Ache (acetylcholinesterase) - Rat Genome Database

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Gene: Ache (acetylcholinesterase) Rattus norvegicus
Analyze
Symbol: Ache
Name: acetylcholinesterase
RGD ID: 69313
Description: Enables acetylcholine binding activity; acetylcholinesterase activity; and choline binding activity. Involved in several processes, including acetylcholine catabolic process; positive regulation of neurogenesis; and response to insulin. Located in several cellular components, including endoplasmic reticulum lumen; neuronal cell body; and synaptic membrane. Is active in neuromuscular junction and synaptic cleft. Biomarker of acute stress disorder and leptospirosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)); PARTICIPATES IN acetylcholine metabolic pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycolipid-anchored form of acetylcholinesterase; Hache
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,042,882 - 25,050,608 (-)NCBIGRCr8
mRatBN7.21219,406,133 - 19,413,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,407,360 - 19,413,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,562,456 - 20,567,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,175,159 - 21,179,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,239,717 - 20,244,333 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,472,358 - 22,477,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,472,358 - 22,478,753 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,487,632 - 24,491,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1221,207,976 - 21,212,604 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-pilocarpine  (EXP,ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-taxifolin  (EXP)
(20R)-protopanaxadiol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-methoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-(3-ethyl-1-methyl-3-azepanyl)phenol  (EXP,ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-Acetylmorphine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-aminoacridine  (ISO)
acephate  (EXP,ISO)
acepromazine  (ISO)
acetaldehyde  (ISO)
acetaldehyde oxime  (ISO)
acetamide  (EXP)
acetamiprid  (EXP)
acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester  (EXP)
acetic acid [4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] ester  (ISO)
acetylcholine  (EXP,ISO)
acrylamide  (EXP)
alachlor  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldicarb  (EXP,ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
Alpinetin  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ambenonium chloride  (ISO)
aminocarb  (ISO)
amisulpride  (ISO)
amitriptyline  (EXP,ISO)
amodiaquine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
aspartame  (EXP,ISO)
atropine  (EXP,ISO)
azamethiphos  (EXP,ISO)
azelastine  (ISO)
azinphos-ethyl  (ISO)
azinphos-methyl  (ISO)
bacitracin  (ISO)
Bacoside a  (ISO)
baicalin  (EXP)
bambuterol  (ISO)
barium chloride  (EXP)
barium(0)  (EXP)
batimastat  (ISO)
bendiocarb  (EXP,ISO)
benfuracarb  (ISO)
Bensulide  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
Besigomsin  (ISO)
Betanin  (EXP)
bexarotene  (EXP)
bifenthrin  (EXP)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (ISO)
Botulinum toxin type A  (EXP)
Bromophos-ethyl  (ISO)
bucladesine  (EXP)
butyrylthiocholine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (EXP)
calycosin  (EXP)
canagliflozin  (EXP)
carbachol  (ISO)
carbamate ester  (ISO)
carbaryl  (EXP,ISO)
carbendazim  (EXP)
carbofuran  (EXP,ISO)
Carbophenothion  (EXP,ISO)
carbosulfan  (EXP,ISO)
Cardamonin  (EXP)
carnosine  (ISO)
