Gene:	Akt3 ( Rattus norvegicus ) v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Description:	kinase that associates with both protein kinase C subspecies and beta gamma subunits of G proteins
Synonyms:	thymoma viral proto-oncogene 3 ; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma); thymoma viral proto-oncogene 3; Pkbg;
ArrayIDs:	D49836_at; 1387592_at;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: AKT3     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Akt3     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Akt3 genome assembly 3.1 13 93002743 - 93299588     Rat Celera Assembly 13 88534573 - 88791412     RGSC genome assembly v3.4 13 92813860 - 93110704     Cytogenetic 13 q24-q26 Mus musculus Akt3 Mouse genome assembly build 36.1 1 178952247 - 179178898     Cytogenetic 1 1 H4-H6 Homo sapiens AKT3 human genome assembly 1 239977575 - 240332594     Human genome assembly build 36.2 1 241718158 - 242073176     Cytogenetic 1 q43-q44   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference capable of phosphorylating several known proteins 724707 Gene Ontology protein binding,  nucleotide binding,  ATP binding ...  (details...)
Biological Process	Gene Ontology protein amino acid phosphorylation,  cellular response to insulin stimulus,  positive regulation of sodium ion transport (details...)
Cellular Component	Gene Ontology soluble fraction,  nucleoplasm,  cytosol (details...)
Pathway	Ontology altered phosphatodylinositol 3-kinase-Akt signaling pathway,  phosphatidylinositol 3-kinase-Akt signaling pathway (details...)
Regulation	Note Reference activated by igf-1, which may play a role in regulating cell survival. 724707
External Links
Databases	DATABASE ID SOURCE SMART: PH IPI SMART: S_TK_X IPI SMART: S_TKc IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PH_DOMAIN IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: AGC_KINASE_CTER IPI PROSITE: PROTEIN_KINASE_ST IPI UNIPARC: UPI0000E825E0 IPI UNIPARC: UPI0001B7A672 IPI KEGG Report: rno:29414 ENTREZGENE HomoloGene Group ID: 55904 ENTREZGENE Germonline: 62390 Pfam: Pkinase_C IPI Pfam: Pkinase IPI Pfam: PH IPI KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04150 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04530 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 05218 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE InterPro: Kinase-like_dom. IPI InterPro: AGC-kinase_C. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Serine/threonine_Kinase_Rac. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Protein_kinase_ATP_BS. IPI InterPro: Pkinase_C. IPI InterPro: Pleckstrin_homology. IPI IPI: IPI00209156 IPI IPI: IPI00782206 IPI Ensembl Protein: ENSRNOP00000054688 IPI Ensembl Protein: ENSRNOP00000031636 IPI Entrez Gene: Akt3 ENTREZGENE UniProt: AKT3_RAT IPI Ensembl Genes: ENSRNOG00000021497 IPI Superfamily-SCOP: Kinase_like IPI PANTHER: Akt IPI
Sequences	Nucleotide: D49836 Get FASTA Search GEO Profiles Nucleotide: NM_031575 Get FASTA Search GEO Profiles Nucleotide: CH473985 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: NP_113763 Get FASTA Protein: EDL94786 Get FASTA Protein: BAA08637 Get FASTA Protein: Q63484 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 10506
References
Curated References	9 references in RGD related to Akt3
Other References	7 other references at PubMed related to Akt3
Database Information
RGD ID	62390
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 26-SEP-08: Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) Akt3 thymoma viral proto-oncogene 3 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-JUN-02: Akt3 thymoma viral proto-oncogene 3 APPROVED Name updated 70584