Pla2g6 (phospholipase A2 group VI) - Rat Genome Database

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Gene: Pla2g6 (phospholipase A2 group VI) Rattus norvegicus
Analyze
Symbol: Pla2g6
Name: phospholipase A2 group VI
RGD ID: 628867
Description: Enables several functions, including ATP-dependent protein binding activity; calcium-independent phospholipase A2 activity; and long-chain fatty acyl-CoA hydrolase activity. Involved in several processes, including cardiolipin acyl-chain remodeling; positive regulation of release of cytochrome c from mitochondria; and positive regulation of secretion. Predicted to be located in extracellular space. Predicted to be active in mitochondrion. Biomarker of pleurisy. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI); PARTICIPATES IN angiotensin II signaling pathway; alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; caI-PLA2; group VI phospholipase A2; GVI PLA2; intracellular membrane-associated calcium-independent phospholipase A2 beta; iPla2; iPLA2-beta; MGC93880; palmitoyl-CoA hydrolase; patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,731,803 - 112,771,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7112,731,803 - 112,771,609 (-)EnsemblGRCr8
mRatBN7.27110,851,378 - 110,891,557 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,851,378 - 110,891,114 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7112,600,016 - 112,639,830 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,823,550 - 114,863,364 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,792,914 - 114,832,727 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,519,479 - 120,559,716 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,519,467 - 120,559,347 (-)Ensemblrn6Rnor6.0
Rnor_5.07120,512,621 - 120,553,123 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47117,266,784 - 117,307,172 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7107,184,586 - 107,224,721 (-)NCBICelera
RGSC_v3.17117,301,013 - 117,341,212 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4',6-tetrachlorobiphenyl  (EXP)
2,6-dinitrotoluene  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Bromoenol lactone  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
fenvalerate  (EXP)
flutamide  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
KT 5720  (EXP)
lipopolysaccharide  (EXP)
methoxychlor  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. iPLA2ß knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology. Blanchard H, etal., Neurochem Res. 2014 Aug;39(8):1522-32. doi: 10.1007/s11064-014-1342-y. Epub 2014 Jun 12.
2. Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells. Bloch-Shilderman E, etal., J Pharmacol Exp Ther. 2002 Jun;301(3):953-62.
3. Gestation age-related increase in 50-kDa rat uterine calcium-independent phospholipase A2 expression influences uterine sensitivity to polychlorinated biphenyl stimulation. Brant K, etal., Biol Reprod. 2006 May;74(5):874-80. Epub 2006 Jan 25.
4. Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation. Carper MJ, etal., Biochemistry. 2008 Nov 18;47(46):12241-9. doi: 10.1021/bi800923s. Epub 2008 Oct 21.
5. The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats. Fevre C, etal., Biochim Biophys Acta. 2011 Jun;1811(6):409-17. Epub 2010 Dec 21.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. Gilroy DW, etal., FASEB J. 2004 Mar;18(3):489-98.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. PLA2G6 mutation underlies infantile neuroaxonal dystrophy. Khateeb S, etal., Am J Hum Genet. 2006 Nov;79(5):942-8. Epub 2006 Sep 19.
10. Possible involvement of Ca2+-independent phospholipase A2 in protease-activated receptor-2-mediated contraction of rat urinary bladder. Kubota Y, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):588-91. Epub 2003 May 15.
11. Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis. Lei X, etal., J Biol Chem. 2008 Dec 12;283(50):34819-32. Epub 2008 Oct 20.
12. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Lopez-Vales R, etal., Brain. 2008 Oct;131(Pt 10):2620-31. Epub 2008 Aug 21.
13. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. Lopez-Vales R, etal., FASEB J. 2011 Dec;25(12):4240-52. Epub 2011 Aug 25.
14. Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin. Ma Z, etal., J Biol Chem 1997 Apr 25;272(17):11118-27.
15. Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta. Ma Z, etal., J Biol Chem. 2001 Apr 20;276(16):13198-208. Epub 2001 Jan 22.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory. Schaeffer EL and Gattaz WF, Psychopharmacology (Berl). 2005 Sep;181(2):392-400. Epub 2005 Oct 14.
23. Calcium-independent phospholipase A(2)-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine. Seegers HC, etal., J Pharmacol Exp Ther. 2002 Sep;302(3):918-23.
