogenetic Map18qUniSTS
D18Chm80  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,927,300 - 75,927,488 (+)MAPPERmRatBN7.2
Rnor_6.01879,398,211 - 79,398,394NCBIRnor6.0
Rnor_5.01878,465,124 - 78,465,309UniSTSRnor5.0
RGSC_v3.41879,017,417 - 79,017,602UniSTSRGSC3.4
Celera1874,564,227 - 74,564,410UniSTS
Cytogenetic Map18qUniSTS
D18Chm79  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,922,567 - 75,922,778 (+)MAPPERmRatBN7.2
Rnor_6.01879,393,478 - 79,393,688NCBIRnor6.0
Rnor_5.01878,459,938 - 78,460,148UniSTSRnor5.0
RGSC_v3.41879,012,683 - 79,012,893UniSTSRGSC3.4
Celera1874,559,493 - 74,559,704UniSTS
Cytogenetic Map18qUniSTS
RH128788  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,966,143 - 75,966,357 (+)MAPPERmRatBN7.2
Rnor_6.01879,437,050 - 79,437,263NCBIRnor6.0
Rnor_5.01878,503,966 - 78,504,179UniSTSRnor5.0
RGSC_v3.41879,057,069 - 79,057,282UniSTSRGSC3.4
Celera1874,602,709 - 74,602,922UniSTS
RH 3.4 Map18809.2UniSTS
Cytogenetic Map18qUniSTS
RH130523  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,939,262 - 75,939,471 (+)MAPPERmRatBN7.2
Rnor_6.01879,410,169 - 79,410,377NCBIRnor6.0
Rnor_5.01878,477,084 - 78,477,292UniSTSRnor5.0
RGSC_v3.41879,029,377 - 79,029,585UniSTSRGSC3.4
Celera1874,576,185 - 74,576,393UniSTS
RH 3.4 Map18809.2UniSTS
Cytogenetic Map18qUniSTS
BE102437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,939,723 - 75,939,877 (+)MAPPERmRatBN7.2
Rnor_6.01879,410,630 - 79,410,783NCBIRnor6.0
Rnor_5.01878,477,545 - 78,477,698UniSTSRnor5.0
RGSC_v3.41879,029,838 - 79,029,991UniSTSRGSC3.4
Celera1874,576,646 - 74,576,799UniSTS
RH 3.4 Map18808.8UniSTS
Cytogenetic Map18qUniSTS
BF402482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,951,947 - 75,952,104 (+)MAPPERmRatBN7.2
Rnor_6.01879,422,854 - 79,423,010NCBIRnor6.0
Rnor_5.01878,489,770 - 78,489,926UniSTSRnor5.0
RGSC_v3.41879,042,228 - 79,042,384UniSTSRGSC3.4
Celera1874,588,651 - 74,588,807UniSTS
RH 3.4 Map18809.2UniSTS
Cytogenetic Map18qUniSTS
BF405689  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,963,040 - 75,963,181 (+)MAPPERmRatBN7.2
Rnor_6.01879,433,947 - 79,434,087NCBIRnor6.0
Rnor_5.01878,500,863 - 78,501,003UniSTSRnor5.0
RGSC_v3.41879,053,966 - 79,054,106UniSTSRGSC3.4
Celera1874,599,606 - 74,599,746UniSTS
RH 3.4 Map18809.2UniSTS
Cytogenetic Map18qUniSTS
RH141640  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,937,176 - 75,937,331 (+)MAPPERmRatBN7.2
Rnor_6.01879,408,083 - 79,408,237NCBIRnor6.0
Rnor_5.01878,474,998 - 78,475,152UniSTSRnor5.0
RGSC_v3.41879,027,291 - 79,027,445UniSTSRGSC3.4
Celera1874,574,099 - 74,574,253UniSTS
RH 3.4 Map18798.0UniSTS
Cytogenetic Map18qUniSTS
BE106956  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,944,503 - 75,944,662 (+)MAPPERmRatBN7.2
Rnor_6.01879,415,410 - 79,415,568NCBIRnor6.0
Rnor_5.01878,482,325 - 78,482,483UniSTSRnor5.0
RGSC_v3.41879,034,618 - 79,034,776UniSTSRGSC3.4
Celera1874,581,426 - 74,581,584UniSTS
RH 3.4 Map18809.6UniSTS
Cytogenetic Map18qUniSTS


Related Rat Strains
The following Strains have been annotated to Mbp
LE-Mbpmd    


Genetic Models
This gene Mbp is modified in the following models/strains:
LE-Mbpmd    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 25
Medium 1 19 10 17 10 6 6 25 4 9 6
Low 2 42 38 31 2 31 2 5 24 35 37 2 2
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF439750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI145512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY208921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC084713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB586909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX131663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX131664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022280   ⟹   ENSRNOP00000022280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1875,855,878 - 75,966,404 (+)Ensembl
Rnor_6.0 Ensembl1879,406,381 - 79,437,310 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000022303   ⟹   ENSRNOP00000022303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1875,855,878 - 75,966,404 (+)Ensembl
