Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) - Rat Genome Database

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Gene: Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) Rattus norvegicus
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Symbol: Grin2b
Name: glutamate ionotropic receptor NMDA type subunit 2B
RGD ID: 2738
Description: Enables several functions, including beta-catenin binding activity; extracellular ligand-gated monoatomic ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ketone; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Used to study attention deficit hyperactivity disorder; cannabis abuse; fetal alcohol spectrum disorder; hyperhomocysteinemia; and transient cerebral ischemia. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; cognitive disorder (multiple); heroin dependence; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B); PARTICIPATES IN excitatory synaptic transmission pathway; long term potentiation; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GluN2B; glutamate [NMDA] receptor subunit epsilon-2; Glutamate receptor ionotropic N-methyl D-aspartate 2B; glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Grin2bem1Mcwi
Genetic Models: LE-Grin2bem1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84170,297,811 - 170,775,420 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4170,322,617 - 170,773,570 (-)EnsemblGRCr8
mRatBN7.24168,580,824 - 169,044,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4174,894,793 - 175,337,242 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04170,675,997 - 171,118,792 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04169,300,441 - 169,742,894 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)Ensemblrn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4157,188,514 - 157,629,365 (-)NCBICelera
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
RH 3.4 Map41026.8RGD
Cytogenetic Map4q43NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (IEP,ISO)
Alzheimer's disease  (ISO)
astigmatism  (ISO)
Ataxia  (ISO)
attention deficit hyperactivity disorder  (IEP,IMP)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autosomal dominant intellectual developmental disorder  (ISO)
autosomal dominant intellectual developmental disorder 6  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (IEP)
cannabis abuse  (IMP)
cerebral palsy  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine dependence  (IEP)
cognitive disorder  (IEP)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
developmental and epileptic encephalopathy 11  (ISO)
developmental and epileptic encephalopathy 27  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
dystonia  (ISO)
egg allergy  (IEP)
epilepsy  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP)
fetal alcohol spectrum disorder  (IEP,IMP)
Fetal Growth Retardation  (IEP)
generalized epilepsy  (ISO)
genetic disease  (ISO)
heroin dependence  (IEP)
Huntington's disease  (ISO)
Hyperalgesia  (IMP,ISO)
hyperhomocysteinemia  (IDA)
hypoglycemia  (IEP)
Hypotension  (ISO)
Hypoxia  (IEP)
intellectual disability  (ISO)
Landau-Kleffner syndrome  (ISO)
Nervous System Trauma  (IEP)
Neurodevelopmental Disorders  (ISO)
nicotine dependence  (ISO)
opioid abuse  (ISO)
phenylketonuria  (ISO)
placental insufficiency  (IEP)
Reperfusion Injury  (IEP)
retinitis pigmentosa  (IEP)
schizophrenia  (IEP,ISO)
sciatic neuropathy  (IEP)
Sleep Deprivation  (IEP)
temporal lobe epilepsy  (ISO)
transient cerebral ischemia  (IMP)
vascular dementia  (ISO)
withdrawal disorder  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-nitropropanoic acid  (EXP)
3-phenoxybenzoic acid  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
alpha-pinene  (EXP)
Amaranth  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (ISO)
amphetamine  (EXP)
Ampicillin Sodium Mixture With Sulbactam Sodium  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asarone  (EXP)
astragaloside IV  (EXP)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Brilliant Blue  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
caffeine  (EXP)
capsaicin  (EXP)
capsazepine  (EXP)
carbaryl  (EXP)
carbon dioxide  (EXP)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
citalopram  (EXP)
clozapine  (EXP)
cocaine  (EXP)
cocaine hydrochloride  (EXP)
colforsin daropate hydrochloride  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP)
diphenyl diselenide  (ISO)
dizocilpine maleate  (EXP,ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
erythrosin B  (EXP)
ethanol  (EXP,ISO)
Ethyl 4-methoxycinnamate  (EXP)
excitatory amino acid agonist  (ISO)
felbamate  (EXP)
fentanyl  (EXP)
