Gclc (glutamate-cysteine ligase, catalytic subunit) - Rat Genome Database

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Gene: Gclc (glutamate-cysteine ligase, catalytic subunit) Rattus norvegicus
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Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
RGD ID: 619868
Description: Enables glutamate-cysteine ligase activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to hepatocyte growth factor stimulus; and cellular response to mechanical stimulus. Part of glutamate-cysteine ligase complex. Used to study liver cirrhosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit); PARTICIPATES IN glutathione metabolic pathway; 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,1'-azobis(N,N-dimethylformamide).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gamma-ECS; gamma-glutamylcysteine synthetase; GCS heavy chain; Glclc; glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase catalytic subunit; Glutamylcysteine gamma synthetase light chain; MGC93096
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,510,251 - 87,548,896 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl887,510,463 - 87,548,893 (+)EnsemblGRCr8
mRatBN7.2878,629,899 - 78,668,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx884,117,437 - 84,155,850 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,394,078 - 82,432,491 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,216,769 - 80,255,182 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)Ensemblrn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera878,379,669 - 78,418,088 (+)NCBICelera
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+/-)-Aegeline  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(chloromethyl)pyridine  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-phenyl-3-furoxancarbonitrile  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-methylcytosine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-dihydroxycoumarin  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (EXP)
acetic acid  (ISO)
acetylcholine  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (EXP)
alachlor  (EXP)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
alloxan  (EXP)
allyl isothiocyanate  (ISO)
allyl methyl disulfide  (ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
alpha-Solamarine  (ISO)
Altertoxin II  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimonite  (ISO)
antimony(0)  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
astilbin  (ISO)
atrazine  (ISO)
Augmentin  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
Bandrowski's base  (ISO)
Bardoxolone methyl  (ISO)
bellidifolin  (EXP)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
benzoquinones  (ISO)
berberine  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bleomycin A5  (ISO)
boric acid  (ISO)
bortezomib  (EXP)
bosentan  (ISO)
brequinar  (ISO)
Brodifacoum  (EXP)
bromobenzene  (ISO)
Bromochloroacetonitrile  (ISO)
Brusatol  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
butane-2,3-dione  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cadmium sulfide  (ISO)
cafestol  (EXP)
caffeine  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon disulfide  (EXP)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
carnosic acid  (EXP,ISO)
Carnosol  (ISO)
carvacrol  (EXP)
celastrol  (EXP)
ceric oxide  (EXP)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
Chloroacetonitrile  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
citraconic acid  (EXP,ISO)
clavulanic acid  (ISO)
Clivoline  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coniferyl aldehyde  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP,ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
cysteamine  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (EXP,ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzoylmethane  (ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichloroacetonitrile  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
diethyl malate  (ISO)
diethyl maleate  (EXP,ISO)
diethyl phthalate  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydrogen  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimerumic acid  (ISO)
dimethyl fumarate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dinoseb  (ISO)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (ISO)
diprotium oxide  (ISO)
diquat  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
domoic acid  (ISO)
dopamine  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
emodin  (EXP)
endosulfan  (EXP)
entacapone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erastin  (EXP)
erdosteine  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl acrylate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesal  (ISO)
farrerol  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
fipronil  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (EXP)
fumaraldehyde  (ISO)
furan  (EXP,ISO)
galactose  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gamma-linolenic acid  (ISO)
Gastrodin  (EXP,ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
ginsenoside Rg1  (ISO)
Ginsenoside Rh4  (EXP,ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glycerol 2-phosphate  (EXP)
guggulsterone  (ISO)
hemin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexane  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (EXP,ISO)
iron atom  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoeugenol  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (ISO)
isorhamnetin  (EXP,ISO)
isothiocyanate  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (EXP)
ketamine  (EXP)
ketoprofen  (ISO)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP)
L-methionine  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP)