Rnor_6.0 Ensembl1879,406,381 - 79,437,310 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000058295   ⟹   ENSRNOP00000055097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1875,855,878 - 75,966,404 (+)Ensembl
Rnor_6.0 Ensembl1879,406,381 - 79,437,310 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000058296   ⟹   ENSRNOP00000055098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1875,855,878 - 75,966,404 (+)Ensembl
Rnor_6.0 Ensembl1879,406,381 - 79,437,310 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089879   ⟹   ENSRNOP00000070157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1875,873,694 - 75,936,382 (+)Ensembl
Rnor_6.0 Ensembl1879,326,738 - 79,407,285 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107098   ⟹   ENSRNOP00000086141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1875,855,878 - 75,966,404 (+)Ensembl
RefSeq Acc Id: NM_001025289   ⟹   NP_001020460
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,130,652 - 78,211,158 (+)NCBI
mRatBN7.21875,855,878 - 75,936,388 (+)NCBI
Rnor_6.01879,326,738 - 79,407,294 (+)NCBI
Rnor_5.01878,385,304 - 78,504,226 (+)NCBI
RGSC_v3.41878,943,608 - 79,057,329 (+)RGD
Celera1874,493,165 - 74,573,310 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001025291   ⟹   NP_001020462
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,210,245 - 78,241,174 (+)NCBI
mRatBN7.21875,935,475 - 75,966,404 (+)NCBI
Rnor_6.01879,406,381 - 79,437,310 (+)NCBI
Rnor_5.01878,385,304 - 78,504,226 (+)NCBI
RGSC_v3.41878,943,608 - 79,057,329 (+)RGD
Celera1874,572,397 - 74,602,969 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001025292   ⟹   NP_001020463
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,210,245 - 78,241,174 (+)NCBI
mRatBN7.21875,935,475 - 75,966,404 (+)NCBI
Rnor_6.01879,406,381 - 79,437,310 (+)NCBI
Rnor_5.01878,385,304 - 78,504,226 (+)NCBI
RGSC_v3.41878,943,608 - 79,057,329 (+)RGD
Celera1874,572,397 - 74,602,969 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001025293   ⟹   NP_001020464
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,210,245 - 78,241,174 (+)NCBI
mRatBN7.21875,935,475 - 75,966,404 (+)NCBI
Rnor_6.01879,406,381 - 79,437,310 (+)NCBI
Rnor_5.01878,385,304 - 78,504,226 (+)NCBI
RGSC_v3.41878,943,608 - 79,057,329 (+)RGD
Celera1874,572,397 - 74,602,969 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001025294   ⟹   NP_001020465
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,210,245 - 78,241,174 (+)NCBI
mRatBN7.21875,935,475 - 75,966,404 (+)NCBI
Rnor_6.01879,406,381 - 79,437,310 (+)NCBI
Rnor_5.01878,385,304 - 78,504,226 (+)NCBI
RGSC_v3.41878,943,608 - 79,057,329 (+)RGD
Celera1874,572,397 - 74,602,969 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017026   ⟹   NP_058722
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,210,245 - 78,241,174 (+)NCBI
mRatBN7.21875,935,475 - 75,966,404 (+)NCBI
Rnor_6.01879,406,381 - 79,437,310 (+)NCBI
Rnor_5.01878,385,304 - 78,504,226 (+)NCBI
RGSC_v3.41878,943,608 - 79,057,329 (+)RGD
Celera1874,572,397 - 74,602,969 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254997   ⟹   XP_006255059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,130,730 - 78,241,165 (+)NCBI
mRatBN7.21875,855,963 - 75,966,403 (+)NCBI
Rnor_6.01879,326,743 - 79,437,309 (+)NCBI
Rnor_5.01878,385,304 - 78,504,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600846   ⟹   XP_017456335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,155,901 - 78,241,165 (+)NCBI
mRatBN7.21875,881,123 - 75,966,403 (+)NCBI
Rnor_6.01879,351,984 - 79,437,309 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600847   ⟹   XP_017456336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,155,896 - 78,241,165 (+)NCBI
mRatBN7.21875,881,122 - 75,966,403 (+)NCBI
Rnor_6.01879,351,984 - 79,437,309 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096568   ⟹   XP_038952496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,155,896 - 78,241,165 (+)NCBI
