Timp1 (TIMP metallopeptidase inhibitor 1) - Rat Genome Database

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Gene: Timp1 (TIMP metallopeptidase inhibitor 1) Rattus norvegicus
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Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
RGD ID: 621675
Description: Enables protease binding activity. Involved in several processes, including cartilage development; cellular response to peptide; and response to peptide hormone. Located in basement membrane. Used to study degenerative disc disease. Biomarker of several diseases, including gastric ulcer; heart disease (multiple); lung disease (multiple); metabolic dysfunction-associated steatohepatitis; and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1); PARTICIPATES IN interleukin-6 signaling pathway; INTERACTS WITH (R)-carnitine; (S)-colchicine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: metalloproteinase inhibitor 1; Timp; TIMP-1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,766,509 - 3,772,578 (-)NCBIGRCr8
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Timp1Ratadrenoleukodystrophy severityISOTIMP1 (Homo sapiens)13204814protein:increased expression:cerebrospinal fluidRGD 
Timp1Ratatherosclerosis amelioratesISOTimp1 (Mus musculus)242905202 RGD 
Timp1RatBrain Injuries  IEP 2290468mRNA:increased expression:brain and astrocytesRGD 
Timp1Ratbreast cancer disease_progressionISOTIMP1 (Homo sapiens)2290345mRNA and protein:increased expression:breastRGD 
Timp1Ratbreast cancer disease_progressionISOTIMP1 (Homo sapiens)2290348mRNA and protein:increased expression:breastRGD 
Timp1Ratbreast cancer disease_progressionISOTIMP1 (Homo sapiens)2290343protein:increased expression:serumRGD 
Timp1RatCAKUT2 treatmentISOTIMP1 (Homo sapiens)13204792 RGD 
Timp1Ratcholestasis  IEP 2290364 RGD 
Timp1Ratchronic obstructive pulmonary disease treatmentIEP 13207319 RGD 
Timp1Ratcongestive heart failure  IEP 2290467protein:increased expression:heart left ventricleRGD 
Timp1RatCOVID-19  ISOTIMP1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Timp1Ratcystic fibrosis  ISOTIMP1 (Homo sapiens)13204794protein:increased expression:serumRGD 
Timp1Ratdegenerative disc disease treatmentIDA 10043178associated with Renal InsufficiencyRGD 
Timp1Ratdiabetes mellitus  ISOTIMP1 (Homo sapiens)2312464protein:decreased expression:glomerulusRGD 
Timp1RatDown syndrome  ISOTIMP1 (Homo sapiens)13204810 RGD 
Timp1RatEmphysema treatmentIEP 13207325 RGD 
Timp1Ratendometrial carcinoma disease_progressionISOTIMP1 (Homo sapiens)2298523protein:increased expression:endometriumRGD 
Timp1RatExperimental Diabetes Mellitus  IEP 2290354protein:increased expression:kidneyRGD 
Timp1RatExperimental Diabetes Mellitus  ISOTIMP1 (Homo sapiens)2312467 RGD 
Timp1RatExperimental Liver Cirrhosis  IEP 2290364mRNA:increased expression:liverRGD 
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Timp1Ratautistic disorder  ISOTIMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Timp1Ratcongenital disorder of glycosylation type IIm  ISOTIMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 22ClinVarPMID:28492532
Timp1Ratimmune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  ISOTIMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Insulin-dependent diabetes mellitus secretory diarrhea syndromeClinVarPMID:11137992 more ...
Timp1Ratneurodegeneration with brain iron accumulation 5  ISOTIMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Beta-propeller protein-associated neurodegenerationClinVarPMID:28492532
Timp1Ratsyndromic X-linked intellectual disability Lubs type  ISOTIMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
Timp1RatX-linked epilepsy with variable learning disabilities and behavior disorders  ISOTIMP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14985377 more ...
Timp1RatX-linked severe congenital neutropenia  ISOTIMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: X-linked severe congenital neutropeniaClinVarPMID:10698340 more ...
