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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:68948 | 6480464 | Tetrachlorodibenzodioxin affects the expression of BCAT2 mRNA | CTD | PMID:22298810 | 2,4-dinitrotoluene | affects expression | ISO | RGD:68948 | 6480464 | 2,4-dinitrotoluene affects the expression of BCAT2 mRNA | CTD | PMID:21346803 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases activity | ISO | RGD:68948 | 6480464 | Puromycin Aminonucleoside results in decreased activity of BCAT2 protein | CTD | PMID:9399633 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | ISO | RGD:68948 | 6480464 | Puromycin Aminonucleoside results in decreased expression of BCAT2 mRNA | CTD | PMID:9399633 | ammonium chloride | affects expression | ISO | RGD:68948 | 6480464 | Ammonium Chloride affects the expression of BCAT2 mRNA | CTD | PMID:16483693 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:68948 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of BCAT2 promoter | CTD | PMID:23359474 | bisphenol A | multiple interactions | ISO | RGD:68948 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of BCAT2 promoter | CTD | PMID:23359474 | clofibric acid | multiple interactions | ISO | RGD:68948 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BCAT2 mRNA | CTD | PMID:17602206 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of BCAT2 mRNA | CTD | PMID:19376846 PMID:19320972 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of BCAT2 mRNA | CTD | PMID:19320972 PMID:19376846 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of BCAT2 mRNA | CTD | PMID:20106945 | dibutyl phthalate | multiple interactions | ISO | RGD:68948 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of BCAT2 promoter | CTD | PMID:23359474 | doxorubicin | decreases expression | ISO | RGD:68948 | 6480464 | Doxorubicin results in decreased expression of BCAT2 mRNA | CTD | PMID:19915844 | isotretinoin | decreases expression | EXP | | 6480464 | Isotretinoin results in decreased expression of BCAT2 mRNA | CTD | PMID:20436886 | mifepristone | decreases expression | EXP | | 6480464 | Mifepristone results in decreased expression of BCAT2 mRNA | CTD | PMID:17584828 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:69003 | 6480464 | Ethylnitrosourea results in increased mutagenesis of BCAT2 gene | CTD | PMID:14755340 | N-methyl-N'-nitro-N-nitrosoguanidine | multiple interactions | ISO | RGD:69003 | 6480464 | [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BCAT2 mRNA | CTD | PMID:19840844 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:68948 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BCAT2 mRNA | CTD | PMID:17602206 | okadaic acid | multiple interactions | ISO | RGD:69003 | 6480464 | [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BCAT2 mRNA | CTD | PMID:19840844 | phenobarbital | increases expression | ISO | RGD:69003 | 6480464 | Phenobarbital results in increased expression of BCAT2 mRNA | CTD | PMID:19482888 | phenobarbital | increases methylation | ISO | RGD:69003 | 6480464 | Phenobarbital results in increased methylation of BCAT2 promoter | CTD | PMID:19482888 | phenobarbital | affects methylation | ISO | RGD:69003 | 6480464 | Phenobarbital affects the methylation of BCAT2 gene | CTD | PMID:19233941 | phorone | affects expression | ISO | RGD:68948 | 6480464 | phorone affects the expression of BCAT2 mRNA | CTD | PMID:18198479 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCAT2 mRNA | CTD | PMID:19710929 | pirinixic acid | multiple interactions | ISO | RGD:69003 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of BCAT2 mRNA] | CTD | PMID:20059764 | pirinixic acid | decreases expression | ISO | RGD:69003 | 6480464 | pirinixic acid results in decreased expression of BCAT2 mRNA | CTD | PMID:20059764 | resveratrol | increases expression | ISO | RGD:69003 | 6480464 | resveratrol results in increased expression of BCAT2 mRNA | CTD | PMID:22610192 | trans-resveratrol | increases expression | ISO | RGD:69003 | 6480464 | resveratrol results in increased expression of BCAT2 mRNA | CTD | PMID:22610192 | valproic acid | decreases expression | ISO | RGD:69003 | 6480464 | Valproic Acid results in decreased expression of BCAT2 mRNA | CTD | PMID:21427059 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | 2-Oxocarboxylic acid metabolism |
| Metabolic pathways | |
| Pantothenate and CoA biosynthesis | |
| Valine, leucine and isoleucine biosynthesis | |
| Valine, leucine and isoleucine degradation | |
Phenotype Annotations
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References - curated| 1. |
Bledsoe RK, etal., Biochim Biophys Acta 1997 Apr 25;1339(1):9-13. |
| 2. |
GOA_HUMAN data from the GO Consortium |
| 3. |
KEGG |
| 4. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 5. |
RGD automated import pipeline for gene-chemical interactions |
| 6. |
Torres N, etal., Eur J Biochem. 2001 Dec;268(23):6132-9. |
| 7. |
Wu JY, etal., J Clin Invest 2004 Feb;113(3):434-40. |
References - uncurated| PubMed | 11170829 |
| 11264579 | |
| 12119021 | |
| 12269802 | |
| 12477932 | |
| 12686109 | |
| 14702039 | |
| 15182179 | |
| 15489334 | |
| 16141215 | |
| 16344560 | |
| 17050531 | |
| 19119849 | |
| 20877624 | |
| 21832049 | |
| 21890473 | |
| 21906983 | |
| 22107788 | |
| 23043456 | |
| 3896163 | |
| 6933702 | |
| 8125298 | |
| 8702755 | |
| 8889548 | |
| 9478945 | |
| 9657861 | |
| 9665099 |
RGD Disease Portals| BCAT2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| BCAT2 (Homo sapiens) |
