Apc (APC regulator of WNT signaling pathway) - Rat Genome Database

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Gene: Apc (APC regulator of WNT signaling pathway) Rattus norvegicus
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Symbol: Apc
Name: APC regulator of WNT signaling pathway
RGD ID: 2123
Description: Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including cell body fiber; lateral plasma membrane; and synaptic vesicle membrane. Part of protein-containing complex. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenomatosis polyposis coli; adenomatous polyposis coli protein; APC, WNT signaling pathway regulator; RATAPC; WNT signaling pathway regulator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: ApcPirc ; Apcm1Kyo
Genetic Models: F344-ApcPirc/Uwm ; ACI.F344-ApcPircUwm ; F344-ApcPirc/UwmRrrc ; F344-ApcPirc/UwmVdrem3Hfd ; BN.F344-ApcPirc ; F344-Apcm1Kyo
Is Marker For: Strains:   F344-Apcm1Kyo
Candidate Gene For: Colcr3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,138,382 - 26,196,021 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1826,102,679 - 26,197,022 (+)EnsemblGRCr8
mRatBN7.21825,828,558 - 25,925,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1825,991,644 - 26,049,283 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01826,754,554 - 26,812,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,089,458 - 26,147,091 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,011,710 - 27,106,323 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,047,382 - 27,105,531 (+)Ensemblrn6Rnor6.0
Rnor_5.01826,725,560 - 26,820,837 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41826,732,147 - 26,790,383 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1825,606,119 - 25,663,749 (+)NCBICelera
RGSC_v3.11826,758,792 - 26,817,029 (+)NCBI
Cytogenetic Map18p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Abdominal Fibromatosis  (ISO)
Aberrant Crypt Foci  (ISO)
acinar cell carcinoma  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adenomatous Polyps  (ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Alzheimer's disease  (ISO)
amenorrhea  (ISO)
anemia  (IMP)
Animal Mammary Neoplasms  (ISO)
ascending colon cancer  (ISO)
Attenuated Adenomatous Polyposis Coli  (ISO)
Attenuated Familial Adenomatous Polyposis  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
breast cancer  (ISO,ISS)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
cholangiocarcinoma  (ISO)
colon adenocarcinoma  (IMP,ISO)
colon cancer  (IAGP,ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (IMP,ISO)
Colonic Polyps  (IMP)
colorectal adenoma  (ISO)
colorectal cancer  (ISO,ISS)
Colorectal Neoplasms  (ISO)
craniopharyngioma  (ISO)
desmoid tumor  (ISO)
Digestive System Neoplasms  (ISO)
duodenum adenocarcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Eye Abnormalities  (ISO)
familial adenomatous polyposis  (IMP,ISO,ISS)
familial adenomatous polyposis 1  (ISO)
familial hyperlipidemia  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
Gardner Syndrome  (ISO)
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach  (ISO)
Gastric Polyposis  (ISO)
Gastrointestinal Hemorrhage  (ISO)
Gastrointestinal Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO,ISS)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary desmoid disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
inflammatory bowel disease  (ISO)
intellectual disability  (ISO)
Intestinal Neoplasms  (IMP,ISO)
Intestinal Polyposis, Osteomas, Sebaceous Cysts  (ISO)
Intestinal Polyps  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Jaw Neoplasms  (IMP)
kidney disease  (ISO)
Klatskin's tumor  (ISO)
Leukocytosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lynch syndrome  (ISO)
macrocytic anemia  (ISO)
medulloblastoma  (ISO)
Mesothelioma  (ISO)
mismatch repair cancer syndrome  (ISO)
Monoclonal B-Cell Lymphocytosis  (ISO)
Neoplastic Cell Transformation  (ISO)
ovarian cancer  (ISO,ISS)
pancreatic cancer  (ISO)
periampullary adenoma  (ISO)
prostate cancer  (ISO,ISS)
Prostatic Neoplasms  (ISO)
rectal benign neoplasm  (ISO)
rectum adenocarcinoma  (ISO)
renal cell carcinoma  (ISO)
sigmoid colon cancer  (ISO)
sigmoid neoplasm  (ISO)
splenic disease  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camptothecin  (ISO)
carmustine  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethosuximide  (EXP)
etodolac  (EXP)
