Egln3 (egl-9 family hypoxia-inducible factor 3) - Rat Genome Database

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Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus
Analyze
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
RGD ID: 71019
Description: Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Involved in regulation of cell population proliferation. Predicted to be active in cytoplasm and nucleus. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; prolyl hydroxylase EGLN3; SM-20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Egln3m1Mcwi
Genetic Models: FHH-Egln3m1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8677,385,549 - 77,411,015 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl677,385,549 - 77,411,015 (-)EnsemblGRCr8
mRatBN7.2671,650,297 - 71,675,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl671,650,297 - 71,675,766 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx672,071,359 - 72,096,960 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0672,378,007 - 72,403,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0671,817,527 - 71,843,127 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)Ensemblrn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera670,500,466 - 70,525,910 (-)NCBICelera
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Cytogenetic Map6q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
andrographolide  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azaspiracid  (ISO)
Bardoxolone methyl  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diallyl trisulfide  (EXP)
diazinon  (EXP,ISO)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
heparin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
iron atom  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
ranitidine  (EXP)
reactive oxygen species  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (EXP)
Tungsten carbide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Bruick RK Genes Dev 2003 Nov 1;17(21):2614-23.
2. Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension. Chen YR, etal., Acta Biochim Biophys Sin (Shanghai). 2006 Jun;38(6):423-34.
3. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation. D'Angelo G, etal., J Biol Chem 2003 Oct 3;278(40):38183-7.
4. Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion. Fallon MJ and MacDonald MJ, Metabolism. 2008 Aug;57(8):1148-54.
5. Prospective study assessing hypoxia-related proteins as markers for the outcome of treatment with sunitinib in advanced clear-cell renal cell carcinoma. Garcia-Donas J, etal., Ann Oncol. 2013 Sep;24(9):2409-14. doi: 10.1093/annonc/mdt219. Epub 2013 Jun 20.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells. Liu Y, etal., Biochem Biophys Res Commun. 2010 Oct 15;401(2):231-7. doi: 10.1016/j.bbrc.2010.09.037. Epub 2010 Sep 16.
8. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
9. Gene Data Set MGD Curation, June 12, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Schodel J, etal., Am J Pathol. 2009 May;174(5):1663-74. doi: 10.2353/ajpath.2009.080687. Epub 2009 Apr 6.
15. Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma. Tanaka T, etal., J Cancer Res Clin Oncol. 2011 May;137(5):789-94. doi: 10.1007/s00432-010-0940-6. Epub 2010 Jul 31.
16. Identification of a novel growth factor-responsive gene in vascular smooth muscle cells. Wax SD, etal., J Biol Chem 1994 Apr 29;269(17):13041-7.
17. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. Willam C, etal., J Mol Cell Cardiol. 2006 Jul;41(1):68-77.
18. Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20. Wolf G, etal., Lab Invest 2002 Oct;82(10):1305-17.
Additional References at PubMed
PMID:10386996   PMID:11060309   PMID:11595184   PMID:11598268   PMID:12615973   PMID:12675908   PMID:12788921   PMID:16407229   PMID:17129494   PMID:18332118   PMID:19420289   PMID:19584355  
PMID:20439489   PMID:20978507   PMID:22286099   PMID:22905089   PMID:22948157   PMID:22955912   PMID:24030251   PMID:25633836   PMID:26108712   PMID:32123074  


