Kcnc1 (potassium voltage-gated channel subfamily C member 1) - Rat Genome Database

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Gene: Kcnc1 (potassium voltage-gated channel subfamily C member 1) Rattus norvegicus
Analyze
Symbol: Kcnc1
Name: potassium voltage-gated channel subfamily C member 1
RGD ID: 2955
Description: Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including nervous system development; potassium ion transmembrane transport; and response to auditory stimulus. Located in several cellular components, including cell surface; neuron projection membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in calyx of Held; postsynaptic membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; Ampullosporin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: KShIIIB; Kv3.1; KV4; NGK2; NGK2-KV4; potassium channel gene 1; Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991); potassium channel, voltage gated Shaw-related subfamily C, member 1; potassium voltage gated channel, Shaw-related subfamily, member 1; RAW2; voltage-gated potassium channel KCNC1; voltage-gated potassium channel subunit Kv3.1; voltage-gated potassium channel subunit Kv4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,039,247 - 106,081,034 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,039,237 - 106,081,033 (+)EnsemblGRCr8
mRatBN7.2196,902,953 - 96,944,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,902,953 - 96,944,744 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,288,979 - 102,330,759 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,760,963 - 110,802,743 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,051,340 - 104,093,133 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,414,352 - 102,456,718 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,414,625 - 102,456,411 (+)Ensemblrn6Rnor6.0
Rnor_5.01103,499,689 - 103,541,476 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,928,275 - 96,970,062 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,151,218 - 91,193,065 (+)NCBICelera
RGSC_v3.1197,006,385 - 97,048,173 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. Boda E, etal., J Mol Neurosci. 2012 Mar;46(3):606-15. doi: 10.1007/s12031-011-9648-6. Epub 2011 Sep 13.
2. Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Choi BH, etal., Neuropharmacology. 2001 Sep;41(4):443-53.
3. Stable expression and regulation of a rat brain K+ channel. Critz SD, etal., J Neurochem. 1993 Mar;60(3):1175-8.
4. Kv3.1b is a novel component of CNS nodes. Devaux J, etal., J Neurosci. 2003 Jun 1;23(11):4509-18.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons. Grabert J and Wahle P, Neuroscience. 2008 Oct 15;156(3):618-29. doi: 10.1016/j.neuroscience.2008.08.008. Epub 2008 Aug 12.
8. Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex. Grabert J and Wahle P, Neuroscience. 2009 Jan 23;158(2):654-64. doi: 10.1016/j.neuroscience.2008.07.035. Epub 2008 Jul 25.
9. Importance of glycosylation on function of a potassium channel in neuroblastoma cells. Hall MK, etal., PLoS One. 2011 Apr 26;6(4):e19317. doi: 10.1371/journal.pone.0019317.
10. Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus. Hernandez-Pineda R, etal., J Neurophysiol. 1999 Sep;82(3):1512-28.
11. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
12. Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Ishikawa T, etal., J Neurosci. 2003 Nov 12;23(32):10445-53.
13. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
14. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. Kanemasa T, etal., J Neurophysiol. 1995 Jul;74(1):207-17.
15. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. Lewis A, etal., J Biol Chem. 2004 Feb 27;279(9):7884-92. Epub 2003 Dec 16.
16. Localization of two high-threshold potassium channel subunits in the rat central auditory system. Li W, etal., J Comp Neurol. 2001 Aug 20;437(2):196-218.
17. The expression of two splice variants of the Kv3.1 potassium channel gene is regulated by different signaling pathways. Liu SJ and Kaczmarek LK, J Neurosci. 1998 Apr 15;18(8):2881-90.
18. Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system. Luneau CJ, etal., Proc Natl Acad Sci U S A 1991 May 1;88(9):3932-6.
19. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. McCrossan ZA, etal., J Neurosci. 2003 Sep 3;23(22):8077-91.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Expression of the mRNAs for the Kv3.1 potassium channel gene in the adult and developing rat brain. Perney TM, etal., J Neurophysiol. 1992 Sep;68(3):756-66.
23. Precise localization of the voltage-gated potassium channel subunits Kv3.1b and Kv3.3 revealed in the molecular layer of the rat cerebellar cortex by a pre-embedding immunogold method. Puente N, etal., Histochem Cell Biol. 2010 Oct;134(4):403-9. doi: 10.1007/s00418-010-0742-6. Epub 2010 Sep 21.
24. Characterization of a Shaw-related potassium channel family in rat brain. Rettig J, etal., EMBO J 1992 Jul;11(7):2473-86.
