Kcnc4 (potassium voltage-gated channel subfamily C member 4) - Rat Genome Database

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Gene: Kcnc4 (potassium voltage-gated channel subfamily C member 4) Rattus norvegicus
Analyze
Symbol: Kcnc4
Name: potassium voltage-gated channel subfamily C member 4
RGD ID: 1589169
Description: Enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in negative regulation of neuronal action potential and nervous system development. Located in several cellular components, including cell surface; dendrite; and neuronal cell body. Is active in several cellular components, including calyx of Held; glycinergic synapse; and synaptic membrane. Colocalizes with synaptic vesicle. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4); INTERACTS WITH (+)-pilocarpine; (5Z,8Z,11Z,13E)-15-HETE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC684516; potassium channel, voltage gated Shaw-related subfamily C, member 4; potassium voltage gated channel, Shaw-related subfamily, member 4; potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3); raw3; similar to Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3); voltage-gated potassium channel subunit Kv3.4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,747,095 - 197,788,467 (-)NCBIGRCr8
mRatBN7.22195,063,967 - 195,100,244 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,071,769 - 195,099,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,720,130 - 202,740,385 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,602,290 - 200,622,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,419,233 - 195,439,487 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,220,908 - 210,241,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,220,908 - 210,241,455 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,694,932 - 229,732,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2187,727,839 - 187,748,108 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. Angulo E, etal., J Neurochem. 2004 Nov;91(3):547-57.
2. Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Baranauskas G, etal., Nat Neurosci. 2003 Mar;6(3):258-66. doi: 10.1038/nn1019.
3. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. Boda E, etal., J Mol Neurosci. 2012 Mar;46(3):606-15. doi: 10.1007/s12031-011-9648-6. Epub 2011 Sep 13.
4. Association of potassium channel Kv3.4 subunits with pre- and post-synaptic structures in brainstem and spinal cord. Brooke RE, etal., Neuroscience. 2004;126(4):1001-10.
5. Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity. Chien LY, etal., J Neurosci. 2007 Sep 12;27(37):9855-65.
6. Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin. Dallas ML, etal., Brain Res. 2008 Jan 16;1189:51-7. Epub 2007 Nov 9.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
9. Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Ishikawa T, etal., J Neurosci. 2003 Nov 12;23(32):10445-53.
10. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1354-63. doi: 10.1016/j.bpj.2011.08.015. Epub 2011 Sep 20.
11. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
12. [Kv3.4 channel is involved in rat pulmonary vasoconstriction induced by 15-hydroxyeicosatetraenoic acid]. Li Q, etal., Sheng Li Xue Bao. 2006 Feb 25;58(1):77-82.
13. Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats. Pacheco Otalora LF, etal., Brain Res. 2011 Jan 12;1368:308-16. doi: 10.1016/j.brainres.2010.10.047. Epub 2010 Oct 21.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Identification of a Kv3.4 channel in corneal epithelial cells. Wang L, etal., Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1796-803.
19. Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats. Zahn RK, etal., Neurobiol Dis. 2008 Feb;29(2):186-200. Epub 2007 Sep 4.
Additional References at PubMed
PMID:1378392   PMID:1840526   PMID:9000078   PMID:10048926   PMID:15610163   PMID:17495071   PMID:18430420   PMID:26039360   PMID:33368632  