carvacrol  (EXP)
catalpol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
Chebulinic acid  (ISO)
chlorfenvinfos  (EXP,ISO)
chlorhexidine  (ISO)
chlorite  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (EXP)
cholesterol  (ISO)
choline  (ISO)
chrysin  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP)
corticosterone  (ISO)
coumaphos  (ISO)
coumarin  (ISO)
Crotoxyphos  (ISO)
Cryptotanshinone  (ISO)
cucurbit[7]uril  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
cypermethrin  (EXP)
cytarabine  (EXP)
D-glucose  (ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
demethoxycurcumin  (EXP)
demeton-S-methyl  (ISO)
dequalinium  (ISO)
desipramine  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diacetylmonoxime  (ISO)
Dialifor  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP,ISO)
diazoxon  (EXP,ISO)
dichlorine  (ISO)
dichlorvos  (EXP,ISO)
diclofop-methyl  (EXP)
dicrotophos  (EXP,ISO)
difenoconazole  (EXP)
dihydroactinidiolide  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
dimethoate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylmercury  (EXP)
dimethylselenide  (ISO)
dioxygen  (EXP,ISO)
Diphosphoramide, N,N',N'',N'''-tetrakis(1-methylethyl)-  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
disulfoton  (EXP)
dithionite(2-)  (ISO)
donepezil hydrochloride  (EXP,ISO)
doxepin  (ISO)
doxorubicin  (ISO)
DPCPX  (EXP)
dyclonine  (ISO)
ecothiopate iodide  (ISO)
edrophonium  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
Eperisone hydrochloride  (ISO)
EPTC  (EXP)
ergothioneine  (ISO)
eseroline  (EXP)
ethanol  (EXP,ISO)
ethoprophos  (EXP,ISO)
Ethyl 4-methoxycinnamate  (EXP,ISO)
ethylbenzene  (EXP)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (EXP,ISO)
eugenol  (EXP)
fenamiphos  (EXP,ISO)
fenitrothion  (EXP,ISO)
fenoxycarb  (EXP)
fenpyroximate  (EXP)
fenthion  (EXP,ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
ferulic acid  (EXP)
flavonoids  (EXP,ISO)
folic acid  (ISO)
formetanate  (EXP)
fructose  (EXP)
Fusaric acid  (EXP)
galactose  (ISO)
galangin  (EXP)
galanthamine  (EXP,ISO)
galanthamine Trifluoroacetic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
geraniol  (EXP)
ginsenoside Rg1  (ISO)
glucose  (ISO)
glutathione  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (EXP,ISO)
harmine  (ISO)
heptenophos  (ISO)
herbicide  (ISO)
heroin  (ISO)
hesperidin  (EXP)
hexachlorophene  (ISO)
high-density lipoprotein cholesterol  (ISO)
HLo7  (EXP,ISO)
homocysteine  (ISO)
huperzine A  (EXP,ISO)
hydrazinecarbothioamide  (ISO)
hypochlorous acid  (ISO)
ifosfamide  (EXP)
imidacloprid  (EXP)
imipramine  (ISO)
indinavir  (ISO)
indole-3-butyric acid  (EXP)
irinotecan  (EXP)
Irisflorentin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
Isazofos  (ISO)
isocarbophos  (EXP,ISO)
isoflurane  (EXP)
kaempferol  (EXP)
Kokusaginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-glutamic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP)
leptophos  (ISO)
Levallorphan  (EXP)
Levorphanol  (EXP)
Licochalcone B  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP,ISO)
lithium chloride  (ISO)
loganin  (ISO)
luteolin  (EXP)
lycopene  (EXP)
malaoxon  (EXP,ISO)
malathion  (EXP,ISO)
mancozeb  (EXP)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese dioxide  (EXP)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
melatonin  (EXP)
memantine  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP)
mercury(0)  (EXP,ISO)
metazocine  (EXP)
metformin  (EXP,ISO)
methamidophos  (EXP,ISO)
methanol  (EXP,ISO)
methiocarb  (EXP)
methomyl  (EXP,ISO)
methotrexate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (EXP)