24. Neuroaxonal dystrophy caused by group VIA phospholipase A2 deficiency in mice: a model of human neurodegenerative disease. Shinzawa K, etal., J Neurosci. 2008 Feb 27;28(9):2212-20.
25. R632W mutation in PLA2G6 segregates with dystonia-parkinsonism in a consanguineous Iranian family. Sina F, etal., Eur J Neurol. 2009 Jan;16(1):101-4.
26. Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry. Smani T, etal., J Biol Chem. 2003 Apr 4;278(14):11909-15. Epub 2003 Jan 23.
27. Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin. Song H, etal., J Biol Chem. 2010 Oct 29;285(44):33843-57. Epub 2010 Aug 23.
28. Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis. Song H, etal., J Biol Chem. 2014 May 16;289(20):14194-210. doi: 10.1074/jbc.M114.561910. Epub 2014 Mar 19.
29. Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission. St-Gelais F, etal., Hippocampus. 2004;14(3):319-25.
30. Proinflammatory treatment of astrocytes with lipopolysaccharide results in augmented Ca2+ signaling through increased expression of via phospholipase A2 (iPLA2). Strokin M, etal., Am J Physiol Cell Physiol. 2011 Mar;300(3):C542-9. Epub 2010 Dec 22.
31. Severe disturbance in the Ca2+ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6. Strokin M, etal., Hum Mol Genet. 2012 Apr 4.
32. Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation. Tajuddin NF, etal., Alcohol. 2013 Feb;47(1):39-45. doi: 10.1016/j.alcohol.2012.09.003. Epub 2012 Oct 25.
33. PLA2G6 variant in Parkinson's disease. Tomiyama H, etal., J Hum Genet. 2011 May;56(5):401-3. Epub 2011 Mar 3.
34. Establishment of an improved mouse model for infantile neuroaxonal dystrophy that shows early disease onset and bears a point mutation in Pla2g6. Wada H, etal., Am J Pathol. 2009 Dec;175(6):2257-63. Epub 2009 Nov 5.
35. Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells. Wang Z, etal., J Biol Chem. 2005 Feb 25;280(8):6840-9. Epub 2004 Dec 2.
36. Clinical study and PLA2G6 mutation screening analysis in Chinese patients with infantile neuroaxonal dystrophy. Wu Y, etal., Eur J Neurol. 2009 Feb;16(2):240-5. Epub 2008 Dec 9.
37. Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells. Xie Z, etal., J Biol Chem. 2007 Aug 31;282(35):25278-89. Epub 2007 Jul 5.
38. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles. Xie Z, etal., J Biol Chem. 2011 Dec 30;286(52):44646-58. Epub 2011 Nov 4.
39. Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism. Yoshino H, etal., Neurology. 2010 Oct 12;75(15):1356-61.
40. Follow-up study of 25 Chinese children with PLA2G6-associated neurodegeneration. Zhang P, etal., Eur J Neurol. 2013 Feb;20(2):322-30. doi: 10.1111/j.1468-1331.2012.03856.x. Epub 2012 Aug 31.
Additional References at PubMed
PMID:12089145   PMID:12477932   PMID:12928445   PMID:15052324   PMID:15630695   PMID:15908428   PMID:16407316   PMID:16603590   PMID:16818490   PMID:16854462   PMID:17267947   PMID:17475622  
PMID:17555549   PMID:17666570   PMID:17685585   PMID:17768607   PMID:17885217   PMID:18171998   PMID:18714013   PMID:19164547   PMID:19741254   PMID:20107037   PMID:20118407   PMID:20132906  
PMID:20406040   PMID:20886109   PMID:21037228   PMID:21094175   PMID:21116712   PMID:22218592   PMID:23533611   PMID:24586040   PMID:25925080   PMID:25979360   PMID:26206229   PMID:26632509  
PMID:27973457   PMID:29637744  


Genomics

Comparative Map Data
Pla2g6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,731,803 - 112,771,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7112,731,803 - 112,771,609 (-)EnsemblGRCr8
mRatBN7.27110,851,378 - 110,891,557 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,851,378 - 110,891,114 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7112,600,016 - 112,639,830 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,823,550 - 114,863,364 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,792,914 - 114,832,727 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,519,479 - 120,559,716 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,519,467 - 120,559,347 (-)Ensemblrn6Rnor6.0
Rnor_5.07120,512,621 - 120,553,123 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47117,266,784 - 117,307,172 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7107,184,586 - 107,224,721 (-)NCBICelera
RGSC_v3.17117,301,013 - 117,341,212 (-)NCBI
Cytogenetic Map7q34NCBI
PLA2G6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,111,495 - 38,181,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,111,495 - 38,214,778 (-)Ensemblhg38GRCh38
GRCh372238,507,502 - 38,577,837 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,837,448 - 36,907,707 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342236,832,002 - 36,902,261NCBI
Celera2222,312,199 - 22,382,453 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,473,858 - 21,543,900 (-)NCBIHuRef