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Timp1Ratadult respiratory distress syndrome  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
Timp1Ratalcoholic liver cirrhosis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23274713
Timp1RatAnimal Disease Models  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21051829
Timp1Rataortic valve insufficiency  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21216836
Timp1Ratautoimmune disease  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
Timp1Ratcalcinosis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
Timp1Ratcholangitis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
Timp1RatExperimental Diabetes Mellitus  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21963884
Timp1RatExperimental Liver Cirrhosis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16507762 more ...
Timp1Ratextrahepatic cholestasis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
Timp1RatFemale Urogenital Diseases  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16002989
Timp1Ratheart disease  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23558518
Timp1Ratheart valve disease  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
Timp1Rathypertension  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21051829
Timp1RatIgA glomerulonephritis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25133636
Timp1RatInflammation  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17569694
Timp1RatNeoplasm Invasiveness  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:1318976
Timp1Ratoral submucous fibrosis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16311067
Timp1Ratpulmonary fibrosis  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21468558
Timp1Rattype 2 diabetes mellitus  ISOTIMP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16023759
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Timp1Rat(-)-demecolcine increases expressionISOTIMP1 (Homo sapiens)6480464Demecolcine results in increased expression of TIMP1 mRNACTDPMID:23649840
Timp1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOTimp1 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]CTDPMID:20438794
Timp1Rat(1->4)-beta-D-glucan multiple interactionsISOTimp1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TIMP1 mRNACTDPMID:36331819
Timp1Rat(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid multiple interactionsISOTimp1 (Mus musculus)6480464argatroban inhibits the reaction [Dietary Fats results in increased expression of TIMP1 mRNA]CTDPMID:22841818
Timp1Rat(R)-carnitine multiple interactionsEXP 6480464Carnitine inhibits the reaction [sunitinib results in increased expression of TIMP1 mRNA]CTDPMID:26581635
Timp1Rat(S)-colchicine increases expressionEXP 6480464Colchicine results in increased expression of TIMP1 mRNACTDPMID:20624997
Timp1Rat(S)-nicotine multiple interactionsISOTIMP1 (Homo sapiens)6480464[Nicotine co-treated with lipopolysaccharide and E. coli O26-B6] affects the expression of TIMP1 mRNACTDPMID:18986645
Timp1Rat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of TIMP1 mRNACTDPMID:34153408
Timp1Rat(S)-nicotine affects expressionISOTIMP1 (Homo sapiens)6480464Nicotine affects the expression of TIMP1 mRNACTDPMID:18986645
Timp1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionISOTIMP1 (Homo sapiens)6480464o and p'-DDT results in decreased expression of TIMP1 mRNACTDPMID:26225806
Timp1Rat1,1-dichloroethene increases expressionISOTimp1 (Mus musculus)6480464vinylidene chloride results in increased expression of TIMP1 mRNACTDPMID:26682919
Timp1Rat1,2,4-trimethylbenzene increases expressionEXP 6480464pseudocumene results in increased expression of TIMP1 proteinCTDPMID:17337753
Timp1Rat1,2-dimethylhydrazine increases expressionISOTimp1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of TIMP1 mRNACTDPMID:22206623
Timp1Rat1,3,5-trinitro-1,3,5-triazinane increases expressionEXP 6480464cyclonite results in increased expression of TIMP1 mRNACTDPMID:25559034
Timp1Rat1-chloro-2,4-dinitrobenzene affects expressionISOTimp1 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of TIMP1 mRNACTDPMID:22302311
Timp1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of TIMP1 mRNACTDPMID:17522070 more ...
Timp1Rat1-naphthyl isothiocyanate multiple interactionsISOTimp1 (Mus musculus)6480464F2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA] more ...CTDPMID:21037076 and PMID:24633426
Timp1Rat1-naphthyl isothiocyanate increases expressionISOTimp1 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA and 1-Naphthylisothiocyanate results in increased expression of TIMP1 proteinCTDPMID:21037076 more ...