mRatBN7.21875,881,122 - 75,966,403 (+)NCBI
RefSeq Acc Id: XM_039096569   ⟹   XP_038952497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,146,827 - 78,241,165 (+)NCBI
mRatBN7.21875,872,056 - 75,966,403 (+)NCBI
RefSeq Acc Id: XM_063277090   ⟹   XP_063133160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,130,730 - 78,241,165 (+)NCBI
RefSeq Acc Id: XM_063277091   ⟹   XP_063133161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,130,730 - 78,241,165 (+)NCBI
RefSeq Acc Id: XM_063277092   ⟹   XP_063133162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,130,730 - 78,241,165 (+)NCBI
RefSeq Acc Id: XM_063277093   ⟹   XP_063133163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81878,130,730 - 78,241,165 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001020460 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020462 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020463 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020464 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020465 (Get FASTA)   NCBI Sequence Viewer  
  NP_058722 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255059 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456335 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456336 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952496 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952497 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133160 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133161 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133162 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133163 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41575 (Get FASTA)   NCBI Sequence Viewer  
  AAH84713 (Get FASTA)   NCBI Sequence Viewer  
  AAH94522 (Get FASTA)   NCBI Sequence Viewer  
  AAL84189 (Get FASTA)   NCBI Sequence Viewer  
  AAO60966 (Get FASTA)   NCBI Sequence Viewer  
  AFP20581 (Get FASTA)   NCBI Sequence Viewer  
  AFP20582 (Get FASTA)   NCBI Sequence Viewer  
  CAA10804 (Get FASTA)   NCBI Sequence Viewer  
  CAA10805 (Get FASTA)   NCBI Sequence Viewer  
  CAA10806 (Get FASTA)   NCBI Sequence Viewer  
  CAA10807 (Get FASTA)   NCBI Sequence Viewer  
  EDL75206 (Get FASTA)   NCBI Sequence Viewer  
  EDL75207 (Get FASTA)   NCBI Sequence Viewer  
  EDL75208 (Get FASTA)   NCBI Sequence Viewer  
  EDL75209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022280
  ENSRNOP00000022280.6
  ENSRNOP00000022303
  ENSRNOP00000022303.5
  ENSRNOP00000055097.4
  ENSRNOP00000055098.4
  ENSRNOP00000070157
  ENSRNOP00000070157.2
  ENSRNOP00000086141.1
GenBank Protein P02688 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001020460   ⟸   NM_001025289
- Peptide Label: isoform 1
- UniProtKB: Q5XFW1 (UniProtKB/TrEMBL),   A0A0G2JX70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001020462   ⟸   NM_001025291
- Peptide Label: isoform 1
- UniProtKB: Q9Z1J5 (UniProtKB/Swiss-Prot),   Q9Z1J4 (UniProtKB/Swiss-Prot),   Q8R4K6 (UniProtKB/Swiss-Prot),   Q505J1 (UniProtKB/Swiss-Prot),   Q9Z1J6 (UniProtKB/Swiss-Prot),   P02688 (UniProtKB/Swiss-Prot),   I7FKL4 (UniProtKB/TrEMBL),   I7EFB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001020463   ⟸   NM_001025292
- Peptide Label: isoform 2
- UniProtKB: P02688 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001020464   ⟸   NM_001025293
- Peptide Label: isoform 3
- UniProtKB: P02688 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001020465   ⟸   NM_001025294
- Peptide Label: isoform 4
- UniProtKB: P02688 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_058722   ⟸   NM_017026
- Peptide Label: isoform 5
- UniProtKB: P02688 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255059   ⟸   XM_006254997
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QCF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456335   ⟸   XM_017600846
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QCS8 (UniProtKB/TrEMBL),   A6K5J1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456336   ⟸   XM_017600847