Fluorocitric acid  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP,ISO)
galactose  (EXP)
glycidol  (EXP)
haloperidol  (ISO)
indigo carmine  (EXP)
ionomycin  (EXP)
isoflurane  (EXP)
kainic acid  (ISO)
ketamine  (EXP,ISO)
Kukoamine B  (ISO)
L-ascorbic acid  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leflunomide  (ISO)
linoleic acid  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melamine  (EXP)
melatonin  (EXP)
memantine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-D-aspartic acid  (ISO)
nickel atom  (EXP)
nobiletin  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP)
Ondansetron  (EXP)
ouabain  (EXP)
oxidopamine  (EXP)
paclitaxel  (EXP)
paraquat  (EXP,ISO)
PCB138  (EXP,ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
pyridine  (EXP)
remifentanil  (EXP)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP)
rimonabant  (ISO)
Ro 25-6981  (EXP)
rottlerin  (ISO)
sarin  (ISO)
sevoflurane  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
spermine  (EXP)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
tannic acid  (EXP)
tartrazine  (EXP)
testosterone  (EXP)
tetrodotoxin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
tributylstannane  (EXP)
trimethyltin  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IMP)
associative learning  (IMP)
auditory behavior  (IEP)
behavioral fear response  (IEA,IMP,ISO)
behavioral response to pain  (ISO)
calcium ion transmembrane import into cytosol  (IEA,ISO,ISS)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cellular response to amino acid stimulus  (IEP)
cellular response to corticosterone stimulus  (IEP)
cellular response to curcumin  (IEP)
cellular response to dsRNA  (IEP)
cellular response to forskolin  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to lipid  (IEP)
cellular response to magnesium starvation  (IEP)
cellular response to manganese ion  (IEP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
excitatory postsynaptic potential  (IBA,IEA,ISO)
fear response  (ISO)
hippocampus development  (IEP)
in utero embryonic development  (ISO)
intracellular calcium ion homeostasis  (IMP)
ionotropic glutamate receptor signaling pathway  (IDA,IEA,ISS)
learning  (IEA,ISO)
learning or memory  (IMP,TAS)
long-term memory  (IEP)
long-term synaptic potentiation  (IBA,IEA,IEP,ISO)
memory  (IDA,IEA,ISO)
modulation of chemical synaptic transmission  (IEA)
monoatomic cation transmembrane transport  (IEA,ISO,ISS,NAS)
monoatomic cation transport  (ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
multicellular organismal response to stress  (IEP)
negative regulation of dendritic spine maintenance  (ISO)
neuron development  (IEP)
positive regulation of excitatory postsynaptic potential  (IDA,IEA,IMP,ISS)
positive regulation of glutamate secretion  (IDA)
positive regulation of inhibitory postsynaptic potential  (IMP)
positive regulation of synaptic transmission  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IDA,IEA,ISS)
protein heterotetramerization  (IDA)
receptor clustering  (IDA)
regulation of ARF protein signal transduction  (IGI)
regulation of cAMP/PKA signal transduction  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of long-term synaptic depression  (IMP)
regulation of MAPK cascade  (IMP)
regulation of membrane potential  (IEA)
regulation of monoatomic cation transmembrane transport  (ISS,NAS)
regulation of neuronal synaptic plasticity  (IEA,NAS)
regulation of postsynaptic membrane potential  (ISO)
regulation of presynaptic membrane potential  (IEA)
regulation of synaptic plasticity  (ISO)
response to amine  (IEP)
response to amphetamine  (IEP)
response to antibiotic  (IEP)
response to calcium ion  (IEP)
response to carbohydrate  (IEP)
response to cocaine  (IEP)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEA,IEP,ISO)
response to fungicide  (IEP)
response to glycoside  (IEP)
response to growth hormone  (IEP)
response to hydrogen sulfide  (IEP)
response to hypoxia  (IDA)
response to lead ion  (IEP)
response to magnesium ion  (IEP)
response to manganese ion  (IEP)
response to mechanical stimulus  (IEA,IEP)
response to methylmercury  (IEP)
response to nicotine  (IEP)
response to other organism  (IEP)
response to toxic substance  (IEP)
rhythmic process  (IDA)
sensitization  (IMP)
sensory organ development  (ISO)
startle response  (ISO)
suckling behavior  (ISO)
synaptic transmission, glutamatergic  (IBA)

References

References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Ampicillin/Sulbactam Treatment Modulates NMDA Receptor NR2B Subunit and Attenuates Neuroinflammation and Alcohol Intake in Male High Alcohol Drinking Rats. Alasmari F, etal., Biomolecules. 2020 Jul 10;10(7):1030. doi: 10.3390/biom10071030.
3. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease. Andreoli V, etal., J Neural Transm (Vienna). 2014 May;121(5):533-42. doi: 10.1007/s00702-013-1125-7. Epub 2013 Dec 1.
4. Enhanced NMDAR1, NMDA2B and mGlu5 receptors gene expression in the cerebellum of insulin induced hypoglycaemic and streptozotocin induced diabetic rats. Anu J, etal., Eur J Pharmacol. 2010 Mar 25;630(1-3):61-8. Epub 2010 Jan 6.
5. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Arning L, etal., Hum Genet. 2007 Sep;122(2):175-82. Epub 2007 Jun 14.
6. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Arning L, etal., Neurogenetics. 2005 Feb;6(1):25-8. Epub 2004 Nov 17.
7. Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors. Aroniadou-Anderjaska V, etal., Neuroscience. 2018 Mar 1;373:145-158. doi: 10.1016/j.neuroscience.2018.01.021. Epub 2018 Jan 13.
8. Subunit-specific NMDA receptor trafficking to synapses. Barria A and Malinow R, Neuron. 2002 Jul 18;35(2):345-53.
9. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Bartlett TE, etal., Neuropharmacology. 2007 Jan;52(1):60-70. Epub 2006 Aug 10.
10. Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Berg LK, etal., Neuroscience. 2013 Jan 29;230:139-50. doi: 10.1016/j.neuroscience.2012.10.061. Epub 2012 Nov 14.
11. Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Bersier MG and Rodriguez de Lores Arnaiz G, Neurochem Res. 2009 Sep;34(9):1650-7. Epub 2009 Mar 26.
12. Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Bidoret C, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31. Epub 2009 Aug 4.
13. Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. Borbely S, etal., Neuroscience. 2009 Mar 3;159(1):358-68. Epub 2008 Dec 27.
14. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
15. NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum. Centonze D, etal., Exp Neurol. 2006 Dec;202(2):470-9. Epub 2006 Aug 17.
16. Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Chapman DE, etal., J Neurophysiol 2003 Jan;89(1):69-80.
17. Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia. Chen WF, etal., Exp Neurol. 2007 Mar;204(1):400-10. Epub 2007 Jan 30.
18. Structural insights into binding of therapeutic channel blockers in NMDA receptors. Chou TH, etal., Nat Struct Mol Biol. 2022 Jun;29(6):507-518. doi: 10.1038/s41594-022-00772-0. Epub 2022 May 30.
19. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. Clapp P, etal., J Pharmacol Exp Ther. 2010 Mar;332(3):720-9. Epub 2009 Dec 14.
20. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
21. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
22. Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. Dalby NO and Mody I, J Neurophysiol 2003 Aug;90(2):786-97.
23. NMDA receptor subunits change in the prefrontal cortex of pure-opioid and multi-drug abusers: a post-mortem study. Daneshparvar H, etal., Eur Arch Psychiatry Clin Neurosci. 2019 Apr;269(3):309-315. doi: 10.1007/s00406-018-0900-8. Epub 2018 May 16.
24. EFFECT of nicotine on hippocampal nicotinic acetylcholine alpha7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats. Delibas N, etal., Int J Neurosci. 2005 Aug;115(8):1151-63. doi: 10.1080/00207450590914437.
25. Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats. Dong J, etal., J ECT. 2010 Jun;26(2):126-30.
26. Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Dos-Anjos S, etal., Neuroscience. 2009 Dec 15;164(3):1119-26. Epub 2009 Sep 15.
27. Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses. Dupuis JP, etal., EMBO J. 2014 Apr 16;33(8):842-61. doi: 10.1002/embj.201386356. Epub 2014 Mar 3.
28. Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. Elagabani MN, etal., J Biol Chem. 2016 Apr 22;291(17):9105-18. doi: 10.1074/jbc.M115.691717. Epub 2016 Feb 16.
29. Up-regulation of anterior cingulate cortex NR2B receptors contributes to visceral pain responses in rats. Fan J, etal., Gastroenterology. 2009 May;136(5):1732-40.e3. Epub 2009 Feb 6.
30. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
31. A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats. Ferrier J, etal., PLoS One. 2013 Oct 30;8(10):e77828. doi: 10.1371/journal.pone.0077828. eCollection 2013.
32. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. Foster KA, etal., J Neurosci. 2010 Feb 17;30(7):2676-85.
33. Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. Fukumori R, etal., J Pharmacol Sci. 2010 Mar 19;112(3):273-81. Epub 2010 Feb 18.
34. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
35. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
36. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
37. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Geng SJ, etal., Exp Neurol. 2010 Apr;222(2):256-66. Epub 2010 Jan 14.
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PMID:17451646   PMID:17509768   PMID:17545075   PMID:17670980   PMID:17706601   PMID:17717018   PMID:17986236   PMID:18006154   PMID:18025808   PMID:18033811   PMID:18033813   PMID:18048007  
PMID:18230675   PMID:18272676   PMID:18339694   PMID:18342306   PMID:18356833   PMID:18378405   PMID:18445116   PMID:18468585   PMID:18538939   PMID:18673451   PMID:18688011   PMID:18694808  
PMID:18706452   PMID:18751892   PMID:18765272   PMID:18826591   PMID:18922773   PMID:18927268   PMID:18936081   PMID:18952054   PMID:19041927   PMID:19088076   PMID:19106110   PMID:19164281  
PMID:19187438   PMID:19193935   PMID:19275891   PMID:19302193   PMID:19335206   PMID:19376094   PMID:19428647   PMID:19520065   PMID:19531642   PMID:19543280   PMID:19587283   PMID:19625512  
PMID:19656178   PMID:19694907   PMID:19726645   PMID:19857555   PMID:19864302   PMID:20107120   PMID:20418887   PMID:20427654   PMID:20508838   PMID:20569495   PMID:20625810   PMID:20661302  
PMID:20698836   PMID:20831617   PMID:20850419   PMID:20887777   PMID:20974938   PMID:21029094   PMID:21144999   PMID:21171386   PMID:21177185   PMID:21182900   PMID:21364640   PMID:21384157  
PMID:21397592   PMID:21427228   PMID:21439793   PMID:21470075   PMID:21575722   PMID:21608225   PMID:21664258   PMID:21669274   PMID:21762679   PMID:21795692   PMID:21862938   PMID:21880917  
PMID:21895803   PMID:22027786   PMID:22055014   PMID:22084102   PMID:22089426   PMID:22100849   PMID:22177709   PMID:22179603   PMID:22335236   PMID:22359056   PMID:22364833   PMID:22366650  
PMID:22375001   PMID:22377595   PMID:22543102   PMID:22558458   PMID:22610100   PMID:22681877   PMID:22740692   PMID:22743575   PMID:22759925   PMID:22776695   PMID:22820466   PMID:22824136  
PMID:22833681   PMID:22871113   PMID:22902837   PMID:22906554   PMID:22931702   PMID:22965452   PMID:22982438   PMID:23022504   PMID:23069667   PMID:23091164   PMID:23146303   PMID:23219940  
PMID:23221411   PMID:23313317   PMID:23429044   PMID:23431156   PMID:23497405   PMID:23516288   PMID:23584669   PMID:23585298   PMID:23611155   PMID:23660833   PMID:23672716   PMID:23676200  
PMID:23811393   PMID:23839940   PMID:23981041   PMID:24032403   PMID:24041503   PMID:24069373   PMID:24120858   PMID:24189275   PMID:24336715   PMID:24388786   PMID:24431445   PMID:24440698  
PMID:24487031   PMID:24491052   PMID:24562683   PMID:24607230   PMID:24631206   PMID:24705401   PMID:24761931   PMID:24824341   PMID:25122884   PMID:25393018   PMID:25404733   PMID:25496357  
PMID:25521238   PMID:25772108   PMID:25838242   PMID:25917873   PMID:26027736   PMID:26190171   PMID:26197883   PMID:26204818   PMID:26229100   PMID:26343542   PMID:26391783   PMID:26401567  
PMID:26440419   PMID:26548659   PMID:26554229   PMID:26609151   PMID:26627310   PMID:26875626   PMID:26881126   PMID:26919761   PMID:26930443   PMID:27217103   PMID:27430327   PMID:27457929  
