RGD Reference Report - Autoantibodies to neuron-specific proteins S100, GFAP, MBP and NGF in the serum of rats with streptozotocin-induced diabetes. - Rat Genome Database

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Autoantibodies to neuron-specific proteins S100, GFAP, MBP and NGF in the serum of rats with streptozotocin-induced diabetes.

Authors: Lotosh, NG  Savel'eva, EK  Selishcheva, AA  Savel'ev, SV 
Citation: Lotosh NG, etal., Bull Exp Biol Med. 2013 May;155(1):48-51.
RGD ID: 7327197
Pubmed: PMID:23667870   (View Abstract at PubMed)

The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin injection and the level of autoantibodies to insulin significantly increased on day 5 indicating the development of diabetes. The levels of antibodies to specific neuronal proteins (S100, GFAP, MBP, and NGF) also increased at this term. It is concluded that diabetes with streptozotocin is associated with damage to the blood-brain barrier.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOMbp (Rattus norvegicus)7327197; 7327197 RGD 
Experimental Diabetes Mellitus  IDA 7327197 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbp  (myelin basic protein)

Genes (Mus musculus)
Mbp  (myelin basic protein)

Genes (Homo sapiens)
MBP  (myelin basic protein)


Additional Information