CHM1_12238,466,463 - 38,536,813 (-)NCBICHM1_1
T2T-CHM13v2.02238,574,672 - 38,644,982 (-)NCBIT2T-CHM13v2.0
Pla2g6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,170,428 - 79,212,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,170,428 - 79,212,590 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381579,286,228 - 79,328,385 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,286,228 - 79,328,390 (-)Ensemblmm10GRCm38
MGSCv371579,116,658 - 79,158,598 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361579,113,483 - 79,155,423 (-)NCBIMGSCv36mm8
Celera1581,406,243 - 81,447,891 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
Pla2g6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,429,589 - 24,482,537 (-)Ensembl
ChiLan1.0NW_00495541324,431,592 - 24,482,229 (-)NCBIChiLan1.0ChiLan1.0
PLA2G6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,941,354 - 48,048,385 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,628,097 - 50,726,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,998,060 - 19,094,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,849,794 - 36,930,403 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,849,794 - 36,919,509 (-)EnsemblpanPan2panpan1.1
PanPan1.1 Ensembl2236,823,637 - 36,848,824 (-)EnsemblpanPan2panpan1.1
PLA2G6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,499,033 - 26,559,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,509,695 - 26,634,087 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1026,454,462 - 26,514,846 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01027,290,620 - 27,351,106 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,290,619 - 27,351,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,011,336 - 27,071,396 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,322,574 - 27,382,942 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,499,582 - 27,559,773 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pla2g6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,001,353 - 10,050,548 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,011,772 - 3,060,986 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,011,752 - 3,060,962 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,713,873 - 9,777,918 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.159,713,809 - 9,777,921 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,996,400 - 7,060,421 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,818,575 - 20,884,243 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045104,880,026 - 104,951,884 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,792,807 - 9,843,457 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247529,792,778 - 9,841,817 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pla2g6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,937,882 - 262,946,092 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pla2g6
225 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:79
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000016827, ENSRNOT00000017108
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
BE108691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,856,315 - 110,856,466 (+)MAPPERmRatBN7.2
Rnor_6.07120,524,416 - 120,524,566NCBIRnor6.0
Rnor_5.07120,517,558 - 120,517,708UniSTSRnor5.0
RGSC_v3.47117,271,722 - 117,271,872UniSTSRGSC3.4
Celera7107,189,524 - 107,189,674UniSTS
RH 3.4 Map7842.8UniSTS
Cytogenetic Map7q34UniSTS
RH141625  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,891,299 - 110,891,517 (+)MAPPERmRatBN7.2
Rnor_6.07120,559,459 - 120,559,676NCBIRnor6.0
Rnor_5.07120,552,866 - 120,553,083UniSTSRnor5.0
RGSC_v3.47117,307,284 - 117,307,501UniSTSRGSC3.4
Celera7107,224,833 - 107,225,050UniSTS
RH 3.4 Map7843.5UniSTS
Cytogenetic Map7q34UniSTS
BI275205  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,882,375 - 110,882,547 (+)MAPPERmRatBN7.2
Rnor_6.07120,550,535 - 120,550,706NCBIRnor6.0
Rnor_5.07120,543,942 - 120,544,113UniSTSRnor5.0
RGSC_v3.47117,298,360 - 117,298,531UniSTSRGSC3.4
Celera7107,215,906 - 107,216,077UniSTS
RH 3.4 Map7842.5UniSTS
Cytogenetic Map7q34UniSTS
BM382819  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,878,748 - 110,878,944 (+)MAPPERmRatBN7.2
Rnor_6.07120,546,908 - 120,547,103NCBIRnor6.0
Rnor_5.07120,540,315 - 120,540,510UniSTSRnor5.0
RGSC_v3.47117,294,733 - 117,294,928UniSTSRGSC3.4
Celera7107,212,279 - 107,212,474UniSTS
RH 3.4 Map7856.3UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC061866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016827   ⟹   ENSRNOP00000016827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,731,803 - 112,770,935 (-)Ensembl
mRatBN7.2 Ensembl7110,851,378 - 110,890,577 (-)Ensembl