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Voltage-gated potassium channel (Kv) subunits expressed in the rat cochlear nucleus. Rusznak Z, etal., J Histochem Cytochem. 2008 May;56(5):443-65. doi: 10.1369/jhc.2008.950303. Epub 2008 Feb 5.
27. Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat. Strumbos JG, etal., Neuroscience. 2010 May 19;167(3):567-72. doi: 10.1016/j.neuroscience.2010.02.046. Epub 2010 Feb 26.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7526924   PMID:12000114   PMID:15240761   PMID:15528247   PMID:16413129   PMID:16595659   PMID:18094255   PMID:18187934   PMID:18682278   PMID:19213956   PMID:19387585   PMID:21106837  
PMID:21147063   PMID:22105078   PMID:22675523   PMID:23487040   PMID:23734863   PMID:24291260   PMID:26348848   PMID:28213922   PMID:28322444  


Genomics

Comparative Map Data
Kcnc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,039,247 - 106,081,034 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,039,237 - 106,081,033 (+)EnsemblGRCr8
mRatBN7.2196,902,953 - 96,944,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,902,953 - 96,944,744 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,288,979 - 102,330,759 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,760,963 - 110,802,743 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,051,340 - 104,093,133 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,414,352 - 102,456,718 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,414,625 - 102,456,411 (+)Ensemblrn6Rnor6.0
Rnor_5.01103,499,689 - 103,541,476 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,928,275 - 96,970,062 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,151,218 - 91,193,065 (+)NCBICelera
RGSC_v3.1197,006,385 - 97,048,173 (+)NCBI
Cytogenetic Map1q22NCBI
KCNC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,734,781 - 17,783,057 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,734,774 - 17,856,804 (+)Ensemblhg38GRCh38
GRCh371117,756,328 - 17,804,604 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,714,090 - 17,750,755 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341117,714,112 - 17,750,753NCBI
Celera1117,890,030 - 17,937,113 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,441,501 - 17,487,861 (+)NCBIHuRef
CHM1_11117,757,215 - 17,804,314 (+)NCBICHM1_1
T2T-CHM13v2.01117,832,488 - 17,880,755 (+)NCBIT2T-CHM13v2.0
Kcnc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,045,643 - 46,088,130 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,045,921 - 46,088,128 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,396,219 - 46,438,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,396,497 - 46,438,704 (+)Ensemblmm10GRCm38
MGSCv37753,651,838 - 53,694,074 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36746,265,584 - 46,306,746 (+)NCBIMGSCv36mm8
Celera741,870,004 - 41,912,217 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.1NCBI
Kcnc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,538,938 - 32,580,370 (+)Ensembl
ChiLan1.0NW_00495541432,538,968 - 32,580,370 (+)NCBIChiLan1.0ChiLan1.0
KCNC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,067,013 - 20,194,651 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,027,491 - 20,149,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,788,010 - 17,936,591 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,472,061 - 17,519,214 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,472,158 - 17,517,892 (+)EnsemblpanPan2panpan1.1
KCNC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,273,366 - 40,315,189 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,273,827 - 40,315,189 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2139,773,451 - 39,814,777 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02141,377,580 - 41,419,665 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,378,304 - 41,419,665 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,391,108 - 40,432,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,598,959 - 40,640,287 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,937,508 - 40,978,698 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,317,707 - 45,359,952 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,351,689 - 1,393,932 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,351,687 - 1,393,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,362,347 - 41,408,127 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1241,362,208 - 41,407,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,432,251 - 44,438,707 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,189,485 - 47,237,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,190,806 - 47,236,775 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038144,582,522 - 144,631,080 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,359,511 - 9,400,106 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247669,360,038 - 9,400,106 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12152,934,126 - 153,100,996 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnc1
170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:101
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000015260
