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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71019
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egln3decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of EGLN3 mRNAPMID:33387578
Egln3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of EGLN3 mRNAPMID:21215274
Egln3affects expressionISOEGLN3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of EGLN3 mRNAPMID:22298810
Egln3affects expressionISOEgln3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of EGLN3 mRNAPMID:21570461 PMID:24680724
Egln3increases expressionISOEGLN3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of EGLN3 mRNAPMID:19619570
Egln3increases expressionISOEgln3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of EGLN3 mRNAPMID:19933214
Egln3multiple interactionsISOEGLN3 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of EGLN3 mRNAPMID:19619570
Egln3multiple interactionsISOEgln3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EGLN3 mRNAPMID:17942748
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