Rnor_6.0 Ensembl7120,519,479 - 120,559,234 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000017108   ⟹   ENSRNOP00000017104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,731,805 - 112,763,331 (-)Ensembl
mRatBN7.2 Ensembl7110,851,378 - 110,882,917 (-)Ensembl
Rnor_6.0 Ensembl7120,519,481 - 120,559,347 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087344   ⟹   ENSRNOP00000072104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,731,803 - 112,771,609 (-)Ensembl
mRatBN7.2 Ensembl7110,851,385 - 110,891,114 (-)Ensembl
Rnor_6.0 Ensembl7120,519,467 - 120,558,805 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090565   ⟹   ENSRNOP00000075311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7120,519,479 - 120,559,157 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121906   ⟹   ENSRNOP00000108803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,731,803 - 112,771,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153317   ⟹   ENSRNOP00000100746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,731,805 - 112,763,331 (-)Ensembl
RefSeq Acc Id: NM_001005560   ⟹   NP_001005560
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,771,609 (-)NCBI
mRatBN7.27110,851,378 - 110,891,188 (-)NCBI
Rnor_6.07120,519,479 - 120,559,347 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
RGSC_v3.47117,266,784 - 117,307,172 (-)RGD
Celera7107,184,586 - 107,224,721 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270796   ⟹   NP_001257725
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,771,496 (-)NCBI
mRatBN7.27110,851,378 - 110,891,075 (-)NCBI
Rnor_6.07120,519,479 - 120,559,234 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Celera7107,184,586 - 107,224,608 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241997   ⟹   XP_006242059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,765,240 (-)NCBI
mRatBN7.27110,851,378 - 110,883,074 (-)NCBI
Rnor_6.07120,519,479 - 120,551,676 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241998   ⟹   XP_006242060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,770,897 (-)NCBI
mRatBN7.27110,851,378 - 110,890,483 (-)NCBI
Rnor_6.07120,519,479 - 120,558,730 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241999   ⟹   XP_006242061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,765,233 (-)NCBI
mRatBN7.27110,851,938 - 110,883,070 (-)NCBI
Rnor_6.07120,519,479 - 120,551,675 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242002   ⟹   XP_006242064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,771,978 (-)NCBI
mRatBN7.27110,851,378 - 110,891,557 (-)NCBI
Rnor_6.07120,519,479 - 120,559,716 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242003   ⟹   XP_006242065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,771,978 (-)NCBI
mRatBN7.27110,851,378 - 110,891,557 (-)NCBI
Rnor_6.07120,519,479 - 120,559,716 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242004   ⟹   XP_006242066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,771,562 (-)NCBI
mRatBN7.27110,851,378 - 110,891,141 (-)NCBI
Rnor_6.07120,519,479 - 120,559,289 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242005   ⟹   XP_006242067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,765,234 (-)NCBI
mRatBN7.27110,851,938 - 110,883,069 (-)NCBI
Rnor_6.07120,519,479 - 120,551,675 (-)NCBI
Rnor_5.07120,512,621 - 120,553,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765757   ⟹   XP_008763979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,765,240 (-)NCBI
mRatBN7.27110,851,378 - 110,883,073 (-)NCBI
Rnor_6.07120,519,479 - 120,551,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079362   ⟹   XP_038935290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,742,546 - 112,765,265 (-)NCBI
mRatBN7.27110,861,609 - 110,883,882 (-)NCBI
RefSeq Acc Id: XM_039079363   ⟹   XP_038935291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,741,886 - 112,765,256 (-)NCBI
mRatBN7.27110,861,464 - 110,883,871 (-)NCBI
RefSeq Acc Id: XM_063263693   ⟹   XP_063119763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,770,897 (-)NCBI
RefSeq Acc Id: XM_063263694   ⟹   XP_063119764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,770,918 (-)NCBI
RefSeq Acc Id: XM_063263695   ⟹   XP_063119765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,731,803 - 112,771,032 (-)NCBI
RefSeq Acc Id: XM_063263696   ⟹   XP_063119766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,742,546 - 112,765,259 (-)NCBI
RefSeq Acc Id: XR_005486652
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,741,959 - 112,765,258 (-)NCBI
mRatBN7.27110,861,532 - 110,883,873 (-)NCBI
RefSeq Acc Id: NP_001005560   ⟸   NM_001005560
- Peptide Label: isoform 1
- UniProtKB: Q66HD1 (UniProtKB/Swiss-Prot),   P97570 (UniProtKB/Swiss-Prot),   G3V7M8 (UniProtKB/Swiss-Prot),   A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257725   ⟸   NM_001270796
