Cx3cl1 (C-X3-C motif chemokine ligand 1) - Rat Genome Database

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Gene: Cx3cl1 (C-X3-C motif chemokine ligand 1) Rattus norvegicus
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Symbol: Cx3cl1
Name: C-X3-C motif chemokine ligand 1
RGD ID: 620458
Description: Enables chemokine activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell population proliferation; and regulation of signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and perinuclear region of cytoplasm. Used to study acute pancreatitis; ischemia; and status epilepticus. Biomarker of several diseases, including borna disease; brain disease (multiple); liver disease (multiple); lung disease (multiple); and pulmonary hypertension. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; Cx3c; CX3C membrane-anchored chemokine; fractalkine; neurotactin; Scyd1; small inducible cytokine subfamily D 1; small inducible cytokine subfamily D, 1; small-inducible cytokine D1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,233,326 - 10,244,856 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1910,233,329 - 10,242,999 (-)EnsemblGRCr8
mRatBN7.21910,227,337 - 10,237,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,227,340 - 10,236,833 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,190,578 - 10,200,058 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,957,425 - 10,966,906 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,244,371 - 10,253,854 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,644,267 - 10,654,861 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,644,244 - 10,653,800 (-)Ensemblrn6Rnor6.0
Rnor_5.01910,638,466 - 10,647,951 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41910,666,940 - 10,676,424 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,113,300 - 10,122,786 (-)NCBICelera
RGSC_v3.11910,671,765 - 10,681,250 (-)NCBI
Cytogenetic Map19p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2-acetamidofluorene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dichloroaniline  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
aripiprazole  (ISO)
Aristolactam I  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
ceric oxide  (EXP)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicyclanil  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzacamene  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
gentamycin  (EXP)
glucose  (ISO)
graphene oxide  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mechlorethamine  (EXP)
methadone  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
morphine  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
naproxen  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
organophosphorus compound  (EXP)
ozone  (EXP,ISO)
p-cresol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sotorasib  (ISO)
sterigmatocystin  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
autocrine signaling  (IGI)
cell adhesion  (IEA,ISO)
cell chemotaxis  (IEA,ISO)
cell-cell adhesion  (IDA)
cellular response to tumor necrosis factor  (IDA)
chemokine-mediated signaling pathway  (IBA,IGI,ISO)
chemotaxis  (IDA,IEA,IGI,ISO)
cytokine-mediated signaling pathway  (ISO)
eosinophil chemotaxis  (IBA)
G protein-coupled receptor signaling pathway  (IGI)
immune response  (IEA)
inflammatory response  (IBA,IEA)
inhibitory postsynaptic potential  (IMP)
integrin activation  (ISO,ISS)
leukocyte migration involved in inflammatory response  (ISO,ISS)
lymphocyte chemotaxis  (ISO)
macrophage chemotaxis  (ISO)
microglial cell activation  (IDA)
microglial cell proliferation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of glutamate receptor signaling pathway  (IDA)
negative regulation of hippocampal neuron apoptotic process  (ISO)
negative regulation of interleukin-1 alpha production  (IDA)
negative regulation of microglial cell activation  (IDA)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vasoconstriction  (IDA)
neuron cellular homeostasis  (IDA)
neutrophil chemotaxis  (ISO)
positive chemotaxis  (ISO)
positive regulation of actin filament bundle assembly  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of calcium-independent cell-cell adhesion  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IGI,ISO)
positive regulation of cell adhesion  (IDA)
positive regulation of cell migration  (IBA,IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of macrophage chemotaxis  (IMP)
positive regulation of MAPK cascade  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of neuroblast proliferation  (IDA)
positive regulation of neuron projection development  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP,ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of transforming growth factor beta1 production  (ISO)
regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
response to hypoxia  (IEP)
response to ischemia  (IGI)
signal transduction  (IEA)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Small airway obstruction in severe pulmonary arterial hypertension correlates with increased airway CD8+ T-cells and fractalkine expression. Ars C, etal., Eur Respir J. 2009 Dec;34(6):1494-6.
2. Delta chemokine (fractalkine)--a novel mediator of pulmonary arterial hypertension in children undergoing cardiac surgery. Avni T, etal., Cytokine. 2010 Dec;52(3):143-5.
3. Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. Bachstetter AD, etal., Neurobiol Aging. 2011 Nov;32(11):2030-44. doi: 10.1016/j.neurobiolaging.2009.11.022. Epub 2009 Dec 16.
4. Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-regulation in a Rat Model of Chronic Stress. Bradesi S, etal., Gastroenterology. 2008 Dec 24.
5. Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling. Briones TL, etal., J Neuroinflammation. 2014 Jan 22;11:13. doi: 10.1186/1742-2094-11-13.
6. Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. Chandrasekar B, etal., Biochem J. 2003 Jul 15;373(Pt 2):547-58. doi: 10.1042/BJ20030207.
7. Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats. Chen YM, etal., Nephrol Dial Transplant. 2003 Dec;18(12):2505-14.
8. Expression of fractalkine (CX3CL1) and its receptor in endotoxin-induced uveitis. Chu L, etal., Ophthalmic Res. 2009;42(3):160-6. Epub 2009 Jul 31.
9. Infiltration of macrophages through the atrial endocardium of inflammation-induced rats: contribution of fractalkine. Date T, etal., Circ J. 2009 May;73(5):932-7. Epub 2009 Mar 12.
10. Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. Eccles R, etal., Respir Res. 2010 Aug 10;11:108.
11. Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation. Echigo T, etal., J Allergy Clin Immunol. 2004 May;113(5):940-8.
12. Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis. Fang IM, etal., Mol Vis. 2005 Jul 1;11:443-51.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Harrison JK, etal., Proc Natl Acad Sci U S A 1998 Sep 1;95(18):10896-901.
16. Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis. Hasegawa M, etal., Ann Rheum Dis. 2005 Jan;64(1):21-8.
17. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Heinisch S and Kirby LG, Neuroscience. 2009 Dec 15;164(3):1210-23. Epub 2009 Sep 10.
18. Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus. Herd KA, etal., J Gen Virol. 2010 May;91(Pt 5):1302-10. Epub 2010 Jan 6.
19. Fractalkine upregulates inflammation through CX3CR1 and the Jak-Stat pathway in severe acute pancreatitis rat model. Huang LY, etal., Inflammation. 2012 Jun;35(3):1023-30. doi: 10.1007/s10753-011-9406-5.
20. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Hughes PM, etal., Glia. 2002 Mar 15;37(4):314-27.
21. Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. Ito Y, etal., Kidney Int. 2002 Jun;61(6):2044-57.
22. Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Ji JF, etal., Stem Cells. 2004;22(3):415-27.
23. Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus. Katsuyama K, etal., Nephron Exp Nephrol. 2009;113(2):e45-56. Epub 2009 Jul 10.
24. Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Kikuchi T, etal., Infect Immun. 2005 Sep;73(9):5350-7.
25. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Kikuchi Y, etal., Nephron Exp Nephrol. 2004;97(1):e17-25.
26. Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome. Landi A, etal., Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28.
27. The chemokine CX3CL1 reduces migration and increases adhesion of neurons with mechanisms dependent on the beta1 integrin subunit. Lauro C, etal., J Immunol. 2006 Dec 1;177(11):7599-606.
28. [Effects of tetramethylpyrazine on fractalkine and tumor necrosis factor-alpha expression in patients with chronic pulmonary heart disease] Li L, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):373-5.
29. Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. Limatola C, etal., J Neuroimmunol. 2005 Sep;166(1-2):19-28. doi: 10.1016/j.jneuroim.2005.03.023.
30. Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barre syndrome. Luongo L, etal., Neurosci Lett. 2008 May 30;437(2):98-102. Epub 2008 Apr 10.
31. Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro. Lyons A, etal., J Neurochem. 2009 Sep;110(5):1547-56. doi: 10.1111/j.1471-4159.2009.06253.x. Epub 2009 Jul 15.
32. Elevated serum levels of soluble CX3CL1 in patients with microscopic polyangiitis. Matsunawa M, etal., Clin Exp Rheumatol. 2009 Jan-Feb;27(1):72-8.
33. CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. McComb JG, etal., Am J Pathol. 2008 Oct;173(4):949-61. Epub 2008 Sep 4.
34. Gut-brain chemokine changes in portal hypertensive rats. Merino J, etal., Dig Dis Sci. 2011 Aug;56(8):2309-17. doi: 10.1007/s10620-011-1625-y. Epub 2011 Feb 24.
35. Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition. Morimura S, etal., Am J Pathol. 2013 May;182(5):1640-7. doi: 10.1016/j.ajpath.2013.01.023. Epub 2013 Mar 5.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Changes in spinal cord expression of fractalkine and its receptor in a rat model of disc herniation by autologous nucleus pulposus. Park HW, etal., Spine (Phila Pa 1976). 2011 Jan 8.
38. Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Perros F, etal., Eur Respir J. 2007 May;29(5):937-43. Epub 2006 Dec 20.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. Rauer M, etal., J Neurovirol. 2002 Jan;8(3):168-79.
41. GOA pipeline RGD automated data pipeline
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. The CX3C chemokine fractalkine in allergic asthma and rhinitis. Rimaniol AC, etal., J Allergy Clin Immunol. 2003 Dec;112(6):1139-46.
44. A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
45. Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. Ruth JH, etal., Arthritis Rheum. 2001 Jul;44(7):1568-81.
46. Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia. Ryu J, etal., Cardiovasc Res. 2008 May 1;78(2):333-40. Epub 2007 Nov 11.
47. Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. Schafer A, etal., Blood. 2004 Jan 15;103(2):407-12. Epub 2003 Sep 11.
48. Neuronal expression of fractalkine in the presence and absence of inflammation. Schwaeble WJ, etal., FEBS Lett 1998 Nov 20;439(3):203-7.
49. NEW evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. Shan S, etal., Neurobiol Aging. 2009 Apr 14.
50. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
51. Greater fractalkine expression in mesenteric arteries of female spontaneously hypertensive rats compared with males. Sullivan JC, etal., Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1080-8. Epub 2009 Feb 6.
52. [Effects of aspirin on CX3CL1 and CX3CR1 in acute pulmonary embolism rats]. Sun C, etal., Zhonghua Yi Xue Za Zhi. 2013 Jan 1;93(1):69-72.
53. Inhibition of the Activation and Recruitment of Microglia-Like Cells Protects Against Neomycin-Induced Ototoxicity. Sun S, etal., Mol Neurobiol. 2014 May 1.
54. CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin. Sunnemark D, etal., J Neuroinflammation. 2005 Jul 29;2:17.
55. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity. Suzuki F, etal., Arthritis Res Ther. 2012 Mar 6;14(2):R48. doi: 10.1186/ar3761.
56. Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat. Tarozzo G, etal., Eur J Neurosci. 2002 May;15(10):1663-8.
57. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Verge GM, etal., Eur J Neurosci 2004 Sep;20(5):1150-60.
58. Expression of CX3CL1 and its receptor, CX3CR1, in the development of periapical lesions. Wang L, etal., Int Endod J. 2014 Mar;47(3):271-9. doi: 10.1111/iej.12143. Epub 2013 Jul 6.
59. [Effect of Shenqi Fuzheng injection on fractalkine expression in lung tissue of rats with lipopolysaccharide-induced acute lung injury]. Wang L, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Jan;27(1):55-9.
60. Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. Yang JL, etal., Mol Brain. 2012 May 30;5:18. doi: 10.1186/1756-6606-5-18.
61. The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus. Yeo SI, etal., J Neuroimmunol. 2011 May;234(1-2):93-102. doi: 10.1016/j.jneuroim.2011.03.005. Epub 2011 Apr 8.
62. Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. Yoshida T, etal., Cardiovasc Res. 2005 Nov 1;68(2):278-88. Epub 2005 Jul 12.
63. Expression of fractalkine and fractalkine receptor in urinary bladder after cyclophosphamide (CYP)-induced cystitis. Yuridullah R, etal., Auton Neurosci. 2006 Jun 30;126-127:380-9. Epub 2006 May 2.
64. The role of CX(3)CL1/CX(3)CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental hepatopulmonary syndrome. Zhang J, etal., J Hepatol. 2012 Oct;57(4):752-8. doi: 10.1016/j.jhep.2012.05.014. Epub 2012 May 29.
65. [The change of fractalkine in lung tissue of rat with hypoxic pulmonary hypertension]. Zheng BX, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Mar;39(2):227-30.
66. Fractalkine and CX3CR1 are involved in the migration of intravenously grafted human bone marrow stromal cells toward ischemic brain lesion in rats. Zhu J, etal., Brain Res. 2009 Sep 1;1287:173-83. Epub 2009 Jun 27.
67. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Zujovic V, etal., Glia. 2000 Feb 15;29(4):305-15.
