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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cx3cl1
Name: C-X3-C motif chemokine ligand 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cx3cl1increases expressionISOCx3cl1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CX3CL1 mRNAPMID:26582142
Cx3cl1increases expressionISOCX3CL1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CX3CL1 mRNAPMID:35811015
Cx3cl1increases secretionISOCX3CL1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of CX3CL1 proteinPMID:32800949
Cx3cl1multiple interactionsISOCx3cl1 (Mus musculus)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CX3CL1 mRNA]PMID:26582142
Cx3cl1multiple interactionsISOCX3CL1 (Homo sapiens)6480464CTD2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased secretion of CX3CL1 protein]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CX3CL1 mRNA]PMID:32800949 PMID:35811015
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