Leonurine  (EXP)
levofloxacin  (EXP)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
luteolin  (EXP)
Luteolin 7-methyl ether  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
maneb  (EXP,ISO)
melatonin  (ISO)
meloxicam  (ISO)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl non-2-ynoate  (ISO)
methyl salicylate  (ISO)
methylene blue  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Methysticin  (ISO)
microcystin  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (EXP)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naled  (ISO)
naphthalene  (EXP,ISO)
naphthalene-1,2-diol  (ISO)
naproxen  (ISO)
naringin  (EXP)
nectandrin B  (ISO)
nefazodone  (EXP)
neoastilbin  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nimustine  (ISO)
nitisinone  (ISO)
nitric oxide  (EXP)
nitrofurantoin  (ISO)
Nivalenol  (ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
norswertianolin  (EXP)
notoginsenoside R1  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
Polpunonic acid  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procyanidin  (ISO)
progesterone  (ISO)
propacetamol  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
prostaglandin J2  (EXP)
puerarin  (EXP,ISO)
pyocyanine  (ISO)
pyrazines  (ISO)
pyrethrins  (EXP)
Pyridostigmine bromide  (EXP)
pyrroloquinoline quinone  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP,ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
rutin  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
selenocystine  (ISO)
selenomethionine  (ISO)
sevoflurane  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
spironolactone  (EXP)
staurosporine  (ISO)
stavudine  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sunitinib  (ISO)
suprofen  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tectorigenin  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP)
thiabendazole  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
Timosaponin b ii  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
triacsin C  (ISO)
tributylstannane  (ISO)
Trichloroacetonitrile  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
tyloxapol  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanillin  (ISO)
verteporfin  (ISO)
vincristine  (ISO)
vitamin E  (EXP,ISO)
water  (ISO)
withaferin A  (ISO)
XAV939  (ISO)
yohimbine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (IEA,ISO,ISS)
cell redox homeostasis  (IEA,ISO,ISS)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hepatocyte growth factor stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to thyroxine stimulus  (IEP)
cysteine metabolic process  (IEA,ISO,ISS)
glutamate metabolic process  (IEA,ISO,ISS)
glutathione biosynthetic process  (IBA,IEA,IMP,ISO,ISS)
glutathione metabolic process  (ISO)
L-ascorbic acid metabolic process  (ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of hepatic stellate cell activation  (IMP)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of protein ubiquitination  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
regulation of mitochondrial depolarization  (ISO)
response to activity  (IEP)
response to arsenic-containing substance  (ISO)
response to auditory stimulus  (ISO)
response to cadmium ion  (IEP)
response to heat  (IEA,ISO,ISS)
response to hormone  (IEA,ISO,ISS)
response to human chorionic gonadotropin  (IEP)
response to interleukin-1  (IEP)
response to nitrosative stress  (IMP)
response to nutrient  (IEP)
response to oxidative stress  (IEA,IMP,ISO,ISS)
response to xenobiotic stimulus  (ISO)

Cellular Component
cytosol  (IEA,ISO)
glutamate-cysteine ligase complex  (IBA,IDA,IEA,ISO)
mitochondrion  (IEA)

Molecular Function
ADP binding  (IEA,ISO,ISS)
ATP binding  (IEA)
catalytic activity  (IEA)
glutamate binding  (IEA,ISO,ISS)
glutamate-cysteine ligase activity  (IBA,IDA,IEA,IMP,ISO,ISS)
ligase activity  (IEA)
magnesium ion binding  (IEA,ISO,ISS)
nucleotide binding  (IEA)
protein binding  (ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity. Akai S, etal., J Biol Chem. 2007 Aug 17;282(33):23996-4003. Epub 2007 Jun 15.
2. Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia. Beutler E, etal., Blood 1990 Jan 1;75(1):271-3.
3. The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. Beutler E, etal., Blood 1999 Oct 15;94(8):2890-4.
4. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. Chen CN, etal., J Gerontol A Biol Sci Med Sci. 2010 Feb;65(2):129-37. doi: 10.1093/gerona/glp194. Epub 2009 Dec 16.
5. Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Dasgupta A, etal., Free Radic Biol Med. 2007 Mar 1;42(5):617-26. Epub 2006 Dec 15.
6. Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons. Diaz-Hernandez JI, etal., J Biol Chem. 2005 Nov 25;280(47):38992-9001. Epub 2005 Sep 23.
7. Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity. Fernandes CJ, etal., Toxicol Lett. 2002 Dec 15;136(2):107-20.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells. Gualtieri AF, etal., Int J Androl. 2009 Jun;32(3):218-25. Epub 2007 Nov 27.
11. HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA. Hui L, etal., Free Radic Biol Med. 2010 Aug 1;49(3):467-73. doi: 10.1016/j.freeradbiomed.2010.05.002. Epub 2010 May 11.
12. Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats. Jang HI, etal., Nutr Res Pract. 2014 Jun;8(3):272-7. doi: 10.4162/nrp.2014.8.3.272. Epub 2014 May 15.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes. Kim SK, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):99-108. Epub 2004 May 28.
15. Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction. Koide S, etal., J Am Coll Cardiol 2003 Feb 19;41(4):539-45.
16. Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Kuo MT, etal., Cancer Res. 1996 Aug 15;56(16):3642-4.
17. Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. Lee JI, etal., Biochem J. 2006 Jan 1;393(Pt 1):181-90.
18. Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study. Marson FA, etal., BMC Med Genet. 2014 Mar 4;15:27. doi: 10.1186/1471-2350-15-27.
19. Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. McKone EF, etal., Am J Respir Crit Care Med. 2006 Aug 15;174(4):415-9. Epub 2006 May 11.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. Ramani K, etal., J Biol Chem. 2012 Oct 19;287(43):36341-55. doi: 10.1074/jbc.M112.370775. Epub 2012 Aug 31.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia. Ristoff E, etal., Blood. 2000 Apr 1;95(7):2193-6.
30. Enhanced expression of pulmonary gamma-glutamylcysteine synthetase heavy subunit in rats exposed to cadmium aerosols. Shukla GS, etal., Toxicol Appl Pharmacol. 2000 Mar 15;163(3):249-59.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. Tran PO, etal., J Biol Chem. 2004 Dec 24;279(52):53988-93. Epub 2004 Oct 12.
33. Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific. Tsai-Turton M and Luderer U, Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E391-402. Epub 2005 Apr 5.
34. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Tsuchiya K, etal., Genomics 1995 Dec 10;30(3):630-2.
35. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
36. Amino acid sequence of rat kidney gamma-glutamylcysteine synthetase. Yan N and Meister A, J Biol Chem 1990 Jan 25;265(3):1588-93.
37. Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone. Yang H, etal., J Biol Chem 2002 Sep 20;277(38):35232-9.
38. Rice protein improves oxidative stress by regulating glutathione metabolism and attenuating oxidative damage to lipids and proteins in rats. Yang L, etal., Life Sci. 2012 Oct 5;91(11-12):389-94. doi: 10.1016/j.lfs.2012.08.003. Epub 2012 Aug 11.
39. Cyclic stretch magnitude and duration affect rat alveolar epithelial gene expression. Yerrapureddy A, etal., Cell Physiol Biochem. 2010;25(1):113-22. doi: 10.1159/000272056. Epub 2009 Dec 22.
40. The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix. Zhao Y, etal., Toxicology. 2010 Jan 12;267(1-3):60-9. Epub 2009 Oct 29.
Additional References at PubMed
PMID:24639   PMID:8104187   PMID:9675072   PMID:9841880   PMID:10395918   PMID:10439045   PMID:10805773   PMID:10966520   PMID:11118286   PMID:11972604   PMID:12384496   PMID:12663448  
PMID:12784246   PMID:12967637   PMID:15288121   PMID:15489334   PMID:15988009   PMID:16081425   PMID:16198230   PMID:16758951   PMID:17045015   PMID:17189825   PMID:17681938   PMID:17721935  
PMID:19459163   PMID:19540342   PMID:20732396   PMID:20732852   PMID:21984568   PMID:23682816   PMID:25016074   PMID:27998794  


Genomics

Comparative Map Data
Gclc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,510,251 - 87,548,896 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl887,510,463 - 87,548,893 (+)EnsemblGRCr8
mRatBN7.2878,629,899 - 78,668,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx884,117,437 - 84,155,850 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,394,078 - 82,432,491 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,216,769 - 80,255,182 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)Ensemblrn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera878,379,669 - 78,418,088 (+)NCBICelera
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Cytogenetic Map8q31NCBI
GCLC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38653,497,341 - 53,545,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl653,497,341 - 53,616,970 (-)Ensemblhg38GRCh38
GRCh37653,362,139 - 53,409,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36653,470,098 - 53,517,790 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34653,470,097 - 53,517,790NCBI
Celera655,024,301 - 55,071,990 (-)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef653,193,712 - 53,241,391 (-)NCBIHuRef
CHM1_1653,363,932 - 53,411,726 (-)NCBICHM1_1
T2T-CHM13v2.0653,337,262 - 53,388,129 (-)NCBIT2T-CHM13v2.0
Gclc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)Ensemblmm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBIMGSCv36mm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
Gclc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554112,593,541 - 2,616,539 (+)Ensembl
ChiLan1.0NW_0049554112,593,523 - 2,617,553 (+)NCBIChiLan1.0ChiLan1.0
GCLC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2567,968,397 - 68,019,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,844,833 - 63,895,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0653,052,145 - 53,102,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1654,687,315 - 54,738,111 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,687,315 - 54,734,994 (-)EnsemblpanPan2panpan1.1
