RGD Reference Report - Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein. - Rat Genome Database

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Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein.

Authors: Matheus, L  Blair, GE 
Citation: Matheus L and Blair GE, Biochim Biophys Acta 2003 Oct 20;1630(1):47-53.
RGD ID: 1358485
Pubmed: PMID:14580679   (View Abstract at PubMed)

The myelin basic proteins (MBPs) are the major proteins of the myelin membrane. Multiple MBP mRNAs and protein isoforms are generated by alternative RNA splicing. Here we describe the isolation and characterisation of a cDNA clone encoding a 17-kDa MBP isoform from the rat (Rattus norvegicus). The isoform is a 158-amino acid protein consisting of exons 1, 3, 4, 6 and 7 of the MBP gene. RT-PCR analysis of brain mRNA showed that transcripts encoding the 17-kDa isoform were expressed at higher levels early in post-natal development, up to 7 days post-partum.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
structural constituent of myelin sheath  TAS 1358485 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbp  (myelin basic protein)


Additional Information