Strain: LE-Mbpmd |
| Symbol: |
LE-Mbpmd |
| Strain: |
LE-Mbpmd |
| Ontology ID: |
RS:0000426
|
| Alleles: |
Mbp |
| Also known as: |
LES;Long Evans Shaker |
| Type: |
mutant |
| Source: |
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada |
| Origin: |
10-12 days old rats had tremors that were followed by ataxia, hind limb paresis, episodes of immobility, and seizures by 5-14 weeks. |
 Phenotype Annotations |
Phenotype Annotations
References - curated RGD Disease Portals
LE-Mbpmd has been annotated in the following RGD Disease Portals.
|
 |
|
Region
Additional Information
RGD Curation Notes
| Note Type |
Note |
Reference |
| strain_characteristics |
Lack myelin formation at all levels in the central nervous system. |
1358775
|
| strain_other |
These have disrupted Mbp gene due to the insertion of an endogenous retrotransposon into the noncoding region of the intron 3. |
1358763
|
| strain_other |
Dispersed labeling of Kv1.1 and Kv1.2, K+ channels and of Caspr, a protein confined to paranodes, velocity and high frequency conduction failure. |
1358762
|
|
|
| RGD Object Information |
| RGD ID: |
1358923 |
| Created: |
2005-07-08 |
| Species: |
Rattus norvegicus |
| Last Modified: |
2005-07-08 |
| Status: |
ACTIVE |
|