metoclopramide  (ISO)
mevinphos  (EXP,ISO)
Mipafox  (EXP,ISO)
monocrotophos  (EXP,ISO)
monosodium L-glutamate  (EXP)
morin  (EXP)
morphine  (ISO)
Muscarine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-L-tryptophan  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naftalofos  (EXP)
naled  (EXP,ISO)
naringin  (EXP)
Neferine  (EXP)
neostigmine  (ISO)
nickel atom  (EXP)
nicotine  (EXP)
nicotinic acid  (ISO)
O-acetyl-L-carnitine  (EXP)
O-methyleugenol  (ISO)
omethoate  (EXP,ISO)
organophosphorus compound  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
oxamyl  (EXP,ISO)
Oxotremorine  (ISO)
oxydemeton-methyl  (ISO)
pancuronium  (ISO)
paracetamol  (EXP)
paraoxon  (EXP,ISO)
Paraoxon-methyl  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP,ISO)
parathion-methyl  (EXP,ISO)
PCB138  (EXP)
pentazocine  (EXP)
pentetrazol  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phenthoate  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
phenytoin  (ISO)
phloretin  (ISO)
phorate  (EXP,ISO)
phosalone  (ISO)
phosmet  (EXP,ISO)
phosphamidon  (ISO)
phosphoryl trichloride  (ISO)
phoxim  (EXP,ISO)
physostigmine  (EXP,ISO)
physostigmine salicylate  (ISO)
phytoestrogen  (ISO)
piperazines  (EXP)
piperidine  (ISO)
Piracetam  (EXP,ISO)
pirimicarb  (ISO)
Pirimiphos-ethyl  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pralidoxime  (EXP,ISO)
pramipexole  (EXP)
proanthocyanidin  (ISO)
prochlorperazine  (ISO)
prodigiosin  (EXP)
profenofos  (EXP,ISO)
propamocarb  (ISO)
propiconazole  (EXP)
propidium  (ISO)
propoxur  (EXP,ISO)
puerarin  (ISO)
pyrazophos  (ISO)
Pyridostigmine bromide  (EXP,ISO)
pyrimidines  (ISO)
quercetin  (EXP)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
quinalphos  (EXP,ISO)
raloxifene  (ISO)
ranitidine  (EXP,ISO)
rapacuronium  (ISO)
reactive oxygen species  (ISO)
remdesivir  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rhodamine 6G  (ISO)
rivastigmine  (EXP,ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (EXP)
sarin  (EXP,ISO)
scopolamine  (EXP,ISO)
selenium atom  (EXP)
serotonin  (ISO)
silicon atom  (EXP)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium benzoate  (EXP)
sodium fluoride  (EXP,ISO)
sodium nitrite  (ISO)
Soman  (EXP,ISO)
sotorasib  (ISO)
staurosporine  (ISO)
stevioside  (EXP)
streptozocin  (EXP,ISO)
tacrine  (EXP,ISO)
tannic acid  (EXP)
Tariquidar  (EXP)
taurine  (EXP)
Tellimagrandin I  (ISO)
telmisartan  (ISO)
temephos  (EXP)
terbufos  (EXP,ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachlorohydroquinone  (ISO)
tetrachloromethane  (EXP)
tetrachlorvinphos  (ISO)
tetraethyllead  (EXP)
tetramethylpyrazine  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thiacloprid  (EXP,ISO)
thiazolidines  (ISO)
Thiobencarb  (EXP)
thiodicarb  (EXP,ISO)
thioflavine T  (ISO)
thymoquinone  (EXP)
Tiapamil  (ISO)
tilorone  (ISO)
titanium dioxide  (EXP,ISO)
tolonium chloride  (ISO)
toluene  (ISO)
trametinib  (ISO)
trandolapril  (EXP)
trans-caffeic acid  (EXP)
triazoles  (ISO)
triazophos  (ISO)
tribufos  (ISO)
tributyl phosphate  (EXP)
trichlorfon  (EXP,ISO)
trichloroacetaldehyde  (ISO)
trifluoperazine  (EXP,ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
tubocurarine  (ISO)
tyloxapol  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vanillin  (EXP)
vincristine  (EXP)
Vinpocetine  (EXP)
vitamin D  (EXP)
vitamin E  (EXP,ISO)
VX nerve agent  (EXP,ISO)
xaliproden  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zineb  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. Akaike A, etal., J Mol Neurosci. 2010 Jan;40(1-2):211-6.
2. Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model. Akinyemi AJ, etal., Metab Brain Dis. 2017 Feb;32(1):87-95. doi: 10.1007/s11011-016-9887-x. Epub 2016 Aug 5.
3. Restoration of acetylcholinesterase activity by Euphorbia hirta in discrete brain regions of chronically stressed rats. Anuradha H, etal., Pharm Biol. 2010 May;48(5):499-503.
4. Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats. Bajgar J Acta Medica (Hradec Kralove). 2008;51(4):223-8.
5. Muscarinic M(1), M(3) receptors function in the brainstem of streptozotocin induced diabetic rats: their role in insulin secretion from the pancreatic islets as a function of age. Balakrishnan S, etal., Eur J Pharmacol. 2009 Apr 17;608(1-3):14-22. doi: 10.1016/j.ejphar.2009.01.047.
6. Cholinesterase activities in cerebrospinal fluid of patients with idiopathic convulsive disorders. Basu PS, etal., Clin Chim Acta. 1995 Feb 28;235(1):107-12.
7. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Ben Assayag E, etal., Mol Med. 2010 Jul-Aug;16(7-8):278-86. doi: 10.2119/molmed.2010.00015. Epub 2010 Apr 14.
8. Cholinesterase modulations in patients with acute bacterial meningitis. Berg RM, etal., Scand J Clin Lab Invest. 2011 Jul;71(4):350-2. doi: 10.3109/00365513.2011.558107. Epub 2011 Feb 8.
9. Exercise modulates synaptic acetylcholinesterase at neuromuscular junctions. Blotnick E and Anglister L, Neuroscience. 2016 Apr 5;319:221-32. doi: 10.1016/j.neuroscience.2016.01.044. Epub 2016 Jan 25.
10. Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus. Chacon MA, etal., J Neurochem 2003 Oct;87(1):195-204.
11. An intronic enhancer containing an N-box motif is required for synapse- and tissue-specific expression of the acetylcholinesterase gene in skeletal muscle fibers. Chan RY, etal., Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4627-32.
12. Acute organophosphorus poisoning. Chowdhary S, etal., Clin Chim Acta. 2014 Apr 20;431C:66-76. doi: 10.1016/j.cca.2014.01.024. Epub 2014 Feb 7.
13. Acetylcholinesterase and choline uptake in striatum from rats with varying sleeping times. Chumakova OV and Liopo AV, Alcohol Alcohol. 1996 Mar;31(2):217-20.
14. Cholinesterases as markers of the inflammatory process in rats infected with Leptospira interrogans serovar Icterohaemorrhagiae. da Silva CB, etal., J Med Microbiol. 2012 Feb;61(Pt 2):278-84. doi: 10.1099/jmm.0.035501-0. Epub 2011 Sep 15.
15. [Effect of truncal vagotomy on the exocrine function of the pancreas in the dog] Dabrowski Z, etal., Pol Tyg Lek 1978 Jul 10;33(28):1093-5.
16. Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD. Deschenes-Furry J, etal., J Biol Chem 2003 Feb 21;278(8):5710-7. Epub 2002 Dec 4.
17. [Sanitary and hygienic evaluation of a technological line for removing manure]. Dolgov VS, Veterinariia. 1978 Dec;(12):61-3.
18. Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. Feng G, etal., J Cell Biol 1999 Mar 22;144(6):1349-60.
19. Cholinesterase activity in the hypoglossal nucleus of the rat and the changes produced by axotomy: a light and electron microscopic study. Flumerfelt BA and Lewis PR, J Anat. 1975 Apr;119(Pt 2):309-31.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Enzymes of the cholinergic system in islets of Langerhans. Godfrey DA and Matschinsky FM, J Histochem Cytochem. 1975 Sep;23(9):645-51.
23. Myasthenia gravis. Juel VC and Massey JM, Orphanet J Rare Dis. 2007 Nov 6;2:44.
24. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
25. Age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon. Kousba AA, etal., Toxicol Sci. 2007 Jan;95(1):147-55. Epub 2006 Oct 3.
