GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:34690
Term: dichlorvos
Definition: An alkenyl phosphate that has formula C4H7Cl2O4P.
CasRN: 62-73-7
Chemical ID: MESH:D004006
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:16036766
PMID:19631781
PMID:8783813
PMID:10975133
multiple interactionsISORGD:7358786480464CTDHI 6 inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

HLo 7 inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

asoxime chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

PMID:8783813
multiple interactionsISORGD:7358786480464CTDTiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

PMID:16193528
PMID:16036766
multiple interactionsISORGD:7358796480464CTDDichlorvos binds to and results in decreased activity of ACHE protein

PMID:16598855
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:17722737
PMID:17188317
PMID:15033007
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:8783813
PMID:10975133
PMID:19631781
PMID:16036766
multiple interactionsISORGD:7358786480464CTDTiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

PMID:16036766
PMID:16193528
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:17188317
PMID:15033007
PMID:17722737
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:19631781
PMID:16036766
PMID:10975133
PMID:8783813
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:17722737
PMID:15033007
PMID:17188317
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:15033007
PMID:21251949
PMID:17188317
PMID:17722737
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:19631781
PMID:21251949
PMID:10975133
PMID:16036766
PMID:8783813
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:21251949
PMID:16036766
PMID:8783813
PMID:10975133
PMID:19631781
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:15033007
PMID:17188317
PMID:17722737
PMID:21251949
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:19100812
PMID:15033007
PMID:17722737
PMID:21251949
PMID:17188317
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:19631781
PMID:8783813
PMID:10975133
PMID:16036766
PMID:21251949
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:10975133
PMID:16036766
PMID:19631781
PMID:21251949
PMID:8783813
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:15033007
PMID:17188317
PMID:17722737
PMID:19100812
PMID:20412842
PMID:21251949
decreases activityISORGD:7358796480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:21767560
PMID:22209767
multiple interactionsEXP 6480464CTDPON1 protein inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

PMID:20412842
multiple interactionsEXP 6480464CTD[pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]

PMID:22783142
increases phosphorylationISORGD:7358786480464CTDDichlorvos results in increased phosphorylation of ACHE protein

PMID:18423506
multiple interactionsISORGD:7358786480464CTD[Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]

PMID:18423506
multiple interactionsISORGD:7358796480464CTDDichlorvos promotes the reaction [malaoxon results in decreased activity of ACHE protein]

PMID:597376
multiple interactionsEXP 6480464CTD[Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein

PMID:20026515
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:15033007
PMID:17188317
PMID:17722737
PMID:19100812
PMID:20412842
PMID:21251949
PMID:22783142
multiple interactionsISORGD:7358786480464CTD[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein

[crotoxyphos co-treated with Dichlorvos] results in decreased activity of ACHE protein

Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]

[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein

[malaoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein

[Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein

[Paraoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein

[Parathion co-treated with Dichlorvos] results in decreased activity of ACHE protein

[Phosphamidon co-treated with Dichlorvos] results in decreased activity of ACHE protein

[Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein

[Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein

PMID:4859365
multiple interactionsISORGD:7358786480464CTDpralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

PMID:1494302
PMID:18070496
PMID:8783813
decreases activityISORGD:7358796480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:15679473
PMID:2086312
PMID:21767560
PMID:22209767
PMID:9268605
PMID:9515941
increases phosphorylationISORGD:7358796480464CTDDichlorvos results in increased phosphorylation of ACHE protein

PMID:10421444
increases acylationISORGD:7358796480464CTDDichlorvos results in increased acylation of ACHE protein

PMID:10421444
multiple interactionsISORGD:7358796480464CTDTrimedoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]

PMID:15679473
decreases response to substanceEXP 6480464CTDACHE protein results in decreased susceptibility to Dichlorvos

PMID:8359835
decreases activityEXP 6480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:119426
PMID:12018594
PMID:1258061
PMID:15033007
PMID:15793557
PMID:15979224
PMID:1609424
PMID:17188317
PMID:17722737
PMID:1855619
PMID:19100812
PMID:20396698
PMID:20412842
PMID:21251949
PMID:21349312
PMID:22783142
PMID:235931
PMID:3247000
PMID:3945941
PMID:475593
PMID:6933967
PMID:7150809
PMID:7218377
PMID:7234437
PMID:7713347
PMID:8231460
PMID:8579882
PMID:9586870
multiple interactionsEXP 6480464CTD[Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein

[sodium arsenite co-treated with Dichlorvos] results in decreased activity of ACHE protein

[sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein

PMID:21349312
multiple interactionsISORGD:7358796480464CTDAtropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]

coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]

Gallamine Triethiodide affects the reaction [Dichlorvos results in increased acylation of ACHE protein]

Gallamine Triethiodide promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]

Propidium promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]

Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]

PMID:10421444
decreases activityISORGD:7358786480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:10975133
PMID:1494302
PMID:16036766
PMID:18070496
PMID:19631781
PMID:21251949
PMID:21673941
PMID:2537085
PMID:473212
PMID:4859365
PMID:8783813
PMID:9268605
PMID:9515941
decreases activityISORGD:7358796480464CTDDichlorvos results in decreased activity of ACHE protein

PMID:15679473
PMID:16978018
PMID:2086312
PMID:21767560
PMID:22209767
PMID:9268605
PMID:9515941
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