RGD Reference Report - [Relationship between anti-myelin basic protein antibody and myelinoclasis in rat brain stem after brain trauma]. - Rat Genome Database

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[Relationship between anti-myelin basic protein antibody and myelinoclasis in rat brain stem after brain trauma].

Authors: Li, W  Chen, SC  Wang, ZG  Song, XB  Wang, YP  Zhang, M 
Citation: Li W, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jun;28(6):1028-30.
RGD ID: 7349333
Pubmed: PMID:18583256   (View Abstract at PubMed)

OBJECTIVE: To investigate the relations between anti-myelin basic protein antibody (anti-MBP) variation and myelinoclasis in the brain stem following brain trauma. METHODS: In rat models of brain trauma, MBP content and anti-MBP titer in the blood were measured using enzyme-linked immunosorbent assay (ELISA) at different time points after brain trauma, and the degree of myelinoclasis in the brain stem slices was assessed with osmic acid staining. RESULTS: Early after brain trauma, MBP content in the blood increased followed by significant reduction 10 days later. Four days after the trauma, anti-MBP titer was markedly increased, accompanied by obvious exacerbation of myelinoclasis in the brain stem, both reaching the highest levels on day 10, at the point of which anti-MBP titer increased by 4 folds and the number of myelinoclasis by 10 folds compared with the control group. Anti-MBP titer and brain stem myelinolysis both lowered 30 days later. Correlation analysis showed an intimate positive correlation between anti-MBP titer and the degree of myelinoclasis. CONCLUSION: After brain trauma, MBP is released as a specific antigen into the blood to stimulate the immune system for anti-MBP production, and the antibody is intimately related to the brain stem myelinoclasis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOMbp (Rattus norvegicus)7349333; 7349333 RGD 
Brain Injuries  IDA 7349333 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbp  (myelin basic protein)

Genes (Mus musculus)
Mbp  (myelin basic protein)

Genes (Homo sapiens)
MBP  (myelin basic protein)


Additional Information