26. Expression of a cDNA encoding the glycolipid-anchored form of rat acetylcholinesterase. Legay C, etal., FEBS Lett 1993 Jan 4;315(2):163-6.
27. Cloning and expression of a rat acetylcholinesterase subunit: generation of multiple molecular forms and complementarity with a Torpedo collagenic subunit. Legay C, etal., J Neurochem 1993 Jan;60(1):337-46.
28. Physiology of the autonomic nervous system. McCorry LK Am J Pharm Educ. 2007 Aug 15;71(4):78.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Treating schizophrenia: novel targets for the cholinergic system. Money TT, etal., CNS Neurol Disord Drug Targets. 2010 Apr;9(2):241-56.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Cholinergic status modulations in human volunteers under acute inflammation. Ofek K, etal., J Mol Med (Berl). 2007 Nov;85(11):1239-51. Epub 2007 Jul 27.
33. Acetylcholinesterase promotes neurite elongation, synapse formation, and surface expression of AMPA receptors in hippocampal neurones. Olivera S, etal., Mol Cell Neurosci 2003 May;23(1):96-106.
34. Quantitative histochemical studies of the hypothalamus enzymes of acetylcholine metabolism. Packman PM, etal., J Histochem Cytochem. 1977 Nov;25(11):1237-46.
35. Different membrane-bound forms of acetylcholinesterase are present at the cell surface of hepatocytes. Perelman A and Brandan E, Eur J Biochem. 1989 Jun 1;182(1):203-7.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Information Derived from GenBank Report RGD, Sept. 2003
41. Distributions of choline acetyltransferase and acetylcholinesterase activities in layers of rat superior colliculus. Ross CD and Godfrey DA, J Histochem Cytochem. 1985 Jul;33(7):631-41.
42. Regional distributions of choline acetyltransferase and acetylcholinesterase activities in layers of rat cerebellar vermis. Ross CD, etal., J Histochem Cytochem. 1983 Jul;31(7):927-37.
43. Acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems. Ruberg M, etal., J Neurol Neurosurg Psychiatry. 1987 May;50(5):538-43.
44. Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study. Santoro A, etal., CNS Drugs. 2010 Feb 1;24(2):163-76. doi: 10.2165/11310960-000000000-00000.
45. High-resolution localization of acetylcholinesterase at the rat neuromuscular junction. Schatz CR and Veh RW, J Histochem Cytochem. 1987 Nov;35(11):1299-307.
46. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Schmatz R, etal., Eur J Pharmacol. 2009 May 21;610(1-3):42-8. Epub 2009 Mar 19.
47. Effect of acute noise stress on acetylcholinesterase activity in discrete areas of rat brain. Sembulingam K, etal., Indian J Med Sci. 2003 Nov;57(11):487-92.
48. Cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats. Shih TM, etal., Arch Toxicol. 2006 Apr 21;.
49. Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET. Shimada H, etal., Neurology. 2009 Jul 28;73(4):273-8. Epub 2009 May 27.
50. Participation of a distant cholinergic mechanism in the response of the vascular bed to intoxication by organophosphorus inhibitors of cholinesterase Skopichev VG, etal., Morfologiia 2000;118(4):66-9.
51. Erythrocyte membrane acetylcholinesterase in type 1 (insulin-dependent) diabetes mellitus. Suhail M and Rizvi SI, Biochem J. 1989 May 1;259(3):897-9.
52. Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse. Sun M, etal., J Physiol. 2007 Feb 1;578(Pt 3):751-64. doi: 10.1113/jphysiol.2006.120147. Epub 2006 Oct 12.
53. Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy. Tejero R, etal., Hum Mol Genet. 2016 Aug 29. pii: ddw297.
54. Differential localization of acetylcholinesterase in neuronal and non-neuronal cells. Thullbery MD, etal., J Cell Biochem. 2005 Oct 15;96(3):599-610.