Evodiamine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
glucose  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
lutein  (ISO)
malonaldehyde  (ISO)
manganese(II) chloride  (ISO)
metacetamol  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
molibresib  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP)
oxybenzone  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP,ISO)
pirinixic acid  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulindac  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
theaflavin  (ISO)
thimerosal  (ISO)
thiram  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
axis specification  (ISO)
axonogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell fate specification  (IBA)
cell migration  (IBA,ISO,ISS)
cellular response to nerve growth factor stimulus  (IEP)
chromosome organization  (ISO)
cytoplasmic microtubule organization  (ISO)
DNA damage response  (ISO,ISS)
dorsal/ventral pattern formation  (ISO)
establishment or maintenance of cell polarity  (IDA)
hair follicle development  (ISO)
insulin receptor signaling pathway  (ISO)
kidney development  (ISO)
metaphase/anaphase transition of mitotic cell cycle  (ISO)
mitotic cytokinesis  (ISO)
mitotic spindle assembly checkpoint signaling  (ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,ISO)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cell cycle G1/S phase transition  (ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO,ISS)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of microtubule depolymerization  (IBA,ISO,ISS)
negative regulation of multicellular organismal process  (IEA)
negative regulation of odontogenesis  (ISO)
negative regulation of Wnt signaling pathway  (IEA,ISO)
nervous system development  (IBA)
neuron projection development  (IMP)
nitrogen cycle metabolic process  (ISO)
pancreas development  (IEP)
pattern specification process  (IBA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell division  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of microtubule polymerization  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein localization to centrosome  (ISO)
positive regulation of pseudopodium assembly  (ISO)
protein-containing complex assembly  (ISO,ISS)
proximal/distal pattern formation  (ISO)
regulation of attachment of spindle microtubules to kinetochore  (ISO)
regulation of cell cycle  (ISO)
regulation of cell differentiation  (ISO)
regulation of cell migration  (ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of glutamate metabolic process  (IDA)
regulation of microtubule-based movement  (ISO)
regulation of microtubule-based process  (ISO,ISS)
regulation of osteoblast differentiation  (ISO)
regulation of osteoclast differentiation  (ISO)
regulation of primary metabolic process  (IEA)
response to alcohol  (IEP)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (ISO)
skin development  (ISO)
somatic stem cell population maintenance  (ISO)
stem cell population maintenance  (ISO)
T cell differentiation in thymus  (ISO)
thymus development  (ISO)
Wnt signaling pathway  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Abraham SC, etal., Am J Pathol. 2002 Mar;160(3):953-62.
2. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Amos-Landgraf JM, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41. Epub 2007 Feb 27.
3. MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. Arif M, etal., J Mol Med (Berl). 2017 Dec;95(12):1369-1385. doi: 10.1007/s00109-017-1591-8. Epub 2017 Sep 25.
4. Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. Attard TM, etal., Cancer. 2007 Feb 15;109(4):761-6.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Periampullary adenomas and adenocarcinomas in familial adenomatous polyposis: cumulative risks and APC gene mutations. Bjork J, etal., Gastroenterology. 2001 Nov;121(5):1127-35.
7. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Blum CA, etal., Mol Carcinog 2003 Apr;36(4):195-203.
8. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
9. Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension. Caro-Gonzalez HY, etal., J Cell Sci. 2012 Mar 1;125(Pt 5):1247-58. doi: 10.1242/jcs.095166. Epub 2012 Mar 7.
10. Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine. Chen PC, etal., BMC Med Genomics. 2011 May 20;4:45. doi: 10.1186/1755-8794-4-45.
11. Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy. Clarke AR, etal., Oncogene. 1995 Nov 2;11(9):1913-20.
