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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Axin2
Name: axin 2
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Axin2decreases expressionISOAXIN2 (Homo sapiens)6480464CTDNiclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 proteinPMID:22576131 PMID:24552774 PMID:24736023
Axin2multiple interactionsISOAXIN2 (Homo sapiens)6480464CTDNiclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]PMID:24534281
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