Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Strain Registration

Strain: LE-Mbpmd

Symbol: LE-Mbpmd
Strain: LE-Mbpmd
RGD ID: 1358923
Citation ID: RRID:RGD_1358923
Ontology ID: RS:0000426
Alleles: Mbpmd;   Mbp
Also Known As: LES;Long Evans Shaker; LE-Mbpmd; LE-Mbp^[md]
Type: mutant
Available Source: Not Available
Origination: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
Description: A spontaneous tremor rat was originated from in-house breeding colony , after purchased from Charles River Laboratory 12 years earlier, at McMaster University Central Animal Facility, Hamilton, Ontario, Canada. 10-12 days old rats had tremors that were followed by ataxia, hind limb paresis, episodes of immobility, and seizures by 5-14 weeks.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,855,878 - 75,966,404RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01879,326,738 - 79,437,310RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01878,385,304 - 78,504,226RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41878,943,608 - 79,057,329RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
ataxia  (IAGP)
dysmyelination  (IAGP)
tremors  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. Familial dysmyelination in a Long Evans rat mutant. Delaney KH, etal., Lab Anim Sci 1995 Oct;45(5):547-53.
2. Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats. Eftekharpour E, etal., Exp Neurol 2005 Jun;193(2):334-49.
3. Insertion of a retrotransposon in Mbp disrupts mRNA splicing and myelination in a new mutant rat. O'Connor LT, etal., J Neurosci 1999 May 1;19(9):3404-13.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Lack myelin formation at all levels in the central nervous system. 1358775
strain_other These have disrupted Mbp gene due to the insertion of an endogenous retrotransposon into the noncoding region of the intron 3. 1358763
strain_other Dispersed labeling of Kv1.1 and Kv1.2, K+ channels and of Caspr, a protein confined to paranodes, velocity and high frequency conduction failure. 1358762

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-05 LE-Mbpmd    LE-Mbpmd    Symbol updated 68687 APPROVED
2017-04-05 LE-Mbpmd    LE-Mbpmd    Symbol updated 68687 APPROVED