12. APC nuclear membrane association and microtubule polarity. Collin L, etal., Biol Cell. 2008 Apr;100(4):243-52.
13. Association between Hepatitis C Virus Infection, p53 Phenotypes, and Gene Variants of Adenomatous Polyposis Coli in Hepatocellular Carcinomas. Council LN, etal., J Dig Dis Hepatol. 2016;2016(5). Epub 2016 Dec 23.
14. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Etienne-Manneville S and Hall A, Nature 2003 Feb 13;421(6924):753-6.
15. Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. Farias GG, etal., J Neurosci. 2007 May 16;27(20):5313-25.
16. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Fodde R, etal., Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8969-73.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Proteomic analysis demonstrates adolescent vulnerability to lasting hippocampal changes following chronic alcohol consumption. Hargreaves GA, etal., Alcohol Clin Exp Res. 2009 Jan;33(1):86-94. Epub 2008 Oct 18.
20. Frequent somatic mutations of the APC gene in human pancreatic cancer. Horii A, etal., Cancer Res. 1992 Dec 1;52(23):6696-8.
21. APC promoter hypermethylation is an early event in endometrial tumorigenesis. Ignatov A, etal., Cancer Sci. 2010 Feb;101(2):321-7. doi: 10.1111/j.1349-7006.2009.01397.x. Epub 2009 Oct 12.
22. Frequent somatic mutations of the APC and p53 genes in sporadic ampullary carcinomas. Imai Y, etal., Jpn J Cancer Res. 1997 Sep;88(9):846-54.
23. Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). Islam MM, etal., J Biol Chem. 2010 Jan 1;285(1):265-76. Epub 2009 Oct 26.
24. Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Kakiuchi H, etal., Proc Natl Acad Sci U S A 1995 Jan 31;92(3):910-4.
25. Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma. Kang YK, etal., Lab Invest. 1999 Apr;79(4):477-83.
26. APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. Kariola R, etal., Fam Cancer. 2005;4(2):187-90. doi: 10.1007/s10689-004-6130-4.
27. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
28. Adenomatous polyposis coli localization is both cell type and cell context dependent. Langford KJ, etal., Cell Motil Cytoskeleton. 2006 Aug;63(8):483-92.
29. Increase of adenomatous polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer's disease and in other pathological conditions. Leroy K, etal., Acta Neuropathol. 2001 Jul;102(1):1-10.
30. Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Liu Z, etal., Mol Cell Endocrinol. 2016 May 15;427:57-64. doi: 10.1016/j.mce.2016.03.004. Epub 2016 Mar 4.
31. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Matsumine A, etal., Science. 1996 May 17;272(5264):1020-3. doi: 10.1126/science.272.5264.1020.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Moreno-Bueno G, etal., Oncogene. 2002 Nov 14;21(52):7981-90.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Colocalization of APC and PSD-95 in the nerve fiber as well as in the post-synapse of matured neurons. Onouchi T, etal., Med Mol Morphol. 2012 Jun;45(3):152-60. Epub 2012 Sep 22.
37. Loss of heterozygosity and protein expression of APC gene in renal cell carcinomas. Pecina-Slaus N, etal., J Mol Med (Berl). 1999 May;77(5):446-53.
38. Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma. Pecina-SLaus N, etal., Pathology. 2004 Apr;36(2):145-51.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
41. [Expression and methylation of adenomatous polyposis coli gene in endometrioid adenocarcinoma]. Qian B, etal., Ai Zheng. 2008 Jun;27(6):585-9.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy. Rosenbaum E, etal., Clin Cancer Res. 2005 Dec 1;11(23):8321-5. doi: 10.1158/1078-0432.CCR-05-1183.
46. Apc deficiency predisposes to renal carcinoma in the mouse. Sansom OJ, etal., Oncogene. 2005 Dec 8;24(55):8205-10.
47. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Sansom OJ, etal., Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. Epub 2006 Sep 7.
48. Subcellular localization of the tumor suppressor protein APC in developing cultured neurons. Shimomura A, etal., Neurosci Lett. 2005 Feb 28;375(2):81-6. Epub 2004 Dec 10.
49. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Strom A, etal., Development. 2007 Aug;134(15):2719-25. Epub 2007 Jun 27.
50. Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. Takahashi T, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6126-33.
51. Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer. Tanwar PS, etal., Cancer Res. 2011 Mar 1;71(5):1584-96. doi: 10.1158/0008-5472.CAN-10-3166.
52. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
53. Computational development of a molecular-based approach to improve risk stratification of endometrial cancer patients. Torricelli F, etal., Oncotarget. 2018 May 22;9(39):25517-25528. doi: 10.18632/oncotarget.25354. eCollection 2018 May 22.
54. A mouse model for endometrioid ovarian cancer arising from the distal oviduct. van der Horst PH, etal., Int J Cancer. 2014 Sep 1;135(5):1028-37. doi: 10.1002/ijc.28746. Epub 2014 Mar 20.
55. Alterations in Wnt-ß-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. van der Zee M, etal., J Pathol. 2013 May;230(1):48-58. doi: 10.1002/path.4160. Epub 2013 Mar 14.
56. Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. Votin V, etal., J Cell Sci. 2005 Dec 15;118(Pt 24):5699-708. Epub 2005 Nov 22.
57. Wnt/beta-catenin signaling pathway is active in pancreatic development of rat embryo. Wang QM, etal., World J Gastroenterol. 2006 Apr 28;12(16):2615-9.
58. Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival. Yadav A, etal., Tumour Biol. 2016 Jun;37(6):8083-95. doi: 10.1007/s13277-015-4728-9. Epub 2015 Dec 29.
59. Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. Yang B, etal., Mod Pathol. 2005 Mar;18(3):412-20.
60. A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. Yang Y, etal., Oncogene. 2013 Jul 18;32(29):3432-42. doi: 10.1038/onc.2012.360. Epub 2012 Aug 20.
61. Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. Yoshimi K, etal., Cancer Sci. 2009 Nov;100(11):2022-7. doi: 10.1111/j.1349-7006.2009.01287.x. Epub 2009 Jul 17.
62. Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Zhang F, etal., Mol Cell Biol. 2001 Dec;21(23):8143-56.
Additional References at PubMed
PMID:1541640   PMID:7806582   PMID:7890674   PMID:7954428   PMID:8521819   PMID:8563176   PMID:8638126   PMID:8670282   PMID:8945508   PMID:8978062   PMID:8978063   PMID:8988060  
PMID:9037065   PMID:9060821   PMID:9135000   PMID:9159163   PMID:9192623   PMID:9288104   PMID:9371501   PMID:9453487   PMID:9506519   PMID:9515784   PMID:9601641   PMID:9707618  
PMID:9771477   PMID:9865728   PMID:9927046   PMID:10334197   PMID:10346819   PMID:10451698   PMID:10506110   PMID:10535960   PMID:10626800   PMID:10708962   PMID:10716720   PMID:10773885  
PMID:10783317   PMID:10919675   PMID:10951583   PMID:10969066   PMID:10982921   PMID:10987272   PMID:11035805   PMID:11166179   PMID:11197776   PMID:11245490   PMID:11274413   PMID:11283619  
PMID:11309311   PMID:11381263   PMID:11385109   PMID:11478486   PMID:11533658   PMID:11533709   PMID:11559569   PMID:11606502   PMID:11731407   PMID:11756652   PMID:11773073   PMID:11809702  
PMID:11972058   PMID:12072559   PMID:12370429   PMID:12645927   PMID:12874278   PMID:12952940   PMID:12955080   PMID:14728717   PMID:14758356   PMID:15198980   PMID:15207235   PMID:15314168  
PMID:15380519   PMID:15550389   PMID:15556865   PMID:15563600   PMID:15684064   PMID:15767571   PMID:15802266   PMID:15958588   PMID:16007074   PMID:16025118   PMID:16188939   PMID:16368433  
PMID:16478791   PMID:16525027   PMID:16611247   PMID:16621792   PMID:16638711   PMID:16641100   PMID:16709231   PMID:16740478   PMID:16753179   PMID:16815997   PMID:16887818   PMID:16950562  
PMID:17002498   PMID:17192415   PMID:17200209   PMID:17227893   PMID:17299058   PMID:17363566   PMID:17371273   PMID:17377531   PMID:17570218   PMID:17615359   PMID:17671182   PMID:17681179  
PMID:17875695   PMID:17893240   PMID:17893885   PMID:17956267   PMID:17989230   PMID:18056981   PMID:18076571   PMID:18258607   PMID:18281465   PMID:18464259   PMID:18485889   PMID:18502210  