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000070157   ⟸   ENSRNOT00000089879
RefSeq Acc Id: ENSRNOP00000022303   ⟸   ENSRNOT00000022303
RefSeq Acc Id: ENSRNOP00000055097   ⟸   ENSRNOT00000058295
RefSeq Acc Id: ENSRNOP00000055098   ⟸   ENSRNOT00000058296
RefSeq Acc Id: ENSRNOP00000022280   ⟸   ENSRNOT00000022280
RefSeq Acc Id: XP_038952497   ⟸   XM_039096569
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QCF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952496   ⟸   XM_039096568
- Peptide Label: isoform X1
- UniProtKB: A6K5J2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086141   ⟸   ENSRNOT00000107098
RefSeq Acc Id: XP_063133160   ⟸   XM_063277090
- Peptide Label: isoform X5
- UniProtKB: A0A8L2UMS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133162   ⟸   XM_063277092
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063133161   ⟸   XM_063277091
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QRV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133163   ⟸   XM_063277093
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A591 (UniProtKB/TrEMBL),   A6K5J3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02688-F1-model_v2 AlphaFold P02688 1-195 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700892
Promoter ID:EPDNEW_R11416
Type:multiple initiation site
Name:Mbp_1
Description:myelin basic protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11417  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01879,326,784 - 79,326,844EPDNEW
RGD ID:13700893
Promoter ID:EPDNEW_R11417
Type:multiple initiation site
Name:Mbp_2
Description:myelin basic protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11416  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01879,406,411 - 79,406,471EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3054 AgrOrtholog
BioCyc Gene G2FUF-6795 BioCyc
Ensembl Genes ENSRNOG00000016516 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022280.6 UniProtKB/TrEMBL
  ENSRNOT00000022303.8 UniProtKB/TrEMBL
  ENSRNOT00000058295.6 UniProtKB/TrEMBL
  ENSRNOT00000058296.6 UniProtKB/TrEMBL
  ENSRNOT00000089879 ENTREZGENE
  ENSRNOT00000089879.2 UniProtKB/TrEMBL
  ENSRNOT00000107098.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303731 IMAGE-MGC_LOAD
  IMAGE:7316167 IMAGE-MGC_LOAD
InterPro Myelin_BP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24547 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105460 IMAGE-MGC_LOAD
  MGC:105461 IMAGE-MGC_LOAD
NCBI Gene 24547 ENTREZGENE
PANTHER MYELIN BASIC PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11429 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myelin_MBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mbp PhenoGen
PRINTS MYELINMBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYELIN_MBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016516 RatGTEx
UniProt A0A0G2JX70 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A591 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QRV9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UMS1 ENTREZGENE, UniProtKB/TrEMBL
  A6K5J1 ENTREZGENE, UniProtKB/TrEMBL
  A6K5J2 ENTREZGENE, UniProtKB/TrEMBL
  A6K5J3 ENTREZGENE, UniProtKB/TrEMBL
  I7EFB0 ENTREZGENE, UniProtKB/TrEMBL
  I7FKL4 ENTREZGENE, UniProtKB/TrEMBL
  MBP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q505J1 ENTREZGENE
  Q5XFW1 ENTREZGENE, UniProtKB/TrEMBL
  Q80Z98_RAT UniProtKB/TrEMBL
  Q8R4K6 ENTREZGENE
  Q9Z1J4 ENTREZGENE
  Q9Z1J5 ENTREZGENE
  Q9Z1J6 ENTREZGENE
UniProt Secondary Q505J1 UniProtKB/Swiss-Prot
  Q8R4K6 UniProtKB/Swiss-Prot
  Q9Z1J4 UniProtKB/Swiss-Prot
  Q9Z1J5 UniProtKB/Swiss-Prot
  Q9Z1J6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mbp  Myelin basic protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization extrinsic membrane protein 729337
gene_regulation promoter activity is enhanced by Phosphatidylinositol-3 kinase (PI3K) p85 subunit in primary oligodendrocytes 729112