Timp1Rat1-octadec-9-enoylglycero-3-phosphate multiple interactionsISOTimp1 (Mus musculus)64804643-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of TIMP1 protein]CTDPMID:25822713
Timp1Rat1-octadec-9-enoylglycero-3-phosphate increases expressionISOTimp1 (Mus musculus)6480464lysophosphatidic acid results in increased expression of TIMP1 proteinCTDPMID:25822713

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Biological Process
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Timp1Ratcartilage development  IEP 8694091 RGD 
Timp1Ratcellular response to peptide  IEP 2290355 RGD 
Timp1Ratcellular response to UV-A involved_inISSUniProtKB:P010331600115GO_REF:0000024UniProtGO_REF:0000024
Timp1Ratcellular response to UV-A involved_inIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratcellular response to UV-A involved_inISOTIMP1 (Homo sapiens)1624291 PMID:31380578RGDPMID:31380578
Timp1Ratconnective tissue replacement involved in inflammatory response wound healing acts_upstream_of_or_withinISOTimp1 (Mus musculus)1624291 PMID:23100531RGDPMID:23100531
Timp1Ratconnective tissue replacement involved in inflammatory response wound healing acts_upstream_of_or_withinIEAUniProtKB:P12032 and ensembl:ENSMUSP000001109991600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratnegative regulation of apoptotic process  IMP 1580121 RGD 
Timp1Ratnegative regulation of catalytic activity involved_inISSUniProtKB:P010331600115GO_REF:0000024UniProtGO_REF:0000024
Timp1Ratnegative regulation of catalytic activity involved_inISOTIMP1 (Homo sapiens)1624291 PMID:3903517RGDPMID:3903517
Timp1Ratnegative regulation of endopeptidase activity involved_inISSUniProtKB:P010331600115GO_REF:0000024UniProtGO_REF:0000024
Timp1Ratnegative regulation of endopeptidase activity involved_inISOTIMP1 (Homo sapiens)1624291 PMID:3903517RGDPMID:3903517
Timp1Ratnegative regulation of membrane protein ectodomain proteolysis involved_inISOTIMP1 (Homo sapiens)1624291 PMID:12714508RGDPMID:12714508
Timp1Ratnegative regulation of membrane protein ectodomain proteolysis involved_inIBAPANTHER:PTN000931945 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Timp1Ratnegative regulation of membrane protein ectodomain proteolysis involved_inIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratnegative regulation of metallopeptidase activity involved_inISOTIMP1 (Homo sapiens)1624291 PMID:9573338RGDPMID:9573338
Timp1Ratnegative regulation of trophoblast cell migration involved_inISOTIMP1 (Homo sapiens)1624291 PMID:21356369RGDPMID:21356369
Timp1Ratnegative regulation of trophoblast cell migration involved_inIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratpositive regulation of cell population proliferation involved_inISSUniProtKB:P010331600115GO_REF:0000024UniProtGO_REF:0000024
Timp1Ratpositive regulation of cell population proliferation involved_inIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Timp1Ratbasement membrane  IDA 2290365 RGD 
Timp1Ratbasement membrane located_inIEAUniProtKB:P12032 and ensembl:ENSMUSP000001109991600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratbasement membrane located_inISOTimp1 (Mus musculus)1624291 PMID:12950084RGDPMID:12950084
Timp1Ratextracellular matrix located_inISOTimp1 (Mus musculus)1624291 PMID:12950084RGDPMID:12950084
Timp1Ratextracellular matrix is_active_inIBAMGI:98752 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Timp1Ratextracellular matrix located_inIEAUniProtKB:P12032 and ensembl:ENSMUSP000001109991600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Timp1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Timp1Ratextracellular space located_inISSUniProtKB:P010331600115GO_REF:0000024UniProtGO_REF:0000024
Timp1Ratextracellular space located_inIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratextracellular space is_active_inIBAPANTHER:PTN000931945 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Timp1Ratextracellular space located_inISOTIMP1 (Homo sapiens)1624291 PMID:3903517RGDPMID:3903517