PMID:18644872   PMID:18656477   PMID:18716223   PMID:18719115   PMID:18725524   PMID:19151759   PMID:19632184   PMID:20623542   PMID:20937854   PMID:21471006   PMID:22898821   PMID:23382461  
PMID:23395091   PMID:25036633   PMID:26658992   PMID:28057765   PMID:30934153   PMID:34003864  


Genomics

Comparative Map Data
Apc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,138,382 - 26,196,021 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1826,102,679 - 26,197,022 (+)EnsemblGRCr8
mRatBN7.21825,828,558 - 25,925,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1825,991,644 - 26,049,283 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01826,754,554 - 26,812,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,089,458 - 26,147,091 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,011,710 - 27,106,323 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,047,382 - 27,105,531 (+)Ensemblrn6Rnor6.0
Rnor_5.01826,725,560 - 26,820,837 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41826,732,147 - 26,790,383 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1825,606,119 - 25,663,749 (+)NCBICelera
RGSC_v3.11826,758,792 - 26,817,029 (+)NCBI
Cytogenetic Map18p12NCBI
APC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385112,707,498 - 112,846,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5112,707,498 - 112,846,239 (+)Ensemblhg38GRCh38
GRCh375112,043,195 - 112,181,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365112,101,483 - 112,209,835 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345112,101,482 - 112,209,834NCBI
Celera5107,988,802 - 108,127,503 (+)NCBICelera
Cytogenetic Map5q22.2NCBI
HuRef5107,222,330 - 107,361,030 (+)NCBIHuRef
CHM1_15111,476,576 - 111,615,241 (+)NCBICHM1_1
T2T-CHM13v2.05113,218,062 - 113,356,772 (+)NCBIT2T-CHM13v2.0
Apc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,353,350 - 34,455,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,353,977 - 34,455,605 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381834,220,297 - 34,322,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,220,924 - 34,322,552 (+)Ensemblmm10GRCm38
MGSCv371834,380,638 - 34,481,844 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361834,385,824 - 34,443,409 (+)NCBIMGSCv36mm8
Celera1834,670,234 - 34,773,431 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.53NCBI
Apc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,566,975 - 2,674,832 (-)Ensembl
ChiLan1.0NW_0049554182,567,804 - 2,675,062 (-)NCBIChiLan1.0ChiLan1.0
APC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24107,966,719 - 108,104,333 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15106,120,377 - 106,257,991 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05108,070,697 - 108,208,273 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15113,873,993 - 114,009,709 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5113,904,352 - 114,009,709 (+)EnsemblpanPan2panpan1.1
APC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13252,052 - 380,506 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3253,081 - 322,993 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha31,652,296 - 1,781,970 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0393,843 - 224,101 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl394,206 - 190,576 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,997 - 217,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,045 - 214,151 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03249,524 - 377,618 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,592,489 - 154,711,938 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365316,899,788 - 7,019,453 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365316,899,580 - 7,019,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2116,812,582 - 117,034,887 