RGD Reference Report - Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barre syndrome. - Rat Genome Database

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Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barre syndrome.

Authors: Luongo, L  Sajic, M  Grist, J  Clark, AK  Maione, S  Malcangio, M 
Citation: Luongo L, etal., Neurosci Lett. 2008 May 30;437(2):98-102. Epub 2008 Apr 10.
RGD ID: 4891968
Pubmed: PMID:18448252   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2008.04.019   (Journal Full-text)

Guillain-Barre syndrome (GBS) is an inflammatory disease of the peripheral nervous system which can cause pain via mechanisms that are poorly understood. Here, we show that in rat experimental autoimmune neuritis (EAN) mechanical allodynia developed up to 9 days before the onset of detectable neurological deficits. Allodynia was associated with an increase in the number of microglial cells in the dorsal horn of the spinal cord. The expression of the chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 were also higher in EAN than in control dorsal horns suggesting spinal microglia and CX3CL1/CX3CR1 may play a role in the pain-like behaviour.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Cx3cl1  (C-X3-C motif chemokine ligand 1)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Mus musculus)
Cx3cl1  (C-X3-C motif chemokine ligand 1)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Homo sapiens)
CX3CL1  (C-X3-C motif chemokine ligand 1)
CX3CR1  (C-X3-C motif chemokine receptor 1)


Additional Information