Gene:	F2 ( Rattus norvegicus ) coagulation factor II (thrombin)
Description:	catalyzes the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptides A and B; involved in blood coagulation and wound repair
Synonyms:	coagulation factor II; coagulation factor 2;
ArrayIDs:	5672073; 5670405; 6694921; M81397_at; 6105363; A_44_P208138; GE1291746; 6559358; 6137484; 1368442_at; 5796386; 6335391; 5675550; 5725205; 6217138; 5922125; 6145724; 5996491; 6484754; A_42_P621864;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: F2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: F2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus F2 genome assembly 3.1 3 75901694 - 75914982     Rat Celera Assembly 3 76801005 - 76814285     RGSC genome assembly v3.4 3 76005323 - 76018608     Cytogenetic 3 q24 Mus musculus F2 Mouse genome assembly build 36.1 2 91465477 - 91476571     Cytogenetic 2 2 E1 Homo sapiens F2 human genome assembly 11 46697330 - 46717631     Human genome assembly build 36.2 11 46697331 - 46717631     Cytogenetic 11 p11   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology thrombospondin receptor activity,  peptidase activity,  serine-type endopeptidase activity ...  (details...)
Biological Process	Gene Ontology platelet activation,  wound healing,  positive regulation of blood coagulation ...  (details...)
Cellular Component	Gene Ontology extracellular space,  extracellular region,  plasma membrane (details...)
Disease	Ontology Glioma,  Diabetes Mellitus, Experimental,  Hyperglycemia ...  (details...)
Pathway	Ontology protein C anticoagulant pathway,  coagulation cascade pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: Tryp_SPc IPI SMART: GLA IPI SMART: KR IPI PROSITE: TRYPSIN_SER IPI PROSITE: GLA_1 IPI PROSITE: GLA_2 IPI PROSITE: KRINGLE_1 IPI PROSITE: KRINGLE_2 IPI PROSITE: TRYPSIN_HIS IPI PROSITE: TRYPSIN_DOM IPI UNIPARC: UPI0000136ECE IPI KEGG Report: rno:29251 ENTREZGENE HomoloGene Group ID: 426 ENTREZGENE Germonline: 61996 Pfam: Kringle IPI Pfam: Gla IPI Pfam: Thrombin_light IPI Pfam: Trypsin IPI KEGG Pathway: 04610 ENTREZGENE KEGG Pathway: 04080 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE InterPro: Kringle. IPI InterPro: Coagulation_factor_Gla. IPI InterPro: GLA_domain. IPI InterPro: Kringle-like. IPI InterPro: Kringle_CS. IPI InterPro: Kringle_sub. IPI InterPro: Peptidase_S1/S6_AS. IPI InterPro: Peptidase_S1_S6. IPI InterPro: Peptidase_S1A. IPI InterPro: Peptidase_S1A_pr. IPI InterPro: Peptidase_S1A_prothrombin. IPI InterPro: Thrombin_light_chain. IPI InterPro: Ser/Cys_Pept_Trypsin-like. IPI Ensembl Protein: ENSRNOP00000022233 IPI IPI: IPI00189981 IPI Gene3D-CATH: Kringle IPI Gene3D-CATH: Thrombin_light_chain IPI Entrez Gene: F2 ENTREZGENE PIRSF: Thrombin IPI TIGR: TC220290 UniProt: THRB_RAT IPI Ensembl Genes: ENSRNOG00000016325 IPI Superfamily-SCOP: Kringle-like IPI Superfamily-SCOP: Pept_Ser_Cys IPI Superfamily-SCOP: VitK_dep_GLA IPI PANTHER: Peptidase_S1A_pr IPI PRINTS: PROTHROMBIN. IPI PRINTS: CHYMOTRYPSIN. IPI PRINTS: GLABLOOD. IPI PRINTS: KRINGLE. IPI
Sequences	Nucleotide: EX492416 Get FASTA Search GEO Profiles Nucleotide: DW392486 Get FASTA Search GEO Profiles Nucleotide: DW391550 Get FASTA Search GEO Profiles Nucleotide: CO575133 Get FASTA Search GEO Profiles Nucleotide: DY318887 Get FASTA Search GEO Profiles Nucleotide: M81397 Get FASTA Search GEO Profiles Nucleotide: CH473949 Get FASTA Search GEO Profiles Nucleotide: X52835 Get FASTA Search GEO Profiles Nucleotide: NM_022924 Get FASTA Search GEO Profiles (View all 9 Nucleotide Accessions) Protein: EDL79531 Get FASTA Protein: AAA42240 Get FASTA Protein: P18292 Get FASTA Protein: EDL79532 Get FASTA Protein: CAA37017 Get FASTA Protein: NP_075213 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 54498
References
Curated References	20 references in RGD related to F2
Other References	18 other references at PubMed related to F2
Database Information
RGD ID	61996
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 09-SEP-08: F2 coagulation factor II (thrombin) F2 coagulation factor II APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 28-MAR-06: coagulation factor II F2 coagulation factor 2 APPROVED Name updated to reflect Human and Mouse nomenclature 1299863 14-DEC-04: F2 coagulation factor 2 APPROVED Symbol and Name status set to approved 1299863 10-JUN-02: F2 coagulation factor 2 PROVISIONAL Name updated 70585