APC (adenomatous polyposis coli) - Rat Genome Database

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Keyword

Gene: APC (adenomatous polyposis coli) Homo sapiens

Symbol:

APC

Name:

adenomatous polyposis coli

Description:

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli protein; BTPS2; deleted in polyposis 2.5; DP2; DP2.5; DP3; GS; OTTHUMP00000159019; OTTHUMP00000222839; OTTHUMP00000222841; OTTHUMP00000222842; PPP1R46; protein phosphatase 1, regulatory subunit 46

Orthologs:

Mus musculus : Apc (adenomatosis polyposis coli) MGI
Rattus norvegicus : Apc (adenomatous polyposis coli)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	112,323,968 - 112,462,808	+	NCBI
Human Genome Assembly HuRef	5	107,222,330 - 107,361,030	+	NCBI
Human Genome Assembly GRCh37	5	112,043,202 - 112,181,936	+	NCBI
Human Genome Assembly Build 36	5	112,101,483 - 112,209,835	+	NCBI
Human Cytogenetic Map	5	q21-q22		NCBI
Human Genome Assembly	5	112,101,482 - 112,209,834		NCBI