Additional References at PubMed
PMID:9177350   PMID:10187784   PMID:10415068   PMID:10869418   PMID:10899174   PMID:11777952   PMID:12125082   PMID:12631113   PMID:12714508   PMID:12815711   PMID:12837921   PMID:15111313  
PMID:15321787   PMID:15525271   PMID:15993821   PMID:16234287   PMID:16272359   PMID:16413026   PMID:16980051   PMID:17174525   PMID:17430890   PMID:17953351   PMID:17971299   PMID:18097059  
PMID:18292196   PMID:18322241   PMID:18971423   PMID:19422292   PMID:19474321   PMID:21829356   PMID:21840883   PMID:22387113   PMID:22435508   PMID:22536384   PMID:22871113   PMID:23125415  
PMID:23147224   PMID:23361876   PMID:23400803   PMID:23718544   PMID:23776243   PMID:23897050   PMID:23953563   PMID:23968561   PMID:24036597   PMID:24175290   PMID:24294368   PMID:24603149  
PMID:24731444   PMID:25195598   PMID:25435433   PMID:25494456   PMID:25559502   PMID:25768734   PMID:27209190   PMID:27923568   PMID:28612258   PMID:28849713   PMID:29313211   PMID:30248434  
PMID:32127397   PMID:32152663   PMID:32664639   PMID:32664984   PMID:32692220   PMID:32819407   PMID:33969675   PMID:34629047   PMID:35382731   PMID:37045646   PMID:38937701  


Genomics

Comparative Map Data
Cx3cl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,233,326 - 10,244,856 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1910,233,329 - 10,242,999 (-)EnsemblGRCr8
mRatBN7.21910,227,337 - 10,237,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,227,340 - 10,236,833 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,190,578 - 10,200,058 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,957,425 - 10,966,906 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,244,371 - 10,253,854 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,644,267 - 10,654,861 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,644,244 - 10,653,800 (-)Ensemblrn6Rnor6.0
Rnor_5.01910,638,466 - 10,647,951 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41910,666,940 - 10,676,424 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,113,300 - 10,122,786 (-)NCBICelera
RGSC_v3.11910,671,765 - 10,681,250 (-)NCBI
Cytogenetic Map19p13NCBI
CX3CL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,372,490 - 57,385,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,372,477 - 57,385,044 (+)Ensemblhg38GRCh38
GRCh371657,406,402 - 57,418,956 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,963,915 - 55,976,457 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341655,963,914 - 55,976,455NCBI
Celera1641,906,410 - 41,918,956 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,274,294 - 43,286,836 (+)NCBIHuRef
CHM1_11658,814,629 - 58,827,168 (+)NCBICHM1_1
T2T-CHM13v2.01663,167,607 - 63,180,165 (+)NCBIT2T-CHM13v2.0
Cx3cl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,498,808 - 95,509,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,498,637 - 95,509,055 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38894,772,180 - 94,782,427 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,772,009 - 94,782,427 (+)Ensemblmm10GRCm38
MGSCv37897,296,080 - 97,306,327 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36897,661,355 - 97,671,556 (+)NCBIMGSCv36mm8
Celera899,100,414 - 99,110,655 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.79NCBI
Cx3cl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,023,050 - 15,034,711 (+)Ensembl
ChiLan1.0NW_00495543315,023,272 - 15,034,650 (+)NCBIChiLan1.0ChiLan1.0
CX3CL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,840,670 - 66,853,297 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,761,444 - 72,774,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,646,447 - 37,659,078 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,779,065 - 56,791,760 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,779,065 - 56,791,760 (+)EnsemblpanPan2panpan1.1
CX3CL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,022,794 - 59,032,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,022,794 - 59,032,095 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha255,652,232 - 55,661,533 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0259,561,127 - 59,570,437 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,559,167 - 59,570,279 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,392,704 - 56,402,005 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,400,382 - 57,409,687 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,293,678 - 58,302,979 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cx3cl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,134,360 - 50,145,250 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,443,733 - 9,455,062 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,443,851 - 9,454,715 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CX3CL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1619,312,351 - 19,324,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,304,118 - 17,315,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CX3CL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,310,711 - 43,323,533 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,310,753 - 43,323,529 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604732,993,345 - 33,006,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cx3cl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,677,709 - 28,689,122 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474628,677,956 - 28,688,638 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cx3cl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1171,660,099 - 1,671,117 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cx3cl1
