ORGANOPHOSPHATE RESPONSE PATHWAY (PW:0001516)

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Description

Organophosphorous compounds (OPCs) are used as pesticides in agriculture, particularly as insecticides, and occasionally in industrial settings. As nerve agents, they have been used in warfare in the past; OPCs have been used in modern chemical warfare and in terrorist attacks. In some countries, OPCs are used for self-poisoning. OPCs poisoning, whether accidental from occupational exposure or intentional, is a serious public health issue. The main mechanism of toxicity is the inhibition of ace

Pathway Diagram:

Elsevier Inc. chlorpyrifos parathion pesticides Respiratory Failure Cardiovascular Failure Ache ---| acetylcholine signaling via nicotinic acetylcholine receptor Ache ---| acetylcholine signaling via muscarinic acetylcholine receptor acetylcholine signaling pathway OPCs ---> developmental neurotoxicity neuron toxicity OPCs ---> neuron toxicity diazepam atropine Ache reactivator --+> Ache OPCs ---> hydrolysis products parathion ---> paraoxon CYP2B6 paraoxon chlorpyrifos oxon OPCs acetylcholine --+> acetylcholine signaling via nicotinic acetylcholine receptor OPCs ---> Cardiovascular Failure enzyme aging ---| Ache reactivator enzyme aging ---| pralidoxime enzyme aging diazepam ---| organophosphorus poisoning symptoms acetylcholine OPCs ---> Alb paraoxon ---> Alb chlorpyrifos oxon ---> Alb Alb Pon1 chlorpyrifos ---> chlorpyrifos oxon hydrolysis products product excretion hydrolysis products ---> product excretion pralidoxime developmental neurotoxicity OPCs ---> organophosphorus poisoning symptoms Ache atropine ---| organophosphorus poisoning symptoms atropine ---| acetylcholine signaling via muscarinic acetylcholine receptor organophosphorus poisoning symptoms Ache reactivator pralidoxime --+> Ache acetylcholine --+> acetylcholine signaling pathway acetylcholine --+> acetylcholine signaling via muscarinic acetylcholine receptor paraoxon ---| Ache OPCs ---| Ache chlorpyrifos oxon ---| Ache acetylcholine signaling via nicotinic acetylcholine receptor acetylcholine signaling via muscarinic acetylcholine receptor chemical warfare ACh hydrolysis, signal termination Ache ---> ACh hydrolysis, signal termination OPCs ---> Respiratory Failure
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Genes in Pathway:

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organophosphate response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:8551790
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:8551793
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:8551792