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Molecular Function
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Timp1Ratcytokine activity enablesISSUniProtKB:P010331600115GO_REF:0000024UniProtGO_REF:0000024
Timp1Ratcytokine activity enablesIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratcytokine activity enablesISOTIMP1 (Homo sapiens)1624291 PMID:3839290RGDPMID:3839290
Timp1Ratenzyme inhibitor activity enablesIEAUniProtKB-KW:KW-04811600115GO_REF:0000043UniProtGO_REF:0000043
Timp1Ratgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043
Timp1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Timp1Ratmetalloendopeptidase inhibitor activity  TAS 730067 RGD 
Timp1Ratmetalloendopeptidase inhibitor activity enablesIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratmetalloendopeptidase inhibitor activity enablesIEAInterPro:IPR0018201600115GO_REF:0000002InterProGO_REF:0000002
Timp1Ratmetalloendopeptidase inhibitor activity enablesIBAFB:FBgn0025879 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Timp1Ratmetalloendopeptidase inhibitor activity enablesISOTIMP1 (Homo sapiens)1624291 PMID:12714508 and PMID:3903517RGDPMID:12714508 and PMID:3903517
Timp1Ratmetalloendopeptidase inhibitor activity enablesISSUniProtKB:P010331600115GO_REF:0000024UniProtGO_REF:0000024
Timp1Ratpeptidase inhibitor activity enablesISOTIMP1 (Homo sapiens)1624291 PMID:9573338RGDPMID:9573338
Timp1Ratpeptidase inhibitor activity enablesIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
Timp1Ratpeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-0483 and UniProtKB-KW:KW-06461600115GO_REF:0000043UniProtGO_REF:0000043
Timp1Ratprotease binding  IPIMmp1 (Rattus norvegicus)7207284 RGD 
Timp1Ratprotein binding enablesIPIUniProtKB:P9815813210547PMID:28659595UniProt 
Timp1Ratprotein binding enablesISOTIMP1 (Homo sapiens)1624291UniProtKB:P08962 more ...RGDPMID:16917503 more ...
Timp1Ratzinc ion binding enablesISOTIMP1 (Homo sapiens)1624291 PMID:22427646RGDPMID:22427646
Timp1Ratzinc ion binding enablesIEAUniProtKB:P01033 and ensembl:ENSP000002183881600115GO_REF:0000107EnsemblGO_REF:0000107
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Imported Annotations - PID (archival)

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Timp1Ratinterleukin-6 signaling pathway   ISOTIMP1 (Homo sapiens)6484113 PIDPID:200146

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Reference Title
Reference Citation
1. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
2. Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment. Avolio C, etal., Mult Scler. 2005 Aug;11(4):441-6.
3. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing-remitting multiple sclerosis treated with interferon beta. Boz C, etal., Clin Neurol Neurosurg. 2006 Feb;108(2):124-8.
4. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
5. ANG II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo. Castoldi G, etal., Am J Physiol Heart Circ Physiol 2003 Feb;284(2):H635-43.
6. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Chua PK, etal., Clin Diagn Lab Immunol. 2003 Mar;10(2):308-14.
7. Localization of preovulatory expression of plasminogen activator inhibitor type-1 and tissue inhibitor of metalloproteinase type-1 mRNAs in the rat ovary. Chun SY, etal., Biol Reprod. 1992 Aug;47(2):245-53.
8. Glomerular Protein Levels of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 Are Lower in Diabetic Subjects. Cornish TC, etal., J Histochem Cytochem. 2009 Jun 8.
9. Cellular localization of tissue inhibitors of metalloproteinases in the rat ovary throughout pseudopregnancy. Curry TE Jr and Wheeler SE, Biol Reprod 2002 Dec;67(6):1943-51.
10. Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. Dagues N, etal., Toxicol Sci. 2007 Nov;100(1):238-47. Epub 2007 Jun 14.
11. Metallothionein-1 messenger RNA transcription in steroid-secreting cells of the rat ovary during the periovulatory period. Espey LL, etal., Biol Reprod 2003 May;68(5):1895-902.
12. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
13. [Metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 levels in children and adolescents with type 1 diabetes.] Florys B, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(3):184-9.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents. Glowinska-Olszewska B and Urban M, Metabolism. 2007 Jun;56(6):799-805.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative intent. Gouyer V, etal., Cancer. 2005 Apr 15;103(8):1676-84.
18. [Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma] Guo W, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Oct;37(10):604-7.
19. Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. Handy JA, etal., Biochem J. 2011 Dec 15;440(3):385-95. doi: 10.1042/BJ20102148.
20. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Heymans S, etal., Circulation. 2005 Aug 23;112(8):1136-44. Epub 2005 Aug 15.
1 to 20 of 84 rows
PMID:1309971   PMID:3839290   PMID:3903517   PMID:7777858   PMID:7926820   PMID:8559663   PMID:9573338   PMID:11860503   PMID:12477932   PMID:12631082   PMID:12714508   PMID:12826691  
PMID:12882763   PMID:12950084   PMID:14695775   PMID:15051730   PMID:15052653   PMID:15300910   PMID:15451430   PMID:15609084   PMID:15793858   PMID:15968723   PMID:16183640   PMID:16191269  
PMID:16488444   PMID:16707552   PMID:16718785   PMID:16762003   PMID:16917503   PMID:16931573   PMID:17033093   PMID:17210139   PMID:17485851   PMID:18000599   PMID:18095594   PMID:18279587  
PMID:18390195   PMID:18471418   PMID:18509851   PMID:18636553   PMID:18675881   PMID:18678246   PMID:18807189   PMID:19184368   PMID:19235898   PMID:19272247   PMID:19330523   PMID:19462901  
PMID:19467832   PMID:19497125   PMID:19537852   PMID:19917734   PMID:20226641   PMID:20388475   PMID:20854798   PMID:20939987   PMID:21180139   PMID:21319376   PMID:21356369   PMID:21468558  
PMID:21535944   PMID:21782897   PMID:21895415   PMID:22092673   PMID:22218048   PMID:22427646   PMID:22449799   PMID:23100531   PMID:23142791   PMID:23207149   PMID:23376485   PMID:23456624  
PMID:23493620   PMID:23500774   PMID:23533145   PMID:23819982   PMID:23886643   PMID:23974514   PMID:24006456   PMID:24322055   PMID:24471921   PMID:24560960   PMID:25028660   PMID:25575598  
PMID:25697011   PMID:25867313   PMID:26087281   PMID:26252163   PMID:26258010   PMID:26277580   PMID:27320964   PMID:27322513   PMID:27323108   PMID:27339256   PMID:28220578   PMID:28259914  
PMID:28506758   PMID:29158549   PMID:29302675   PMID:30121936   PMID:31099017   PMID:31200003   PMID:32122211   PMID:32194232   PMID:32570968   PMID:33355364   PMID:37700105   PMID:38499842  



Timp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,766,509 - 3,772,578 (-)NCBIGRCr8
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
TIMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,582,436 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBIT2T-CHM13v2.0
Timp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,524 - 20,740,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)EnsemblGRCm39 Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBIMGSCv36mm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
Timp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516505,789 - 512,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516507,113 - 511,360 (-)NCBIChiLan1.0ChiLan1.0
TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,208,573 - 49,213,215 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,212,076 - 49,216,587 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,018,190 - 40,022,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,914,906 - 47,919,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,914,906 - 47,919,419 (+)Ensemblpanpan1.1panPan2
TIMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBIUU_Cfam_GSD_1.0
Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,345,832 - 13,350,248 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,102,172 - 42,106,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,103,251 - 42,106,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,372,604 - 47,375,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
LOC103231892
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,759,412 - 44,763,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,760,531 - 44,765,571 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656624,012 - 27,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978121,803 - 124,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978120,723 - 125,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Timp1
6 total Variants