83 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:330
Count of miRNA genes:195
Interacting mature miRNAs:250
Transcripts:ENSRNOT00000022128
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
U92565  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,227,908 - 10,228,061 (+)MAPPERmRatBN7.2
Rnor_6.01910,644,839 - 10,644,991NCBIRnor6.0
Rnor_5.01910,639,030 - 10,639,182UniSTSRnor5.0
RGSC_v3.41910,667,504 - 10,667,656UniSTSRGSC3.4
Celera1910,113,864 - 10,114,016UniSTS
Cytogenetic Map19p12UniSTS
BF390094  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,235,251 - 10,235,409 (+)MAPPERmRatBN7.2
Rnor_6.01910,652,182 - 10,652,339NCBIRnor6.0
Rnor_5.01910,646,373 - 10,646,530UniSTSRnor5.0
RGSC_v3.41910,674,845 - 10,675,002UniSTSRGSC3.4
Celera1910,121,207 - 10,121,364UniSTS
RH 3.4 Map1997.1UniSTS
Cytogenetic Map19p12UniSTS
PMC86945P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,229,962 - 10,230,173 (+)MAPPERmRatBN7.2
Rnor_6.01910,646,893 - 10,647,103NCBIRnor6.0
Rnor_5.01910,641,084 - 10,641,294UniSTSRnor5.0
RGSC_v3.41910,669,558 - 10,669,768UniSTSRGSC3.4
Celera1910,115,918 - 10,116,128UniSTS
Cytogenetic Map19p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 38 59 6 302 138 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022128   ⟹   ENSRNOP00000022128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1910,233,329 - 10,242,999 (-)Ensembl
mRatBN7.2 Ensembl1910,227,340 - 10,236,833 (-)Ensembl
Rnor_6.0 Ensembl1910,644,244 - 10,653,800 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112965   ⟹   ENSRNOP00000077452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,227,340 - 10,232,896 (-)Ensembl
RefSeq Acc Id: NM_134455   ⟹   NP_604450
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,233,334 - 10,242,820 (-)NCBI
mRatBN7.21910,227,345 - 10,236,832 (-)NCBI
Rnor_6.01910,644,275 - 10,653,761 (-)NCBI
Rnor_5.01910,638,466 - 10,647,951 (-)NCBI
RGSC_v3.41910,666,940 - 10,676,424 (-)RGD
Celera1910,113,300 - 10,122,786 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772329   ⟹   XP_008770551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,233,326 - 10,244,856 (-)NCBI
mRatBN7.21910,227,337 - 10,237,826 (-)NCBI
Rnor_6.01910,644,267 - 10,654,861 (-)NCBI
Sequence:
RefSeq Acc Id: NP_604450   ⟸   NM_134455
- Peptide Label: precursor
- UniProtKB: O55145 (UniProtKB/Swiss-Prot),   Q6IRF7 (UniProtKB/TrEMBL),   A6JY48 (UniProtKB/TrEMBL),   F7EX30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770551   ⟸   XM_008772329
- Peptide Label: isoform X1
- UniProtKB: O55145 (UniProtKB/Swiss-Prot),   Q6IRF7 (UniProtKB/TrEMBL),   A6JY48 (UniProtKB/TrEMBL),   F7EX30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022128   ⟸   ENSRNOT00000022128
Ensembl Acc Id: ENSRNOP00000077452   ⟸   ENSRNOT00000112965
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55145-F1-model_v2 AlphaFold O55145 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700942
Promoter ID:EPDNEW_R11466
Type:single initiation site
Name:Cx3cl1_1
Description:C-X3-C motif chemokine ligand 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01910,653,810 - 10,653,870EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620458 AgrOrtholog
BioCyc Gene G2FUF-6512 BioCyc
Ensembl Genes ENSRNOG00000016326 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022128 ENTREZGENE
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099250 IMAGE-MGC_LOAD
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CX3C UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:89808 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91495 IMAGE-MGC_LOAD
NCBI Gene 89808 ENTREZGENE
PANTHER PTHR12015 UniProtKB/Swiss-Prot
  PTHR12015:SF92 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Cx3cl1 PhenoGen
PRINTS FRACTALKINE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016326 RatGTEx
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A0ABZ3NN76_RAT UniProtKB/TrEMBL
  A6JY48 ENTREZGENE, UniProtKB/TrEMBL
  F7EX30 ENTREZGENE, UniProtKB/TrEMBL
  O55145 ENTREZGENE
  Q6IRF7 ENTREZGENE
  X3CL1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Cx3cl1  C-X3-C motif chemokine ligand 1  Cx3cl1  chemokine (C-X3-C motif) ligand 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Cx3cl1  chemokine (C-X3-C motif) ligand 1      Symbol and Name status set to approved 625702 APPROVED
2003-03-04 Cx3cl1  chemokine (C-X3-C motif) ligand 1  Scyd1  small inducible cytokine subfamily D, 1  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-08-07 Scyd1  small inducible cytokine subfamily D, 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a Cys-X-X-X-Cys motif 728291