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12116,913,354 - 116,985,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22121,515,522 - 121,573,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12315,992,437 - 16,135,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2316,042,287 - 16,137,067 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603462,320,613 - 62,469,122 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474330,546,323 - 30,635,737 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474330,517,034 - 30,635,740 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Apc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11510,036,601 - 10,128,388 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apc
541 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:112
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000027691
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181221923726822399Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181221923726822399Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181221923726822399Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181221923726822399Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181221923726822399Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181221923726822399Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181221923726822399Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
PMC122454P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,918,112 - 25,918,430 (+)MAPPERmRatBN7.2
Rnor_6.01827,101,582 - 27,101,899NCBIRnor6.0
Rnor_5.01826,815,121 - 26,815,438UniSTSRnor5.0
RGSC_v3.41826,786,632 - 26,786,949UniSTSRGSC3.4
Celera1825,659,998 - 25,660,315UniSTS
Cytogenetic Map18p12UniSTS
RH138935  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81826,145,594 - 26,146,459 (+)Marker Load Pipeline
mRatBN7.21825,871,434 - 25,872,299 (+)MAPPERmRatBN7.2
Rnor_6.01827,054,594 - 27,055,458NCBIRnor6.0
Rnor_5.01826,768,424 - 26,769,288UniSTSRnor5.0
RGSC_v3.41826,739,361 - 26,740,225UniSTSRGSC3.4
Celera1825,613,340 - 25,614,204UniSTS
RH 3.4 Map18364.1UniSTS
Cytogenetic Map18p12UniSTS
Apc  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,915,866 - 25,916,194 (+)MAPPERmRatBN7.2
Rnor_6.01827,099,336 - 27,099,663NCBIRnor6.0
Rnor_5.01826,812,875 - 26,813,202UniSTSRnor5.0
RGSC_v3.41826,784,386 - 26,784,713UniSTSRGSC3.4
Celera1825,657,752 - 25,658,079UniSTS
Cytogenetic Map18p12UniSTS
UniSTS:237769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,920,013 - 25,920,121 (+)MAPPERmRatBN7.2
Rnor_6.01827,103,483 - 27,103,590NCBIRnor6.0
Rnor_5.01826,817,022 - 26,817,129UniSTSRnor5.0
RGSC_v3.41826,788,533 - 26,788,640UniSTSRGSC3.4
Celera1825,661,899 - 25,662,006UniSTS
Cytogenetic Map18p12UniSTS


Related Rat Strains
The following Strains have been annotated to Apc
F344-Apcm1Kyo    


Genetic Models
This gene Apc is modified in the following models/strains:
F344-ApcPirc/Uwm     ACI.F344-ApcPircUwm     F344-ApcPirc/UwmRrrc     F344-ApcPirc/UwmVdrem3Hfd     BN.F344-ApcPirc     F344-Apcm1Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 13 81 200 91 90 59 148 59 6 455 268 18 182 102 116 31 33 33

Sequence


Ensembl Acc Id: ENSRNOT00000027691   ⟹   ENSRNOP00000027691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1826,102,679 - 26,197,022 (+)Ensembl
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)Ensembl
Rnor_6.0 Ensembl1827,047,382 - 27,105,333 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090264   ⟹   ENSRNOP00000074593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1826,127,534 - 26,197,022 (+)Ensembl
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)Ensembl
Rnor_6.0 Ensembl1827,047,418 - 27,105,531 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102176   ⟹   ENSRNOP00000080591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1826,129,755 - 26,197,022 (+)Ensembl