Genomics

Comparative Map Data
Egln3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8677,385,549 - 77,411,015 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl677,385,549 - 77,411,015 (-)EnsemblGRCr8
mRatBN7.2671,650,297 - 71,675,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl671,650,297 - 71,675,766 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx672,071,359 - 72,096,960 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0672,378,007 - 72,403,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0671,817,527 - 71,843,127 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)Ensemblrn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera670,500,466 - 70,525,910 (-)NCBICelera
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Cytogenetic Map6q23NCBI
EGLN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381433,924,227 - 33,951,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1433,924,227 - 34,462,774 (-)Ensemblhg38GRCh38
GRCh371434,393,433 - 34,420,280 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361433,463,172 - 33,490,035 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341433,463,172 - 33,490,037NCBI
Celera1414,258,646 - 14,285,539 (-)NCBICelera
Cytogenetic Map14q13.1NCBI
HuRef1414,510,074 - 14,536,960 (-)NCBIHuRef
CHM1_11434,391,710 - 34,418,579 (-)NCBICHM1_1
T2T-CHM13v2.01428,121,430 - 28,148,293 (-)NCBIT2T-CHM13v2.0
Egln3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391254,225,767 - 54,250,660 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1254,225,767 - 54,250,646 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381254,178,981 - 54,203,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1254,178,981 - 54,203,860 (-)Ensemblmm10GRCm38
MGSCv371255,279,968 - 55,304,861 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361255,100,608 - 55,125,474 (-)NCBIMGSCv36mm8
Celera1255,491,368 - 55,516,127 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.9NCBI
Egln3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540926,939,933 - 26,967,156 (+)Ensembl
ChiLan1.0NW_00495540926,939,933 - 26,967,156 (+)NCBIChiLan1.0ChiLan1.0
EGLN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21535,243,634 - 35,269,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11434,460,135 - 34,486,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01414,689,398 - 14,716,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11432,880,330 - 32,907,248 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1432,880,324 - 32,907,241 (-)EnsemblpanPan2panpan1.1
EGLN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1812,873,755 - 12,901,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl812,875,387 - 12,901,709 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha812,682,830 - 12,710,865 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0812,977,975 - 13,005,981 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl812,979,608 - 13,005,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1812,659,735 - 12,687,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0812,742,506 - 12,770,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0813,031,833 - 13,059,696 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Egln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864044,734,378 - 44,761,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364948,238,858 - 8,267,606 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364948,240,272 - 8,267,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGLN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl765,805,522 - 65,833,529 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1765,805,513 - 65,833,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2770,667,662 - 70,695,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGLN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2410,736,619 - 10,763,840 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Egln3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248382,819,631 - 2,847,827 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248382,819,719 - 2,848,094 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Egln3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1767,559,876 - 67,585,084 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Egln3
170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:145
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000007219
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
RH142305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2671,651,356 - 71,651,532 (+)MAPPERmRatBN7.2
Rnor_6.0675,051,389 - 75,051,564NCBIRnor6.0
Rnor_5.0684,593,954 - 84,594,129UniSTSRnor5.0
RGSC_v3.4674,452,098 - 74,452,273UniSTSRGSC3.4
Celera670,501,526 - 70,501,701UniSTS
Cytogenetic Map6q23UniSTS
RH135011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2671,651,054 - 71,651,263 (+)MAPPERmRatBN7.2
Rnor_6.0675,051,087 - 75,051,295NCBIRnor6.0
Rnor_5.0684,593,652 - 84,593,860UniSTSRnor5.0
RGSC_v3.4674,451,796 - 74,452,004UniSTSRGSC3.4
Celera670,501,224 - 70,501,432UniSTS
Cytogenetic Map6q23UniSTS


Genetic Models
This gene Egln3 is modified in the following models/strains:
FHH-Egln3m1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007219   ⟹   ENSRNOP00000007219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl677,385,549 - 77,411,015 (-)Ensembl
mRatBN7.2 Ensembl671,650,297 - 71,675,766 (-)Ensembl
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)Ensembl
RefSeq Acc Id: NM_019371   ⟹   NP_062244
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8677,385,549 - 77,411,015 (-)NCBI
mRatBN7.2671,650,297 - 71,675,766 (-)NCBI
Rnor_6.0675,050,329 - 75,075,795 (-)NCBI
Rnor_5.0684,592,894 - 84,618,360 (-)NCBI
RGSC_v3.4674,451,038 - 74,476,506 (-)RGD
Celera670,500,466 - 70,525,910 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062244 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19321 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007219
GenBank Protein Q62630 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062244   ⟸   NM_019371
- UniProtKB: G3V6N9 (UniProtKB/TrEMBL),   A6HBJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007219   ⟸   ENSRNOT00000007219
Protein Domains
Fe2OG dioxygenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62630-F1-model_v2 AlphaFold Q62630 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71019 AgrOrtholog
BioCyc Gene G2FUF-37555 BioCyc
BioCyc Pathway PWY-7894 [procollagen hydroxylation and glycosylation] BioCyc
BioCyc Pathway Image PWY-7894 BioCyc
Ensembl Genes ENSRNOG00000005053 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007219 ENTREZGENE
Gene3D-CATH q2cbj1_9rhob like domain UniProtKB/Swiss-Prot
InterPro HIF_prolyl_hydroxylases UniProtKB/Swiss-Prot
  Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot
  Pro_4_hyd_alph UniProtKB/Swiss-Prot
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/Swiss-Prot
KEGG Report rno:54702 UniProtKB/Swiss-Prot
NCBI Gene 54702 ENTREZGENE
PANTHER EGL NINE HOMOLOG-RELATED UniProtKB/Swiss-Prot
  PROLYL HYDROXYLASE EGLN3 UniProtKB/Swiss-Prot
Pfam 2OG-FeII_Oxy_3 UniProtKB/Swiss-Prot
PhenoGen Egln3 PhenoGen
PROSITE FE2OG_OXY UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005053 RatGTEx
SMART P4Hc UniProtKB/Swiss-Prot
UniProt A6HBJ8 ENTREZGENE, UniProtKB/TrEMBL
  EGLN3_RAT UniProtKB/Swiss-Prot
  G3V6N9 ENTREZGENE, UniProtKB/TrEMBL
  Q62630 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Egln3  egl-9 family hypoxia-inducible factor 3  Egln3  EGL nine homolog 3 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Egln3  EGL nine homolog 3 (C. elegans)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is down-regulated by angiotensin II induced AT2 receptor activity 728483