Genomics

Comparative Map Data
Kcnc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,747,095 - 197,788,467 (-)NCBIGRCr8
mRatBN7.22195,063,967 - 195,100,244 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,071,769 - 195,099,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,720,130 - 202,740,385 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,602,290 - 200,622,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,419,233 - 195,439,487 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,220,908 - 210,241,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,220,908 - 210,241,455 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,694,932 - 229,732,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2187,727,839 - 187,748,108 (-)NCBICelera
Cytogenetic Map2q34NCBI
KCNC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,210,314 - 110,284,080 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,210,314 - 110,283,100 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,752,936 - 110,776,666 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,555,588 - 110,578,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,466,018 - 110,478,710NCBI
Celera1109,000,516 - 109,023,855 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,625,031 - 108,648,390 (+)NCBIHuRef
CHM1_11110,868,669 - 110,892,012 (+)NCBICHM1_1
T2T-CHM13v2.01110,225,284 - 110,300,705 (+)NCBIT2T-CHM13v2.0
Kcnc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,345,614 - 107,367,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,345,619 - 107,366,868 (-)EnsemblGRCm39 Ensembl
GRCm383107,438,298 - 107,460,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,438,303 - 107,459,552 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,241,221 - 107,261,816 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,566,359 - 107,586,954 (-)NCBIMGSCv36mm8
Celera3109,770,042 - 109,791,022 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
Kcnc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,728,708 - 13,750,660 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,728,272 - 13,750,420 (+)NCBIChiLan1.0ChiLan1.0
KCNC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,703,093 - 116,828,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,952,375 - 115,976,166 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,860,887 - 112,884,687 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,457,895 - 127,480,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,458,968 - 127,480,182 (-)Ensemblpanpan1.1panPan2
KCNC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,743,214 - 41,764,572 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl641,738,653 - 41,764,578 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,496,309 - 44,541,283 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,051,239 - 42,096,226 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,075,855 - 42,096,111 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0641,742,375 - 41,787,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,177,396 - 42,222,420 (-)NCBIUU_Cfam_GSD_1.0
Kcnc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,424,809 - 18,446,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,667,387 - 1,689,348 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,667,387 - 1,689,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,885,116 - 109,908,476 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,885,116 - 109,908,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,280,838 - 120,310,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,241,279 - 23,328,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2023,304,679 - 23,327,382 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,131,024 - 35,168,004 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247725,967,071 - 5,991,484 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247725,967,042 - 6,004,647 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnc4
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:78
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000072174
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
D2Rat259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,108,573 - 195,108,792 (+)MAPPERmRatBN7.2
Rnor_6.02210,250,800 - 210,251,018NCBIRnor6.0
Rnor_5.02229,724,205 - 229,724,423UniSTSRnor5.0
Celera2187,757,448 - 187,757,666UniSTS
FHH x ACI Map288.8099RGD
FHH x ACI Map288.8099UniSTS
Cytogenetic Map2q34UniSTS
RH135159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,108,542 - 195,108,739 (+)MAPPERmRatBN7.2
Rnor_6.02210,250,769 - 210,250,965NCBIRnor6.0
Rnor_5.02229,724,174 - 229,724,370UniSTSRnor5.0
Celera2187,757,417 - 187,757,613UniSTS
RH 3.4 Map21388.3UniSTS
Cytogenetic Map2q34UniSTS
RH143000  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,096,317 - 195,096,502 (+)MAPPERmRatBN7.2
Rnor_6.02210,238,545 - 210,238,729NCBIRnor6.0
Rnor_5.02229,712,569 - 229,712,753UniSTSRnor5.0
Celera2187,745,185 - 187,745,369UniSTS
RH 3.4 Map21377.3UniSTS
Cytogenetic Map2q34UniSTS
BE108672  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,104,398 - 195,104,575 (+)MAPPERmRatBN7.2
Rnor_6.02210,246,625 - 210,246,801NCBIRnor6.0
Rnor_5.02229,720,030 - 229,720,206UniSTSRnor5.0
Celera2187,753,273 - 187,753,449UniSTS
RH 3.4 Map21377.3UniSTS
Cytogenetic Map2q34UniSTS
BE108676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,102,583 - 195,102,735 (+)MAPPERmRatBN7.2
Rnor_6.02210,244,810 - 210,244,961NCBIRnor6.0
Rnor_5.02229,718,215 - 229,718,366UniSTSRnor5.0
Celera2187,751,458 - 187,751,609UniSTS
RH 3.4 Map21376.9UniSTS
Cytogenetic Map2q34UniSTS
RH136805  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,109,249 - 195,109,390 (+)MAPPERmRatBN7.2
Rnor_6.02210,251,476 - 210,251,616NCBIRnor6.0
Rnor_5.02229,724,881 - 229,725,021UniSTSRnor5.0
Celera2187,758,124 - 187,758,264UniSTS
RH 3.4 Map21388.3UniSTS
Cytogenetic Map2q34UniSTS
RH137842  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,110,538 - 195,110,694 (+)MAPPERmRatBN7.2
Rnor_6.02210,252,765 - 210,252,920NCBIRnor6.0
Rnor_5.02229,726,170 - 229,726,325UniSTSRnor5.0
Celera2187,759,413 - 187,759,568UniSTS
RH 3.4 Map21378.5UniSTS
Cytogenetic Map2q34UniSTS
KCNC4_1814  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,087,602 - 195,088,387 (+)MAPPERmRatBN7.2
Rnor_6.02210,229,830 - 210,230,614NCBIRnor6.0
Rnor_5.02229,703,854 - 229,704,638UniSTSRnor5.0
Celera2187,736,470 - 187,737,254UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 10 38 7
Low 2 8 1 1 26 23 24 5 1
Below cutoff 3 39 14 7 18 7 8 12 11 5