- Peptide Label: isoform 2
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242064   ⟸   XM_006242002
- Peptide Label: isoform X4
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242065   ⟸   XM_006242003
- Peptide Label: isoform X4
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242066   ⟸   XM_006242004
- Peptide Label: isoform X4
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242060   ⟸   XM_006241998
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242067   ⟸   XM_006242005
- Peptide Label: isoform X7
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242059   ⟸   XM_006241997
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242061   ⟸   XM_006241999
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q8G5 (UniProtKB/TrEMBL),   A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763979   ⟸   XM_008765757
- Peptide Label: isoform X5
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075311   ⟸   ENSRNOT00000090565
Ensembl Acc Id: ENSRNOP00000072104   ⟸   ENSRNOT00000087344
Ensembl Acc Id: ENSRNOP00000016827   ⟸   ENSRNOT00000016827
Ensembl Acc Id: ENSRNOP00000017104   ⟸   ENSRNOT00000017108
RefSeq Acc Id: XP_038935291   ⟸   XM_039079363
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038935290   ⟸   XM_039079362
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063119765   ⟸   XM_063263695
- Peptide Label: isoform X9
- UniProtKB: Q66HD1 (UniProtKB/Swiss-Prot),   P97570 (UniProtKB/Swiss-Prot),   G3V7M8 (UniProtKB/Swiss-Prot),   A0A8L2R578 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119764   ⟸   XM_063263694
- Peptide Label: isoform X8
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL),   A0A8L2Q8C9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119763   ⟸   XM_063263693
- Peptide Label: isoform X6
- UniProtKB: A0A8L2R578 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119766   ⟸   XM_063263696
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000108803   ⟸   ENSRNOT00000121906
Ensembl Acc Id: ENSRNOP00000100746   ⟸   ENSRNOT00000153317
Protein Domains
PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97570-F1-model_v2 AlphaFold P97570 1-807 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695482
Promoter ID:EPDNEW_R6004
Type:initiation region
Name:Pla2g6_1
Description:phospholipase A2 group VI
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07120,559,198 - 120,559,258EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628867 AgrOrtholog
BioCyc Gene G2FUF-32765 BioCyc
Ensembl Genes ENSRNOG00000012295 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016827 ENTREZGENE
  ENSRNOT00000017108 ENTREZGENE
  ENSRNOT00000087344 ENTREZGENE
  ENSRNOT00000121906 ENTREZGENE
  ENSRNOT00000153317 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  Cytosolic phospholipase A2 catalytic domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112407 IMAGE-MGC_LOAD
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot
  Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  PLPL9 UniProtKB/Swiss-Prot
  PNPLA_dom UniProtKB/Swiss-Prot
KEGG Report rno:360426 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93880 IMAGE-MGC_LOAD
NCBI Gene Pla2g6 ENTREZGENE
PANTHER 85/88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 UniProtKB/Swiss-Prot
  CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  Patatin UniProtKB/Swiss-Prot
PhenoGen Pla2g6 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  PNPLA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012295 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
  SSF52151 UniProtKB/Swiss-Prot
UniProt A0A8L2Q8C9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q8G5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R578 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LGY9_RAT UniProtKB/TrEMBL
  A0ABK0LV00_RAT UniProtKB/TrEMBL
  G3V7M8 ENTREZGENE
  P97570 ENTREZGENE, UniProtKB/Swiss-Prot
  Q66HD1 ENTREZGENE
UniProt Secondary G3V7M8 UniProtKB/Swiss-Prot
  Q66HD1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pla2g6  phospholipase A2 group VI  Pla2g6  phospholipase A2, group VI (cytosolic, calcium-independent)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pla2g6  phospholipase A2, group VI (cytosolic, calcium-independent)  Pla2g6  phospholipase A2, group VI  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pla2g6  phospholipase A2, group VI      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Pla2g6  phospholipase A2, group VI      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains amino acid residues 150-414 contain a domain that is homologous to tubulin binding and integral membrane protein binding domains of ankyrin 729507