Pathway Gene Annotations

Disease Annotations Associated with Genes in the organophosphate response pathway
Disease TermsGene Symbols
Acute Coronary SyndromeAlb , Pon1
Acute Kidney InjuryAlb
Acute Lung InjuryAlb
Adenocarcinoma of LungAlb
Agricultural Workers' DiseasesPon1
AlbuminuriaAlb , Pon1
Alzheimer DiseaseAche , Pon1
Amphetamine-Related DisordersAche
AmyloidosisAche
Amyotrophic Lateral Sclerosis 1Pon1
ANALBUMINEMIAAlb
AnemiaPon1
Anemia, Iron-DeficiencyPon1
Anemia, Sickle CellPon1
AngioedemaAlb
AnuriaAlb
ArteriosclerosisPon1
ArteritisPon1
Arthritis, ExperimentalAlb
Arthritis, RheumatoidPon1
AtherosclerosisPon1
Autistic DisorderPon1
AzoospermiaAlb
Behcet SyndromePon1
Beta-ThalassemiaPon1
Biliary Tract NeoplasmsAlb
Birth WeightPon1
Blood Protein DisordersAlb
Bone DiseasesPon1
Brain DiseasesAlb
Brain InjuriesAlb
Brain IschemiaAlb
Brain NeoplasmsPon1
Breast NeoplasmsAche , Pon1
BurnsAlb
Capillary Leak SyndromePon1
Carcinoid TumorAlb
Carcinoma, HepatocellularAlb
Carcinoma, Non-Small-Cell LungAlb
Carcinoma, Pancreatic DuctalAlb
Carcinoma, Renal CellAche
Cardiovascular DiseasesAlb , Pon1
CataractPon1
Celiac DiseasePon1
Cerebral InfarctionPon1
CholangiocarcinomaAlb
CholestasisAlb
Chronic Allograft NephropathyAlb
Chronic Lymphoid LeukemiaPon1
Colorectal NeoplasmsAlb
ConstipationPon1
Coronary Artery DiseasePon1
Coronary DiseasePon1
Coronary VasospasmPon1
Crohn DiseasePon1
DementiaPon1
Depressive DisorderAlb , Pon1
Diabetes MellitusPon1
Diabetes Mellitus, ExperimentalAche , Pon1
Diabetes Mellitus, Type 1Ache , Pon1
Diabetes Mellitus, Type 2Pon1
Diabetic AngiopathiesAlb , Pon1
Diabetic NephropathiesAlb , Pon1
Diabetic RetinopathyPon1
Disease Models, AnimalAlb
Drug-Induced Liver InjuryAlb , Pon1
Drug-Related Side Effects and Adverse ReactionsAche , Alb
Dysalbuminemic HyperthyroxinemiaAlb
EchinococcosisAlb
Ehlers-Danlos Syndrome, Type VII, Autosomal DominantAlb
EndotoxemiaAche
EpilepsyAche , Alb
Esophageal and Gastric VaricesAlb
Exfoliation SyndromePon1
Fatty LiverPon1
Fetofetal TransfusionAlb
FibrosisAlb
Glaucoma, Open-AnglePon1
Glaucoma, Primary Open AnglePon1
GlomerulonephritisAlb
Glomerulonephritis, MembranoproliferativeAlb , Pon1
Glomerulonephritis, MembranousAlb
Glucose IntolerancePon1
Growth DisordersAche
Heart DiseasesAlb
Heart FailureAlb , Pon1
Hemangioma, Cavernous, Central Nervous SystemPon1
Hematologic NeoplasmsPon1
Hemolytic-Uremic SyndromeAlb
Hemorrhagic Fever with Renal SyndromeAlb
HemorrhoidsPon1
HepatitisAlb
Hirschsprung DiseaseAche
HIV InfectionsAlb
HIV SeropositivityAlb
Huntington DiseaseAche
Hydrops FetalisAlb
HypercholesterolemiaPon1
HyperglycemiaPon1
HyperhomocysteinemiaPon1
HyperlipidemiasAlb
Hyperlipoproteinemia Type IIPon1
HyperlipoproteinemiasPon1
HypersensitivityAlb
Hypersensitivity, DelayedAlb
HypertensionAlb
HyperthyroidismPon1
HyperthyroxinemiaAlb
Hyperthyroxinemia, Familial DysalbuminemicAlb
HypoalbuminemiaAlb
HypoproteinemiaAlb
HypotensionAlb
Infarction, Middle Cerebral ArteryAlb
Infertility, MalePon1
Inflammatory Bowel Disease 11Pon1
Insulin ResistancePon1
Jaundice, ObstructiveAlb
KeloidAlb
KeratoconusPon1
Kidney DiseasesAlb
Kidney Failure, ChronicAlb
Learning DisordersAche
LeptospirosisAche
LeukemiaAlb
Liver CirrhosisAlb
Liver Cirrhosis, ExperimentalAche , Alb
Liver Failure, AcuteAlb
Lung NeoplasmsPon1
LymphomaPon1
Lymphoma, Non-HodgkinPon1
Macular DegenerationPon1
MelanomaAlb
Melanoma, Cutaneous Malignant, Susceptibility To, 1Alb
Memory DisordersAche
Meningitis, AsepticAlb
Meningitis, BacterialAche
Metabolic Syndrome XPon1
Microvascular Complications of Diabetes, Susceptibility To, 5Pon1
Movement DisordersAche
Multiple MyelomaAlb , Pon1
Multiple SclerosisAche
Muscular DiseasesAlb
Muscular DystrophiesAche
Myasthenia GravisAche
Myocardial InfarctionPon1
Myocardial Reperfusion InjuryAlb
Nasal PolypsPon1
NephritisAlb
Nephritis, InterstitialAlb
NephrosisAlb
Nephrotic SyndromeAlb
Nervous System DiseasesAche
Neuroectodermal Tumors, PrimitivePon1
Neurotoxicity SyndromesPon1
Occupational DiseasesAlb , Pon1
Organophosphate PoisoningAche , Pon1
PainAlb
Pancreatic DiseasesAlb
Pancreatic FistulaAlb
Pancreatic NeoplasmsAlb
PancreatitisAlb
Parkinson DiseaseAche
Parkinson Disease, SecondaryPon1
Paroxysmal Atrial FibrillationAlb
Persian Gulf SyndromePon1
Pleomorphic Xanthoastrocytoma Ache , Pon1
PneumoniaAlb
PoisoningAche , Alb
Postoperative ComplicationsAlb
Pre-EclampsiaAlb
Precursor Cell Lymphoblastic Leukemia-LymphomaPon1
Prenatal InjuriesAche
Prostatic NeoplasmsAche , Pon1
Protein-Energy MalnutritionAlb
ProteinuriaAlb , Pon1
PsoriasisAlb
Pulmonary Disease, Chronic ObstructivePon1
Pulmonary EmphysemaAlb
Purpura, Schoenlein-HenochPon1
Purpura, Thrombocytopenic, IdiopathicAlb
Reperfusion InjuryAlb
Respiratory Distress Syndrome, AdultAlb
Respiratory Tract DiseasesAlb
Retinal Vein OcclusionPon1
Rhinitis, AllergicPon1
Rhinitis, Allergic, PerennialAlb
Root CariesAlb
Sarcoma, ExperimentalAlb
SeizuresAche
SepsisAlb
Serum SicknessAlb
Sjogren's SyndromePon1
Spinal Cord InjuriesPon1
Spinal DysraphismPon1
Stevens-Johnson SyndromeAlb
Stomach NeoplasmsAlb
Stress Disorders, TraumaticAche
StrokeAche , Alb
Thalassemia, Beta+, Silent AllelePon1
ThrombocytopeniaAlb
TremorAche
UrticariaAlb
UveitisAlb
Vitamin B 12 DeficiencyPon1
Wet Macular DegenerationPon1
Zinc, Elevated PlasmaAlb
Zollinger-Ellison SyndromeAlb
Pathway Annotations Associated with Genes in the organophosphate response pathway
Phenotype Annotations Associated with Genes in the organophosphate response pathway

References Associated with the organophosphate response pathway:

Ontology Path Diagram:

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