PMID:27487820   PMID:27497478   PMID:27523302   PMID:27531837   PMID:27839871   PMID:27865917   PMID:27926876   PMID:28160495   PMID:28326942   PMID:28358367   PMID:28393079   PMID:28497343  
PMID:28682239   PMID:28916627   PMID:29335819   PMID:29353374   PMID:29476059   PMID:29490264   PMID:30054528   PMID:30142538   PMID:30176218   PMID:30269991   PMID:30350722   PMID:30400767  
PMID:30639357   PMID:31080121   PMID:31213568   PMID:31245854   PMID:31277281   PMID:31424425   PMID:31672664   PMID:31840160   PMID:32032782   PMID:32386416   PMID:32606037   PMID:32816128  
PMID:32929031   PMID:33420399   PMID:33485963   PMID:33509021   PMID:33550485   PMID:33843051   PMID:34360755   PMID:34445376   PMID:35181828   PMID:35183034   PMID:35257794   PMID:36085433  
PMID:36344756   PMID:36521778   PMID:36527595   PMID:36563833   PMID:37085778   PMID:37394125   PMID:37700085   PMID:38037367   PMID:38416255   PMID:38471625   PMID:38764325   PMID:38853550  
PMID:39085540  


Genomics

Comparative Map Data
Grin2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84170,297,811 - 170,775,420 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4170,322,617 - 170,773,570 (-)EnsemblGRCr8
mRatBN7.24168,580,824 - 169,044,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4174,894,793 - 175,337,242 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04170,675,997 - 171,118,792 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04169,300,441 - 169,742,894 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)Ensemblrn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4157,188,514 - 157,629,365 (-)NCBICelera
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
RH 3.4 Map41026.8RGD
Cytogenetic Map4q43NCBI
GRIN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381213,537,337 - 13,982,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1213,437,942 - 13,982,002 (-)Ensemblhg38GRCh38
GRCh371213,690,271 - 14,135,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,605,411 - 14,024,319 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341213,605,410 - 14,024,319NCBI
Celera1218,858,978 - 19,277,660 (-)NCBICelera
Cytogenetic Map12p13.1NCBI
HuRef1213,479,858 - 13,898,402 (-)NCBIHuRef
CHM1_11213,679,406 - 14,098,101 (-)NCBICHM1_1
T2T-CHM13v2.01213,411,758 - 13,856,548 (-)NCBIT2T-CHM13v2.0
Grin2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396135,690,219 - 136,150,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6135,690,231 - 136,150,509 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386135,713,221 - 136,173,615 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6135,713,233 - 136,173,511 (-)Ensemblmm10GRCm38
MGSCv376135,679,813 - 136,123,529 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366135,697,791 - 136,009,994 (-)NCBIMGSCv36mm8
Celera6138,678,301 - 139,123,902 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.38NCBI
Grin2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541310,376,597 - 10,779,145 (-)Ensembl
ChiLan1.0NW_00495541310,358,931 - 10,780,004 (-)NCBIChiLan1.0ChiLan1.0
GRIN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21018,992,799 - 19,432,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11218,972,796 - 19,429,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01213,543,104 - 13,987,437 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,943,936 - 14,272,195 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,969,387 - 14,388,799 (-)EnsemblpanPan2panpan1.1
GRIN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12732,470,889 - 32,883,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2732,471,153 - 32,877,680 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2713,572,169 - 13,850,223 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02732,702,956 - 33,191,598 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,702,672 - 33,190,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12732,798,882 - 33,078,120 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02732,748,401 - 33,027,217 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02713,302,777 - 13,581,228 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grin2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494593,677,907 - 94,094,419 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365873,405,698 - 3,804,664 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365873,406,055 - 3,806,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl558,480,528 - 58,927,558 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1558,477,862 - 58,948,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,874,217 - 62,275,930 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11113,444,155 - 13,873,034 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1113,456,968 - 13,873,202 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606921,440,620 - 21,872,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475224,135,487 - 24,459,288 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475224,008,520 - 24,480,834 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grin2b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1613,267,567 - 13,771,078 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grin2b
3368 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:72
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000011697
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
RH94749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,599,595 - 168,599,850 (+)MAPPERmRatBN7.2
Rnor_6.04169,559,999 - 169,560,253NCBIRnor6.0
Rnor_5.04233,824,084 - 233,824,338UniSTSRnor5.0
RGSC_v3.44172,721,945 - 172,722,199UniSTSRGSC3.4
Celera4157,188,564 - 157,188,818UniSTS
RH 3.4 Map41026.8UniSTS
Cytogenetic Map4q43UniSTS
RH94750  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,041,996 - 169,042,191 (+)MAPPERmRatBN7.2
Rnor_6.04169,998,166 - 169,998,360NCBIRnor6.0
Rnor_5.04234,258,645 - 234,258,839UniSTSRnor5.0
RGSC_v3.44173,182,905 - 173,183,099UniSTSRGSC3.4
Celera4157,629,083 - 157,629,277UniSTS
Cytogenetic Map4q43UniSTS
RH143997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,800,230 - 168,800,345 (+)MAPPERmRatBN7.2
Rnor_6.04169,761,521 - 169,761,635NCBIRnor6.0
Rnor_5.04234,025,258 - 234,025,372UniSTSRnor5.0
RGSC_v3.44172,924,073 - 172,924,187UniSTSRGSC3.4
Celera4157,389,977 - 157,390,091UniSTS
RH 3.4 Map41026.2UniSTS
Cytogenetic Map4q43UniSTS
Grin2b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,600,099 - 168,600,280 (+)MAPPERmRatBN7.2
Rnor_6.04169,560,503 - 169,560,683NCBIRnor6.0
Rnor_5.04233,824,588 - 233,824,768UniSTSRnor5.0
RGSC_v3.44172,722,449 - 172,722,629UniSTSRGSC3.4
Celera4157,189,068 - 157,189,248UniSTS
Cytogenetic Map4q43UniSTS
UniSTS:465389  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,601,222 - 168,601,681 (+)MAPPERmRatBN7.2
Rnor_6.04169,561,626 - 169,562,084NCBIRnor6.0
Rnor_5.04233,825,711 - 233,826,169UniSTSRnor5.0
RGSC_v3.44172,723,572 - 172,724,030UniSTSRGSC3.4
Celera4157,190,191 - 157,190,649UniSTS
Cytogenetic Map4q43UniSTS


Genetic Models
This gene Grin2b is modified in the following models/strains:
LE-Grin2bem1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 6 17 154 51 51 21 29 21 6 156 70 5 138 51 74 30 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000011697   ⟹   ENSRNOP00000011697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4170,330,865 - 170,773,570 (-)Ensembl
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)Ensembl
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108335   ⟹   ENSRNOP00000083097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4170,470,670 - 170,773,570 (-)Ensembl
mRatBN7.2 Ensembl4168,739,363 - 169,042,279 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159969   ⟹   ENSRNOP00000102212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4170,322,617 - 170,773,570 (-)Ensembl
RefSeq Acc Id: NM_012574   ⟹   NP_036706
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84170,330,865 - 170,773,570 (-)NCBI
mRatBN7.24168,599,546 - 169,042,279 (-)NCBI
Rnor_6.04169,559,949 - 169,998,448 (-)NCBI
Rnor_5.04233,806,406 - 234,260,360 (-)NCBI
RGSC_v3.44172,721,895 - 173,183,187 (-)RGD
Celera4157,188,514 - 157,629,365 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592436   ⟹   XP_017447925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,774,841 (-)NCBI
mRatBN7.24168,580,824 - 169,043,806 (-)NCBI