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132670   ⟹   ENSRNOP00000108854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1826,102,679 - 26,197,022 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134323   ⟹   ENSRNOP00000101387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1826,102,735 - 26,197,022 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000172936   ⟹   ENSRNOP00000101470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1826,102,679 - 26,197,022 (+)Ensembl
RefSeq Acc Id: NM_012499   ⟹   NP_036631
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,138,382 - 26,196,021 (+)NCBI
mRatBN7.21825,864,222 - 25,921,864 (+)NCBI
Rnor_6.01827,047,382 - 27,105,333 (+)NCBI
Rnor_5.01826,725,560 - 26,820,837 (+)NCBI
RGSC_v3.41826,732,147 - 26,790,383 (+)RGD
Celera1825,606,119 - 25,663,749 (+)RGD
Sequence:
RefSeq Acc Id: NP_036631   ⟸   NM_012499
- UniProtKB: P70478 (UniProtKB/Swiss-Prot),   A6J2T3 (UniProtKB/TrEMBL),   G3V8Q9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074593   ⟸   ENSRNOT00000090264
Ensembl Acc Id: ENSRNOP00000027691   ⟸   ENSRNOT00000027691
Ensembl Acc Id: ENSRNOP00000080591   ⟸   ENSRNOT00000102176
Ensembl Acc Id: ENSRNOP00000101470   ⟸   ENSRNOT00000172936
Ensembl Acc Id: ENSRNOP00000108854   ⟸   ENSRNOT00000132670
Ensembl Acc Id: ENSRNOP00000101387   ⟸   ENSRNOT00000134323
Protein Domains
Adenomatous polyposis coli N-terminal dimerisation   Adenomatous polyposis coli protein basic   EB-1 binding

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2123 AgrOrtholog
BioCyc Gene G2FUF-7966 BioCyc
Ensembl Genes ENSRNOG00000020423 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027691 ENTREZGENE
Gene3D-CATH 1.20.5.10 UniProtKB/Swiss-Prot
  1.25.10.10 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
InterPro APC_15aa_rpt UniProtKB/Swiss-Prot
  APC_basic_dom UniProtKB/Swiss-Prot
  APC_dom UniProtKB/Swiss-Prot
  Apc_fam UniProtKB/Swiss-Prot
  APC_N UniProtKB/Swiss-Prot
  APC_N_sf UniProtKB/Swiss-Prot
  APC_rep UniProtKB/Swiss-Prot
  APC_rpt UniProtKB/Swiss-Prot
  ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Armadillo UniProtKB/Swiss-Prot
  EB1-bd UniProtKB/Swiss-Prot
  SAMP UniProtKB/Swiss-Prot
KEGG Report rno:24205 UniProtKB/Swiss-Prot
NCBI Gene 24205 ENTREZGENE
PANTHER PTHR12607 UniProtKB/Swiss-Prot
  PTHR12607:SF11 UniProtKB/Swiss-Prot
Pfam APC_15aa UniProtKB/Swiss-Prot
  APC_basic UniProtKB/Swiss-Prot
  APC_N_CC UniProtKB/Swiss-Prot
  APC_r UniProtKB/Swiss-Prot
  APC_rep UniProtKB/Swiss-Prot
  APC_u13 UniProtKB/Swiss-Prot
  APC_u14 UniProtKB/Swiss-Prot
  APC_u15 UniProtKB/Swiss-Prot
  APC_u5 UniProtKB/Swiss-Prot
  APC_u9 UniProtKB/Swiss-Prot
  Arm UniProtKB/Swiss-Prot
  Arm_APC_u3 UniProtKB/Swiss-Prot
  EB1_binding UniProtKB/Swiss-Prot
  SAMP UniProtKB/Swiss-Prot
  Suppressor_APC UniProtKB/Swiss-Prot
PhenoGen Apc PhenoGen
PROSITE ARM_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020423 RatGTEx
SMART ARM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF58050 UniProtKB/Swiss-Prot
  SSF82931 UniProtKB/Swiss-Prot
TIGR TC228425
UniProt A0A0G2K8G0_RAT UniProtKB/TrEMBL
  A0A8I5ZR24_RAT UniProtKB/TrEMBL
  A0ABK0LDU7_RAT UniProtKB/TrEMBL
  A0ABK0LDU8_RAT UniProtKB/TrEMBL
  A0ABK0LDZ4_RAT UniProtKB/TrEMBL
  A6J2T0_RAT UniProtKB/TrEMBL
  A6J2T3 ENTREZGENE, UniProtKB/TrEMBL
  A6J2T5_RAT UniProtKB/TrEMBL
  A6J2T6_RAT UniProtKB/TrEMBL
  APC_RAT UniProtKB/Swiss-Prot
  G3V8Q9 ENTREZGENE, UniProtKB/TrEMBL
  P70478 ENTREZGENE
  Q920M0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Apc  Adenomatosis polyposis coli      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations are associated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced colon tumors 634649
gene_disease human homolog is involved in colon tumorigenesis 634649
gene_function interacts with microtubles 632398
gene_process may play a role in the regulation of cell polarity 632398