55. Effect of diabetes on the cholinergic enzyme activities of the urinary bladder and the seminal vesicles of the rat. Wahba ZZ, etal., Exp Clin Endocrinol. 1992;99(1):26-30.
56. Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study. Winblad B, etal., Lancet. 2006 Apr 1;367(9516):1057-65.
57. Rectal biopsy in children with Down syndrome and chronic constipation: Hirschsprung disease vs. non-Hirschsprung disease. Yin H, etal., Pediatr Dev Pathol. 2011 Oct 12.
58. Effects of adult-onset streptozotocin-induced diabetes on the rat brain antioxidant status and the activities of acetylcholinesterase, (Na(+),K (+))- and Mg(2+)-ATPase: modulation by L-cysteine. Zarros A, etal., Metab Brain Dis. 2009 Jun;24(2):337-48. Epub 2009 Mar 19.
59. Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation. Zhou J, etal., Neurosci Lett. 2001 Jun 22;306(1-2):53-6.
Additional References at PubMed
PMID:1517212   PMID:3954986   PMID:7512968   PMID:7885444   PMID:8349597   PMID:8460160   PMID:8626792   PMID:10995443   PMID:12477932   PMID:12524166   PMID:12533614   PMID:12736766  
PMID:14645660   PMID:14678761   PMID:14766237   PMID:15454088   PMID:15474030   PMID:15488307   PMID:15526038   PMID:15579149   PMID:15869839   PMID:16262697   PMID:16270756   PMID:16429571  
PMID:16434405   PMID:16678265   PMID:16773467   PMID:16871442   PMID:17165152   PMID:17280650   PMID:17484629   PMID:17580119   PMID:17606622   PMID:17948252   PMID:18256932   PMID:18341513  
PMID:18406032   PMID:18437545   PMID:18980714   PMID:19049969   PMID:19378919   PMID:19411116   PMID:19490106   PMID:19680821   PMID:20153305   PMID:20399201   PMID:20450904   PMID:20599604  
PMID:20832780   PMID:21571001   PMID:21881966   PMID:22028090   PMID:22328136   PMID:22922167   PMID:22982053   PMID:23046746   PMID:23117006   PMID:23119107   PMID:24010172   PMID:24039284  
PMID:24517892   PMID:24590316   PMID:24632022   PMID:25711085   PMID:26948151   PMID:27019979   PMID:27694000   PMID:28849127   PMID:28916328  


Genomics

Comparative Map Data
Ache
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,042,882 - 25,050,608 (-)NCBIGRCr8
mRatBN7.21219,406,133 - 19,413,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,407,360 - 19,413,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,562,456 - 20,567,072 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,175,159 - 21,179,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,239,717 - 20,244,333 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,472,358 - 22,477,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,472,358 - 22,478,753 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,487,632 - 24,491,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1221,207,976 - 21,212,604 (-)NCBICelera
Cytogenetic Map12q12NCBI
ACHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,889,994 - 100,896,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,889,994 - 100,896,974 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,487,615 - 100,494,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,325,551 - 100,331,477 (-)NCBINCBI36Build 36hg18NCBI36
Build 347100,132,268 - 100,138,147NCBI
Celera795,218,191 - 95,224,120 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,117,968 - 95,123,900 (-)NCBIHuRef
CHM1_17100,418,205 - 100,424,133 (-)NCBICHM1_1
T2T-CHM13v2.07102,130,076 - 102,137,081 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,847,220 - 99,853,146 (-)NCBI
Ache
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,286,516 - 137,292,728 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,285,781 - 137,292,728 (+)EnsemblGRCm39 Ensembl
GRCm385137,288,247 - 137,294,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,287,519 - 137,294,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,729,505 - 137,735,691 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,518,065 - 137,524,251 (+)NCBIMGSCv36mm8
Celera5134,271,243 - 134,277,456 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.32NCBI
Ache
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495557380,298 - 85,799 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495557379,606 - 85,799 (+)NCBIChiLan1.0ChiLan1.0
ACHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,793,619 - 118,800,634 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,058,249 - 167,065,263 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,915,065 - 92,922,079 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,311,944 - 106,318,190 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,311,944 - 106,318,184 (-)Ensemblpanpan1.1panPan2
ACHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,874,747 - 8,879,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,873,584 - 8,879,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,580,127 - 10,585,994 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,809,869 - 8,815,742 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,809,457 - 8,816,935 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,661,436 - 8,668,230 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,640,504 - 8,646,368 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,822,240 - 8,828,117 (+)NCBIUU_Cfam_GSD_1.0
Ache
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,174,520 - 133,179,854 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543856,676 - 862,109 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543856,678 - 862,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,732,441 - 8,738,605 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,732,451 - 8,738,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,159,377 - 8,165,197 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACHE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,328,304 - 12,335,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,331,039 - 12,335,076 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,993,802 - 4,000,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ache
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,275,117 - 16,281,793 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,275,108 - 16,280,639 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ache
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:47
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000075504
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat

Markers in Region
D12Wox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1221,213,565 - 21,213,775UniSTS
RH130210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,407,423 - 19,407,618 (+)MAPPERmRatBN7.2
Rnor_6.01222,472,422 - 22,472,616NCBIRnor6.0
Rnor_5.01224,487,696 - 24,487,890UniSTSRnor5.0
Celera1221,208,040 - 21,208,234UniSTS
UniSTS:463940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,410,275 - 19,410,579 (+)MAPPERmRatBN7.2
Rnor_6.01222,475,317 - 22,475,620NCBIRnor6.0
Rnor_5.01224,489,625 - 24,489,928UniSTSRnor5.0
Celera1221,210,869 - 21,211,172UniSTS
Ache  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,410,122 - 19,411,412 (+)MAPPERmRatBN7.2
Rnor_6.01222,475,164 - 22,476,453NCBIRnor6.0
Rnor_5.01224,489,472 - 24,490,761UniSTSRnor5.0
Celera1221,210,716 - 21,212,005UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 7 6 4 6 4 7 46 4
Low 2 43 50 35 15 35 4 4 28 35 41 11 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_172009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF134349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ338831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ338832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT531403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT531408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT531409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S50879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000075504   ⟹   ENSRNOP00000064185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,408,253 - 19,413,651 (-)Ensembl
Rnor_6.0 Ensembl1222,472,578 - 22,477,052 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086915   ⟹   ENSRNOP00000072252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1222,473,963 - 22,478,753 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089392   ⟹   ENSRNOP00000073951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,407,360 - 19,413,651 (-)Ensembl
Rnor_6.0 Ensembl1222,472,358 - 22,478,752 (-)Ensembl
RefSeq Acc Id: NM_172009   ⟹   NP_742006
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,042,882 - 25,050,410 (-)NCBI
mRatBN7.21219,406,133 - 19,413,665 (-)NCBI
Rnor_6.01222,472,358 - 22,477,052 (-)NCBI
Rnor_5.01224,487,632 - 24,491,360 (-)NCBI
Celera1221,207,976 - 21,212,604 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089837   ⟹   XP_038945765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,044,108 - 25,050,454 (-)NCBI
mRatBN7.21219,407,359 - 19,413,710 (-)NCBI
