Gene: NUP85 (nucleoporin 85kDa)
Homo sapiens
Symbol:
NUP85
Name:
nucleoporin 85kDa
Description:
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
85 kDa nucleoporin; FLJ12549; frount; nuclear pore complex protein Nup85; nucleoporin Nup75; nucleoporin Nup85; Nup75; pericentrin 1; pericentrin-1
Orthologs:
Mus musculus : Nup85
(nucleoporin 85)
MGI
Nup85
(nucleoporin 85)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 17 74,285,476 - 74,315,668 + NCBI Human Genome Assembly HuRef 17 68,611,339 - 68,641,549 + NCBI Human Genome Assembly GRCh37 17 73,201,597 - 73,231,854 + NCBI Human Genome Assembly Build 36 17 70,713,192 - 70,743,449 + NCBI Human Cytogenetic Map 17 q25.1 NCBI Human Genome Assembly 17 70,713,380 - 70,743,447 NCBI
Model
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NUP85 mRNA CTD PMID:22079256 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1311942 6480464 Tetrachlorodibenzodioxin results in decreased expression of NUP85 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551928 6480464 Tetrachlorodibenzodioxin affects the expression of NUP85 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1311942 6480464 2,4-dinitrotoluene affects the expression of NUP85 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1311942 6480464 2,6-dinitrotoluene affects the expression of NUP85 mRNA CTD PMID:21346803 2-butoxyethanol increases expression ISO RGD:1551928 6480464 n-butoxyethanol results in increased expression of NUP85 mRNA CTD PMID:19812364 4-hydroxynon-2-enal increases expression ISO RGD:1551928 6480464 4-hydroxy-2-nonenal results in increased expression of NUP85 mRNA CTD PMID:19191707 benzo[a]pyrene increases expression ISO RGD:1551928 6480464 Benzo(a)pyrene results in increased expression of NUP85 mRNA CTD PMID:22228805 copper(2+) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of NUP85 mRNA CTD PMID:19549813 coumestrol increases expression EXP 6480464 Coumestrol results in increased expression of NUP85 mRNA CTD PMID:19167446 dibutyl phthalate decreases expression ISO RGD:1551928 6480464 Dibutyl Phthalate results in decreased expression of NUP85 mRNA CTD PMID:21266533 paracetamol affects expression ISO RGD:1551928 6480464 Acetaminophen affects the expression of NUP85 mRNA CTD PMID:17562736 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of NUP85 mRNA CTD PMID:21420995 piroxicam decreases expression EXP 6480464 Piroxicam results in decreased expression of NUP85 mRNA CTD PMID:21858171 quercetin increases expression EXP 6480464 Quercetin results in increased expression of NUP85 mRNA CTD PMID:21632981 sodium dichromate affects expression ISO RGD:1311942 6480464 sodium bichromate affects the expression of NUP85 mRNA CTD PMID:22110744
Gene Ontology Annotations
Biological Process carbohydrate metabolic process TAS 2290271 Reactome:REACT_474 Reactome Reactome:REACT_474 cytokine-mediated signaling pathway TAS 2290271 Reactome:REACT_25229 Reactome Reactome:REACT_25229 glucose transport TAS 2290271 Reactome:REACT_212 Reactome Reactome:REACT_212 hexose transport TAS 2290271 Reactome:REACT_9441 Reactome Reactome:REACT_9441 lamellipodium assembly IEA Ensembl:ENSMUSP00000021085 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 M phase of mitotic cell cycle TAS 2290271 Reactome:REACT_910 Reactome Reactome:REACT_910 macrophage chemotaxis IEA Ensembl:ENSMUSP00000021085 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 mitotic anaphase TAS 2290271 Reactome:REACT_1275 Reactome Reactome:REACT_1275 mitotic cell cycle TAS 2290271 Reactome:REACT_152 Reactome Reactome:REACT_152 mitotic prometaphase TAS 2290271 