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000013745
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat

AA957593  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8458,571,228 - 58,571,436 (+)Marker Load Pipeline
mRatBN7.2457,605,811 - 57,606,019 (+)MAPPERmRatBN7.2
Rnor_6.0456,283,244 - 56,283,451NCBIRnor6.0
Rnor_5.0456,030,613 - 56,030,820UniSTSRnor5.0
RGSC_v3.4455,873,680 - 55,873,887UniSTSRGSC3.4
Celera452,717,188 - 52,717,395UniSTS
RH 3.4 Map4307.2UniSTS
Cytogenetic MapXq12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 21 of 21 rows
RefSeq Transcripts NM_053819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF411319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L31883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000013745   ⟹   ENSRNOP00000013745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)Ensembl
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)Ensembl
RefSeq Acc Id: NM_053819   ⟹   NP_446271
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,766,524 - 3,771,122 (-)NCBI
mRatBN7.2X1,212,984 - 1,217,582 (-)NCBI
Rnor_6.0X1,364,786 - 1,369,384 (-)NCBI
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBI
RGSC_v3.4X12,542,496 - 12,547,094 (-)RGD
CeleraX1,780,586 - 1,785,184 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256608   ⟹   XP_006256670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,766,509 - 3,772,578 (-)NCBI
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBI
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBI
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099406   ⟹   XP_038955334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,766,509 - 3,771,251 (-)NCBI
mRatBN7.2X1,212,969 - 1,217,669 (-)NCBI
RefSeq Acc Id: XM_039099407   ⟹   XP_038955335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,766,509 - 3,771,208 (-)NCBI
mRatBN7.2X1,212,969 - 1,217,655 (-)NCBI
RefSeq Acc Id: NP_446271   ⟸   NM_053819
- Peptide Label: precursor
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256670   ⟸   XM_006256608
- Peptide Label: isoform X1
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013745   ⟸   ENSRNOT00000013745
RefSeq Acc Id: XP_038955334   ⟸   XM_039099406
- Peptide Label: isoform X1
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955335   ⟸   XM_039099407
- Peptide Label: isoform X1
- UniProtKB: P70533 (UniProtKB/Swiss-Prot),   P30120 (UniProtKB/Swiss-Prot),   Q53YM7 (UniProtKB/Swiss-Prot),   A6JZR1 (UniProtKB/TrEMBL)
NTR

Name Modeler Protein Id AA Range Protein Structure
AF-P30120-F1-model_v2 AlphaFold P30120 1-217 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701691
Promoter ID:EPDNEW_R12215
Type:multiple initiation site
Name:Timp1_1
Description:TIMP metallopeptidase inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X1,369,397 - 1,369,457EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3199 BioCyc
Ensembl Genes ENSRNOG00000010208 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013745 ENTREZGENE
  ENSRNOT00000013745.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  3.90.370.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930800 IMAGE-MGC_LOAD
InterPro Netrin_domain UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
  TIMP_C UniProtKB/Swiss-Prot
  TIMP_CS UniProtKB/Swiss-Prot
KEGG Report rno:116510 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124582 IMAGE-MGC_LOAD
NCBI Gene 116510 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot
  PTHR11844:SF20 UniProtKB/Swiss-Prot
Pfam TIMP UniProtKB/Swiss-Prot
PhenoGen Timp1 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010208 RatGTEx
SMART NTR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
UniProt A6JZR1 ENTREZGENE, UniProtKB/TrEMBL
  P30120 ENTREZGENE
  P70533 ENTREZGENE
  Q53YM7 ENTREZGENE
  TIMP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P70533 UniProtKB/Swiss-Prot
  Q53YM7 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Timp1  TIMP metallopeptidase inhibitor 1  Timp1  tissue inhibitor of metalloproteinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Timp1  tissue inhibitor of metalloproteinase 1  Timp1  tissue inhibitor of metallopeptidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-06-29   tissue inhibitor of metallopeptidase 1  Timp1  tissue inhibitor of metalloproteinase 1  Name updated 1299863 APPROVED
2004-09-10 Timp1  tissue inhibitor of metalloproteinase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Timp1  tissue inhibitor of metalloproteinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_regulation mRNA expression increases in response to angiotensin II 730067