Sequence


RefSeq Acc Id: ENSRNOT00000086420   ⟹   ENSRNOP00000068863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,071,769 - 195,099,233 (-)Ensembl
Rnor_6.0 Ensembl2210,220,908 - 210,241,455 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093977   ⟹   ENSRNOP00000087803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,075,994 - 195,099,233 (-)Ensembl
RefSeq Acc Id: NM_001122776   ⟹   NP_001116248
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,766,650 - 197,788,433 (-)NCBI
mRatBN7.22195,078,461 - 195,100,244 (-)NCBI
Rnor_6.02210,220,908 - 210,241,447 (-)NCBI
Rnor_5.02229,694,932 - 229,732,890 (-)NCBI
Celera2187,727,839 - 187,748,108 (-)RGD
Sequence:
RefSeq Acc Id: NM_001415110   ⟹   NP_001402039
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,766,650 - 197,788,433 (-)NCBI
mRatBN7.22195,078,461 - 195,100,244 (-)NCBI
RefSeq Acc Id: XM_039103129   ⟹   XP_038959057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,766,650 - 197,788,467 (-)NCBI
mRatBN7.22195,079,615 - 195,098,870 (-)NCBI
RefSeq Acc Id: XM_039103131   ⟹   XP_038959059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,747,095 - 197,787,221 (-)NCBI
mRatBN7.22195,063,967 - 195,098,870 (-)NCBI
RefSeq Acc Id: XR_010063660
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,747,095 - 197,787,221 (-)NCBI
RefSeq Acc Id: XR_010063661
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,747,095 - 197,787,221 (-)NCBI
RefSeq Acc Id: NP_001116248   ⟸   NM_001122776
- Peptide Label: isoform 2
- UniProtKB: Q63734 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068863   ⟸   ENSRNOT00000086420
RefSeq Acc Id: XP_038959059   ⟸   XM_039103131
- Peptide Label: isoform X2
- UniProtKB: Q63734 (UniProtKB/Swiss-Prot),   A0A0G2JTV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959057   ⟸   XM_039103129
- Peptide Label: isoform X1
- UniProtKB: Q63734 (UniProtKB/Swiss-Prot),   A0A8I6GGE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087803   ⟸   ENSRNOT00000093977
RefSeq Acc Id: NP_001402039   ⟸   NM_001415110
- Peptide Label: isoform 1
- UniProtKB: Q63734 (UniProtKB/Swiss-Prot)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63734-F1-model_v2 AlphaFold Q63734 1-625 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589169 AgrOrtholog
BioCyc Gene G2FUF-51672 BioCyc
Ensembl Genes ENSRNOG00000060988 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086420.2 UniProtKB/TrEMBL
  ENSRNOT00000093977.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3.4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3_ID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:684516 UniProtKB/Swiss-Prot
NCBI Gene 684516 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Potassium_chann UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnc4 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV34CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAWCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060988 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JTV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GGE0 ENTREZGENE, UniProtKB/TrEMBL
  KCNC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnc4  potassium voltage-gated channel subfamily C member 4  Kcnc4  potassium channel, voltage gated Shaw-related subfamily C, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnc4  potassium channel, voltage gated Shaw-related subfamily C, member 4  Kcnc4  potassium voltage gated channel, Shaw-related subfamily, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-23 Kcnc4   potassium voltage gated channel, Shaw-related subfamily, member 4   LOC684516  similar to Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC684516  similar to Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3)      Symbol and Name status set to provisional 70820 PROVISIONAL