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| Bcat2 (Mus musculus) |
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| Bcat2 (Rattus norvegicus) |
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Position Markers| BCAT2_8226 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_013003 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001164773 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001190 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NR_028450 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NR_028451 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01032966 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC026803 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF268047 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF268048 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK023909 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK093627 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK223522 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK309428 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK310101 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK310243 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK314548 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01009908 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC001900 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC004243 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BE139200 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BM802402 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BU178552 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CA310873 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB049110 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471177 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DA129578 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DC395685 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HC897076 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U62739 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U68418 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001164773 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001158245 | ||||||||||||||||||||
| Peptide Label: | isoform b | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001190 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001181 | |||||||||||||||||||||||||
| Peptide Label: | isoform a precursor | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NR_028450 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | NON-CODING | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NR_028451 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | NON-CODING | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001158245 | (Get FASTA) |
| NP_001181 | (Get FASTA) | |
| GenBank Protein | AAB53087 | (Get FASTA) |
| AAB67672 | (Get FASTA) | |
| AAH01900 | (Get FASTA) | |
| AAH04243 | (Get FASTA) | |
| AAK38368 | (Get FASTA) | |
| AAK38369 | (Get FASTA) | |
| ABM83276 | (Get FASTA) | |
| ABM86480 | (Get FASTA) | |
| BAD97242 | (Get FASTA) | |
| BAG37134 | (Get FASTA) | |
| BAG52745 | (Get FASTA) | |
| CBN62949 | (Get FASTA) | |
| EAW52403 | (Get FASTA) | |
| O15382 | (Get FASTA) |
Promoters| RGD ID: | 6870776 | ||||||||||
| Promoter ID: | EPDNEW_H8553 | ||||||||||
| Type: | multiple initiation site | ||||||||||
| Name: | HIST1H3C_1 | ||||||||||
| Description: | histone cluster 1, H3c | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6795194 | ||||||||||
| Promoter ID: | HG_KWN:30481 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4 | ||||||||||
| Transcripts: | UC002PKQ.2, UC002PKR.1, UC002PKS.1, UC002PKT.1, UC010EMH.1, UC010EMI.1, UC010EMJ.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | BCAT2 | COSMIC |
| Ensembl Genes | ENSG00000105552 | ENTREZGENE |
| Ensembl Protein | ENSP00000322991 | ENTREZGENE |
| ENSP00000440973 | ENTREZGENE | |
| Ensembl Transcript | ENST00000316273 | ENTREZGENE |
| ENST00000545387 | ENTREZGENE | |
| Entrez Gene | 587 | ENTREZGENE |
| Germonline | ENSG00000105552 | |
| HGNC ID | 977 | ENTREZGENE |
| HomoloGene Group ID | 81684 | ENTREZGENE |
| HPRD ID | 00217 | ENTREZGENE |
| InterPro | Aminotrans_IV | UniProtKB/Swiss-Prot |
| Aminotrans_IV_CS | UniProtKB/Swiss-Prot | |
| B_amino_transII | UniProtKB/Swiss-Prot | |
| IPI | IPI00181135 | UniProtKB/TrEMBL |
| IPI00396258 | UniProtKB/Swiss-Prot | |
| IPI01009966 | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:587 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 113530 | OMIM |
| PANTHER | Aminotrans_IV | UniProtKB/Swiss-Prot |
| Pfam | Aminotran_4 | UniProtKB/Swiss-Prot |
| PharmGKB | PA25289 | PharmGKB |
| PIRSF | BCAT1 | UniProtKB/Swiss-Prot |
| PROSITE | AA_TRANSFER_CLASS_4 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Aminotrans_IV | UniProtKB/Swiss-Prot |
| TIGRFAMs | IlvE_II | UniProtKB/Swiss-Prot |
| UniGene | Hs.512670 | ENTREZGENE |
| UniProt | B3KSI3_HUMAN | UniProtKB/TrEMBL |
| BCAT2_HUMAN | UniProtKB/Swiss-Prot | |
| M0QXF9_HUMAN | UniProtKB/TrEMBL | |
| M0QZ10_HUMAN | UniProtKB/TrEMBL | |
| M0QZP4_HUMAN | UniProtKB/TrEMBL | |
| M0R2K7_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-17 | BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | BCAT2 | branched chain aminotransferase 2, mitochondrial | Symbol and/or name change | 39860 | APPROVED |
| More on BCAT2 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 69002 |
| Created: | 2001-11-06 |
| Species: | Homo sapiens |
| Last Modified: | 2013-03-06 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




