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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pla2g6
Name: phospholipase A2 group VI
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pla2g6affects response to substanceEXP 6480464CTDPLA2G6 protein affects the susceptibility to ThapsigarginPMID:17885217
Pla2g6increases activityEXP 6480464CTDThapsigargin results in increased activity of PLA2G6 proteinPMID:17885217
Pla2g6increases expressionEXP 6480464CTDThapsigargin results in increased expression of PLA2G6 proteinPMID:25762722
Pla2g6multiple interactionsEXP 6480464CTDPLA2G6 mutant form inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; UCN protein inhibits the reaction [Thapsigargin results in increased activity of PLA2G6 protein]PMID:17885217 PMID:25762722
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