Gene:	Axin2 ( Rattus norvegicus ) axin2
Description:	inhibits axis formation; acts as a negative regulator of the Wnt signaling pathway by inducing GSK-3beta-dependent phosphorylation of beta-catenin
Synonyms:	axin 2; axin-like; axil;
ArrayIDs:	5860574; 6303101; 6524318; 1387184_at; 6187888; 6471502; 5918519; 1390429_at; 6071283; GE1215469; AF017757_at; A_43_P12420; GE13191; 6025500; rc_AI008633_at; 5836030; 5892874; 5910822; 6525194; A_44_P262371; 6339817;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: AXIN2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Axin2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Axin2 genome assembly 3.1 10 98308835 - 98336196     Rat Celera Assembly 10 92568362 - 92589883     RGSC genome assembly v3.4 10 98294466 - 98321830     Cytogenetic 10 q32.1 Mus musculus Axin2 Mouse genome assembly build 36.1 11 108781680 - 108812097     Cytogenetic 11 11 E1 Homo sapiens AXIN2 human genome assembly 17 60956105 - 60985289     Human genome assembly build 36.2 17 60955143 - 60988227     Cytogenetic 17 q23-q24   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology signal transducer activity,  protein binding,  protein kinase binding ...  (details...)
Biological Process	Gene Ontology cell death,  multicellular organismal development,  regulation of Wnt receptor signaling pathway ...  (details...)
Cellular Component	Gene Ontology nucleus,  intracellular,  cytoplasm ...  (details...)
Disease	Ontology Colorectal Neoplasms,  Metaplasia (details...)
Pathway	Ontology altered canonical Wnt signaling pathway,  colorectal cancer pathway,  canonical Wnt signaling pathway (details...)
Physical interaction	Note Reference binds glycogen synthase kinase 3beta and beta catenin 68736
External Links
Databases	DATABASE ID SOURCE SMART: RGS IPI SMART: DAX IPI PROSITE: RGS IPI PROSITE: DIX IPI UNIPARC: UPI0001B7A4C4 IPI UNIPARC: UPI00001266A1 IPI KEGG Report: rno:29134 ENTREZGENE HomoloGene Group ID: 3420 ENTREZGENE Germonline: 69259 Pfam: DIX IPI Pfam: Axin_b-cat_bind IPI Pfam: RGS IPI KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE InterPro: Regulat_G_prot_signal_superfam. IPI InterPro: Regulat_G_prot_signal. IPI InterPro: DIX. IPI InterPro: Axin_b-cat_bd. IPI IPI: IPI00951171 IPI IPI: IPI00196619 IPI Ensembl Protein: ENSRNOP00000004898 IPI Ensembl Protein: ENSRNOP00000063271 IPI Entrez Gene: Axin2 ENTREZGENE TIGR: TC230314 UniProt: AXN2_RAT IPI Ensembl Genes: ENSRNOG00000003612 IPI Superfamily-SCOP: Regulat_G_prot_signal_superfam IPI PRINTS: RGSPROTEIN. IPI
Sequences	Nucleotide: XM_001081593 Get FASTA Search GEO Profiles Nucleotide: NM_024355 Get FASTA Search GEO Profiles Nucleotide: CH473948 Get FASTA Search GEO Profiles Nucleotide: AF017757 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: O70240 Get FASTA Protein: AAC40089 Get FASTA Protein: NP_077331 Get FASTA Protein: XP_001081593 Get FASTA Protein: EDM06451 Get FASTA (View all 5 Protein Accessions)
Clusters	UniGene: 162212
References
Curated References	10 references in RGD related to Axin2
Other References	2 other references at PubMed related to Axin2
Database Information
RGD ID	69259
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Axin2 axin 2 APPROVED Name updated 70584