Rnor_6.04169,558,166 - 169,999,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592437   ⟹   XP_017447926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,775,420 (-)NCBI
mRatBN7.24168,599,546 - 169,044,110 (-)NCBI
Rnor_6.04169,558,166 - 170,000,216 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592438   ⟹   XP_017447927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,775,301 (-)NCBI
mRatBN7.24168,599,546 - 169,044,002 (-)NCBI
Rnor_6.04169,558,166 - 170,000,138 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592439   ⟹   XP_017447928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,775,289 (-)NCBI
mRatBN7.24168,580,824 - 169,043,803 (-)NCBI
Rnor_6.04169,541,620 - 169,999,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285520   ⟹   XP_063141590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,774,443 (-)NCBI
RefSeq Acc Id: NP_036706   ⟸   NM_012574
- Peptide Label: precursor
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447928   ⟸   XM_017592439
- Peptide Label: isoform X2
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447926   ⟸   XM_017592437
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   G3V746 (UniProtKB/TrEMBL),   A6IMH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447927   ⟸   XM_017592438
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   G3V746 (UniProtKB/TrEMBL),   A6IMH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447925   ⟸   XM_017592436
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   G3V746 (UniProtKB/TrEMBL),   A6IMH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011697   ⟸   ENSRNOT00000011697
Ensembl Acc Id: ENSRNOP00000083097   ⟸   ENSRNOT00000108335
RefSeq Acc Id: XP_063141590   ⟸   XM_063285520
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   A6IMH0 (UniProtKB/TrEMBL),   G3V746 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102212   ⟸   ENSRNOT00000159969
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and   Receptor ligand binding region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00960-F1-model_v2 AlphaFold Q00960 1-1482 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2738 AgrOrtholog
BioCyc Gene G2FUF-42625 BioCyc
Ensembl Genes ENSRNOG00000008766 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000011697 ENTREZGENE
  ENSRNOT00000159969 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  NMDAR2_C UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24410 UniProtKB/Swiss-Prot
NCBI Gene 24410 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  NMDAR2_C UniProtKB/Swiss-Prot
PhenoGen Grin2b PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008766 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt A0A8I5ZW91_RAT UniProtKB/TrEMBL
  A0ABK0LAK0_RAT UniProtKB/TrEMBL
  A6IMH0 ENTREZGENE, UniProtKB/TrEMBL
  G3V746 ENTREZGENE, UniProtKB/TrEMBL
  NMDE2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62684 ENTREZGENE
UniProt Secondary Q62684 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin2b  glutamate ionotropic receptor NMDA type subunit 2B  Grin2b  glutamate receptor, ionotropic, N-methyl D-aspartate 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Grin2b  glutamate receptor, ionotropic, N-methyl D-aspartate 2B    glutamate receptor, ionotropic, NMDA2B   Name updated 1299863 APPROVED
2002-11-06 Grin2b  glutamate receptor, ionotropic, NMDA2B     Glutamate receptor, ionotropic, N-methyl D-aspartate 2B  Name updated 625702 APPROVED
2002-06-10 Grin2b  Glutamate receptor, ionotropic, N-methyl D-aspartate 2B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA expression in the dorsal hippocampus decreases during hyperthyroidism 728772
gene_expression expression increases significantly in hypothalami of older femals compared to the younger ones 625682
gene_expression expressed in majority of gonadotrophin releasing hormone (GnRH) neurons 625682
gene_function subunit of pentameric N-methyl-D-aspartate receptor (NMDAR) 625682
gene_process receptor for glutamate that influences reproductive physiology in female rats 625682
gene_process may play an important role in the neuronal stimulation assosicated with female reproductive physiology 625682
gene_regulation age-dependent increase in expression in hypothalamus may be involved in altered neuroendocrine function 625682