Reactome:REACT_682 Reactome Reactome:REACT_682 mRNA transport IEA UniProtKB-KW:KW-0509 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 protein transport IEA UniProtKB-KW:KW-0653 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 regulation of glucose transport TAS 2290271 Reactome:REACT_6804 Reactome Reactome:REACT_6804 small molecule metabolic process TAS 2290271 Reactome:REACT_111217 Reactome Reactome:REACT_111217 transmembrane transport TAS 2290271 Reactome:REACT_15518 Reactome Reactome:REACT_15518 transmembrane transport TAS 2290271 Reactome:REACT_19118 Reactome Reactome:REACT_19118 viral reproduction TAS 2290271 Reactome:REACT_6185 Reactome Reactome:REACT_6185 viral reproduction TAS 2290271 Reactome:REACT_6256 Reactome Reactome:REACT_6256 viral reproductive process TAS 2290271 Reactome:REACT_6361 Reactome Reactome:REACT_6361
1298512 RA29_H Rheumatoid arthritis QTL 29 (human) .0017 Joint/bone inflammation rheumatoid arthritis 17 59681011 85681011 Human 1298461 BP20_H Blood pressure QTL 20 (human) .0256 Blood pressure hypertension susceptibility 17 53547832 79547832 Human 1298465 BP14_H Blood pressure QTL 14 (human) 1.9 .0029 Blood pressure hypertension susceptibility 17 55465561 81465561 Human 1559242 FBRL6_H Fibrinogen level QTL 6 (human) 1.5 Fibrinogen level 17 10859378 80253028 Human 1559256 SCL59_H Serum cholesterol level QTL 59 (human) 2.48 Lipid level total cholesterol 17 16064515 80253028 Human 1559134 SCL35_H Serum cholesterol level QTL 35 (human) 2.33 Lipid level LDL cholesterol 17 67078373 93078373 Human 1581525 BP63_H Blood pressure QTL 63 (human) 3.6 .001 Blood pressure pulse pressure 17 53547832 79547832 Human 2289203 BW364_H Body weight QTL 364 (human) .0463 Body fat amount percent fat 17 64802303 90802303 Human 1643051 BW116_H Body Weight QTL 116 (human) 2.48 .00036 Body weight 17 64802303 90802303 Human 1643091 BP90_H Blood pressure QTL 90 (human) 1.5 .0043 Blood pressure 17 59681011 85681011 Human 1643284 BW332_H Body Weight QTL 332 (human) 1.41 .005 Body weight body mass index 17 59681011 85681011 Human 1643572 GLUCO9_H Glucose level QTL 9 (human) 1.6 Glucose level non-insulin-dependent 17 64802303 90802303 Human 2289618 BW487_H Body weight QTL 487 (human) 1.44 Body weight BMI 17 59681011 85681011 Human 2289580 BW461_H Body weight QTL 461 (human) 2.44 Body weight BMI 17 72680935 74506938 Human 1643267 SADIPOQ6_H Serum adiponectin level QTL 6 (human) 1.32 Hormone level serum adiponectin level 17 59681011 85681011 Human 2289581 BW460_H Body weight QTL 460 (human) 3.05 Body fat amount abdominal 17 72680935 74506938 Human 2289583 BW462_H Body weight QTL 462 (human) 1.92 Body morphometry waist circumference 17 72680935 74506938 Human 1643463 BW110_H Body weight QTL 110 (human) 2.21 .0007 Body fat amount abdominal visceral 17 72680935 98680935 Human 1643448 BW109_H Body weight QTL 109 (human) 1.53 .004 Body fat amount abdominal visceral 17 56331449 82331449 Human 2292917 PRSTS128_H Prostate tumor susceptibility QTL 128 (human) 2.2 Prostate tumor susceptibility 17 48436413 74436413 Human 2314710 GLUCO61_H Glucose level QTL 61 (human) 1.74 .576 Glucose level insulin sensitivity 17 64802303 90802303 Human 2315441 INSUL42_H Insulin level QTL 42 (human) 3.2 .0012 Insulin level 17 61431471 87431471 Human 2315444 GLUCO140_H Glucose level QTL 140 (human) 2.38 .0087 Glucose level 17 61431471 87431471 Human 2315805 GLUCO174_H Glucose level QTL 174 (human) 1.48 .0081 Glucose level 17 68465446 76234787 Human 2316339 GLUCO234_H Glucose level QTL 234 (human) 1.29 Glucose level 17 59681011 85681011 Human
Gene Ontology Annotations