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH129997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,944,542 - 96,944,727 (+)MAPPERmRatBN7.2
Rnor_6.01102,456,210 - 102,456,394NCBIRnor6.0
Rnor_5.01103,541,275 - 103,541,459UniSTSRnor5.0
RGSC_v3.4196,969,861 - 96,970,045UniSTSRGSC3.4
Celera191,192,864 - 91,193,048UniSTS
Cytogenetic Map1q22UniSTS
Y07521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,934,428 - 96,934,506 (+)MAPPERmRatBN7.2
Rnor_6.01102,446,099 - 102,446,176NCBIRnor6.0
Rnor_5.01103,531,164 - 103,531,241UniSTSRnor5.0
RGSC_v3.4196,959,750 - 96,959,827UniSTSRGSC3.4
Celera191,182,739 - 91,182,816UniSTS
Cytogenetic Map1q22UniSTS
BE106226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,928,701 - 96,928,867 (+)MAPPERmRatBN7.2
Rnor_6.01102,440,372 - 102,440,537NCBIRnor6.0
Rnor_5.01103,525,437 - 103,525,602UniSTSRnor5.0
RGSC_v3.4196,954,023 - 96,954,188UniSTSRGSC3.4
Celera191,177,010 - 91,177,175UniSTS
RH 3.4 Map1909.9UniSTS
Cytogenetic Map1q22UniSTS
RH138274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,915,387 - 96,915,516 (+)MAPPERmRatBN7.2
Rnor_6.01102,427,058 - 102,427,186NCBIRnor6.0
Rnor_5.01103,512,123 - 103,512,251UniSTSRnor5.0
RGSC_v3.4196,940,709 - 96,940,837UniSTSRGSC3.4
Celera191,163,696 - 91,163,824UniSTS
RH 3.4 Map1909.6UniSTS
Cytogenetic Map1q22UniSTS
RH27338  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81106,070,180 - 106,070,357 (+)Marker Load Pipeline
mRatBN7.2196,933,887 - 96,934,063 (+)MAPPERmRatBN7.2
Rnor_6.01102,445,558 - 102,445,733NCBIRnor6.0
Rnor_5.01103,530,623 - 103,530,798UniSTSRnor5.0
RGSC_v3.4196,959,209 - 96,959,384UniSTSRGSC3.4
Celera191,182,198 - 91,182,373UniSTS
Cytogenetic Map1q22UniSTS
KCNC1_879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,933,648 - 96,934,441 (+)MAPPERmRatBN7.2
Rnor_6.01102,445,319 - 102,446,111NCBIRnor6.0
Rnor_5.01103,530,384 - 103,531,176UniSTSRnor5.0
RGSC_v3.4196,958,970 - 96,959,762UniSTSRGSC3.4
Celera191,181,959 - 91,182,751UniSTS
Cytogenetic Map1q22UniSTS
UniSTS:531455  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,933,873 - 96,934,281 (+)MAPPERmRatBN7.2
Rnor_6.01102,445,544 - 102,445,951NCBIRnor6.0
Rnor_5.01103,530,609 - 103,531,016UniSTSRnor5.0
Celera191,182,184 - 91,182,591UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 11 50 150 50 48 18 34 18 6 192 114 8 123 41 83 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000089488   ⟹   ENSRNOP00000074146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,039,237 - 106,081,033 (+)Ensembl
mRatBN7.2 Ensembl196,902,953 - 96,944,744 (+)Ensembl
Rnor_6.0 Ensembl1102,414,625 - 102,456,411 (+)Ensembl
RefSeq Acc Id: NM_012856   ⟹   NP_036988
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,039,247 - 106,081,034 (+)NCBI
mRatBN7.2196,902,953 - 96,944,744 (+)NCBI
Rnor_6.01102,414,625 - 102,456,411 (+)NCBI
Rnor_5.01103,499,689 - 103,541,476 (+)NCBI
RGSC_v3.4196,928,275 - 96,970,062 (+)RGD
Celera191,151,218 - 91,193,065 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036988 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41501 (Get FASTA)   NCBI Sequence Viewer  
  EDM07265 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074146
  ENSRNOP00000074146.1
GenBank Protein P25122 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036988   ⟸   NM_012856
- UniProtKB: P25122 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074146   ⟸   ENSRNOT00000089488
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25122-F1-model_v2 AlphaFold P25122 1-585 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690061
Promoter ID:EPDNEW_R586
Type:initiation region
Name:Kcnc1_1
Description:potassium voltage-gated channel subfamily C member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,414,665 - 102,414,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2955 AgrOrtholog
BioCyc Gene G2FUF-59626 BioCyc
Ensembl Genes ENSRNOG00000055401 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089488 ENTREZGENE
  ENSRNOT00000089488.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv3 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv3.1 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  VG_K_chnl UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25327 UniProtKB/Swiss-Prot
NCBI Gene 25327 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 1 UniProtKB/Swiss-Prot
  PTHR11537 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Kcnc1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KV31CHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
  SHAWCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055401 RatGTEx
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC219176
UniProt A6JBB9_RAT UniProtKB/TrEMBL
  KCNC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnc1  potassium voltage-gated channel subfamily C member 1  Kcnc1  potassium channel, voltage gated Shaw-related subfamily C, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnc1  potassium channel, voltage gated Shaw-related subfamily C, member 1  Kcnc1  potassium voltage gated channel, Shaw-related subfamily, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Kcnc1  potassium voltage gated channel, Shaw-related subfamily, member 1      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript has alternative forms arising from alternative exon usage 728931