GCLC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,999,815 - 21,047,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1220,898,243 - 20,947,109 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01221,495,557 - 21,544,499 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,996,643 - 21,045,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01221,104,936 - 21,153,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01221,243,198 - 21,292,135 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gclc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,541,439 - 56,588,950 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,371,149 - 7,418,958 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364767,371,270 - 7,418,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl727,209,565 - 27,253,530 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1727,209,565 - 27,253,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2731,702,759 - 31,747,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCLC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,012,994 - 19,060,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604453,368,286 - 53,415,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gclc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850749,050 - 793,959 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624850749,046 - 793,654 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gclc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1872,004,657 - 72,040,891 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gclc
153 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:236
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000033196
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat

Markers in Region
RH128816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2878,668,270 - 78,668,474 (+)MAPPERmRatBN7.2
Rnor_6.0885,097,195 - 85,097,398NCBIRnor6.0
Rnor_5.0884,665,912 - 84,666,115UniSTSRnor5.0
RGSC_v3.4882,762,572 - 82,762,775UniSTSRGSC3.4
Celera878,417,812 - 78,418,015UniSTS
RH 3.4 Map8923.9UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033196   ⟹   ENSRNOP00000035540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl887,510,463 - 87,548,893 (+)Ensembl
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)Ensembl
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119398   ⟹   ENSRNOP00000081649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl887,510,463 - 87,548,893 (+)Ensembl
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)Ensembl
RefSeq Acc Id: NM_012815   ⟹   NP_036947
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,510,476 - 87,548,896 (+)NCBI
mRatBN7.2878,630,127 - 78,668,547 (+)NCBI
Rnor_6.0885,059,051 - 85,097,471 (+)NCBI
Rnor_5.0884,627,768 - 84,666,188 (+)NCBI
RGSC_v3.4882,724,429 - 82,762,848 (+)RGD
Celera878,379,669 - 78,418,088 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080870   ⟹   XP_038936798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,510,251 - 87,541,472 (+)NCBI
mRatBN7.2878,629,899 - 78,661,120 (+)NCBI
RefSeq Acc Id: XM_063264945   ⟹   XP_063121015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,528,434 - 87,548,896 (+)NCBI
RefSeq Acc Id: NP_036947   ⟸   NM_012815
- UniProtKB: P19468 (UniProtKB/Swiss-Prot),   A6I1G6 (UniProtKB/TrEMBL),   A0A8I5ZU55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035540   ⟸   ENSRNOT00000033196
RefSeq Acc Id: XP_038936798   ⟸   XM_039080870
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000081649   ⟸   ENSRNOT00000119398
RefSeq Acc Id: XP_063121015   ⟸   XM_063264945
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZU55 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19468-F1-model_v2 AlphaFold P19468 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619868 AgrOrtholog
BioCyc Gene G2FUF-29780 BioCyc
BioCyc Pathway GLUTATHIONESYN-PWY [glutathione biosynthesis] BioCyc
BioCyc Pathway Image GLUTATHIONESYN-PWY BioCyc
Ensembl Genes ENSRNOG00000006302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033196 ENTREZGENE
  ENSRNOT00000033196.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.8.960 UniProtKB/Swiss-Prot
  3.30.590.50 UniProtKB/Swiss-Prot
InterPro GCS UniProtKB/Swiss-Prot
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:25283 UniProtKB/Swiss-Prot
NCBI Gene 25283 ENTREZGENE
PANTHER GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
  PTHR11164 UniProtKB/Swiss-Prot
Pfam GCS UniProtKB/Swiss-Prot
PhenoGen Gclc PhenoGen
RatGTEx ENSRNOG00000006302 RatGTEx
Superfamily-SCOP SSF55931 UniProtKB/Swiss-Prot
UniProt A0A8I5ZU55 ENTREZGENE, UniProtKB/TrEMBL
  A6I1G6 ENTREZGENE, UniProtKB/TrEMBL
  A6I1G7_RAT UniProtKB/TrEMBL
  A6I1G8_RAT UniProtKB/TrEMBL
  GSH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gclc  glutamate-cysteine ligase, catalytic subunit    glutamate-cysteine ligase catalytic subunit  Name updated 1299863 APPROVED
2003-04-09 Gclc  glutamate-cysteine ligase catalytic subunit      Symbol and Name updated 629477 APPROVED
2003-03-14 Gclc  glutamate-cysteine ligase catalytic subunit  Glclc  Glutamylcysteine gamma synthetase light chain  Data merged from RGD:2700 628472 PROVISIONAL
2002-08-07 Gclc        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Glclc  Glutamylcysteine gamma synthetase light chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression reduced in response to some types of liver damage 70249
gene_protein 637 amino acids; 72.6 kDA 632745