ACETYLCHOLINE SIGNALING PATHWAY VIA MUSCARINIC ACETYLCHOLINE RECEPTOR (PW:0000843)

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Description

Acetylcholine (ACh) is a major neurotransmitter and neuromodulator that plays important roles in the central and peripheral nervous systems, the autonomic nervous system (ANS), and also in non-neuronal cells. In cholinergic neurons acetylcholine is synthetized from acetyl-CoA and choline by the choline O-acetyltransferase Chat. The glucose-derived pyruvate metabolism is the primary source of acetyl-CoA in the brain. Once synthesized, ACh is loaded into synaptic vesicles by the vesicular ACh tran

Pathway Diagram:

Elsevier Inc. Gnai proteins in ACh Rgs4 Rgs6 Gnaq proteins in ACh G protein mediated signaling pathway via Galphai family released ACh acetylcholine Ca2+ DAG G protein mediated signaling pathway via Galphaq family choline ---> acetylcholine ACh hydrolysis, signal termination ---> choline Ache Grk5 ---| ai-Chrm2 Grk5 Grk5 ---| ai-Chrm4 Slc5a7 presynaptic autoreceptor ACh inhibition ---| released ACh presynaptic autoreceptor ACh inhibition released ACh ---> presynaptic autoreceptor ACh inhibition Rgs4 ---| Gnai proteins in ACh Rgs6 ---| Gnai proteins in ACh Rgs2 Adrbk1 ---| Chrm2 Adrbk1 ---| Chrm4 Adrbk1 ---| Chrm5 Adrbk1 Adrbk1 ---| Chrm1 Chrm1 Adrbk1 ---| Chrm3 Chrm3 cAMP Chrm2 ---- Gnai proteins in ACh Chrm4 ---- Gnai proteins in ACh Chrm5 Chrm5 ---- Gnaq proteins in ACh Chrm3 ---- Gnaq proteins in ACh Chrm1 ---- Gnaq proteins in ACh Chrm2 ---- released ACh Chrm4 ---- released ACh calcium/calcium-mediated signaling pathway calcium transport pathway IP3 acetylcholine ---> released ACh Chrm1 ---- released ACh Chrm3 ---- released ACh Chrm5 ---- released ACh ai-Chrm2 ---- released ACh ai-Chrm4 ---- released ACh released ACh ---> ACh hydrolysis, signal termination Slc18a3 acetyl-CoA Chat choline protein kinase C (PKC) signaling pathway IP3 --+> Ca2+ G protein mediated signaling pathway via Galphai family ---| cAMP Chrm2 decreased heart rate Chrm2 ---> decreased heart rate Chrm3 ---> bronchoconstriction ACh hydrolysis, signal termination Chrm4 Chrm4 ---> synaptic plasticity synaptic plasticity Chrm1 ---> synaptic plasticity bronchoconstriction G protein mediated signaling pathway via Galphaq family --+> IP3 G protein mediated signaling pathway via Galphaq family --+> DAG Rgs2 ---| Gnaq proteins in ACh ai-Chrm2 ai-Chrm4 cholinergic neuron acetyl-CoA ---> acetylcholine
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Genes in Pathway:

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acetylcholine signaling pathway via muscarinic acetylcholine receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:8549506
G Chat choline O-acetyltransferase JBrowse link 16 8,576,858 8,686,131 RGD:8549504
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:8549590
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:8549592
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:8549594
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:8549594
G Rgs6 regulator of G-protein signaling 6 JBrowse link 6 106,310,442 106,598,668 RGD:8549594
G Slc18a3 solute carrier family 18 member A3 JBrowse link 16 8,682,668 8,685,529 RGD:8549504
G Slc5a7 solute carrier family 5 member 7 JBrowse link 9 5,294,377 5,330,822 RGD:8549504
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrm2 cholinergic receptor, muscarinic 2 JBrowse link 4 64,089,028 64,091,090 RGD:8549585
G Chrm4 cholinergic receptor, muscarinic 4 JBrowse link 3 80,833,272 80,841,165 RGD:8549585
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:8549590
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:8549590
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:8549585
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:8549585
G Chrm5 cholinergic receptor, muscarinic 5 JBrowse link 3 103,966,451 104,018,815 RGD:8549585
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:8549590
G Gna14 G protein subunit alpha 14 JBrowse link 1 235,165,775 235,347,986 RGD:8549590
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:8549590

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassG alphaq in ACh
Functional ClassG alphai in ACh

Pathway Gene Annotations

Disease Annotations Associated with Genes in the acetylcholine signaling pathway via muscarinic acetylcholine receptor
Disease TermsGene Symbols
Alzheimer DiseaseAche , Chat , Grk5 , Slc18a3
Amphetamine-Related DisordersAche
AmyloidosisAche
Arthritis, RheumatoidGrk2 , Grk5
AsthmaChat , Slc18a3 , Slc5a7
Brain InjuriesSlc18a3
Breast NeoplasmsAche , Rgs2
Carcinoma, Renal CellAche
CardiomegalyGrk2
CardiomyopathiesGrk2
Cardiovascular DiseasesGrk2 , Grk5
Congenital AbnormalitiesGrk2
Congenital Myasthenic Syndrome with Episodic ApneaChat
Dermatitis, Allergic ContactGrk2
Diabetes Mellitus, ExperimentalAche
Diabetes Mellitus, Type 1Ache
Drug-Related Side Effects and Adverse ReactionsAche
Embryo LossGrk2
EndometriosisRgs4
EndotoxemiaAche , Slc18a3
EpilepsyAche
Glaucoma, Angle-ClosureChat
Growth DisordersAche
Heart FailureGrk2
Hirschsprung DiseaseAche
Huntington DiseaseAche , Chat , Slc18a3
HyperglycemiaGrk2
HypertensionGrk2 , Rgs2
Hypertension, PortalGrk2
Hypertrophy, Left VentricularGrk2
InflammationGrk5
Insulin ResistanceGrk2
Learning DisordersAche
LeptospirosisAche
Leukemia, Myeloid, AcuteRgs2
Liver Cirrhosis, ExperimentalAche , Grk2 , Rgs2
Liver DiseasesGrk5
Lung Diseases, ObstructiveGrk5
Memory DisordersAche
Meningitis, BacterialAche
Movement DisordersAche
Multiple SclerosisAche
Muscular DystrophiesAche
Myasthenia GravisAche
Myasthenic Syndromes, CongenitalChat
Nervous System DiseasesAche
Neuropathy, Distal Hereditary Motor, Type VIIASlc5a7
Organophosphate PoisoningAche
Parkinson DiseaseAche , Grk2 , Grk5
Parkinson Disease, SecondaryRgs2
PoisoningAche
Prenatal InjuriesAche
Prostatic NeoplasmsAche , Slc5a7
Reperfusion InjuryChat
Retinal DiseasesChat
SchizophreniaRgs4
SeizuresAche , Chat
SepsisGrk2 , Grk5
Status EpilepticusSlc18a3
Stomach NeoplasmsRgs2
Stress Disorders, TraumaticAche
StrokeAche
Temporomandibular Joint DisordersGrk5
Transplant RejectionSlc5a7
TremorAche
Urinary Bladder DiseasesSlc18a3
Pathway Annotations Associated with Genes in the acetylcholine signaling pathway via muscarinic acetylcholine receptor

References Associated with the acetylcholine signaling pathway via muscarinic acetylcholine receptor:

Ontology Path Diagram:

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