RefSeq Acc Id: XM_039089838   ⟹   XP_038945766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,042,889 - 25,050,458 (-)NCBI
mRatBN7.21219,407,359 - 19,413,713 (-)NCBI
RefSeq Acc Id: XM_039089841   ⟹   XP_038945769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,047,377 - 25,050,608 (-)NCBI
mRatBN7.21219,410,564 - 19,413,699 (-)NCBI
RefSeq Acc Id: XM_039089842   ⟹   XP_038945770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,044,989 - 25,050,405 (-)NCBI
mRatBN7.21219,407,359 - 19,411,202 (-)NCBI
RefSeq Acc Id: XM_063271715   ⟹   XP_063127785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,042,889 - 25,050,436 (-)NCBI
RefSeq Acc Id: XM_063271716   ⟹   XP_063127786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,042,889 - 25,050,436 (-)NCBI
RefSeq Acc Id: XM_063271717   ⟹   XP_063127787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,044,989 - 25,047,829 (-)NCBI
RefSeq Acc Id: XM_063271718   ⟹   XP_063127788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,042,889 - 25,047,829 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_742006   ⟸   NM_172009
- Peptide Label: precursor
- UniProtKB: P37136 (UniProtKB/Swiss-Prot),   A0A0G2K6V0 (UniProtKB/TrEMBL),   A0A9K3Y822 (UniProtKB/TrEMBL),   Q505J2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064185   ⟸   ENSRNOT00000075504
RefSeq Acc Id: ENSRNOP00000073951   ⟸   ENSRNOT00000089392
RefSeq Acc Id: ENSRNOP00000072252   ⟸   ENSRNOT00000086915
RefSeq Acc Id: XP_038945766   ⟸   XM_039089838
- Peptide Label: isoform X1
- UniProtKB: M0R4A5 (UniProtKB/TrEMBL),   A0A7G5X9Q5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945765   ⟸   XM_039089837
- Peptide Label: isoform X1
- UniProtKB: M0R4A5 (UniProtKB/TrEMBL),   A0A7G5X9Q5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945770   ⟸   XM_039089842
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038945769   ⟸   XM_039089841
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127785   ⟸   XM_063271715
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K6V0 (UniProtKB/TrEMBL),   A0A9K3Y822 (UniProtKB/TrEMBL),   Q505J2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127786   ⟸   XM_063271716
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063127788   ⟸   XM_063271718
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063127787   ⟸   XM_063271717
- Peptide Label: isoform X6
Protein Domains
Acetylcholinesterase tetramerisation   Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37136-F1-model_v2 AlphaFold P37136 1-614 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698534
Promoter ID:EPDNEW_R9048
Type:single initiation site
Name:Ache_1
Description:acetylcholinesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,478,766 - 22,478,826EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69313 AgrOrtholog
BioCyc Gene G2FUF-19694 BioCyc
Ensembl Genes ENSRNOG00000050841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075504.3 UniProtKB/TrEMBL
  ENSRNOT00000089392 ENTREZGENE
  ENSRNOT00000089392.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7315968 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AChE_tetra UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cholinesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83817 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105302 IMAGE-MGC_LOAD
NCBI Gene 83817 ENTREZGENE
PANTHER ACETYLCHOLINESTERASE UniProtKB/Swiss-Prot
  ACETYLCHOLINESTERASE UniProtKB/Swiss-Prot
  ACETYLCHOLINESTERASE UniProtKB/TrEMBL
  ACETYLCHOLINESTERASE UniProtKB/TrEMBL
Pfam AChE_tetra UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ACHE RGD
PhenoGen Ache PhenoGen
PRINTS CHOLNESTRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050841 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6V0 ENTREZGENE
  A0A7G5X9Q2_RAT UniProtKB/TrEMBL
  A0A7G5X9Q4_RAT UniProtKB/TrEMBL
  A0A7G5X9Q5 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y822 ENTREZGENE, UniProtKB/TrEMBL
  ACES_RAT UniProtKB/Swiss-Prot
  M0R4A5 ENTREZGENE, UniProtKB/TrEMBL
  P37136 ENTREZGENE
  Q505J2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2K6V0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Ache  acetylcholinesterase  Hache  glycolipid-anchored form of acetylcholinesterase  Data merged from RGD:620262 737654 PROVISIONAL
2002-08-07 Hache  glycolipid-anchored form of acetylcholinesterase      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ache  acetylcholinesterase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference